Reossification of osteolytic metastases at the acetabulum following gefitinib and multidisciplinary treatment for lung cancer: a case report with autopsy findings

Excerpt

Patients with bone metastases often suffer from skeletal-related events (SREs), which result in increased pain, impaired mobility, and a reduced quality of life (QoL). Some previous studies have shown that gefitinib treatment leads to a reduction in osteolytic metastases, as determined by radiological examinations and the level of pain experienced on movement [1, 2]. However, to the best of our knowledge, no pathological analysis of the reduction of an osteolytic lesion has previously been reported. Here we present the case of a woman with osteolytic metastasis in the acetabulum who reacquired pain-free mobility after gefitinib and multidisciplinary treatment for lung adenocarcinoma harboring epidermal growth factor receptor (EGFR) mutation. Very early osteosclerotic change in the acetabular osteolytic lesion was identified on radiological examination, and its reossification was apparent upon pathological analysis. …