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Journal of Cancer Research and Clinical Oncology

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01.01.2016 | Original Article – Cancer Research

Replication analysis confirms the association of several variants with acute myeloid leukemia in Chinese population

verfasst von: Songyu Cao, Guohua Yang, Juan Zhang, Yunfeng Shen, Hongxia Ma, Xifeng Qian, Zhibin Hu

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 1/2016

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Abstract

Purpose

Two genome-wide association studies (GWASs) have identified several new acute leukemia susceptibility loci in populations of European descent. However, the roles of these loci in the development of acute leukemia in other populations are largely unknown.

Methods

We genotyped 16 single-nucleotide polymorphisms selected from published GWASs in an independent case–control study with a total of 545 acute myeloid leukemia (AML) cases and 1034 cancer-free controls in a Chinese population. Multivariate logistic regression was used to analyze the associations between these variants and AML risk.

Results

We found that with the similar effect to GWASs, risk alleles of rs2191566, rs9290663, rs11155133, rs2239633, rs10821936, and rs2242041 significantly increased the risk of AML in at least one genetic model [odds ratios (ORs) range from 1.26 to 4.34, P values range from <0.001 to 0.043]. However, the variant T allele of rs10873876 decreased the AML risk, which was in the opposite effect direction (OR 0.62, P < 0.001 in additive model). Besides, we found significant multiplicative interaction between rs9290663 and age (≤45 years old and >45 years old; P = 0.009).

Conclusion

Our results indicated that genetic variants associated with acute leukemia risk in European populations may also play important roles in AML development in Chinese population.

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Avgeris M, Koutalellis G, Fragoulis EG, Scorilas A (2008) Expression analysis and clinical utility of L-Dopa decarboxylase (DDC) in prostate cancer. Clin Biochem 41:1140–1149PubMedCrossRef

Bănescu C, Tilinca M, Benedek EL, Demian S, Macarie I, Duicu C, Dobreanu M (2013) XRCC3 Thr241Met polymorphism and risk of acute myeloid leukemia in a Romanian population. Gene 526:478–483PubMedCrossRef

Belson M, Kingsley B, Holmes A (2007) Risk factors for acute leukemia in children: a review. Environ Health Perspect 115:138–145PubMedPubMedCentralCrossRef

Bourquin JP, Subramanian A, Langebrake C, Reinhardt D, Bernard O, Ballerini P, Baruchel A, Cavé H, Dastugue N, Hasle H, Kaspers GL, Lessard M, Michaux L, Vyas P, van Wering E, Zwaan CM, Golub TR, Orkin SH (2006) Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. Proc Natl Acad Sci USA 103:3339–3344PubMedPubMedCentralCrossRef

Chang LW, Payton JE, Yuan W, Ley TJ, Nagarajan R, Stormo GD (2008) Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia. Genome Biol 9:R38PubMedPubMedCentralCrossRef

Chokkalingam AP, Hsu LI, Metayer C, Hansen HM, Month SR, Barcellos LF, Wiemels JL, Buffler PA (2013) Genetic variants in ARID5B and CEBPE are childhood ALL susceptibility loci in Hispanics. Cancer Causes Control 24:1789–1795PubMedPubMedCentralCrossRef

Deschler B, Lübbert M (2006) Acute myeloid leukemia: epidemiology and etiology. Cancer 107:2099–2107PubMedCrossRef

Eden T (2010) Aetiology of childhood leukaemia. Cancer Treat Rev 36:286–297PubMedCrossRef

Ellinghaus E, Stanulla M, Richter G, Ellinghaus D, te Kronnie G, Cario G, Cazzaniga G, Horstmann M, Panzer Grümayer R, Cavé H, Trka J, Cinek O, Teigler-Schlegel A, ElSharawy A, Häsler R, Nebel A, Meissner B, Bartram T, Lescai F, Franceschi C, Giordan M, Nürnberg P, Heinzow B, Zimmermann M, Schreiber S, Schrappe M, Franke A (2012) Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Leukemia 26:902–909PubMedPubMedCentralCrossRef

