Background
Methods
Study population
Mammographic density assessment
Blood collection and laboratory assay
IGF measure | QC measures | Premenopausal (N = 193) | Postmenopausal (N = 103) | |||||
---|---|---|---|---|---|---|---|---|
CV (%) | ICC (%) | Median1 | 10th percentile | 90th percentile | Median | 10th percentile | 90th percentile | |
IGF-I | 2.03 | 99.6 | 120 | 83.7 | 182 | 111 | 72.5 | 143 |
IGFBP-12 | 7.50 | 99.0 | 2.05 | 0.03 | 6.39 | 1.86 | 0.03 | 7.31 |
IGFBP-2 | 3.75 | 99.4 | 341 | 177 | 639 | 357 | 149 | 616 |
IGFBP-3 | 6.19 | 92.2 | 3502 | 2715 | 4455 | 3519 | 2676 | 4508 |
IGFBP-4 | 5.70 | 95.3 | 130 | 99 | 176 | 156 | 117 | 218 |
IGFBP-5 | 5.32 | 96.1 | 387 | 280 | 508 | 402 | 291 | 521 |
IGFBP-6 | 5.45 | 94.2 | 188 | 143 | 240 | 176 | 128 | 238 |
IGFBP-7 | 5.43 | 92.2 | 105 | 86.2 | 134 | 115 | 99.1 | 139 |
Statistical analysis
Results
Participant characteristics
Distribution of IGF and IGFBPs in women stratified by menopausal status
Relationship of circulating IGF measures with select participant characteristics
Characteristics |
N
| IGF-I | IGFBP-1 | IGFBP-2 | IGFBP-3 | IGFBP-4 | IGFBP-5 | IGFBP-6 | IGFBP-7 |
Mean1 (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | ||
Age at biopsy (years) | |||||||||
< 45 | 56 | 131 (121–142) | 1.08 (0.46–1.71) | 340 (298–381) | 3499 (3321–3678) | 135 (126–143) | 402 (378–425) | 178 (167–189) | 105 (100–110) |
45–49 | 83 | 123 (114–131) | 0.78 (0.40–1.17) | 344 (311–378) | 3393 (3243–3542) | 130 (123–137) | 390 (366–414) | 185 (178–193) | 107 (102–111) |
≥ 50 | 54 | 112 (104–120) | 0.60 (0.21–0.99) | 308 (263–354) | 3511 (3328–3694) | 128 (121–135) | 363 (338–388) | 199 (187–210) | 111 (105–117) |
p trend (p het) |
0.005 (0.02)
| 0.18 (0.88) | 0.30 (0.4) | 0.94 (0.53) | 0.25 (0.50) | 0.04 (0.11) |
0.009 (0.03)
| 0.15 (0.31) | |
Education | |||||||||
≤ High school grad/GED | 27 | 107 (94–121) | 3.69 (2.46-4.92) | 326 (264–388) | 3509 (3198–3820) | 132 (120–144) | 336 (307–365) | 191 (178–205) | 106 (96–115) |
Some college/tech school | 37 | 122 (109–135) | 2.42 (1.66-3.18) | 277 (231–323) | 3483 (3245–3721) | 129 (120–138) | 376 (351–401) | 191 (181–201) | 101 (95–107) |
≥ College graduate | 129 | 125 (119–131) | 3.42 (2.95-3.88) | 352 (324–380) | 3438 (3326–3549) | 131 (126–137) | 400 (381–419) | 185 (177–192) | 110 (106–113) |
p trend (p het) | 0.02 (0.05) | 0.77 (0.11) | 0.11 (0.03) | 0.58 (0.86) | 0.96 (0.89) |
0.001 (0.005)
| 0.37 (0.62) | 0.12 (0.05) | |
Body mass index (kg/m2) | |||||||||
< 25 | 97 | 124 (117–131) | 2.06 (1.34–2.79) | 399 (364–433) | 3343 (3200–3485) | 128 (121–134) | 396 (375–418) | 185 (177–192) | 107 (103–112) |
