nach oben

International Journal of Mental Health and Addiction

Erschienen in:

05.07.2017 | Original Article

Relapse Risk Factors in Heroin Addicts Treated with Naltrexone and Naltrexone-Behavioural Psychotherapy

verfasst von: Jasmina Knežević Tasić, Maša Karleuša Valkanou, Borislav Đukanović, Dragić Banković, Vladimir Janjić

Erschienen in: International Journal of Mental Health and Addiction | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

To construct a successful treatment model for heroin addiction, it is important to define factors that contribute to relapse. In this translational ambidirectional cohort study, we evaluated 2 groups of heroin addicts that underwent the same therapeutic procedures with different outcomes (133 abstainers and 56 relapsers). The study found a new variable, “relapse marker”, defined by the synergy of the following factors: (a) non-use of tramadol before treatment (p < 0.0005), (b) absence of sense of loss of control over behaviour as a motive for treatment initiation (p = 0.048), (c) use of benzodiazepines in recovery (p < 0.0005), (d) substituting heroin addiction with gambling (p < 0.009), e) younger age (p = 0.012), and (f) explicit parental demand as a treatment motive (p = 0.040). This study reports a mathematical model that predicts relapse and inability to sustain stable abstinence as an outcome of heroin addiction treatment.

Adinoff, B. (2004). Neurobiological processes in drug reward and addiction. Harvard Review of Psychiatry, 12(6), 305–320. doi:10.1080/10673220490910844.CrossRefPubMedPubMedCentral

Allen, T. J., Moeller, F. G., Rhoades, H. M., & Cherek, D. R. (1998). Impulsivity and history of drug dependence. Drug and Alcohol Dependence, 50(2), 137–145.CrossRefPubMed

Best, D. W., Ghufran, S., Day, E., Ray, R., & Loaring, J. (2008). Breaking the habit: a retrospective analysis of desistance factors among formerly problematic heroin users. Drug and Alcohol Review, 27(6), 619–624.CrossRefPubMed

Boyle, K., Polinksy, J. L., & Hser, Y. I. (2000). Resistance to drug abuse treatment: a comparison of drug users who accept or decline treatment referral assessment. Journal of Drug Issues, 30(3), 555–574.CrossRef

Brewer, J. A., & Potenza, M. N. (2008). The neurobiology and genetics of impulse control disorders: relationships to drug addictions. Biochemical Pharmacology, 75(1), 63–75.CrossRefPubMed

Bühringer, G., Kräplin, A., & Behrendt, S. (2012). Universal characteristics and consequences of the addiction syndrome. In H. J. Shaffer (Ed.), APA addiction syndrome handbook (pp. 291–316). Washington: American Psychological Association.

Casavant, L. & Collin, C. (2001). Illegal drug use and crime: a complex relationship Political and Social Affairs Division. Retrieved at http://www.parl.gc.ca/content/sen/committee/371/ille/library/collin-e.htm#_ftn1

Cavedini, P., Riboldi, G., Keller, R., D’Annucci, A., & Bellodi, L. (2002). Frontal lobe dysfunction in pathological gambling patients. Biological Psychiatry, 51(4), 334–341.CrossRefPubMed

Chandler, R. K., Fletcher, B. W., & Volkow, N. D. (2009). Treating drug abuse and addiction in the criminal justice system: Improving public health and safety. The Journal of the American Medical Association, 301(2), 183–190.CrossRefPubMed

Darke, S., Williamson, A., Ross, J., Mills, K. L., Havard, A., & Teesson, M. (2007). Patterns of nonfatal heroin overdose over a 3-year period: findings from the Australian treatment outcome study. Journal of Urban Health, 84(2), 283–291.CrossRefPubMedPubMedCentral

Dodge, R., Sindelar, J., & Sinha, R. (2005). The role of depressive symptoms in predicting drug abstinence in outpatient substance abuse treatment. Journal of Substance Abuse Treatment, 28, 189–196.CrossRefPubMed

