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Erschienen in: Acta Neurochirurgica 12/2017

07.09.2017 | Original Article - Vascular

Relationship between intracranial aneurysms and the severity of autosomal dominant polycystic kidney disease

verfasst von: Hiroki Yoshida, Eiji Higashihara, Keisuke Maruyama, Kikuo Nutahara, Toshiaki Nitatori, Isao Miyazaki, Yoshiaki Shiokawa

Erschienen in: Acta Neurochirurgica | Ausgabe 12/2017

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Abstract

Background

Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary kidney disease characterized by the progressive enlargement of innumerable renal cysts. Although the association of intracranial aneurysms (ICANs) with ADPKD is well known, the relationship between the ICAN and the disease severity including total kidney volume (TKV) and estimated glomerular filtration rate (eGFR) is poorly understood.

Methods

We screened 265 patients with ADPKD (mean age, 48.8 years; range, 14.9–88.3 years) with MR angiography. The patients with a past history related to ICANs were excluded from the study. The incidence and characteristics of ICAN in patients with ADPKD were evaluated. TKV was measured by volumetric analyses of MR imaging.

Results

We detected 65 ICANs in 49 patients (37 women and 12 men, mean age, 52.7 years; range, 20.4–86 years). The incidence of ICANs was 18.5% and female patients had was higher incidence (23.1%) than male patients (11.4%) (p = 0.02). An age of those with ICANs was significantly higher than those without (p = 0.006), and the cumulative risk of diagnosis of ICANs increased with age. TKV was significantly larger in those with ICANs than those without (p = 0.001), but eGFR was not different between two groups (p = 0.07). By multivariate analyses, only TKV was significantly related to the development of ICANs (p = 0.02).

Conclusions

The incidence of ICANs increased with age, was higher in females, and correlated with kidney enlargement in patients with ADPKD. Necessity of screening ICANs would be particularly high in elderly women with large kidneys.
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Metadaten
Titel
Relationship between intracranial aneurysms and the severity of autosomal dominant polycystic kidney disease
verfasst von
Hiroki Yoshida
Eiji Higashihara
Keisuke Maruyama
Kikuo Nutahara
Toshiaki Nitatori
Isao Miyazaki
Yoshiaki Shiokawa
Publikationsdatum
07.09.2017
Verlag
Springer Vienna
Erschienen in
Acta Neurochirurgica / Ausgabe 12/2017
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-017-3316-8

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