25.0–29.9 | 48 | 122 (111–133) | 0.91 (0.35–1.48) | 340 (297–383) | 3483 (3292–3675) | 133 (125–141) | 380 (357–404) | 189 (177–201) | 107 (102–113) |
≥ 30 | 48 | 118 (107–128) | 0.10 (0.04–0.16) | 225 (200–250) | 3670 (3506–3833) | 136 (127–145) | 370 (342–398) | 189 (176–201) | 108 (102–113) |
p trend (p het) | 0.31 (0.59) |
< 0.0001 (< 0.0001)
|
< 0.0001 (< 0.0001)
|
0.007 (0.03)
| 0.11 (0.27) | 0.12 (0.29) | 0.53 (0.76) | 0.98 (0.99) | |
Age at menarche (years) | |||||||||
≤ 12 | 69 | 122 (112–131) | 0.79 (0.38–1.21) | 320 (283–358) | 3561 (3394–3728) | 136 (129–144) | 381 (351–411) | 187 (177–197) | 113 (107–119) |
13 | 73 | 122 (114–130) | 0.99 (0.47–1.51) | 343 (304–382) | 3449 (3287–3611) | 129 (123–136) | 387 (367–401) | 184 (175–193) | 106 (102–110) |
≥ 14 | 48 | 123 (114–132) | 0.58 (0.19–0.97) | 335 (290–380) | 3342 (3162–3522) | 128 (119–136) | 394 (373–415) | 191 (179–203) | 104 (98–110) |
p trend (p het) | 0.83 (0.97) | 0.55 (0.71) | 0.58 (0.67) | 0.09 (0.23) | 0.12 (0.25) | 0.49 (0.78) | 0.71 (0.65) | 0.02 (0.05) | |
Age at first birth (years) | |||||||||
Nulliparous/ ≥ 30 years | 94 | 118 (111–126) | 0.83 (0.44–1.22) | 338 (302–373) | 3324 (3188–3461) | 132 (125–139) | 392 (370–414) | 184 (176–192) | 108 (104–113) |
< 30 years | 98 | 126 (119–133) | 0.77 (0.42–1.12) | 329 (299–359) | 3593 (3459–3727) | 130 (124–135) | 379 (361–398) | 191 (183–199) | 107 (103–111) |
p het | 0.14 | 0.81 | 0.70 |
0.007
| 0.60 | 0.39 | 0.22 | 0.61 | |
Parity | |||||||||
Nulliparous (0) | 45 | 111 (100–122) | 0.55 (0.15–0.96) | 329 (274–383) | 3251 (3052–3450) | 130 (121–139) | 378 (350–407) | 179 (168–191) | 102 (97–106) |
1 | 20 | 122 (108–135) | 0.51 (0.003–1.02) | 272 (220–325) | 3414 (3124–3704) | 136 (119–154) | 394 (328–460) | 180 (165–197) | 116 (101–132) |
2 | 82 | 127 (119–134) | 0.81 (0.41–1.21) | 344 (309–378) | 3528 (3388–3667) | 128 (121–135) | 390 (370–409) | 190 (182–199) | 109 (105–114) |
≥ 3 | 46 | 126 (115–137) | 1.36 (0.54–2.18) | 346 (300–391) | 3557 (3340–3774) | 135 (127–142) | 382 (354–411) | 191 (179–204) | 106 (101–111) |
p trend (p het) | 0.02 (0.08) | 0.05 (0.39) | 0.35 (0.25) | 0.02 (0.10) | 0.76 (0.53) | 0.81 (0.90) | 0.09 (0.35) | 0.35 (0.05) | |
Characteristics |
N
| IGF-I | IGFBP-1 | IGFBP-2 | IGFBP-3 | IGFBP-4 | IGFBP-5 | IGFBP-6 | IGFBP-7 |
Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | ||
Oral contraceptive use | |||||||||
Never | 28 | 124 (108–139) | 0.71 (0.06–1.35) | 339 (280–399) | 3372 (3108–3637) | 123 (110–135) | 397 (354–439) | 196 (182–210) | 104 (97–111) |
