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The International Journal of Cardiovascular Imaging

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05.01.2022 | Original Paper

Relationship between hemoglobin A1C and characteristics of plaque vulnerability in stable coronary disease: an optical coherence tomography study

verfasst von: Hiroki Ueyama, Keisuke Yasumura, Naotaka Okamoto, Yuliya Vengrenyuk, Nitin Barman, Benjamin Benhuri, Vishal Kapur, Choudhury Hasan, Joseph Sweeny, Samin K. Sharma, Jagat Narula, Annapoorna S. Kini, Usman Baber

Erschienen in: The International Journal of Cardiovascular Imaging | Ausgabe 2/2022

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Abstract

Patients with diabetes mellitus are at increased risk of cardiovascular events. We aimed to analyze the impact of serum HbA1c levels on coronary plaque characteristics in stable coronary disease. Two hundred sixty-one patients who underwent optical coherence tomography (OCT) examination before elective percutaneous coronary intervention for a de novo obstructive lesions were included in this single-center retrospective analysis. Patients were divided into tertiles according to HbA1c level (tertile 1: HbA1c < 6.3%, tertile 2: 6.3 ≤ HbA1c < 7.8%, tertile 3: HbA1c ≥ 7.8%) and OCT findings were compared. Fibrous cap thickness (FCT) was significantly thinner in tertile 3 compared to tertile 1 and tertile 2 (103.9 ± 48.2 µm [tertile 1] vs. 107.5 ± 60.6 µm [tertile 2] vs. 86.2 ± 35.8 µm [tertile 3], p = 0.03). Higher prevalence of thin-cap fibroatheroma (TCFA) was observed in tertile 3 vs tertile 1 and tertile 2 (19.5% [tertile 1] vs. 19.5% [tertile 2] vs. 33.3% [tertile 3], p = 0.04). HbA1c inversely correlated with FCT (beta coefficient − 4.89, 95% confidence interval − 8.40 to − 1.39, p < 0.01). The logistic regression model revealed that the probability of having TCFA was positively associated with HbA1c with a small change in the range of low and medium HbA1c and a big change in the range of high HbA1c. Furthermore, minimal lumen area and reference lumen area were smaller in tertile 3. In patients with stable coronary disease, high serum HbA1c levels are associated with higher plaque burden and thinner FCT on OCT, while low and medium HbA1c levels result in similar plaque vulnerability.

Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, Di Angelantonio E, Ingelsson E, Lawlor DA, Selvin E, Stampfer M, Stehouwer CD, Lewington S, Pennells L, Thompson A, Sattar N, White IR, Ray KK, Danesh J (2010) Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet 375(9733):2215–2222. https://doi.org/10.1016/s0140-6736(10)60484-9CrossRefPubMed

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Judd SE, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Mackey RH, Magid DJ, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER 3rd, Moy CS, Mussolino ME, Neumar RW, Nichol G, Pandey DK, Paynter NP, Reeves MJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Wong ND, Woo D, Turner MB (2014) Heart disease and stroke statistics–2014 update: a report from the American Heart Association. Circulation 129(3):e28–e292. https://doi.org/10.1161/01.cir.0000441139.02102.80CrossRefPubMed

Donahoe SM, Stewart GC, McCabe CH, Mohanavelu S, Murphy SA, Cannon CP, Antman EM (2007) Diabetes and mortality following acute coronary syndromes. JAMA 298(7):765–775. https://doi.org/10.1001/jama.298.7.765CrossRefPubMed

Bezerra HG, Costa MA, Guagliumi G, Rollins AM, Simon DI (2009) Intracoronary optical coherence tomography: a comprehensive review clinical and research applications. JACC Cardiovasc Interv 2(11):1035–1046. https://doi.org/10.1016/j.jcin.2009.06.019CrossRefPubMedPubMedCentral

Kato K, Yonetsu T, Kim SJ, Xing L, Lee H, McNulty I, Yeh RW, Sakhuja R, Zhang S, Uemura S, Yu B, Mizuno K, Jang IK (2012) Comparison of nonculprit coronary plaque characteristics between patients with and without diabetes: a 3-vessel optical coherence tomography study. JACC Cardiovasc Interv 5(11):1150–1158. https://doi.org/10.1016/j.jcin.2012.06.019CrossRefPubMed