Edenberg, H. J., & Foroud, T. (2006). Review: the genetics of alcoholism: identifying specific genes through family studies. Addiction Biology, 11(3–4), 386–396.CrossRefPubMed

Enoch, M. A. (2011). The role of early life stress as a predictor for alcohol and drug dependence. Psychopharmacology, 214, 17–31.CrossRefPubMed

Ersche, K. D., Turton, A. J., Pradhan, S., Bullmore, E. T., & Robbins, T. W. (2010). Drug addiction endophenotypes: impulsive versus sensation-seeking personality traits. Biological Psychiatry, 68(8), 770–773.CrossRefPubMedPubMedCentral

Evans, J. L., Hahn, J. A., Lum, P. J., Stein, E. S., & Page, K. (2009). Predictors of injection drug use cessation and relapse in a prospective cohort of young injection drug users in San Francisco, CA (UFO Study). Drug and Alcohol Dependence, 101(3), 152–157. doi:10.1016/j.drugalcdep.2008.12.007.CrossRefPubMedPubMedCentral

Eysenck, H. J. (1997). Addiction, personality and motivation. Human Psychopharmacology: Clinical and Experimental, 12(S2), S79–S87.CrossRef

Fulcher, G. M. (2009). Motherhood and motivation for substance abuse treatment and behavior change. Berkeley, ProQuest, Los Angeles: University of California.

Galvan, A., Hare, T., Parra, C., Penn, J., Voss, H., Glover, G., & Casey, B. J. (2006). Earlier development of the accumbens relative to orbitofrontal cortex might underlie risk-taking behavior in adolescents. Journal of Neuroscience, 26(25), 6885–6892. doi:10.1523/JNEUROSCI.1062-06.2006.CrossRefPubMed

Gluckman, P., Low, F. Franko K. et al. (2011). Improving the transition: reducing social and psychological morbidity during adolescence. A report from the Prime Minister’s Chief Science Advisor. Office of the Prime Minister’s Science Advisory Committee, New Zealand.

Gossop, M., Stewart, D., Browne, N., & Marsden, J. (2002). Factors associated with abstinence, lapse or relapse to heroin use after residential treatment: protective effect of coping responses. Addiction, 97, 1259–1267.CrossRefPubMed

Grace, A. A. (2000). The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving. Addiction, 95, S119–S128.CrossRefPubMed

Grant, J. E., Potenza, M. N., Weinstein, A., & Gorelick, D. A. (2010). Introduction tobehavioral addictions. The American Journal of Drug and Alcohol Abuse, 36(5), 233–241.CrossRefPubMedPubMedCentral

Gyollai, Á. D., Griffiths, M., Barta, C., Vereczkei, A., Urbán, R., Kun, B., & Demetrovics, Z. (2014). The genetics of problem and pathological gambling: a systematic review. Current Pharmaceutical Design, 20(25), 3993–3999.CrossRefPubMed

Heinz, A. J., Wu, J., Witkiewitz, K., Epstein, D. H., & Preston, K. L. (2009). Marriage and relationship closeness as predictors of cocaine and heroin use. Addictive Behaviors, 34(3), 258–263. doi:10.1016/j.addbeh.2008.10.020.CrossRefPubMed

Henkel, L.J., (2007). Substance abuse severity, treatment motivation, and criminal thinking factors: predictors of treatment retention with substance abusing parolees in a correctional aftercare program (Psychology Dissertations). Philadelphia College of Osteopathic Medicine, paper 61.

Hser, Y. I. (2007). Predicting long-term stable recovery from heroin addiction: Findings from a 33-year follow-up study. Journal of Addiction Disorders, 26(1), 51–60.CrossRef

Ibáñez, A., Blanco, C., de Castro, I. P., Fernandez-Piqueras, J., & Sáiz-Ruiz, J. (2003). Genetics of pathological gambling. Journal of Gambling Studies, 19(1), 11–22.CrossRefPubMed

James, L. (2012). Understanding the process of recovery from heroin addiction: initiating and maintaining factors (Unpublished doctoral dissertation). Cardiff University and the South Wales.