Former | 165 | 122 (116–127) | 0.82 (0.53–1.10) | 331 (307–356) | 3471 (3366–3575) | 132 (128–137) | 384 (369–399) | 185 (179–192) | 108 (105–111) |
p het | 0.80 | 0.76 | 0.81 | 0.48 | 0.12 | 0.54 | 0.19 | 0.31 | |
Menopausal hormone use | |||||||||
Never | 169 | 123 (118–128) | 0.88 (0.58–1.18) | 342 (317–366) | 3448 (3349–3546) | 130 (126–135) | 387 (371–402) | 189 (183–195) | 107 (104–111) |
Former | 22 | 117 (100–133) | 0.41 (−0.02–0.84) | 267 (210–324) | 3555 (3153–3958) | 132 (118–146) | 372 (338–407) | 177 (157–196) | 109 (101–118) |
p het | 0.45 | 0.15 |
0.03
| 0.50 | 0.81 | 0.53 | 0.18 | 0.69 | |
Family history of breast cancer in a first-degree relative | |||||||||
None | 145 | 124 (118–130) | 0.74 (0.46–1.03) | 331 (305–357) | 3460 (3343–3577) | 131 (126–136) | 390 (373–407) | 186 (179–192) | 107 (103–111) |
1 or more | 47 | 115 (108–123) | 1.08 (0.45–1.71) | 335 (286–385) | 3426 (3258–3594) | 131 (124–138) | 376 (351–400) | 189 (179–202) | 109 (104–114) |
p het | 0.15 | 0.33 | 0.88 | 0.77 | 0.93 | 0.39 | 0.52 | 0.64 | |
Cigarette smoking | |||||||||
Never | 100 | 126 (119–134) | 0.89 (0.49–1.30) | 339 (306–372) | 3462 (3323–3601) | 135 (129–141) | 402 (383–421) | 189 (181–198) | 109 (105–113) |
Former | 65 | 116 (109–124) | 0.77 (0.36–1.18) | 322 (283–360) | 3417 (3264–3570) | 123 (115–131) | 368 (343–393) | 182 (172–192) | 105 (99–111) |
Current | 20 | 118 (101–136) | 0.54 (−0.08–1.16) | 357 (292–423) | 3566 (3215–3917) | 141 (129–153) | 346 (313–379) | 195 (182–207) | 108 (98–118) |
p trend (p het) | 0.12 (0.19) | 0.38 (0.11) | 0.98 (0.65) | 0.79 (0.70) | 0.58 (0.01) |
0.005 (0.02)
| 0.85 (0.36) | 0.45 (0.42) | |
Breast biopsy prior to enrollment | |||||||||
Never | 130 | 122 (116–128) | 0.71 (0.43–0.99) | 321 (295–347) | 3433 (3311–3556) | 132 (126–137) | 388 (371–405) | 184 (177–191) | 109 (105–113) |
Ever | 63 | 122 (113–131) | 1.02 (0.45–1.58) | 357 (311–402) | 3504 (3348–3660) | 129 (123–136) | 381 (355–407) | 194 (184–204) | 104 (99–108) |
p het | 0.94 | 0.31 | 0.16 | 0.51 | 0.63 | 0.66 | 0.10 | 0.09 | |
Biopsy diagnosis | |||||||||
Benign non-proliferative | 70 | 119 (111–126) | 0.58 (0.26–0.91) | 310 (277–343) | 3425 (3277–3573) | 137 (128–145) | 401 (375–427) | 180 (171–190) | 107 (101–113) |
Proliferative with/without atypia | 97 | 125 (118–133) | 1.16 (0.66–1.66) | 353 (317–389) | 3467 (3329–3605) | 128 (123–134) | 382 (363–400) | 189 (181–197) | 108 (104–112) |
In situ/invasive | 26 | 119 (102–137) | 0.46 (0.03–0.88) | 321 (264–377) | 3502 (3181–3823) | 124 (113–136) | 361 (324–398) | 198 (183–213) | 107 (100–115) |