Niccoli G, Giubilato S, Di Vito L, Leo A, Cosentino N, Pitocco D, Marco V, Ghirlanda G, Prati F, Crea F (2013) Severity of coronary atherosclerosis in patients with a first acute coronary event: a diabetes paradox. Eur Heart J 34(10):729–741. https://doi.org/10.1093/eurheartj/ehs393CrossRefPubMed

Sugiyama T, Yamamoto E, Bryniarski K, Xing L, Fracassi F, Lee H, Jang IK (2018) Coronary plaque characteristics in patients with diabetes mellitus who presented with acute coronary syndromes. J Am Heart Assoc. https://doi.org/10.1161/jaha.118.009245

Stratton IM, Adler AI, Neil HAW, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR (2000) Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 321(7258):405–412. https://doi.org/10.1136/bmj.321.7258.405CrossRefPubMedPubMedCentral

Association AD (2020) Glycemic Targets: Standards of Medical Care in Diabetes-2020. Diabetes Care 43(Suppl 1):S66-s76. https://doi.org/10.2337/dc20-S006CrossRef

10.

Group AC, Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, Marre M, Cooper M, Glasziou P, Grobbee D, Hamet P, Harrap S, Heller S, Liu L, Mancia G, Mogensen CE, Pan C, Poulter N, Rodgers A, Williams B, Bompoint S, de Galan BE, Joshi R, Travert F (2008) Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 358(24):2560–2572. https://doi.org/10.1056/NEJMoa0802987CrossRef

11.

Action to Control Cardiovascular Risk in Diabetes Study G, Gerstein HC, Miller ME, Byington RP, Goff DC Jr, Bigger JT, Buse JB, Cushman WC, Genuth S, Ismail-Beigi F, Grimm RH Jr, Probstfield JL, Simons-Morton DG, Friedewald WT (2008) Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 358(24):2545–2559. https://doi.org/10.1056/NEJMoa0802743CrossRef

12.

Tearney GJ, Regar E, Akasaka T, Adriaenssens T, Barlis P, Bezerra HG, Bouma B, Bruining N, Cho JM, Chowdhary S, Costa MA, de Silva R, Dijkstra J, Di Mario C, Dudek D, Falk E, Feldman MD, Fitzgerald P, Garcia-Garcia HM, Gonzalo N, Granada JF, Guagliumi G, Holm NR, Honda Y, Ikeno F, Kawasaki M, Kochman J, Koltowski L, Kubo T, Kume T, Kyono H, Lam CC, Lamouche G, Lee DP, Leon MB, Maehara A, Manfrini O, Mintz GS, Mizuno K, Morel MA, Nadkarni S, Okura H, Otake H, Pietrasik A, Prati F, Raber L, Radu MD, Rieber J, Riga M, Rollins A, Rosenberg M, Sirbu V, Serruys PW, Shimada K, Shinke T, Shite J, Siegel E, Sonoda S, Suter M, Takarada S, Tanaka A, Terashima M, Thim T, Uemura S, Ughi GJ, van Beusekom HM, van der Steen AF, van Es GA, van Soest G, Virmani R, Waxman S, Weissman NJ, Weisz G, International Working Group for Intravascular Optical Coherence T (2012) Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation. J Am Coll Cardiol 59(12):1058–1072. https://doi.org/10.1016/j.jacc.2011.09.079CrossRefPubMed

13.

Narula J, Nakano M, Virmani R, Kolodgie FD, Petersen R, Newcomb R, Malik S, Fuster V, Finn AV (2013) Histopathologic characteristics of atherosclerotic coronary disease and implications of the findings for the invasive and noninvasive detection of vulnerable plaques. J Am Coll Cardiol 61(10):1041–1051. https://doi.org/10.1016/j.jacc.2012.10.054CrossRefPubMedPubMedCentral

14.

Burke AP, Farb A, Malcom GT, Liang YH, Smialek J, Virmani R (1997) Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med 336(18):1276–1282. https://doi.org/10.1056/NEJM199705013361802CrossRefPubMed

15.

