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Critical Care

Erschienen in:

01.06.2010 | Letter

Renal function and thromboprophylaxis in critically ill patients

verfasst von: Gareth M Scholey, Anton G Saayman, Christopher D Hingston, Matt P Wise

Erschienen in: Critical Care | Ausgabe 3/2010

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Excerpt

Robinson and colleagues [1] recently examined the effective dose of enoxaparin for thromboprophylaxis in critically ill patients recorded over 24 hours. The study concluded that the standard dose of 40 mg led to subtherapeutic anti-factor Xa activity (aFXa) and 60 mg daily was optimal. The high rate of thromboembolic disease observed in critically ill patients could thus be explained by inadequate aFXa with the standard 40 mg dose. …

Robinson S, Zincuk A, Strom T, Larsen TB, Rasmussen B, Toft P: Enoxaparin effective dosage for intensive care patients: double blinded randomised control trial. Crit Care 2010, 14: R41. 10.1186/cc8924PubMedCentralCrossRefPubMed

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Mahe I, Aghassarian M, Drouet L, Bal Dit-Sollier C, Lacut K, Heilmann JJ, Mottier D, Bergmann JF: Tinzaparin and enoxaparin given at prophylactic dose for eight days in medical elderly patients with impaired renal function: a comparative pharmacokinetic study. Thromb Haemost 2007, 97: 581-586.PubMed

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Mayr AJ, Dünser M, Jochberger S, Fries D, Klingler A, Joannidis M, Hasibeder W, Schobersberger W: Antifactor Xa activity in intensive care patients receiving thromboembolic prophylaxis with standard doses of enoxaparin. Thromb Res 2002, 105: 201-204. 10.1016/S0049-3848(02)00028-2CrossRefPubMed

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Brophy DF, Carr ME Jr, Martin EJ, Venitz J, Gehr TW: The pharmacokinetics of enoxaparin do not correlate with its pharmacodynamic effect in patients receiving dialysis therapies. J Clin Pharmacol 2006, 46: 887-894. 10.1177/0091270006289975CrossRefPubMed

Titel: Renal function and thromboprophylaxis in critically ill patients
verfasst von: Gareth M Scholey
Anton G Saayman
Christopher D Hingston
Matt P Wise
Publikationsdatum: 01.06.2010
Verlag: BioMed Central
Erschienen in: Critical Care / Ausgabe 3/2010
Elektronische ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc8985

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