Geomela PA, Kontos CK, Yiotakis I, Fragoulis EG, Scorilas A (2012) L-DOPA decarboxylase mRNA expression is associated with tumor stage and size in head and neck squamous cell carcinoma: a retrospective cohort study. BMC Cancer 12:484PubMedPubMedCentralCrossRef

Gutiérrez-Camino Á, López-López E, Martín-Guerrero I, Sánchez-Toledo J, García de Andoin N, Carboné Bañeres A, García-Miguel P, Navajas A, García-Orad Á (2013) Intron 3 of the ARID5B gene: a hot spot for acute lymphoblastic leukemia susceptibility. J Cancer Res Clin Oncol 139:1879–1886PubMedCrossRef

Han S, Lee KM, Park SK, Lee JE, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Kang D (2010) Genome-wide association study of childhood acute lymphoblastic leukemia in Korea. Leuk Res 34:1271–1274PubMedCrossRef

Healy J, Richer C, Bourgey M, Kritikou EA, Sinnett D (2010) Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia. Haematologica 95:1608–1611PubMedPubMedCentralCrossRef

Huang X, Ma D, Dong W, Li P, Lu T, He N, Tian T, Liu N, DU Y, Ji C (2013) Gene expression profiling of the DNMT3A R882 mutation in acute leukemia. Oncol Lett 6:268–274PubMedPubMedCentral

Krajinovic M, Labuda D, Richer C, Karimi S, Sinnett D (1999) Susceptibility to childhood acute lymphoblastic leukemia: influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 genetic polymorphisms. Blood 93:1496–1501PubMed

Krajinovic M, Sinnett H, Richer C, Labuda D, Sinnett D (2002) Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Int J Cancer 97:230–236PubMedCrossRef

Li N, Xu Y, Zheng J, Jiang L, You Y, Wu H, Li W, Wu D, Zhou Y (2013) NBS1 rs1805794G > C polymorphism is associated with decreased risk of acute myeloid leukemia in a Chinese population. Mol Biol Rep 40:3749–3756PubMedCrossRef

Lightfoot TJ, Johnston WT, Painter D, Simpson J, Roman E, Skibola CF, Smith MT, Allan JM, Taylor GM, United Kingdom Childhood Cancer Study (2010) Genetic variation in the folate metabolic pathway and risk of childhood leukemia. Blood 115:3923–3929PubMedPubMedCentralCrossRef

Linabery AM, Blommer CN, Spector LG, Davies SM, Robison LL, Ross JA (2013) ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: a report from the Children’s Oncology Group. Leuk Res 37:936–942PubMedPubMedCentralCrossRef

Mi S, Lu J, Sun M, Li Z, Zhang H, Neilly MB, Wang Y, Qian Z, Jin J, Zhang Y, Bohlander SK, Le Beau MM, Larson RA, Golub TR, Rowley JD, Chen J (2007) MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci USA 104:19971–19976PubMedPubMedCentralCrossRef

Migliorini G, Fiege B, Hosking FJ, Ma Y, Kumar R, Sherborne AL, da Silva Filho MI, Vijayakrishnan J, Koehler R, Thomsen H, Irving JA, Allan JM, Lightfoot T, Roman E, Kinsey SE, Sheridan E, Thompson P, Hoffmann P, Nöthen MM, Mühleisen TW, Eisele L, Zimmermann M, Bartram CR, Schrappe M, Greaves M, Stanulla M, Hemminki K, Houlston RS (2013) Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype. Blood 122:3298–3307PubMedCrossRef