Knežević-Tasić, J., & Đukanović, B. (2015). Bihevioralne zavisnosti u Srbiji. Beograd: Izdavačka knjižarnica Zorana Stojanovića.

Koob, G. F., & Volkow, N. D. (2010). Neurocircuitry of addiction. Neuropsychopharmacology, 35(1), 217–238. doi:10.1038/npp.2009.110.CrossRefPubMed

Koob, G. F., Ahmed, S. H., Boutrel, B., et al. (2004). Neurobiological mechanisms in the transition from drug use to drug dependence. Neuroscience Biobehavior Review, 27, 739–749.CrossRef

Kosten, T. A., Ball, S. A., & Rounsaville, B. J. (1994). A sibling study of sensation seeking and opiate addiction. Journal of Nervous and Mental Disease, 182(5), 284–289.CrossRefPubMed

Krupitsky, E., Zvartau, E., Masalov, D., Tsoi, M., Burakov, A., Egorova, V., Didenko, T., Romanova, T., Ivanova, E., Bespalov, A., Verbitskaya, E., Neznanov, N., Grinenko, A., O'Brien, C., & Woody, G. (2004). Naltrexone for heroin dependence treatment in St. Petersburg, Russia. Journal of Substance Abuse Treatment, 26(4), 285–294.CrossRefPubMed

Lin, S. S., & Tsai, C. C. (2002). Sensation seeking and internet dependence of Taiwanese high school adolescents. Computers in Human Behavior, 18(4), 411–426.CrossRef

Lobo, D. S., & Kennedy, J. L. (2006). The genetics of gambling and behavioural addictions. CNS Spectrums, 11(12), 931–939.CrossRefPubMed

McKay, J. R., Rutherford, M. J., Alterman, A. I., et al. (1995). An examination of the cocaine relapse process. Drug Alcohol Dependance, 38, 35–43.CrossRef

Miller, W. R., & Rollnick, S. (2012). Motivational interviewing: helping people change. Guilford press.

National Institute on Drug Abuse (2010). Comorbidity: addiction and other mental illnesses–in-depth report on co-occurring drug use and other mental disorders. Retrieved at https://www.drugabuse.gov/sites/default/files/rrcomorbidity.pdf

Pavlović, Z., & Jakovljević, B. (2008). Učestalost i faktori rizika od upotrebe psihoaktivnih supstancija kod mladih. Vojnosanitetski Pregled, 65(6), 441–448.CrossRefPubMed

Prochaska, J. O., & DiClemente, C. C. (1984). The transtheoretic approach: crossing traditional boundaries of therapy. Homewood, Illinois: Dow Jones/Irwin.

Prochaska, J. O., & DiClemente, C. C. (1992). The trans-theoretical approach. In J. C. Norcross & M. R. Goldfried (Eds.), Handbook of psychotherapy integration (pp. 330–334). New York: Basic Books, Inc..

Rapp, R. C., Siegel, H. A., & DeLiberty, R. N. (2003). Demographic and clinical correlates of client motivation among substance abusers. Health & Social Work, 28(2), 107–115.CrossRef

Schmitz, J., Stotts, A., Rhoades, H., & Grabowski, J. (2001). Naltrexone and relapse prevention treatment for cocaine-dependent patients. Addictive Behaviors., 26(2), 167–180.CrossRefPubMed

Schuckit, M. A. (2009). An overview of genetic influences in alcoholism. Journal of Substance Abuse Treatment, 36(1), 5–14.

Shaffer, H. (2012). APA Addiction Syndrome Handbook: Foundations, Influences, and Expressions of Addiction, Vol 1. Washington, DC: American Psychological Association.

