10.11.2020 | Original Article
Relationship of HbA1c with plasma atherogenic index and non-HDL cholesterol in patients with type 2 diabetes mellitus
Wichtige Hinweise
The sample sizes are very limited in the previous studies that investigate the correlation between PAI and glucose and HbA1c levels. The data gained with this study show that the atherogenic index and non-HDL cholesterol values increase with the elevated levels of HbA1c. Although non-HDL cholesterol is paid more attention in clinical practice, PAI may have a stronger relationship with HbA1c in diabetic patients. Paying enough attention to PAI may be beneficial for long-term cardiovascular risk management in diabetic patients.
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Abstract
Purpose
Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular diseases (CVD). The plasma atherogenic index (PAI) has been suggested as a novel marker of atherosclerosis and coronary heart disease. The present study is conducted to investigate the relationship between glycated hemoglobin (HbA1c), non-HDL (high-density lipoprotein) cholesterol, and atherogenic index within patients with T2DM.
Materials and methods
A total of 4252 patients with T2DM were screened retrospectively and parameters including glucose, HbA1c, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride, TSH, age, and gender were recorded. Non-HDL cholesterol and PAI were calculated as follows:
$$ \mathrm{PAI}=\mathrm{TG}\div \mathrm{HDL}\ \mathrm{cholesterol} $$
$$ \mathrm{non}-\mathrm{HDL}=\mathrm{total}\ \mathrm{cholesterol}-\mathrm{HDL}\ \mathrm{cholesterol} $$
Results
Mean age was 57.06 ± 11.39 years. Mean HbA1c was 8.49 ± 1.86%, PAI ratio was 4.12 ± 3.88 mg/dl, and mean non-HDL cholesterol was 156.50 ± 45.39 mg/dl. Non-HDL cholesterol (r = 0.427; p < 0.001), HbA1c (r = 0.163; p < 0.001), and glucose (r = 0.154; p < 0.001) showed a significantly positive correlation with PAI.
Conclusion
Although a respectable attention is drawn to non-HDL cholesterol based on the present data, PAI may have a stronger relationship with HbA1c in patients with T2DM. PAI may be beneficial in predicting patients who have high risk for CVD in clinical practice.