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01.03.2012 | Original Article

Relationship between expression of apoptosis-related proteins and the efficacy of postoperative chemotherapy in patients with T3 gastric cancer

verfasst von: Shunichi Tsujitani, Hiroaki Saito, Toshiro Wakatsuki, Masahide Ikeguchi, Ken Shirabe, Masaru Morita, Yoshihiro Kakeji, Tokujiro Yano, Yoshihiko Maehara

Erschienen in: Surgery Today | Ausgabe 3/2012

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Abstract

Purpose

We investigated the relationship between the p53-dependent apoptotic pathway and the survival of patients with gastric cancer, retrospectively, to elucidate new biomarkers of uracil/tegafur (UFT) chemotherapy.

Methods

We examined the expression of p53, p21, Bax, and myeloid cell leukemia 1 (Mcl-1) proteins immunohistochemically in 105 patients who underwent curative gastrectomy for gastric cancer invading the serosa. Postoperative oral UFT was prescribed for 1 year. Kaplan–Meier survival curves were compared with the two-sided log-rank test.

Results

Positive staining for p53, p21, Bax, and Mcl-1 proteins was found in 63.8, 52.4, 39.0, and 72.4% of the subjects, respectively. Survival time did not differ significantly between the patients with and those without p53, p21, and Bax expression. However, patients with Mcl-1(−) tumors survived longer than those with Mcl-1(+) tumors. Postoperative UFT treatment did not improve survival; however, adjuvant UFT significantly prolonged the survival of patients with p53(−), p21(−), Bax(+), or Mcl-1(+) tumors, but not of patients with p53(+), p21(+), Bax(−), or Mcl-1(−) tumors.

Conclusions

The efficacy of adjuvant chemotherapy for gastric cancer may be affected by the status of apoptosis-related proteins such as p53, p21, Bax, and Mcl-1. However, because susceptibility to apoptosis did not explain the sensitivity of chemotherapeutic agents, further investigation of the mutual interaction between apoptosis-related proteins is required.

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Titel: Relationship between expression of apoptosis-related proteins and the efficacy of postoperative chemotherapy in patients with T3 gastric cancer
verfasst von: Shunichi Tsujitani
Hiroaki Saito
Toshiro Wakatsuki
Masahide Ikeguchi
Ken Shirabe
Masaru Morita
Yoshihiro Kakeji
Tokujiro Yano
Yoshihiko Maehara
Publikationsdatum: 01.03.2012
Verlag: Springer-Verlag
Erschienen in: Surgery Today / Ausgabe 3/2012
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-011-0062-z

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Relationship between expression of apoptosis-related proteins and the efficacy of postoperative chemotherapy in patients with T3 gastric cancer

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Methods

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Conclusions

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