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28.11.2016 | Original Article | Ausgabe 3/2017

International Journal of Diabetes in Developing Countries 3/2017

Relationship between serum pro- and anti-inflammatory cytokine and growth factor concentrations with the age and gender adjusted prevalence of diabetes and pre-diabetes

Zeitschrift:
International Journal of Diabetes in Developing Countries > Ausgabe 3/2017
Autoren:
Elahe Mahdipour, Maryam Azizian, Seyed Reza Mirhafez, Shiva Ganjali, Sara Shoeibi, Mohsen Nematy, Habibollah Esmaily, Gordon AA Ferns, Majid Ghayour Mobarhan

Abstract

The main goal of the present study is to compare the serum pro- and anti-inflammatory cytokines and growth factor profile (IL-1α, IL-1β, IL-2, IL-6, IL-8, IFN-γ, MCP-1, TNF-α, IL-10, IL-4, VEGF, and EGF) in individuals with diabetes or pre-diabetes and control subjects matched for age and gender. This study included 270 normal control subjects, 41 pre-diabetics, and 104 diabetic subjects. Demographic and anthropometric characteristics and serum biochemistry parameters, smoking status, and blood pressure were determined. Serum cytokine and growth factor measurements were performed using a multiplex biochip array based method. After removing the effects of confounders such as age, sex, smoking, BMI, serum triglyceride and cholesterol, hypertension, and treatment with anti-diabetic drugs, serum IL-4 (p = 0.015), IL-1α (p = 0.031), and VEGF (p = 0.012) were significantly associated with the presence of diabetes mellitus. The presence of pre-diabetes was positively associated with serum IL-4 (p < 0.001), and IL-1α (p = 0.026). We have found a positive association between serum IL-1α, and IL-4, and a negative association of serum VEGF with the presence of diabetes, or pre-diabetes.

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