Relationship between impaired myocardial blood flow by positron emission tomography and low-attenuation plaque burden and pericoronary adipose tissue attenuation from coronary computed tomography: From the prospective PACIFIC trial
- 16.01.2023
- ORIGINAL ARTICLE
Erschienen in:
- Verfasst von
- Keiichiro Kuronuma, MD, PhD
- Pepijn A. van Diemen, MD
- Donghee Han, MD
- Andrew Lin, MBBS, PhD
- Kajetan Grodecki, MD
- Jacek Kwiecinski, MD, PhD
- Manish Motwani, MBChB, PhD
- Priscilla McElhinney, BSc
- Guadalupe Flores Tomasino, MD
- Caroline Park, BSc
- Alan Kwan, MD
- Evangelos Tzolos, MD
- Eyal Klein, MD
- Benjamin Shou, BSc
- Balaji Tamarappoo, MD, PhD
- Sebastien Cadet, MSc
- Ibrahim Danad, MD
- Roel S. Driessen, MD
- Daniel S. Berman, MD
- Piotr J. Slomka, PhD
- Damini Dey, PhD
- Paul Knaapen, MD, PhD
- Erschienen in
- Journal of Nuclear Cardiology | Ausgabe 4/2023
Abstract
Background
Positron emission tomography (PET) is the clinical gold standard for quantifying myocardial blood flow (MBF). Pericoronary adipose tissue (PCAT) attenuation may detect vascular inflammation indirectly. We examined the relationship between MBF by PET and plaque burden and PCAT on coronary CT angiography (CCTA).
Methods
This post hoc analysis of the PACIFIC trial included 208 patients with suspected coronary artery disease (CAD) who underwent [15O]H2O PET and CCTA. Low-attenuation plaque (LAP, < 30HU), non-calcified plaque (NCP), and PCAT attenuation were measured by CCTA.
Results
In 582 vessels, 211 (36.3%) had impaired per-vessel hyperemic MBF (≤ 2.30 mL/min/g). In multivariable analysis, LAP burden was independently and consistently associated with impaired hyperemic MBF (P = 0.016); over NCP burden (P = 0.997). Addition of LAP burden improved predictive performance for impaired hyperemic MBF from a model with CAD severity and calcified plaque burden (P < 0.001). There was no correlation between PCAT attenuation and hyperemic MBF (r = − 0.11), and PCAT attenuation was not associated with impaired hyperemic MBF in univariable or multivariable analysis of all vessels (P > 0.1).
Conclusion
In patients with stable CAD, LAP burden was independently associated with impaired hyperemic MBF and a stronger predictor of impaired hyperemic MBF than NCP burden. There was no association between PCAT attenuation and hyperemic MBF.
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- Titel
- Relationship between impaired myocardial blood flow by positron emission tomography and low-attenuation plaque burden and pericoronary adipose tissue attenuation from coronary computed tomography: From the prospective PACIFIC trial
- Verfasst von
-
Keiichiro Kuronuma, MD, PhD
Pepijn A. van Diemen, MD
Donghee Han, MD
Andrew Lin, MBBS, PhD
Kajetan Grodecki, MD
Jacek Kwiecinski, MD, PhD
Manish Motwani, MBChB, PhD
Priscilla McElhinney, BSc
Guadalupe Flores Tomasino, MD
Caroline Park, BSc
Alan Kwan, MD
Evangelos Tzolos, MD
Eyal Klein, MD
Benjamin Shou, BSc
Balaji Tamarappoo, MD, PhD
Sebastien Cadet, MSc
Ibrahim Danad, MD
Roel S. Driessen, MD
Daniel S. Berman, MD
Piotr J. Slomka, PhD
Damini Dey, PhD
Paul Knaapen, MD, PhD
- Publikationsdatum
- 16.01.2023
- Verlag
- Springer International Publishing
- Erschienen in
-
Journal of Nuclear Cardiology / Ausgabe 4/2023
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551 - DOI
- https://doi.org/10.1007/s12350-022-03194-z
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