Relationship between mammographic calcifications and the clinicopathologic characteristics of breast cancer in Western China: a retrospective multi-center study of 7317 female patients
- 02.08.2017
- Epidemiology
Erschienen in:
- Verfasst von
- Ke Zheng
- Jin-Xiang Tan
- Fan Li
- Yu-Xian Wei
- Xue-Dong Yin
- Xin-Liang Su
- Hong-Yuan Li
- Qi-Lun Liu
- Bin-Lin Ma
- Jiang-Hua Ou
- Hui Li
- Sui-Sheng Yang
- Ai-Mei Jiang
- Qing Ni
- Jian-Lun Liu
- Jin-Ping Liu
- Hong Zheng
- Zhang-Jun Song
- Ling Wang
- Jian-Jun He
- Tian-Ning Zou
- Jun Jiang
- Guo-Sheng Ren
- Erschienen in
- Breast Cancer Research and Treatment | Ausgabe 2/2017
Abstract
Background and purpose
Limited information is available regarding the correlations between mammographic calcifications and the epidemiological features of patients with breast cancer living different lifestyles in Western China. Thus, this study aimed to investigate the relationship between mammographic calcifications and the epidemiological characteristics of female patients with breast cancer in Western China.
Methods
This was a hospital-based, retrospective, multi-center epidemiological study of patients with breast cancer. Using the Western China Clinical Cooperation Group (WCCCG) database, we obtained the records of 7317 patients (with mammographic data) diagnosed with breast cancer between March 2011 and June 2016. These patients were divided into Groups I (mass alone) and II (mass combined with calcification), and their clinical and pathological data were compared.
Results
A total of 4211 patients were enrolled in Group I, and 3106 patients were enrolled in Group II. The tumors in Group II were more likely to be larger (P < 0.0001), higher grade (P = 0.0029), estrogen receptor (ER)+/progesterone receptor (PR)− (P = 0.0319), and human epidermal growth factor receptor 2 (HER-2)-positive (P < 0.0001), and to have axillary lymph node metastasis (P = 0.0033) than those in Group I. Regarding treatment, patients in Group II were more likely to have undergone chemotherapy (P = 0.0108) and anti-HER2 therapy (P = 0.0102), whereas patients in Group I were more likely to have undergone endocrine therapy (P < 0.0001).
Conclusions
In conclusion, mammographic calcifications in tumors were associated with distinct clinicopathologic characteristics and aggressive treatments.
Anzeige
- Titel
- Relationship between mammographic calcifications and the clinicopathologic characteristics of breast cancer in Western China: a retrospective multi-center study of 7317 female patients
- Verfasst von
-
Ke Zheng
Jin-Xiang Tan
Fan Li
Yu-Xian Wei
Xue-Dong Yin
Xin-Liang Su
Hong-Yuan Li
Qi-Lun Liu
Bin-Lin Ma
Jiang-Hua Ou
Hui Li
Sui-Sheng Yang
Ai-Mei Jiang
Qing Ni
Jian-Lun Liu
Jin-Ping Liu
Hong Zheng
Zhang-Jun Song
Ling Wang
Jian-Jun He
Tian-Ning Zou
Jun Jiang
Guo-Sheng Ren
- Publikationsdatum
- 02.08.2017
- Verlag
- Springer US
- Erschienen in
-
Breast Cancer Research and Treatment / Ausgabe 2/2017
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217 - DOI
- https://doi.org/10.1007/s10549-017-4406-2
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