Background
Methods
Literature search
Selection criteria
Data extraction
Risk of Bias assessment
Accessing the quality of evidence
Statistical analysis
Results
Trial selection
Trials characteristics
Risk of Bias assessment
Users of Fluoroquinolones vs. nonusers or users of other antibiotics
Primary outcome: the first occurrence of aortic dissection or aortic aneurysm
The first occurrence of aortic dissection and aortic aneurysm
The NNH for aortic aneurysm or dissection
Sensitivity analysis
GRADE evidence and publication Bias
Discussion
Main findings
Comparison with other meta-analyses
Author/Year | Singh S et al. 2017 | Noman AT et al. 2019 | Yu X et al. 2019 | Rawla P et al. 2019 | Current Meta-analysis |
---|---|---|---|---|---|
Number of observational studies | 2 | 3 | 3 | 4 | 5 |
Number of participants | 1,893,537 | 2,613,713 | 2,613,713 | 2,616,139 | 2,829,385 |
Year of search strategy | 2017 | 2018 | 2019 | 2018 | 2019 |
OR/RR of AA or AD | AA (OR, 2.25; 95% CI,2.03–2.49) | AA or AD (OR,2.04; 95% CI, 1.67–2.48) | AA or AD (OR,2.20; 95% CI, 1.92–2.52) | AA or AD (RR,2.14; 95% CI, 1.93–2.36) | AA or AD (OR, 2.23; 95% CI, 1.80–2.77) |
AD (OR, 2.07; 95% CI, 1.33–3.21) | |||||
AD (OR, 2.79; 95% CI,2.31–3.37) | AD (OR, 2.25; 95% CI,1.42–3.56) | ||||
AA (OR, 1.74; 95% CI, 1.13–2.66) | |||||
GRADE | moderate | moderate | NR | moderate | moderate |
NNH | 618 (AA) | 1376 | NR | NR | 1301 |