p trend (p het) | 0.65 (0.49) | 0.73 (0.07) | 0.38 (0.21) | 0.60 (0.87) | 0.04 (0.10) | 0.07 (0.19) | 0.04 (0.13) | 0.93 (0.97) |
Characteristics |
N
| IGF-I | IGFBP-1 | IGFBP-2 | IGFBP-3 | IGFBP-4 | IGFBP-5 | IGFBP-6 | IGFBP-7 |
Mean1 (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | ||
Age at biopsy (years) | |||||||||
<55 | 30 | 105 (94–116) | 0.66 (0.09–1.23) | 335 (271–398) | 3563 (3248–3878) | 150 (135–165) | 388 (357–420) | 184 (166–201) | 113 (106–121) |
55–59 | 38 | 111 (101–121) | 0.40 (0.09–0.72) | 333 (275–392) | 3578 (3370–3787) | 159 (145–172) | 416 (384–447) | 164 (150–177) | 115 (110–121) |
≥ 60 | 35 | 92 (81–103) | 0.94 (0.42–1.63) | 333 (278–388) | 3340 (3027–3652) | 159 (147–170) | 377 (348–405) | 181 (168–194) | 121 (114–128) |
p trend (p het) | 0.67 (0.03) | 0.51 (0.32) | 0.97 (0.99) | 0.26 (0.40) | 0.38 (0.61) | 0.54 (0.18) | 0.87 (0.10) | 0.08 (0.20) | |
Education | |||||||||
≤ High school grad/GED | 22 | 108 (93–124) | 3.13 (1.88-4.37) | 287 (221–353) | 3694 (3383–4005) | 167 (147–186) | 398 (356–440) | 173 (155–192) | 119 (107–131) |
Some college/tech school | 19 | 105 (93–118) | 2.79 (1.81-3.78) | 314 (252–375) | 3389 (3031–3748) | 151 (136–166) | 415 (379–451) | 191 (165–216) | 116 (107–126) |
≥ College graduate | 62 | 100 (92–108) | 3.42 (2.68-4.15) | 359 (311–406) | 3453 (3236–3670) | 154 (145–164) | 386 (363–409) | 171 (162–181) | 116 (113–120) |
p trend (p het) | 0.31 (0.59) | 0.56 (0.67) | 0.07 (0.20) | 0.33 (0.44) | 0.29 (0.39) | 0.46 (0.50) | 0.58 (0.25) | 0.65 (0.88) | |
Body mass index (kg/m2) | |||||||||
< 25 | 41 | 104 (95–112) | 1.62 (0.61–2.63) | 446 (397–494) | 3343 (3154–3532) | 141 (130–153) | 396 (371–421) | 166 (154–177) | 114 (110–119) |
25.0–29.9 | 31 | 103 (91–114) | 0.83 (0.20–1.47) | 323 (263–383) | 3631 (3328–3934) | 168 (153–182) | 388 (354–423) | 179 (164–193) | 112 (106–118) |
≥ 30 | 31 | 101 (87–115) | 0.13 (0.03–0.23) | 235 (194–276) | 3554 (3183–3926) | 166 (155–177) | 398 (362–433) | 185 (166–203) | 125 (117–133) |
p trend (p het) | 0.78 (0.96) |
< 0.0001 (< .0001)
|
< 0.0001 (< .0001)
| 0.25 (0.30) |
0.005 (0.004)
| 0.95 (0.92) | 0.06 (0.16) |
0.03 (0.02)
| |
Age at menarche (years) | |||||||||
≤ 12 | 42 | 105 (97–112) | 0.44 (0.11–0.76) | 317 (262–371) | 3587 (3352–3821) | 157 (146–168) | 389 (363–416) | 180 (166–194) | 114 (109–119) |
13 | 34 | 99 (86–111) | 0.89 (0.17–1.61) | 374 (311–436) | 3365 (3055–3675) | 149 (136–161) | 392 (360–423) | 176 (164–188) | 120 (114–126) |
