Skip to main content
Erschienen in: Virchows Archiv 3/2016

09.12.2015 | Original Article

Renal cell carcinoma with rhabdoid-like features lack intracytoplasmic inclusion bodies and show aggressive behavior

verfasst von: Masaaki Sugimoto, Kenichi Kohashi, Kentaro Kuroiwa, Tatsuro Abe, Yuichi Yamada, Masaki Shiota, Kenjiro Imada, Seiji Naito, Yoshinao Oda

Erschienen in: Virchows Archiv | Ausgabe 3/2016

Einloggen, um Zugang zu erhalten

Abstract

In renal cell carcinoma (RCC), tumor cells with rhabdoid features are characterized by eccentric nuclei, prominent nucleoli, and eosinophilic cytoplasm with intracytoplasmic inclusion bodies. In RCC, tumor cells have also been observed resembling rhabdomyoblasts or rhabdoid but without intracytoplasmic inclusion bodies, and here, we defined these rhabdoid-like features of these cells. To this end, we studied a series of clear cell RCC (ccRCC) with rhabdoid features and compared them with a series of ccRCC with rhabdoid-like features to clarify the differences in the immunohistochemical profile and biological behavior. From 695 cases of ccRCC (80.8 % of all RCCs), 18 cases with rhabdoid features (2.1 % of all RCCs) and 25 cases with rhabdoid-like features (2.9 % of all RCCs) were investigated. The 5-year survival rate for ccRCC with rhabdoid features was 44.7 % and for ccRCC with rhabdoid-like features 30.3 %. Although ccRCC with rhabdoid features showed immunohistochemical co-expression of epithelial markers and vimentin as seen in malignant rhabdoid tumors, ccRCC with rhabdoid-like features showed no such co-expression. Multivariate analyses of cancer-specific survival revealed that perinephric tissues invasion was an independent prognostic factor in ccRCC with rhabdoid features (p = 0.0253) but not in ccRCC with rhabdoid-like features. In summary, although their prognosis is similar, the marker profile and pattern of extension of ccRCC with rhabdoid-like is different from that of ccRCC with rhabdoid features. Therefore, ccRCC with rhabdoid-like features should be distinguished from ccRCC with rhabdoid features.
Literatur
1.
Zurück zum Zitat Beckwith JB, Palmer NF (1978) Histopathology and prognosis of Wilms’ tumors: results from the first national Wilms’ tumor study. Cancer 41:1937–1948CrossRefPubMed Beckwith JB, Palmer NF (1978) Histopathology and prognosis of Wilms’ tumors: results from the first national Wilms’ tumor study. Cancer 41:1937–1948CrossRefPubMed
2.
Zurück zum Zitat Oda Y, Tsuneyoshi M (2006) Extrarenal rhabdoid tumors of soft tissue: clinicopathological and molecular genetic review and distinction from other soft-tissue sarcomas with rhabdoid features. Pathol Int 56:287–295CrossRefPubMed Oda Y, Tsuneyoshi M (2006) Extrarenal rhabdoid tumors of soft tissue: clinicopathological and molecular genetic review and distinction from other soft-tissue sarcomas with rhabdoid features. Pathol Int 56:287–295CrossRefPubMed
3.
Zurück zum Zitat Fanburg-Smith JC, Hengge M, Hengge UR, et al. (1998) Extrarenal rhabdoid tumors of soft tissue: a clinicopathologic and immunohistochemical study of 18 cases. Ann Diagn Pathol 2:351–362CrossRefPubMed Fanburg-Smith JC, Hengge M, Hengge UR, et al. (1998) Extrarenal rhabdoid tumors of soft tissue: a clinicopathologic and immunohistochemical study of 18 cases. Ann Diagn Pathol 2:351–362CrossRefPubMed
4.
Zurück zum Zitat Saini G, Kumar M, Julka PK, et al. (2009) Rhabdoid variant of lung cancer: clinicopathological details of a case and a review of literature. J Cancer Res Ther 5:54–57CrossRefPubMed Saini G, Kumar M, Julka PK, et al. (2009) Rhabdoid variant of lung cancer: clinicopathological details of a case and a review of literature. J Cancer Res Ther 5:54–57CrossRefPubMed
5.
Zurück zum Zitat Agaimy A, Rau TT, Hartmann A, et al. (2014) SMARCB1 (INI1)-negative rhabdoid carcinomas of the gastrointestinal tract: clinicopathologic and molecular study of a highly aggressive variant with literature review. Am J Surg Pathol 38:910–920CrossRefPubMed Agaimy A, Rau TT, Hartmann A, et al. (2014) SMARCB1 (INI1)-negative rhabdoid carcinomas of the gastrointestinal tract: clinicopathologic and molecular study of a highly aggressive variant with literature review. Am J Surg Pathol 38:910–920CrossRefPubMed
