The online version of this article (doi:10.1186/s12890-015-0036-9) contains supplementary material, which is available to authorized users.
Pierantonio Laveneziana and Paolo Palange contributed equally to this work.
The authors declare that they have no competing interests.
Conception and design: DS, MDP, PL, PP; acquisition of data: DS, MDP, MI; analysis and interpretation: DS, MDP, PO, NS, SQ, BW. Drafting the manuscript for important intellectual content: DS, MDP, PO, NS, MI, SQ, BW, PL, PP. Final approval of the version to be published: DS, MDP, PO, NS, MI, SQ, BW, PL, PP.
The best clinical practice to investigate aerobic fitness includes measurements obtained during cardiopulmonary exercise testing (CPET), however it remains an underutilised clinical measure in cystic fibrosis (CF). To investigate this further, different methods of quantifying exercise capacity in CF are required. The possibility that measuring physical activity (PA) by a portable accelerometer could be used to assess the CF aerobic state and could be added among the CPET surrogates has not been investigated. The aim of this study was to examine the relationship between PA and exercise fitness both at submaximal and maximal levels in clinically stable adults with CF.
Thirty CF patients (FEV1 71 ± 19% predicted) and fifteen healthy controls undertook an incremental CPET on a cycle ergometer. CPET-related measurements included: oxygen uptake (V’O2), carbon dioxide production (V’CO2), ventilatory profile, heart rate (HR) and oxygen pulse (V’O2/HR) throughout exercise and at lactic threshold (LT) and peak. LT measures represent submaximal exercise related data. PA was assessed using the accelerometer SenseWear Pro3 Armband.
Moderate (>4.8 metabolic equivalents (METS)) and moderate + vigorous (>7.2 METS) PA was related to V’O2 (p = 0.005 and p = 0.009, respectively) and work rate (p = 0.004 and p = 0.002, respectively) at LT. Moderate PA or greater was positively related to peak V’O2 (p = 0.005 and p = 0.003, respectively). Daily PA levels were similar in CF and healthy controls. Except for peak values, V’O2 profile and the V’O2 at LT were comparable between CF and healthy controls.
In adult CF patients daily PA positively correlated with aerobic capacity. PA measurements are a valuable tool in the assessment of exercise performance in an adult CF population and could be used for interventional exercise trials to optimize exercise performance and health status. PA levels and parameters obtained at submaximal exercise are similar in CF and in healthy controls.
Additional file 1: Table E1. Daily physical activities measured by the accelerometer in patients with cystic fibrosis (CF) and control subjects.12890_2015_36_MOESM1_ESM.docx
Selvaduray HC, Blimkie CJ, Meyers N, Mellis CM, Cooper PJ, Van Asperen PP. Randomized controlled study of in-hospital exercise training programs in children with cystic fibrosis. Pediatr Pulmonol. 2002;33:194–200. CrossRef
Standards for the clinical care of children and adults with cystic fibrosis in the UK. Cystic Fibrosis Trust; 2001 ( http://www.cftrust.org.uk/aboutcf/publications/consensusdoc/C_3000Standards_of_Care.pdf (accessed 18th October 2008)).
Cohen SP, Orenstein DM. How does heart rate recovery after sub-maximal exercise correlate with maximal exercise testing in children with CF? J Cyst Fibros. 2014;doi: 10.1016/j.jcf.2014.05.011
Gruber W, Orenstein DM, Braumann KM, Paul K, Hüls G. Effects of an exercise program in children with cystic fibrosis-are there differences between females and males? J Pediatr. 2011;158:58–63. CrossRef
Morris JF, Koski A, Temple WP, Claremont A, Thomas DR. Fifteen-year interval spirometric evaluation of the Oregon predictive equations. Chest. 1998;93:123–7. CrossRef
Crapo RO, Morris AH, Clayton PD, Nixon CR. Lung volumes in healthy nonsmoking adults. Bull Eur Physiopathol Respir. 1982;18:419–25. PubMed
American Thoracic Society; American College of Chest Physicians. ATS/ACCP statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med. 2003;167:211–77. CrossRef
Borg GA. Psychophysical basis of perceived exertion. Med Sci Sports Exerc. 1982;14:377–81. PubMed
Jones NL, Makrides L, Hitchcock C, Chypchar T, McCartney N. Normal standards for an incremental progressive cycle ergometer test. Am Rev Respir Dis. 1985;131:700–8. PubMed
Wasserman K, Hansen JE, Sue DY, Casaburi R, Whipp BJ. Principles of exercise testing and interpretation. fourthth ed. Lippincott: Williams & Wilkins; 2005. p. 144–5.
Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, et al. American college of sports medicine; american heart association: physical activity and public health: updated recommendation for adults from the american college of sports medicine and american heart association. Circulation. 2007;116:1081–93. CrossRefPubMed
Booth FW, Gordon SE, Carlson CJ, Hamilton MT. Waging war on modern chronic diseases: primary prevention through exercise biology. J Appl Physiol. 2000;88:774–87. PubMed
Cerny FJ, Cropp GJA, Bye MR. Hospital therapy improves exercise tolerance and lung function in cystic fibrosis. Am J Dis Child. 1984;138:261–5. PubMed
- Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis
Marcello Di Paolo
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