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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Pulmonary Medicine 1/2015

Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis

Zeitschrift:
BMC Pulmonary Medicine > Ausgabe 1/2015
Autoren:
Daniela Savi, Marcello Di Paolo, Nicholas Simmonds, Paolo Onorati, Mattia Internullo, Serena Quattrucci, Banya Winston, Pierantonio Laveneziana, Paolo Palange
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12890-015-0036-9) contains supplementary material, which is available to authorized users.
Pierantonio Laveneziana and Paolo Palange contributed equally to this work.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

Conception and design: DS, MDP, PL, PP; acquisition of data: DS, MDP, MI; analysis and interpretation: DS, MDP, PO, NS, SQ, BW. Drafting the manuscript for important intellectual content: DS, MDP, PO, NS, MI, SQ, BW, PL, PP. Final approval of the version to be published: DS, MDP, PO, NS, MI, SQ, BW, PL, PP.

Abstract

Background

The best clinical practice to investigate aerobic fitness includes measurements obtained during cardiopulmonary exercise testing (CPET), however it remains an underutilised clinical measure in cystic fibrosis (CF). To investigate this further, different methods of quantifying exercise capacity in CF are required. The possibility that measuring physical activity (PA) by a portable accelerometer could be used to assess the CF aerobic state and could be added among the CPET surrogates has not been investigated. The aim of this study was to examine the relationship between PA and exercise fitness both at submaximal and maximal levels in clinically stable adults with CF.

Methods

Thirty CF patients (FEV1 71 ± 19% predicted) and fifteen healthy controls undertook an incremental CPET on a cycle ergometer. CPET-related measurements included: oxygen uptake (V’O2), carbon dioxide production (V’CO2), ventilatory profile, heart rate (HR) and oxygen pulse (V’O2/HR) throughout exercise and at lactic threshold (LT) and peak. LT measures represent submaximal exercise related data. PA was assessed using the accelerometer SenseWear Pro3 Armband.

Results

Moderate (>4.8 metabolic equivalents (METS)) and moderate + vigorous (>7.2 METS) PA was related to V’O2 (p = 0.005 and p = 0.009, respectively) and work rate (p = 0.004 and p = 0.002, respectively) at LT. Moderate PA or greater was positively related to peak V’O2 (p = 0.005 and p = 0.003, respectively). Daily PA levels were similar in CF and healthy controls. Except for peak values, V’O2 profile and the V’O2 at LT were comparable between CF and healthy controls.

Conclusions

In adult CF patients daily PA positively correlated with aerobic capacity. PA measurements are a valuable tool in the assessment of exercise performance in an adult CF population and could be used for interventional exercise trials to optimize exercise performance and health status. PA levels and parameters obtained at submaximal exercise are similar in CF and in healthy controls.
Zusatzmaterial
Additional file 1: Table E1. Daily physical activities measured by the accelerometer in patients with cystic fibrosis (CF) and control subjects.
12890_2015_36_MOESM1_ESM.docx
Literatur
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