6.
7.
Zurück zum Zitat Raspollini MR, Li Marzi V, Nicita G, et al. (2012) The challenging diagnosis of the rhabdoid carcinoma of the pelvis: a case report with literature review. Appl Immunohistochem Mol Morphol 20:177–183CrossRefPubMed Raspollini MR, Li Marzi V, Nicita G, et al. (2012) The challenging diagnosis of the rhabdoid carcinoma of the pelvis: a case report with literature review. Appl Immunohistochem Mol Morphol 20:177–183CrossRefPubMed
8.
Zurück zum Zitat Parwani AV, Herawi M, Volmar K, et al. (2006) Urothelial carcinoma with rhabdoid features: report of 6 cases. Hum Pathol 37:168–172CrossRefPubMed Parwani AV, Herawi M, Volmar K, et al. (2006) Urothelial carcinoma with rhabdoid features: report of 6 cases. Hum Pathol 37:168–172CrossRefPubMed
9.
Zurück zum Zitat Savage N, Linn D, McDonough C, et al. (2012) Molecularly confirmed primary malignant rhabdoid tumor of the urinary bladder: implications of accurate diagnosis. Ann Diagn Pathol 16:504–507CrossRefPubMedPubMedCentral Savage N, Linn D, McDonough C, et al. (2012) Molecularly confirmed primary malignant rhabdoid tumor of the urinary bladder: implications of accurate diagnosis. Ann Diagn Pathol 16:504–507CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Perry A, Louis DN, Scheithauer BW, et al. (2007) Rhabdoid meningioma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) world health organization classification of tumours of the central nervous system, 4th edn. IARC Press, Lyon, France, p. 168 Perry A, Louis DN, Scheithauer BW, et al. (2007) Rhabdoid meningioma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) world health organization classification of tumours of the central nervous system, 4th edn. IARC Press, Lyon, France, p. 168
11.
Zurück zum Zitat Abolfotoh M, Tavanaiepour D, Hong C, et al. (2012) Primary calcified rhabdoid meningioma of the cranio-cervical junction: a case report and review of literature. J Craniovert Jun Spine 3:32–37CrossRef Abolfotoh M, Tavanaiepour D, Hong C, et al. (2012) Primary calcified rhabdoid meningioma of the cranio-cervical junction: a case report and review of literature. J Craniovert Jun Spine 3:32–37CrossRef
12.
Zurück zum Zitat Gokden N, Nappi O, Swanson PE, et al. (2000) Renal cell carcinoma with rhabdoid features. Am J Surg Pathol 24:1329–1338CrossRefPubMed Gokden N, Nappi O, Swanson PE, et al. (2000) Renal cell carcinoma with rhabdoid features. Am J Surg Pathol 24:1329–1338CrossRefPubMed
13.
Zurück zum Zitat Oda Y, Biegel JA (2013) Extrarenal rhabdoid tumour. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F (eds) World health organization classification of tumours of soft tissue and bone, 4th edn. IARC Press, Lyon, France, pp. 228–229 Oda Y, Biegel JA (2013) Extrarenal rhabdoid tumour. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F (eds) World health organization classification of tumours of soft tissue and bone, 4th edn. IARC Press, Lyon, France, pp. 228–229
14.
Zurück zum Zitat Kuroiwa K, Kinoshita Y, Shiratsuchi H, et al. (2002) Renal cell carcinoma with rhabdoid features: an aggressive neoplasm. Histopathology 41:538–548CrossRefPubMed Kuroiwa K, Kinoshita Y, Shiratsuchi H, et al. (2002) Renal cell carcinoma with rhabdoid features: an aggressive neoplasm. Histopathology 41:538–548CrossRefPubMed
15.
Zurück zum Zitat Chapman-Fredricks JR, Herrera L, Bracho J, et al. (2011) Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma. Ann Diagn Pathol 15:333–337CrossRefPubMed Chapman-Fredricks JR, Herrera L, Bracho J, et al. (2011) Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma. Ann Diagn Pathol 15:333–337CrossRefPubMed
16.
