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Arthritis Research & Therapy
Erschienen in: Arthritis Research & Therapy 3/2006

01.06.2006 | Review

Relevance of the stroma and epithelial-mesenchymal transition (EMT) for the rheumatic diseases

verfasst von: Nathan J Zvaifler

Erschienen in: Arthritis Research & Therapy | Ausgabe 3/2006

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Abstract

Epithelial-mesenchymal transition (EMT) is a term applied to the process whereby cells undergo a switch from an epithelial phenotype with tight junctions, lateral, apical, and basal membranes, and lack of mobility into mesenchymal cells that have loose interactions with other cells, are non-polarized, motile and produce an extracellular matrix. The importance of this process was initially recognized from a very early step in embryology, but more recently as a potential mechanism for the progression and spread of epithelial cancers. As the sequence of morphological changes has become understood in molecular terms, diseases characterized by alterations in stromal elements and fibrosis are being considered as examples of EMT. This review will focus on the pathogenetic features of immune-mediated renal disease, systemic sclerosis and rheumatoid arthritis that could be explained by EMT.
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Metadaten
Titel
Relevance of the stroma and epithelial-mesenchymal transition (EMT) for the rheumatic diseases
verfasst von
Nathan J Zvaifler
Publikationsdatum
01.06.2006
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 3/2006
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1963

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