≥ 14 | 26 | 109 (96–122) | 0.63 (0.09–1.17) | 315 (256–374) | 3558 (3259–3858) | 163 (144–181) | 409 (371–447) | 166 (147–184) | 117 (108–126) |
p trend (p het) | 0.72 (0.46) | 0.45 (0.44) | 0.87 (0.32) | 0.76 (0.48) | 0.71 (0.38) | 0.43 (0.68) | 0.19 (0.41) | 0.40 (0.44) | |
Age at first birth (years) | |||||||||
Nulliparous/ ≥ 30 years | 37 | 108 (98–118) | 0.54 (0.11–0.97) | 359 (300–418) | 3588 (3351–3825) | 151 (137–165) | 388 (357–419) | 178 (163–193) | 116 (111–122) |
< 30 years | 66 | 100 (92–108) | 0.67 (0.29–1.05) | 320 (279–361) | 3438 (3225–3650) | 159 (150–168) | 397 (376–419) | 174 (163–184) | 117 (112–122) |
p het | 0.24 | 0.64 | 0.29 | 0.39 | 0.30 | 0.63 | 0.64 | 0.82 | |
Parity | |||||||||
Nulliparous (0) | 22 | 103 (89–116) | 0.43 (− 0.02–0.89) | 326 (253–398) | 3542 (3197–3888) | 160 (140–180) | 365 (334–395) | 187 (167–208) | 118 (110–125) |
1 | 20 | 105 (90–119) | 0.71 (− 0.09–1.52) | 326 (244–408) | 3468 (3151–3785) | 152 (135–168) | 417 (375–458) | 171 (151–192) | 113 (107–119) |
2 | 42 | 99 (88–110) | 0.76 (0.24–1.29) | 338 (288–389) | 3445 (3150–3739) | 163 (153–173) | 393 (366–420) | 179 (168–190) | 121 (114–128) |
≥ 3 | 19 | 110 (99–120) | 0.51 (−0.05–1.06) | 341 (255–428) | 3559 (3278–3841) | 142 (125–160) | 408 (356–460) | 158 (138–178) | 111 (104–118) |
p trend (p het) | 0.78 (0.71) | 0.72 (0.80) | 0.72 (0.99) | 0.95 (0.95) | 0.40 (0.23) | 0.23 (0.27) | 0.09 (0.15) | 0.71 (0.17) | |
Characteristics |
N
| IGF-I | IGFBP-1 | IGFBP-2 | IGFBP-3 | IGFBP-4 | IGFBP-5 | IGFBP-6 | IGFBP-7 |
Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | ||
Oral contraceptive use | |||||||||
Never | 15 | 90 (77–103) | 1.14 (−0.04–2.32) | 291 (230–352) | 3214 (2799–3630) | 164 (138–190) | 414 (374–454) | 175 (151–199) | 117 (109–126) |
Former | 88 | 105 (98–112) | 0.56 (0.27–0.84) | 342 (303–380) | 3540 (3367–3714) | 155 (147–163) | 391 (371–410) | 175 (166–184) | 117 (113–121) |
p het | 0.08 | 0.29 | 0.28 | 0.15 | 0.41 | 0.38 | 0.99 | 0.89 | |
Menopausal hormone use | |||||||||
Never | 67 | 101 (93–110) | 0.65 (0.28–1.01) | 329 (287–372) | 3464 (3270–3659) | 159 (149–168) | 392 (371–413) | 174 (164–184) | 116 (111–121) |
Former | 36 | 105 (96–115) | 0.57 (0.11–1.03) | 342 (287–398) | 3541 (3252–3830) | 152 (139–165) | 398 (365–431) | 177 (161–193) | 118 (113–124) |
p het | 0.55 | 0.81 | 0.72 | 0.66 | 0.40 | 0.75 | 0.79 | 0.60 | |
Family history of breast cancer in a first-degree relative | |||||||||
None | 75 | 103 (97–110) | 0.53 (0.24–0.83) | 333 (295–371) | 3490 (3321–3660) | 155 (146–164) | 391 (371–412) | 172 (162–182) | 117 (112–121) |
