Anzeige
Erschienen in:
02.09.2015 | Retinal Disorders
Relationship between plasma levels of vasoactive mediators and optic nerve head circulation shown by laser speckle flowgraphy
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 6/2016
Einloggen, um Zugang zu erhaltenAbstract
Propose
To evaluate relationships between optic nerve head (ONH) circulation by laser speckle flowgraphy (LSFG), and secretion levels of plasma norepinephrine (NE), plasma renin activity (PRA), plasma aldosterone concentration (PAC), and plasma cortisol.
Method
Forty subjects were included in the study. The mean blur rates (MBR) throughout the ONH (MBR–all), in the tissue (MBR–tissue), and in vessels (MBR–vessel) were analyzed. In 29 subjects the following parameters were evaluated: plasma NE and ONH circulation in the evening and morning (Δ plasma NE, Δ MBR–all, –tissue, –vessel, and Δ area ratio of blood stream).
Results
Plasma NE was significantly correlated with MBR–all (r = 0.39, P = 0.01) and MBR–vessel (r = 0.51, P = 0.0008). Plasma cortisol was significantly correlated with MBR–vessel (r =0.35, P = 0.03). The PRA (r = 0.31, P = 0.05) and PAC (r = 0.31, P = 0.05) tended to correlate with MBR–vessel. The multiple regression analysis revealed that plasma NE, PAC, and ocular perfusion pressure (OPP) were identified as factors contributing independently to the MBR–vessel (plasma NE: standard regression = 0.48, t-value = 3.12, P = 0.004; PAC: 0.43, 3.10, 0.04; OPP: 0.58, 2.34, 0.03, r = 0.71). Positive correlations between Δ plasma NE and Δ MBR–all (r = 0.46, P = 0.01), Δ MBR–tissue (0.38, 0.04), Δ MBR–vessel (0.41, 0.03), and Δ area ratio of blood stream (0.38, 0.04) were observed.
Conclusion
Our results clarified that the measurements of ONH circulation by LSFG is reflecting the plasma secretion levels of vasoactive mediators.