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Erschienen in: Clinical Autonomic Research 6/2018

04.09.2017 | Review

REM sleep behavior disorder, autonomic dysfunction and synuclein-related neurodegeneration: where do we stand?

verfasst von: Giacomo Chiaro, Giovanna Calandra-Buonaura, Annagrazia Cecere, Francesco Mignani, Luisa Sambati, Giuseppe Loddo, Pietro Cortelli, Federica Provini

Erschienen in: Clinical Autonomic Research | Ausgabe 6/2018

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Abstract

Introduction

From newfound parasomnia to a marker of future synucleinopathy, since its first description in 1986, REM sleep behavior disorder (RBD) has been systematically tackled from virtually many viewpoints in basic, translational, and clinical studies. The time delay between RBD and synucleinopathy onset offers an exceptional window for observation and design of neuroprotective trials. In the last few years, research has focused on characterizing possible differences within RBD patients in order to draw potential profiles more or less susceptible to further neurodegeneration. Attention has been drawn towards autonomic dysfunction in RBD as one of such variables.

Overview

In this review, REM sleep physiology and relevant brain anatomy is briefly mentioned and integrated with neuroanatomical and physiological concepts regarding the central autonomic network. A detailed summary of works showing the presence of autonomic dysfunction in RBD is provided, and clinical and electrophysiological features of RBD in synucleinopathies are discussed. A short overview of RBD in other neurodegenerative diseases is also provided.
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Metadaten
Titel
REM sleep behavior disorder, autonomic dysfunction and synuclein-related neurodegeneration: where do we stand?
verfasst von
Giacomo Chiaro
Giovanna Calandra-Buonaura
Annagrazia Cecere
Francesco Mignani
Luisa Sambati
Giuseppe Loddo
Pietro Cortelli
Federica Provini
Publikationsdatum
04.09.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Autonomic Research / Ausgabe 6/2018
Print ISSN: 0959-9851
Elektronische ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-017-0460-4

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