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Current Oncology Reports

Erschienen in:

01.12.2017 | Head and Neck Cancers (EY Hanna, Section Editor)

Reirradiation of Skull Base Tumors With Advanced Highly Conformal Techniques

verfasst von: Jennifer C. Ho, Jack Phan

Erschienen in: Current Oncology Reports | Ausgabe 12/2017

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Abstract

Purpose of Review

Skull base reirradiation is challenging due to complex anatomy, enrichment of treatment-resistant clonogens, and increased risk of severe treatment complications. Without local therapy, early mortality is certain and tumor progression can result in debilitating symptoms. Modern radiotherapy advancements, such as image-guided radiation therapy (IGRT), intensity-modulated radiation therapy (IMRT), particle therapy, and stereotactic radiation therapy (SRT), are attractive for skull base reirradiation.

Recent Findings

Although limited by their retrospective nature and heterogeneous patient populations, several studies have demonstrated that reirradiation with these highly conformal techniques is feasible. Compared to IMRT or particle therapy reirradiation, SRT reirradiation appears promising with lower toxicity and increased convenience.

Summary

Here, we provide thorough explanations for each technology and summarize the most relevant and recent studies, with particular attention to efficacy and toxicity. Skull base reirradiation using these extremely conformal therapy techniques requires meticulous treatment planning and should be delivered by experienced teams.

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Titel: Reirradiation of Skull Base Tumors With Advanced Highly Conformal Techniques
verfasst von: Jennifer C. Ho
Jack Phan
Publikationsdatum: 01.12.2017
Verlag: Springer US
Erschienen in: Current Oncology Reports / Ausgabe 12/2017
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-017-0639-9

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Reirradiation of Skull Base Tumors With Advanced Highly Conformal Techniques

Abstract

Purpose of Review

Recent Findings

Summary

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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Recent Findings

Summary

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