Virmani R, Burke AP, Farb A, Kolodgie FD (2006) Pathology of the vulnerable plaque. J Am Coll Cardiol 47(8 Suppl):C13-18. https://doi.org/10.1016/j.jacc.2005.10.065CrossRefPubMed

16.

Kubo T, Imanishi T, Takarada S, Kuroi A, Ueno S, Yamano T, Tanimoto T, Matsuo Y, Masho T, Kitabata H, Tsuda K, Tomobuchi Y, Akasaka T (2007) Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy. J Am Coll Cardiol 50(10):933–939. https://doi.org/10.1016/j.jacc.2007.04.082CrossRefPubMed

17.

Tanaka A, Imanishi T, Kitabata H, Kubo T, Takarada S, Tanimoto T, Kuroi A, Tsujioka H, Ikejima H, Ueno S, Kataiwa H, Okouchi K, Kashiwaghi M, Matsumoto H, Takemoto K, Nakamura N, Hirata K, Mizukoshi M, Akasaka T (2008) Morphology of exertion-triggered plaque rupture in patients with acute coronary syndrome: an optical coherence tomography study. Circulation 118(23):2368–2373. https://doi.org/10.1161/CIRCULATIONAHA.108.782540CrossRefPubMed

18.

Jang IK, Tearney GJ, MacNeill B, Takano M, Moselewski F, Iftima N, Shishkov M, Houser S, Aretz HT, Halpern EF, Bouma BE (2005) In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography. Circulation 111(12):1551–1555. https://doi.org/10.1161/01.Cir.0000159354.43778.69CrossRefPubMedPubMedCentral

19.

Xing L, Higuma T, Wang Z, Aguirre AD, Mizuno K, Takano M, Dauerman HL, Park SJ, Jang Y, Kim CJ, Kim SJ, Choi SY, Itoh T, Uemura S, Lowe H, Walters DL, Barlis P, Lee S, Lerman A, Toma C, Tan JWC, Yamamoto E, Bryniarski K, Dai J, Zanchin T, Zhang S, Yu B, Lee H, Fujimoto J, Fuster V, Jang IK (2017) Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography: A 4-Year Follow-Up Study. J Am Coll Cardiol 69(20):2502–2513. https://doi.org/10.1016/j.jacc.2017.03.556CrossRefPubMed

20.

Mizukoshi M, Kubo T, Takarada S, Kitabata H, Ino Y, Tanimoto T, Komukai K, Tanaka A, Imanishi T, Akasaka T (2013) Coronary superficial and spotty calcium deposits in culprit coronary lesions of acute coronary syndrome as determined by optical coherence tomography. Am J Cardiol 112(1):34–40. https://doi.org/10.1016/j.amjcard.2013.02.048CrossRefPubMed

21.

Ehara S, Kobayashi Y, Yoshiyama M, Shimada K, Shimada Y, Fukuda D, Nakamura Y, Yamashita H, Yamagishi H, Takeuchi K, Naruko T, Haze K, Becker AE, Yoshikawa J, Ueda M (2004) Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: an intravascular ultrasound study. Circulation 110(22):3424–3429. https://doi.org/10.1161/01.Cir.0000148131.41425.E9CrossRefPubMed

22.

Milzi A, Burgmaier M, Burgmaier K, Hellmich M, Marx N, Reith S (2017) Type 2 diabetes mellitus is associated with a lower fibrous cap thickness but has no impact on calcification morphology: an intracoronary optical coherence tomography study. Cardiovasc Diabetol 16(1):152. https://doi.org/10.1186/s12933-017-0635-2CrossRefPubMedPubMedCentral

23.

Colayco DC, Niu F, McCombs JS, Cheetham TC (2011) A1C and cardiovascular outcomes in type 2 diabetes: a nested case-control study. Diabetes Care 34(1):77–83. https://doi.org/10.2337/dc10-1318CrossRefPubMed

24.

Ciobanu DM, Bogdan F, Pătruţ CI, Roman G (2019) Glycated albumin is correlated with glycated hemoglobin in type 2 diabetes. Med Pharm Rep 92(2):134–138. https://doi.org/10.15386/mpr-1247CrossRefPubMedPubMedCentral

25.

Bornfeldt KE, Tabas I (2011) Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab 14(5):575–585. https://doi.org/10.1016/j.cmet.2011.07.015CrossRefPubMedPubMedCentral

26.

