The authors declare that they have no competing interests.
Conception and design of the work: DS. Acquisition, analysis or interpretation of data for the work: DS, NS, MDP, SQ, PP, WB, NSH and DB. Drafting the article or revising it critically for important intellectual content: DS, NS, MDP, SQ, PP, WB, NSH and DB. Final approval of the version to be published: DS, NS, MDP, SQ, PP, WB, NSH and DB.
The aim of this study was to examine the relationship between pulmonary exacerbations and physical activity (PA) in adults with cystic fibrosis (CF).
We grouped adults with CF according to their exacerbation status in the year before study enrolment: (1) <1 exacerbation/year; (2) 1–2 exacerbations/year; and (3) >2 exacerbations/year. PA was assessed objectively by means of an accelerometer at the time of study enrolment.
Patients with >2 exacerbations/year spent less time in PA; specifically, fewer activities of mild intensity [>3 metabolic equivalents (METs)], and lower active energy expenditure (P = 0.01 and P = 0.03, respectively). After correcting for relevant confounders, PA levels were not related to the exacerbation frequency in the preceding year. PA at moderate intensity (4.8–7.2 METs) or greater (>7.2 METs) was independently associated with gender and FEV1 % predicted (P = 0.007 and P = 0.04, respectively). Compared with men, women had reduced vigorous activities (P = 0.01) and active energy expenditure (P = 0.01).
Adult CF patients with more pulmonary exacerbations in the preceding year have more advanced disease and are less active than their peers. PA was independently associated with gender and airflow obstruction. Gender differences in PA are evident in CF adults.
Cystic Fibrosis Foundation Patient Registry 2008. Annual Report to the Center Directors. Bethesda: Cystic Fibrosis Foundation; 2009.
Wilkes DL, Schneiderman JE, Nguyen T, Heale L, Moola F, Ratjen F, et al. Exercise and physical activity in children with cystic fibrosis. Paediatric Respir Rev. 2009;10(3):105–9. CrossRef
van de Weert-van Leeuwen PB, Arets HG, van der Ent CK, Beekman JM. Infection, inflammation and exercise in cystic fibrosis. Respir Res. 2013;14:32. CrossRef
Dwyer TJ, Elkins MR, Bye PTP. The role of exercise in maintaining health in cystic fibrosis. Current Opinion in Pumonary Medicine. 2011;17:455–60.
Flume PA, Mogayzel Jr PJ, Robinson KA, Goss CH, Rosenblatt RL, Kuhn RJ, et al. Clinical Practice Guidelines for Pulmonary Therapies Committee. Clinical Practice Guidelines for Pulmonary Therapies Committee. Cystic fibrosis pulmonary guidelines: treatment of pulmonary exacerbations. Am J Respir Crit Care Med. 2009;180:802–8. CrossRefPubMed
Crapo RO, Morris AH, Gardner RM. Reference spirometric values using techniques and equipment that meet ATS recommendations. Am Rev Respir Dis. 1981;123:659–64. PubMed
Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, et al. American College of Sports Medicine; American Heart Association. American College of Sports Medicine; American Heart Association: Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and American Heart Association. Circulation. 2007;116:1081–93. CrossRefPubMed
- Relationship between pulmonary exacerbations and daily physical activity in adults with cystic fibrosis
Marcello Di Paolo
Nicholas S. Hopkinson
- BioMed Central
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