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Journal of NeuroVirology

Erschienen in:

18.12.2017

Relationship between brain large artery characteristics and their downstream arterioles

verfasst von: Jose Gutierrez, Jacinta Murray, Christina Chon, Susan Morgello

Erschienen in: Journal of NeuroVirology | Ausgabe 1/2018

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Abstract

We aimed to test the hypothesis that brain large artery diameters relate to distal downstream arteriolar diameters. In a sample of 110 autopsied individuals (69% men, 76% HIV+, mean age 51), we used multilevel models to relate large artery lumen and lumen-to-wall ratio to left frontal lobe arteriolar lumen and lumen-to-wall ratio adjusting for demographics and vascular risk factors. Comparing the large artery characteristics of the whole brain did not disclose significant associations with frontal lobe arteriolar characteristics. However, restricting the comparison to large arteries upstream of the studied arterioles demonstrated an independent association between left-sided frontal lobe arteriolar luminal diameter with large artery luminal diameters (B = 1.82 ± 0.77, P = 0.01) and with large artery lumen-to-wall ratio (B = 0.58 ± 0.29, P = 0.05). In stratified models, the point estimates in the HIV+ subsample were larger than in the HIV− subsample. These finding suggest coupling between higher proximal blood flow represented by large artery diameter and lower distal resistance represented by arteriolar dilatation. The relationship between arteriolar dilatation and brain parenchyma homeostasis should be further studied.

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Titel: Relationship between brain large artery characteristics and their downstream arterioles
verfasst von: Jose Gutierrez
Jacinta Murray
Christina Chon
Susan Morgello
Publikationsdatum: 18.12.2017
Verlag: Springer International Publishing
Erschienen in: Journal of NeuroVirology / Ausgabe 1/2018
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-017-0606-0

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Relationship between brain large artery characteristics and their downstream arterioles

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