Background
Methods
MSUS definition of pathology, scanning protocol and equipment
Statistical analysis
Results
Age (years) mean ± SD | 10.6 ± 5.1 |
---|---|
Gender: # female/male | 23/7 |
JIA Subtype n(%) | Polyarticular 18 (60%) |
Oligoarticular 12 (40%) | |
Disease duration (years) mean ± SD | 5.4 + 1.9 |
Painful joint count mean ± SD | 4.9 ± 1.7 |
Swollen joint count mean ± SD | 3.5 ± 1.8 |
Limited joint count mean ± SD | 1.9 ± 0.9 |
Joints clinically affected n (%) | |
Wrist | 17 (28) |
MCP 2 | 14 (23) |
MCP 3 | 10 (17) |
ESR mm/hr mean ± SD | 17.5 ± 14.2 |
CRP mg/L mean ± SD | 15 ± 0.7 |
Positive Rheumatoid factor number (%) | 14 (43%) |
Positive Antinuclear antibodies number (%) | 19 (57%) |
Treatment n (%) | Methotrexate 28 (86%) Sulfasalazine 10 (30%) Biologic therapy 6 (20%) Prednisone 5 (16%) |
Joint | Presence of synovitis n (%) | Grayscale grade 1 n (%) | PD grade 1 n (%) | Grayscale grade 2 n (%) | PD grade 2 n (%) | Grayscale grade 3 n (%) | PD grade 3 n (%) |
---|---|---|---|---|---|---|---|
Wrist | 37 (62) | 15 (30) | 6 (10) | 17 (28) | 0 (0) | 5 (8) | 2 (3) |
MCP 2 | 18 (30) | 5 (8) | 3 (5) | 8 (13) | 1 (2) | 5 (8) | 3 (5) |
MCP 3 | 13 (22) | 2 (3) | 3 (5) | 8 (13) | 0 (0) | 3 (5) | 0 (0) |
Elementary lesions by US | Overall agreement (%) Presence/absence | Kappa Cohen | 95% CI | P value |
---|---|---|---|---|
Synovitis | ||||
Wrist | 95 | .87 | .71–1.0 | .001 |
MCP 2 | 84 | .61 | .34–89 | .001 |
MCP 3 | 95 | .84 | .63–1.0 | .001 |
Abnormal power Doppler signal | ||||
Wrist | 95 | .87 | .71–1.0 | .001 |
MCP 2 | 100 | 1.0 | 1.0–1.0 | .001 |
MCP 3 | 100 | 1.0 | 1.0–1.0 | .001 |
Tenosinovitis flexor tendon | ||||
Grayscale | 95 | .88 | .74–1.0 | .001 |
Power Doppler | 100 | 1.0 | 1.0–1.0 | .001 |
Cartilage Damage | ||||
MCP 2 | 94 | .82 | .59–1.0 | .001 |
MCP 3 | 97 | .94 | .84–1.0 | .001 |
Bone erosion | 100 | 1.0 | 1.0–1.0 | .001 |
Synovitis grading | Agreement (%) | Weighted kappa | 95% CI | P value |
Synovitis in all joints by US grayscale | ||||
Grade 0 | 100 | 1.0 | 1.0–1.0 | .001 |
Grade 1 | 73 | .61 | .43–.83 | .004 |
Grade 2 | 83 | .71 | .51–87 | .003 |
Grade 3 | 87 | .84 | .63–.91 | .001 |
Abnormal power Doppler signal | ||||
Grade 0 | 100 | 1.0 | 1.0–10 | .001 |
Grade 1 | 95 | .88 | .71–1.0 | .001 |
Grade 2 | 87 | .83 | .69–.96 | .001 |
Grade 3 | 100 | 1.0 | 1.0–1.0 | .001 |
Elementary lesions by US | Overall agreement (%) Presence/absence | Kappa Cohen | 95% CI | P value |
---|---|---|---|---|
Synovitis | ||||
Wrist | 96 | .90 | .80–1.0 | .001 |
MCP 2 | 92 | .81 | .67–95 | .001 |
MCP 3 | 97 | .92 | .82–1.0 | .001 |
Abnormal power Doppler signal | ||||
Wrist | 97 | .93 | .85–1.0 | .001 |
MCP 2 | 100 | 1.0 | 1.0–1.0 | .001 |
MCP 3 | 97 | .87 | .74–1.0 | .001 |
Tenosinovitis flexor tendon | ||||
Grayscale | 94 | .89 | .78–.99 | .001 |
Power Doppler | 98 | .66 | .39–1.0 | .001 |
Cartilage Damage | ||||
MCP 2 | 94 | .89 | .78–.99 | .001 |
MCP 3 | 94 | .89 | .78–.99 | .001 |
Bone erosion | 100 | 1.0 | 1.0–1.0 | .001 |
Synovitis grading | Agreement (%) | Weighted kappa | 95% CI | P value |
Synovitis in all joints by US grayscale | ||||
Grade 0 | 100 | 1.0 | 1.0–1.0 | .001 |
Grade 1 | 66 | .61 | .53–.74 | .007 |
Grade 2 | 69 | .64 | .57–.86 | .004 |
Grade 3 | 91 | .81 | .63–.97 | .001 |
Abnormal power Doppler signal | ||||
Grade 0 | 100 | 1.0 | 1.0–10 | .001 |
Grade 1 | 67 | .63 | .58–.91 | .004 |
Grade 2 | 72 | .67 | .60–.93 | .002 |
Grade 3 | 88 | .85 | .67–.96 | .001 |