Zurück zum Zitat Zhang BY, Cheville JC, Thompson RH, et al. (2015) Impact of rhabdoid differentiation on prognosis for patients with grade 4 renal cell carcinoma. Eur Urol 68:5–7CrossRefPubMed Zhang BY, Cheville JC, Thompson RH, et al. (2015) Impact of rhabdoid differentiation on prognosis for patients with grade 4 renal cell carcinoma. Eur Urol 68:5–7CrossRefPubMed
17.
Zurück zum Zitat Yang X, Xi C, Jin J, et al. (2015) Adult renal cell carcinoma with rhabdoid differentiation: incidence and clinicopathologic features in Chinese patients. Ann Diagn Pathol 19:57–63CrossRefPubMed Yang X, Xi C, Jin J, et al. (2015) Adult renal cell carcinoma with rhabdoid differentiation: incidence and clinicopathologic features in Chinese patients. Ann Diagn Pathol 19:57–63CrossRefPubMed
18.
Zurück zum Zitat Delahunt B, Cheville JC, Martignoni G, et al. (2013) The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters. Am J Surg Pathol 37:1490–1504CrossRefPubMed Delahunt B, Cheville JC, Martignoni G, et al. (2013) The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters. Am J Surg Pathol 37:1490–1504CrossRefPubMed
19.
Zurück zum Zitat Sobin LH, Gospodariwicz M, Wittekind C (2009) UICC International Union Against Cancer. 7th edn. In: TNM classification of malignant tumors. Wiley-Blackwell, London, pp. 255–257 Sobin LH, Gospodariwicz M, Wittekind C (2009) UICC International Union Against Cancer. 7th edn. In: TNM classification of malignant tumors. Wiley-Blackwell, London, pp. 255–257
20.
Zurück zum Zitat Imada K, Shiota M, Kohashi K, et al. (2013) Mutual regulation between Raf/MEK/ERK signaling and Y-box-binding protein-1 promotes prostate cancer progression. Clin Cancer Res 19:4638–4650CrossRefPubMed Imada K, Shiota M, Kohashi K, et al. (2013) Mutual regulation between Raf/MEK/ERK signaling and Y-box-binding protein-1 promotes prostate cancer progression. Clin Cancer Res 19:4638–4650CrossRefPubMed
21.
Zurück zum Zitat Hertwig F, Meyer K, Braun S, et al. (2012) Definition of genetic events directing the development of distinct types of brain tumors from postnatal neural stem/progenitor cells. Cancer Res 72:3381–3392CrossRefPubMedPubMedCentral Hertwig F, Meyer K, Braun S, et al. (2012) Definition of genetic events directing the development of distinct types of brain tumors from postnatal neural stem/progenitor cells. Cancer Res 72:3381–3392CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Croce S, Young RH, Oliva E (2014) Uterine leiomyomas with bizarre nuclei: a clinicopathologic study of 59 cases. Am J Surg Pathol 38:1330–1339CrossRefPubMed Croce S, Young RH, Oliva E (2014) Uterine leiomyomas with bizarre nuclei: a clinicopathologic study of 59 cases. Am J Surg Pathol 38:1330–1339CrossRefPubMed
23.
Zurück zum Zitat Machado I, López-Soto MV, Rubio L, et al. (2015) Soft tissue myoepithelial carcinoma with rhabdoid-like features and EWSR1 rearrangement: fine needle aspiration cytology with histologic correlation. Diagn Cytopathol 43:421–426CrossRefPubMed Machado I, López-Soto MV, Rubio L, et al. (2015) Soft tissue myoepithelial carcinoma with rhabdoid-like features and EWSR1 rearrangement: fine needle aspiration cytology with histologic correlation. Diagn Cytopathol 43:421–426CrossRefPubMed
24.
Zurück zum Zitat Patard JJ, Leray E, Rioux-Leclercq N, et al. (2005) Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience. J Clin Oncol 23:2763–2771CrossRefPubMed Patard JJ, Leray E, Rioux-Leclercq N, et al. (2005) Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience. J Clin Oncol 23:2763–2771CrossRefPubMed
25.
Zurück zum Zitat Waldert M, Haitel A, Marberger M, et al. (2008) Comparison of type I and II papillary renal cell carcinoma (RCC) and clear cell RCC. BJU Int 102:1381–1384PubMed Waldert M, Haitel A, Marberger M, et al. (2008) Comparison of type I and II papillary renal cell carcinoma (RCC) and clear cell RCC. BJU Int 102:1381–1384PubMed
26.
Zurück zum Zitat Karakiewicz PI, Suardi N, Capitanio U, et al. (2009) Conditional survival predictions after nephrectomy for renal cell carcinoma. J Urol 182:2607–2612CrossRefPubMed Karakiewicz PI, Suardi N, Capitanio U, et al. (2009) Conditional survival predictions after nephrectomy for renal cell carcinoma. J Urol 182:2607–2612CrossRefPubMed