1 or more | 27 | 102 (86–118) | 0.90 (0.13–1.67) | 344 (270–418) | 3469 (3073–3865) | 160 (145–174) | 404 (366–441) | 184 (167–200) | 117 (111–123) |
p het | 0.83 | 0.33 | 0.78 | 0.91 | 0.59 | 0.55 | 0.26 | 0.88 | |
Age at menopause | |||||||||
< 45 | 17 | 95 (77–113) | 0.91 (− 0.01–1.84) | 287 (208–367) | 3389 (2996–3783) | 168 (143–193) | 411 (378–444) | 181 (158–203) | 118 (111–126) |
45–49 | 26 | 114 (103–126) | 0.40 (0.02–0.79) | 305 (245–365) | 3585 (3257–3913) | 153 (140–166) | 415 (377–453) | 164 (148–180) | 119 (109–130) |
≥ 50 | 48 | 105 (97–112) | 0.57 (0.18–0.96) | 351 (300–402) | 3607 (3411–3803) | 153 (142–165) | 380 (353–407) | 180 (168–193) | 115 (111–120) |
p trend (p het) | 0.53 (0.11) | 0.67 (0.54) | 0.14 (0.32) | 0.36 (0.58) | 0.28 (0.42) | 0.14 (0.23) | 0.70 (0.28) | 0.48 (0.69) | |
Cigarette smoking | |||||||||
Never | 37 | 103 (91–116) | 0.68 (0.16–1.21) | 357 (296–418) | 3491 (3144–3838) | 157 (145–168) | 387 (358–416) | 184 (168–201) | 119 (113–124) |
Former | 47 | 105 (97–114) | 0.40 (0.12–0.68) | 296 (250–342) | 3546 (3371–3722) | 155 (144–167) | 418 (391–444) | 174 (164–184) | 117 (112–122) |
Current | 11 | 89 (71–108) | 2.60 (−0.06–5.25) | 382 (297–466) | 3167 (2789–3544) | 178 (151–204) | 355 (307–402) | 149 (125–173) | 113 (93–133) |
p trend (p het) | 0.39 (0.31) | 0.45 (0.06) | 0.66 (0.16) | 0.45 (0.36) | 0.29 (0.25) | 0.87 (0.07) |
0.02 (0.04)
| 0.43 (0.70) | |
Breast biopsy prior to enrollment | |||||||||
Never | 62 | 102 (94–109) | 0.67 (0.26–1.08) | 344 (300–387) | 3429 (3251–3607) | 158 (148–168) | 404 (384–425) | 175 (163–186) | 115 (112–119) |
Ever | 39 | 105 (93–117) | 0.50 (0.13–0.87) | 313 (258–369) | 3610 (3287–3933) | 156 (144–167) | 379 (346–412) | 177 (163–190) | 119 (112–127) |
p het | 0.66 | 0.55 | 0.39 | 0.30 | 0.76 | 0.18 | 0.84 | 0.32 | |
Biopsy diagnosis | |||||||||
Benign non-proliferative | 31 | 103 (93–113) | 0.94 (0.19–1.68) | 369 (313–426) | 3556 (3282–3830) | 152 (137–166) | 409 (379–439) | 169 (152–186) | 114 (107–121) |
Proliferative with/without atypia | 47 | 103 (92–114) | 0.47 (0.13–0.80) | 307 (257–356) | 3499 (3237–3760) | 163 (151–175) | 381 (353–409) | 180 (168–192) | 121 (115–127) |
In-situ/invasive | 25 | 103 (91–114 s) | 0.63 (0.05–1.21) | 345 (271–418) | 3397 (3097–3698) | 149 (136–162) | 401 (368–433) | 175 (159–191) | 112 (107–117) |
p trend (p het) | 0.95 (0.99) | 0.49 (0.46) | 0.55 (0.29) | 0.49 (0.78) | 0.87 (0.28) | 0.67 (0.39) | 0.57 (0.56) | 0.75 (0.12) |
Age
Education
Body mass index
Age at first birth
Cigarette smoking
Relationship of circulating IGF-I and IGFBPs with mammographic density measures
