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Erschienen in: Pediatric Nephrology 5/2016

04.12.2015 | Original Article

Renal abnormalities in a cohort of HIV-infected children and adolescents

verfasst von: Flávia Vanesca Felix Leão, Regina Célia de Menezes Succi, Daisy Maria Machado, Aída de Fátima Thomé Barbosa Gouvêa, Fabiana Bononi do Carmo, Suenia Vasconcelos Beltrão, Maria Aparecida de Paula Cançado, João Tomas de Abreu Carvalhaes

Erschienen in: Pediatric Nephrology | Ausgabe 5/2016

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Abstract

Background

This study aimed to identify the prevalence of renal abnormalities and the evolution of glomerular filtration rate (GFR) among human immunodeficiency virus (HIV)- infected children and adolescents followed up in an infectious disease outpatient pediatric clinic.

Methods

We performed a cohort study of 115 children and adolescents. Outcomes of two evaluations for urinalysis, microalbuminuria/urinary creatinine ratio, urinary retinol-binding protein (uRBP) concentration, and estimated GFR (eGFR) were obtained for each patient, with an average interval of 6 months between evaluations. These changes were correlated with gender, age, race, body mass index (BMI), height-for-age (H/A) percentile, clinical and immunological classification of HIV infection, use of antiretroviral therapy (ART), HIV viral load (VL), and CD4+ T-lymphocyte count.

Results

Mean patient age at the time of inclusion in the study was 12.6 ± 3.2 years; 50.4 % were male, 81.7 % had acquired immune defeciency syndrome (AIDS), 80.9 % had CD4+ < 500 cells/mm3, and 87.8 % were on ART. Urinary changes included hematuria (11.3 %), proteinuria (7 %), and microalbuminuria (11.6 %); uRBP was present in 3.8 %; and mean eGFR was 163 ± 32 ml/min/1.73 m2.

Conclusions

The subclinical renal abnormalities found in this study may indicate early manifestations of a broad spectrum of renal dysfunction associated with HIV and involves the decision to initiate or modify ART.
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Metadaten
Titel
Renal abnormalities in a cohort of HIV-infected children and adolescents
verfasst von
Flávia Vanesca Felix Leão
Regina Célia de Menezes Succi
Daisy Maria Machado
Aída de Fátima Thomé Barbosa Gouvêa
Fabiana Bononi do Carmo
Suenia Vasconcelos Beltrão
Maria Aparecida de Paula Cançado
João Tomas de Abreu Carvalhaes
Publikationsdatum
04.12.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Nephrology / Ausgabe 5/2016
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-015-3260-x

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