27.
Zurück zum Zitat Steffens S, Roos FC, Janssen M, et al. (2014) Clinical behavior of chromophobe renal cell carcinoma is less aggressive than that of clear cell renal cell carcinoma, independent of Fuhrman grade or tumor size. Virchows Arch 465:439–444CrossRefPubMed Steffens S, Roos FC, Janssen M, et al. (2014) Clinical behavior of chromophobe renal cell carcinoma is less aggressive than that of clear cell renal cell carcinoma, independent of Fuhrman grade or tumor size. Virchows Arch 465:439–444CrossRefPubMed
28.
Zurück zum Zitat Trpkov K, Grignon DJ, Bonsib SM, et al. (2013) Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations. Am J Surg Pathol 37:1505–1517CrossRefPubMed Trpkov K, Grignon DJ, Bonsib SM, et al. (2013) Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations. Am J Surg Pathol 37:1505–1517CrossRefPubMed
29.
Zurück zum Zitat Przybycin CG, McKenney JK, Reynolds JP, et al. (2014) Rhabdoid differentiation is associated with aggressive behavior in renal cell carcinoma: a clinicopathologic analysis of 76 cases with clinical follow-up. Am J Surg Pathol 38:1260–1265PubMed Przybycin CG, McKenney JK, Reynolds JP, et al. (2014) Rhabdoid differentiation is associated with aggressive behavior in renal cell carcinoma: a clinicopathologic analysis of 76 cases with clinical follow-up. Am J Surg Pathol 38:1260–1265PubMed
30.
Zurück zum Zitat Teloken PE, Thompson RH, Tickoo SK, et al. (2009) Prognostic impact of histological subtype on surgically treated localized renal cell carcinoma. J Urol 182:2132–2136CrossRefPubMedPubMedCentral Teloken PE, Thompson RH, Tickoo SK, et al. (2009) Prognostic impact of histological subtype on surgically treated localized renal cell carcinoma. J Urol 182:2132–2136CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Shannon B, Stan Wisniewski Z, Bentel J, et al. (2002) Adult rhabdoid renal cell carcinoma. Arch Pathol Lab Med 126:1506–1510PubMed Shannon B, Stan Wisniewski Z, Bentel J, et al. (2002) Adult rhabdoid renal cell carcinoma. Arch Pathol Lab Med 126:1506–1510PubMed
32.
Zurück zum Zitat Leroy X, Zini L, Buob D, et al. (2007) Renal cell carcinoma with rhabdoid features: an aggressive neoplasm with overexpression of p53. Arch Pathol Lab Med 131:102–106PubMed Leroy X, Zini L, Buob D, et al. (2007) Renal cell carcinoma with rhabdoid features: an aggressive neoplasm with overexpression of p53. Arch Pathol Lab Med 131:102–106PubMed
33.
Zurück zum Zitat Brcic I, Spajic B, Kruslin B (2012) Chromophobe renal cell carcinoma with rhabdoid differentiation in an adult. Wien Klin Wochenschr 124:419–421CrossRefPubMed Brcic I, Spajic B, Kruslin B (2012) Chromophobe renal cell carcinoma with rhabdoid differentiation in an adult. Wien Klin Wochenschr 124:419–421CrossRefPubMed
34.
Zurück zum Zitat Kuroda N, Satake H, Miyazaki E, et al. (2004) Collecting duct carcinoma exhibiting diastase-resistant PAS-positive globular cytoplasmic inclusions and rhabdoid features arising in adult polycystic kidney disease: a case report. Int J Surg Pathol 12(2):171–177CrossRefPubMed Kuroda N, Satake H, Miyazaki E, et al. (2004) Collecting duct carcinoma exhibiting diastase-resistant PAS-positive globular cytoplasmic inclusions and rhabdoid features arising in adult polycystic kidney disease: a case report. Int J Surg Pathol 12(2):171–177CrossRefPubMed
Metadaten
Titel
Renal cell carcinoma with rhabdoid-like features lack intracytoplasmic inclusion bodies and show aggressive behavior
verfasst von
Masaaki Sugimoto
Kenichi Kohashi
Kentaro Kuroiwa
Tatsuro Abe
Yuichi Yamada
Masaki Shiota
Kenjiro Imada
Seiji Naito
Yoshinao Oda
Publikationsdatum
09.12.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Virchows Archiv / Ausgabe 3/2016
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-015-1885-6

Weitere Artikel der Ausgabe 3/2016

Virchows Archiv 3/2016 Zur Ausgabe

Editorial

In this issue

Neu im Fachgebiet Pathologie