IGF measures | % MD-V1 | % MD-A | Absolute MD-V | Absolute MD-A | Non-dense volume | Non-dense area | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
β
|
p
4
|
β
|
p
|
β
|
p
|
β
|
p
|
β
|
p
|
β
|
p
| |
IGF-I | 0.11 | 0.97 | − 1.29 | 0.69 | − 0.39 | 0.95 | − 0.42 | 0.92 | − 10.33 | 0.33 | − 1.99 | 0.65 |
IGFBP-13 | 17.19 | 0.51 | 21.93 | 0.51 | − 5.38 | 0.94 | 18.15 | 0.66 | − 133.91 | 0.22 | − 34.22 | 0.46 |
IGFBP-2 | 1.49 |
0.02
| 1.55 | 0.05 | 0.35 | 0.83 | 1.48 | 0.13 | − 6.56 |
0.01
| − 1.74 | 0.11 |
IGFBP-3 | − 0.20 | 0.15 | − 0.34 | 0.05 | 0.03 | 0.93 | − 0.24 | 0.28 | 0.57 | 0.33 | 0.33 | 0.18 |
IGFBP-4 | − 7.19 |
0.01
| − 5.08 | 0.18 | − 5.55 | 0.46 | − 4.13 | 0.38 | 25.06 |
0.04
| 5.09 | 0.33 |
IGFBP-5 | − 0.50 | 0.50 | 0.37 | 0.69 | − 0.37 | 0.84 | 0.45 | 0.70 | 0.48 | 0.88 | − 1.21 | 0.35 |
IGFBP-6 | 0.89 | 0.71 | 2.37 | 0.44 | 9.34 | 0.12 | 5.26 | 0.17 | 1.73 | 0.86 | 0.34 | 0.94 |
IGFBP-7 | − 0.80 | 0.83 | − 0.89 | 0.85 | − 3.52 | 0.71 | − 2.59 | 0.66 | − 0.90 | 0.95 | − 1.59 | 0.81 |
IGF-I:IGFBP-1 | < 0.001 | 0.91 | < − 0.001 | 0.62 | < − 0.001 | 0.67 | < − 0.001 | 0.43 | < − 0.001 | 0.61 | < − 0.001 | 0.71 |
IGF-I:IGFBP-2 | − 0.17 | 0.07 | − 0.20 | 0.10 | −0.17 | 0.47 | −0.19 | 0.21 | 0.39 | 0.33 | 0.10 | 0.56 |
IGF-I:IGFBP-3 | 3.31 | 0.28 | 3.29 | 0.40 | 0.003 | 0.99 | 3.27 | 0.50 | − 22.38 | 0.08 | − 7.38 | 0.17 |
IGF-I:IGFBP-4 | 0.05 | 0.46 | − 0.03 | 0.73 | 0.05 | 0.80 | − 0.01 | 0.92 | − 0.40 | 0.18 | − 0.04 | 0.74 |
IGF-I:IGFBP-5 | − 0.02 | 0.93 | − 0.32 | 0.25 | 0.01 | 0.99 | − 0.23 | 0.51 | − 0.37 | 0.69 | 0.36 | 0.36 |
IGF-I:IGFBP-6 | − 0.03 | 0.83 | − 0.19 | 0.29 | − 0.37 | 0.29 | − 0.27 | 0.23 | − 0.64 | 0.28 | − 0.11 | 0.64 |
IGF-I:IGFBP-7 | − 0.04 | 0.54 | − 0.07 | 0.41 | − 0.05 | 0.78 | − 0.04 | 0.70 | − 0.08 | 0.76 | 0.01 | 0.93 |
IGF-I:Total IGFBP | 2.99 | 0.46 | 1.35 | 0.80 | 0.20 | 0.98 | 1.76 | 0.78 | − 24.14 | 0.16 | − 6.35 | 0.37 |
IGF measures | % MD-V1 | % MD-A | Absolute MD-V | Absolute MD-A | Non-Dense Volume | Non-Dense Area | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
β
|
p
4
|
β
|
p
|
β
|
p
|
β
|
p
|
β
|
p
|
β
|
p
| |
IGF-I | − 0.55 | 0.89 | 1.97 | 0.70 | − 6.57 | 0.49 | 3.10 | 0.64 | − 5.95 | 0.77 | − 5.26 | 0.48 |
IGFBP-13 | 50.06 | 0.15 | − 49.56 | 0.28 | − 84.48 | 0.34 | − 77.58 | 0.20 | − 418.94 |
0.02
| − 8.09 | 0.91 |
IGFBP-2 | 2.04 |
0.003
| − 0.01 | 0.99 | − 1.29 | 0.47 | − 0.89 | 0.47 | − 13.13 |
0.0003
| − 1.33 | 0.33 |
IGFBP-3 | − 0.13 | 0.37 | 0.21 | 0.28 | − 0.51 | 0.16 | 0.32 | 0.20 | 0.06 | 0.93 | − 0.26 | 0.36 |
