Background
Methods
Study population
General survey and physical examination
2
). Waist circumference (WC) was measured on standing participants with a soft tape midway between the lowest rib and iliac crest. Blood pressure was measured with a standard mercury sphygmomanometer using the first and fifth Korotkoff sounds as systolic and diastolic blood pressure in the sedentary position while participants had rested for at least 5 min. Appropriate size of cuff was based on arm circumference. Pulse pressure (PP) is the difference between systolic and diastolic blood pressure. Cigarette smoking was defined as the consumption of one or more cigarettes per day for at least 1 year [11]. Alcohol drinking was defined as the consumption of 30 g or more alcohols per week for at least 1 year [12].Peripheral arterial stiffness
Laboratory test
Statistical analysis
Results
Characteristics | Nonsmokers (n = 1901) | Smokers (n = 723) |
P valuea
| Nondrinkers (n = 1821) | Drinkers (n = 803) |
P valueb
|
---|---|---|---|---|---|---|
Age (year) | 54(40–66) | 54(39–67) | 0.955 | 58(47–68) | 42(32–57) | <0.001 |
Males (%) | 729(38.3) | 629(87.0) | <0.001 | 607(33.3) | 751(93.5) | <0.001 |
BMI (kg/m2) | 24.98(22.72–27.25) | 25.39(23.32–27.52) | 0.002 | 24.98(22.67–27.39) | 25.39(23.46–27.18) | 0.015 |
WC (cm) | 84(77–91) | 89(83–95) | <0.001 | 85(77–92) | 87(81–93) | <0.001 |
Alcohol drinking (%) | 391(20.6) | 412(57.0) | <0.001 | |||
Cigarette smoking (%) | 311(17.1) | 412(51.3) | <0.001 | |||
PP (mmHg) | 48(40–60) | 48(40–58) | 0.427 | 50(40–60) | 46(40–54) | <0.001 |
FBG (mmol/L) | 4.92(4.57–5.39) | 4.95(4.55–5.47) | 0.513 | 4.95(4.56–5.49) | 4.90(4.59–5.25) | 0.014 |
LDL-c (mmol/L) | 2.75(2.25–3.25) | 2.76(2.29–3.22) | 0.962 | 2.85(2.34–3.35) | 2.54(2.11–3.01) | <0.001 |
HDL-c (mmol/L) | 1.38(1.18–1.63) | 1.26(1.06–1.48) | <0.001 | 1.36(1.16–1.62) | 1.31(1.10–1.53) | <0.001 |
crPWV (m/s) | 9.2(8.4–10.0) | 9.8(9.1–10.9) | 0.001 | 9.2(8.3–10.0) | 9.8(9.0–10.9) | 0.008 |
Characteristics | crPWV (m/s) | ||
---|---|---|---|
OR value (95% CI) |
P value | ||
Only one in modelsa
| |||
Alcohol drinking | Unjusted model | 2.299(1.936–2.729) | <0.001 |
1st modelc
| 1.227(0.989–1.521) | 0.063 | |
2nd modeld
| 1.209(0.973–1.502) | 0.087 | |
Cigarette smoking | Unjusted model | 2.291(1.918–2.737) | <0.001 |
1st modelc
| 1.343(1.099–1.641) | 0.004 | |
2nd modeld
| 1.293(1.056–1.584) | 0.013 | |
Both two in modelsb
| |||
Alcohol drinking | Unjusted model | 1.892(1.577–2.270) | <0.001 |
Cigarette smoking | Unjusted model | 1.845(1.528–2.229) | <0.001 |
Alcohol drinking | 1st modelc
| 1.163(0.934–1.449) | 0.177 |
Cigarette smoking | 1st modelc
| 1.308(1.067–1.605) | 0.010 |
Alcohol drinking | 2nd modeld
| 1.154(0.925–1.440) | 0.204 |
Cigarette smoking | 2nd modeld
| 1.262(1.027–1.551) | 0.027 |