Shaffer, H. J., LaPlante, D. A., LaBrie, R. A., Kidman, R. C., Donato, A. N., & Stanton, M. V. (2004). Toward a syndrome model of addiction: multiple expressions, common etiology. Harvard Review Psychiatry, 12(6), 367–374.CrossRef

Sinha, R. (2001). How does stress increase risk of drug abuse and relapse? Psychopharmacology, 158, 343–359.CrossRefPubMed

Sinha, R. (2008). Chronic stress, drug use, and vulnerability to addiction. Annals of the New York Academy of Sciences, 1141, 105–130. doi:10.1196/annals.1441.030.CrossRefPubMedPubMedCentral

Sinha, R. (2011). New findings on biological factors predicting addiction relapse vulnerability. Current Psychiatry Reports, 13(5), 398–405. doi:10.1007/s11920-011-0224-0.CrossRefPubMedPubMedCentral

Tsogia, D., Capello, A., & Orford, J. (2001). Entering treatment for substance misuse: a review of the literature. Journal of Mental Health, 10(5), 481–499.CrossRef

Ubale, V. M., Jaju, J. B., Gosavi, P. A., Pawar, G. R., Dharmadhikari, S. C., & Parekar, S. M. (2015). Evaluation of antidepressant activity of tramadol in mice: an experimental study. International Journal of Basic & Clinical Pharmacology, 4(3), 463–468. doi:10.18203/2319-2003.ijbcp20150017.CrossRef

United Nations Office on Drugs and Crime (2013). Opioid overdose: preventing and reducing opioid overdose mortality. United Nations Office at Vienna. Retrieved at https://www.unodc.org/docs/treatment/overdose.pdf. Accessed 27 Oct 2015.

United Nations Office on Drugs and Crime (2015). World drug report 2015. United Nations Office at Vienna.

United Nations Office for Drug and Crime (2016). UNODC-WHO The International Standards for the Treatment of Drug Use Disorders. Retrieved at https://www.unodc.org/unodc/en/drug-prevention-and-treatment/publications.html

UNODC, Addiction, Crime and Insurgency (2009). Heroin. Retrieved at https://www.unodc.org/documents/data-and-analysis/tocta/5.Heroin.pdf

Volkow, N. D., Wang, G. J., Fowler, J. S., Franceschi, D., Thanos, P. K., Wong, C., et al. (2000). Cocaine abusers show a blunted response to alcohol intoxication in limbic brain regions. Life Science, 66, PL161–PL167.CrossRef

Zule, P., Lam, W. K. K., & Wechsberg, W. M. (2003). Treatment readiness among out-of-treatment African-American crack users. Journal of Psychoactive Drugs, 35(4), 502–510.CrossRef

Titel: Relapse Risk Factors in Heroin Addicts Treated with Naltrexone and Naltrexone-Behavioural Psychotherapy
verfasst von: Jasmina Knežević Tasić
Maša Karleuša Valkanou
Borislav Đukanović
Dragić Banković
Vladimir Janjić
Publikationsdatum: 05.07.2017
Verlag: Springer US
Erschienen in: International Journal of Mental Health and Addiction / Ausgabe 2/2018
Print ISSN: 1557-1874
Elektronische ISSN: 1557-1882
DOI: https://doi.org/10.1007/s11469-017-9782-7

Neu im Fachgebiet Psychiatrie

23.04.2024 | Demenz | Nachrichten

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Relapse Risk Factors in Heroin Addicts Treated with Naltrexone and Naltrexone-Behavioural Psychotherapy

Abstract

Neu im Fachgebiet Psychiatrie

Demenzkranke durch Antipsychotika vielfach gefährdet

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Update Psychiatrie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2018

Health and Social Problems Associated with Recent Novel Psychoactive Substance (NPS) Use Amongst Marginalised, Nightlife and Online Users in Six European Countries

Facilitators and Barriers to Family Involvement in Problem Gambling Treatment

Exercise Addiction and Psychophysiological Health in Korean Collegiate Students

Situating the Post-Secondary Instructor in a Supportive Role for the Mental Health and Well-Being of Students

Psychoactive Substance Use and Problematic Internet Use as Predictors of Bullying and Cyberbullying Victimization

Substance Abuse Among American Indians and Alaska Natives: An Integrative Cultural Framework for Advancing Research

Neu im Fachgebiet Psychiatrie

Demenzkranke durch Antipsychotika vielfach gefährdet

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Update Psychiatrie