Dong N, Xie Z, Dai J, Wang W, Sun R, Zhan Y, Sun M, Tian J, Yu B (2016) Statin-induced improvements in vulnerable plaques are attenuated in poorly controlled diabetic patients with coronary atherosclerosis disease: a serial optical coherence tomography analysis. Acta Diabetol 53(6):999–1008. https://doi.org/10.1007/s00592-016-0902-9CrossRefPubMed

27.

Stone GW, Maehara A, Lansky AJ, de Bruyne B, Cristea E, Mintz GS, Mehran R, McPherson J, Farhat N, Marso SP, Parise H, Templin B, White R, Zhang Z, Serruys PW (2011) A prospective natural-history study of coronary atherosclerosis. N Engl J Med 364(3):226–235. https://doi.org/10.1056/NEJMoa1002358CrossRefPubMed

28.

Kini AS, Motoyama S, Vengrenyuk Y, Feig JE, Pena J, Baber U, Bhat AM, Moreno P, Kovacic JC, Narula J, Sharma SK (2015) Multimodality Intravascular Imaging to Predict Periprocedural Myocardial Infarction During Percutaneous Coronary Intervention. JACC Cardiovasc Interv 8(7):937–945. https://doi.org/10.1016/j.jcin.2015.03.016CrossRefPubMed

29.

Kuroda M, Shinke T, Sakaguchi K, Otake H, Takaya T, Hirota Y, Osue T, Kinutani H, Konishi A, Takahashi H, Terashita D, Uzu K, Hirata K (2015) Association between daily glucose fluctuation and coronary plaque properties in patients receiving adequate lipid-lowering therapy assessed by continuous glucose monitoring and optical coherence tomography. Cardiovasc Diabetol 14:78. https://doi.org/10.1186/s12933-015-0236-xCrossRefPubMedPubMedCentral

30.

Gohbara M, Hibi K, Mitsuhashi T, Maejima N, Iwahashi N, Kataoka S, Akiyama E, Tsukahara K, Kosuge M, Ebina T, Umemura S, Kimura K (2016) Glycemic variability on continuous glucose monitoring system correlates with non-culprit vessel coronary plaque vulnerability in patients with first-episode acute coronary syndrome - optical coherence tomography study. Circ J 80(1):202–210. https://doi.org/10.1253/circj.CJ-15-0790CrossRefPubMed

31.

Ferrannini G, Manca ML, Magnoni M, Andreotti F, Andreini D, Latini R, Maseri A, Maggioni AP, Ostroff RM, Williams SA, Ferrannini E (2020) Coronary artery disease and type 2 diabetes: a proteomic study. Diabetes Care 43(4):843–851. https://doi.org/10.2337/dc19-1902CrossRefPubMed

32.

Jensen LO, Thayssen P, Mintz GS, Maeng M, Junker A, Galloe A, Christiansen EH, Hoffmann SK, Pedersen KE, Hansen HS, Hansen KN (2007) Intravascular ultrasound assessment of remodelling and reference segment plaque burden in type-2 diabetic patients. Eur Heart J 28(14):1759–1764. https://doi.org/10.1093/eurheartj/ehm175CrossRefPubMed

Titel: Relationship between hemoglobin A1C and characteristics of plaque vulnerability in stable coronary disease: an optical coherence tomography study
verfasst von: Hiroki Ueyama
Keisuke Yasumura
Naotaka Okamoto
Yuliya Vengrenyuk
Nitin Barman
Benjamin Benhuri
Vishal Kapur
Choudhury Hasan
Joseph Sweeny
Samin K. Sharma
Jagat Narula
Annapoorna S. Kini
Usman Baber
Publikationsdatum: 05.01.2022
Verlag: Springer Netherlands
Erschienen in: The International Journal of Cardiovascular Imaging / Ausgabe 2/2022
Print ISSN: 1569-5794
Elektronische ISSN: 1875-8312
DOI: https://doi.org/10.1007/s10554-021-02297-x

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Springer Medizin

Relationship between hemoglobin A1C and characteristics of plaque vulnerability in stable coronary disease: an optical coherence tomography study

Abstract

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