The authors declare that they have no competing interests.
ML, with the most contribution to the study, was responsible for the study design, data collection, and manuscript writing. PL, RT, YP, SY, and WH helped with the acquisition and interpretation of data and with manuscript revisions. PL also analyzed the data. LH guaranteed this work, provided academic guidance, and took responsibility for the accuracy of the data analysis. All authors read and approved the final manuscript.
Insulin resistance (IR) plays a vital role in the pathogenesis of Type 2 Diabetes Mellitus (T2DM). The mechanism of IR may be associated with inflammation, whereas the neutrophil-lymphocyte ratio (NLR) is a new indicator of subclinical inflammation. Scholars have rarely investigated the relationship between IR and NLR. This study aims to evaluate the relationship between IR and NLR, and determine whether or not NLR is a reliable marker for IR.
The sample consists of a total of 413 patients with T2DM, 310 of whom have a HOMA-IR value of > 2.0. The control group consists of 130 age and BMI matched healthy subjects.
The NLR values of the diabetic patients were significantly higher than those of the healthy control (P < 0.001), and the NLR values of the patients with a HOMA-IR value of > 2.0 are notably greater than those of the patients with a HOMA-IR value of ≤ 2.0 (P < 0.001). Pearson correlation analysis showed a significant positive correlation of NLR with HOMA-IR (r = 0.285) (P < 0.001). Logistic regression analysis showed that the risk predictors of IR include NLR, TG and HbA1c. NLR (P < 0.001, EXP(B) = 7.231, 95% CI = 4.277–12.223) levels correlated positively with IR. The IR odds ratio increased by a factor of 7.231 (95% CI, 4.277–12.223) for every one unit increase in NLR.
Increased NLR was significantly associated with IR, and high NLR values may be a reliable predictive marker of IR.
DallaVestra M, Mussap M, Gallina P, Bruseghin M, Cernigoi A, Saller A, et al. Acute-phase markers of inflammation and glomerular structure in patients with type 2 diabetes. J Am Soc Nephrol. 2005;16:78–82. CrossRef
Ross R. Atherosclerosis is an inflammatory disease. Am Heart J. 1999;138:419–20. CrossRef
Mansoori D, Jamaati H, Arami S, Zadsar M, Abbasian L, Reza A, et al. Comparison of lymphocyte number and their subsets in patients with diabetes mellitus type II, tuberculosis and concomitant TB and diabetes. Tanaffos. 2002;1:45–50.
Von Vietinghoff S, Ley K. Homeostatic regulation of blood neutrophil counts. J Immunol. 2008;181:5183–8. CrossRef
Stewart GJ. Neutrophils and deep venous thrombosis. Haemostasis. 1993;1:127–40.
Rudiger A, Burckhardt OA, Harpes P, Muller SA, Follath F. The relative lymphocyte count on hospital admission is a risk factor for long-term mortality in patients with acute heart failure. Am J Emerg Med. 2006;2009(24):451–4. CrossRef
Gorasia DG, Dudek NL, Veith PD, Shankar R, Safavi-Hemami H, Williamson NA, Reynolds EC, Hubbard MJ, Purcell AW: Pancreatic Beta Cells Are Highly Susceptible to Oxidative and ER Stresses during the Development of Diabetes J Proteome Res 2014 Dec 8.
Zahorec R. Ratio of neutrophil to lymphocyte counts–rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102:5–14. PubMed
Heianza Y, Arase Y, Fujihara K, Tsuji H, Saito K, Hsieh SD, et al. High normal HbA(1c) levels were associated with impaired insulin secretion without escalating insulin resistance in Japanese individuals: the toranomon hospital health management center study 8 (TOPICS 8). Diabet Med. 2012;29:1285–90. CrossRefPubMed
Kelley DE, Slasky BS, Janosky J. Skeletal muscle density: effects of obesity and non-insulin-dependent diabetes mellitus. Am J Clin Nutr. 1991;54:509–15. PubMed
Gorden ES: Non-esterified fatty acids in blood of obese and lean subjects. Am J Clin Nutr 1960, 740–747.
- Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients
- BioMed Central
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