Erschienen in:
19.03.2018 | Editorials
Relative importance of strategies for improving the sample size selection and reporting of small randomized clinical trials in anesthesiology
verfasst von:
Emine Ozgur Bayman, PhD, Franklin Dexter, MD, PhD, FASA
Erschienen in:
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
|
Ausgabe 6/2018
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Excerpt
In the current issue of the
Journal, Chow
et al.1 report the results of a survey of the quality of sample size calculations for two-arm, parallel group, superiority, randomized clinical trials (RCTs) published in six high-impact-factor anesthesiology journals. Trials reporting continuous or binary outcomes published in 2010 and 2016 were included. The authors recorded the variables used to estimate sample size and the actual outcome measures reported for treatment and control groups in the trials. Among 255 RCTs published in these journals in 2010 and 2016, the sample size calculations were not presented or were reported with insufficient data for replication in 33/143 (23%) and 24/112 (21%) of reports, respectively. …