IGFBP-4 | − 1.72 | 0.55 | − 2.22 | 0.56 | 2.74 | 0.70 | − 1.03 | 0.84 | 12.02 | 0.43 | 8.42 | 0.13 |
IGFBP-5 | − 0.74 | 0.53 | − 0.10 | 0.95 | − 0.36 | 0.91 | 0.80 | 0.70 | 2.67 | 0.67 | − 0.29 | 0.90 |
IGFBP-6 | − 3.08 | 0.21 | − 4.67 | 0.15 | 2.20 | 0.72 | − 3.89 | 0.37 | 26.46 |
0.04
| 11.89 |
0.01
|
IGFBP-7 | 3.56 | 0.53 | − 5.21 | 0.49 | 14.32 | 0.32 | − 9.46 | 0.34 | − 1.77 | 0.95 | 8.43 | 0.45 |
IGF-I:IGFBP-1 | < − 0.001 |
0.04
| < 0.001 | 0.70 | < − 0.001 | 0.85 | < 0.001 | 0.33 | 0.0002 |
0.03
| < 0.001 | 0.75 |
IGF-I:IGFBP-2 | − 0.16 | 0.06 | 0.12 | 0.30 | − 0.08 | 0.72 | 0.22 | 0.16 | 0.88 | 0.06 | − 0.03 | 0.86 |
IGF-I:IGFBP-3 | 3.07 | 0.53 | − 5.59 | 0.39 | 4.70 | 0.70 | − 8.64 | 0.31 | − 13.09 | 0.61 | 0.61 | 0.95 |
IGF-I:IGFBP-4 | 0.01 | 0.96 | 0.14 | 0.41 | − 0.14 | 0.67 | 0.19 | 0.38 | − 0.11 | 0.87 | − 0.25 | 0.31 |
IGF-I:IGFBP-5 | 0.12 | 0.71 | 0.24 | 0.57 | − 0.15 | 0.86 | 0.26 | 0.65 | − 0.58 | 0.73 | − 0.23 | 0.71 |
IGF-I:IGFBP-6 | 0.11 | 0.44 | 0.19 | 0.32 | − 0.32 | 0.38 | 0.16 | 0.53 | − 1.26 | 0.10 | − 0.62 |
0.03
|
IGF-I:IGFBP-7 | − 0.07 | 0.54 | 0.11 | 0.45 | − 0.20 | 0.45 | 0.22 | 0.24 | 0.11 | 0.84 | − 0.11 | 0.59 |
IGF-I:Total IGFBP | 0.72 | 0.91 | − 2.95 | 0.72 | 1.37 | 0.93 | − 4.15 | 0.71 | − 4.38 | 0.90 | − 2.71 | 0.83 |
Mammographic measures of percent dense volume/area
BMI | |||||||
< 25 kg/m2 (N = 97) | 25–29.9 kg/m2 (N = 48) | ≥ 30 kg/m2 (N = 48) | |||||
MD measure |
β
|
p
1
|
β
|
p
|
β
|
p
| p -int |
Premenopausal women (N = 193)
| |||||||
% MD-V | 1.32 | 0.07 | 2.32 | 0.06 | −0.58 | 0.79 | 0.57 |
% MD-A | 1.24 | 0.20 | 2.31 | 0.13 | 0.10 | 0.97 | 0.55 |
BMI | |||||||
Postmenopausal women (N = 103)
| < 25 kg/m2 (N = 41) | 25–29.9 kg/m2 (N = 31) | ≥ 30 kg/m2 (N = 31) | ||||
% MD-V | 5.32 |
0.0002
| 0.81 | 0.24 | − 0.29 | 0.85 |
0.0003
|
% MD-A | 3.24 | 0.07 | − 1.35 | 0.28 | − 1.75 | 0.34 |
0.03
|
Mammographic measure of absolute dense and non-dense volume/area
Factor analysis
% MD-V1 | % MD-A | Absolute MD-V | Absolute MD-A | Non-dense volume | Non-dense area | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
β
|
p
3
|
β
|
p
|
β
|
p
|
β
|
p
|
β
|
p
|
β
|
p
| |
Premenopausal women | ||||||||||||
Factor 12 | − 0.13 | 0.08 | − 0.18 | 0.05 | 0.01 | 0.97 | − 0.13 | 0.27 | 0.40 | 0.19 | 0.16 | 0.23 |
Factor 2 | − 0.05 | 0.49 | − 0.04 | 0.65 | − 0.11 | 0.53 | − 0.73 | 0.50 | 0.07 | 0.80 | − 0.04 | 0.74 |
Postmenopausal women | ||||||||||||
Factor 1 | − 0.19 |
0.02
| 0.09 | 0.43 | − 0.09 | 0.67 | 0.20 | 0.17 | 0.91 |
0.04
| − 0.01 | 0.93 |
Factor 2 | − 0.03 | 0.73 | − 0.66 | 0.55 | 0.02 | 0.94 | − 0.07 | 0.61 | 0.06 | 0.98 | 0.09 | 0.59 |