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16.04.2016 | Original Article | Ausgabe 1/2017

Irish Journal of Medical Science (1971 -) 1/2017

Relationship between leptin concentration and body fat with peripheral blood mononuclear cells cytokines among obese and overweight adults

Zeitschrift:
Irish Journal of Medical Science (1971 -) > Ausgabe 1/2017
Autoren:
M. Zarrati, E. Salehi, E. Razmpoosh, R. S. Shoormasti, M. J. Hosseinzadeh-attar, F. Shidfar

Abstract

Background

Overweight and obesity has been suggested to be well correlated with altered levels of pro-inflammatory cytokines.

Aim

The purpose of this study is to assess the relationship of body fat mass (BFM), body fat percentage (BFP) and leptin levels with peripheral blood mononuclear cells (PBMCs) cytokines among obese and overweight adults.

Methods

Eighty-two overweight and obese individuals were divided into two BMI-category groups (BMI <30 and BMI ≥30 kg/m2) in this study. Balanced blocked randomization was used based on their sex and BMI ranges. Fasting blood samples, PBMCs cytokines, leptin and anthropometric indices were measured and PBMCs were cultured.

Results

Mean of leptin concentrations were 23.14 ± 4.07 and 28.25 ± 4.35 pg/ml among individuals with BMI <30 and BMI ≥30 kg/m2, respectively. The mean values of anthropometric measurements (all P < 0.001), the concentrations of TNF-α (P = 0.028) and IFN-γ (P = 0.029) were significantly higher among obese individuals. BFP had a significant positive correlation with leptin (P < 0.001, r = 0.445) and TGF-β (P = 0.03, r = 0.243). BFM has significant positive correlation with leptin (P < 0.001, r = 0.521). Leptin had a positive significant correlation with IFN-γ (p = 0.03, r = 0.251).

Conclusions

Regarding these results, we proved that BFP, BFM and leptin levels have significant correlations with some PBMC cytokines. Focusing on such strategies may lead to promises for alleviating obesity and its co-morbidities.

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