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Pediatric Nephrology

Erschienen in:

18.02.2020 | Review

Renin-angiotensin system in mammalian kidney development

verfasst von: Ihor V. Yosypiv

Erschienen in: Pediatric Nephrology | Ausgabe 3/2021

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Abstract

Mutations in the genes of the renin-angiotensin system result in congenital anomalies of the kidney and urinary tract (CAKUT), the main cause of end-stage renal disease in children. The molecular mechanisms that cause CAKUT are unclear in most cases. To improve the care of children with CAKUT, it is critical to determine the underlying mechanisms of CAKUT. In this review, we discuss recent advances that have helped to better understand how disruption of the renin-angiotensin system during kidney development contributes to CAKUT.

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Titel: Renin-angiotensin system in mammalian kidney development
verfasst von: Ihor V. Yosypiv
Publikationsdatum: 18.02.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 3/2021
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-020-04496-5

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Renin-angiotensin system in mammalian kidney development

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