Erschienen in:
04.09.2017 | Review
REM sleep behavior disorder, autonomic dysfunction and synuclein-related neurodegeneration: where do we stand?
verfasst von:
Giacomo Chiaro, Giovanna Calandra-Buonaura, Annagrazia Cecere, Francesco Mignani, Luisa Sambati, Giuseppe Loddo, Pietro Cortelli, Federica Provini
Erschienen in:
Clinical Autonomic Research
|
Ausgabe 6/2018
Einloggen, um Zugang zu erhalten
Abstract
Introduction
From newfound parasomnia to a marker of future synucleinopathy, since its first description in 1986, REM sleep behavior disorder (RBD) has been systematically tackled from virtually many viewpoints in basic, translational, and clinical studies. The time delay between RBD and synucleinopathy onset offers an exceptional window for observation and design of neuroprotective trials. In the last few years, research has focused on characterizing possible differences within RBD patients in order to draw potential profiles more or less susceptible to further neurodegeneration. Attention has been drawn towards autonomic dysfunction in RBD as one of such variables.
Overview
In this review, REM sleep physiology and relevant brain anatomy is briefly mentioned and integrated with neuroanatomical and physiological concepts regarding the central autonomic network. A detailed summary of works showing the presence of autonomic dysfunction in RBD is provided, and clinical and electrophysiological features of RBD in synucleinopathies are discussed. A short overview of RBD in other neurodegenerative diseases is also provided.