Perez-Andreu V, Roberts KG, Harvey RC, Yang W, Cheng C, Pei D, Xu H, Gastier-Foster J, E S, Lim JY, Chen IM, Fan Y, Devidas M, Borowitz MJ, Smith C, Neale G, Burchard EG, Torgerson DG, Klussmann FA, Villagran CR, Winick NJ, Camitta BM, Raetz E, Wood B, Yue F, Carroll WL, Larsen E, Bowman WP, Loh ML, Dean M, Bhojwani D, Pui CH, Evans WE, Relling MV, Hunger SP, Willman CL, Mullighan CG, Yang JJ (2013) Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse. Nat Genet 45:1494–1498

Pakakasama S, Sirirat T, Kanchanachumpol S, Udomsubpayakul U, Mahasirimongkol S, Kitpoka P, Thithapandha A, Hongeng S (2007) Genetic polymorphisms and haplotypes of DNA repair genes in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 48:16–20PubMedCrossRef

Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Tomlinson IP, Taylor M, Greaves M, Houlston RS (2009) Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet 41:1006–1010PubMedCrossRef

Qiu W, Zhang S, Xiao C, Xu W, Ma Y, Liu Y, Wu Q (2003) Molecular cloning and characterization of a mouse spermatogenesis-related ring finger gene znf230. Biochem Biophys Res Commun 306:347–353PubMedCrossRef

Redaelli A, Laskin BL, Stephens JM, Botteman MF, Pashos CL (2005) A systematic literature review of the clinical and epidemiological burden of acute lymphoblastic leukaemia (ALL). Eur J Cancer Care (Engl) 14:53–62CrossRef

Rudant J, Orsi L, Bonaventure A, Goujon-Bellec S, Corda E, Baruchel A, Bertrand Y, Nelken B, Robert A, Michel G, Sirvent N, Chastagner P, Ducassou S, Rialland X, Hémon D, Leverger G, Clavel J (2013) Are ARID5B and IKZF1 polymorphisms also associated with childhood acute myeloblastic leukemia: the ESCALE study (SFCE)? Leukemia 27:746–748PubMedCrossRef

Schnatter AR, Armstrong TW, Thompson LS, Nicolich MJ, Katz AM, Huebner WW, Pearlman ED (1996) The relationship between low-level benzene exposure and leukemia in Canadian petroleum distribution workers. Environ Health Perspect 104(Suppl 6):1375–1379PubMedPubMedCentralCrossRef

Siegel R, Ma J, Zou Z, Jemal A (2014) Cancer statistics, 2014. CA Cancer J Clin 64:9–29PubMedCrossRef

Song H, Su D, Lu P, Yang J, Zhang W, Yang Y, Liu Y, Zhang S (2008) Expression and localization of the spermatogenesis-related gene, Znf230, in mouse testis and spermatozoa during postnatal development. BMB Rep 41:664–669PubMedCrossRef

Sorour A, Ayad MW, Kassem H (2013) The genotype distribution of the XRCC1, XRCC3, and XPD DNA repair genes and their role for the development of acute myeloblastic leukemia. Genet Test Mol Biomarkers 17:195–201PubMedCrossRef

Treviño LR, Yang W, French D, Hunger SP, Carroll WL, Devidas M, Willman C, Neale G, Downing J, Raimondi SC, Pui CH, Evans WE, Relling MV (2009) Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet 41:1001–1005PubMedPubMedCentralCrossRef

Wang Y, Chen J, Li J, Deng J, Rui Y, Lu Q, Wang M, Tong N, Zhang Z, Fang Y (2013) Association of three polymorphisms in ARID5B, IKZF1 and CEBPE with the risk of childhood acute lymphoblastic leukemia in a Chinese population. Gene 524:203–207PubMedCrossRef

Xu W, Zhang S, Qiu W, He G, Liu Y, Sun Y, Ma Y, Dong J, Zhang W (2009) Spermatogenesis-related ring finger gene ZNF230 promoter: identification and functional analysis. Mol Biol Rep 36:1187–1193PubMedCrossRef

Xu H, Yang W, Perez-Andreu V, Devidas M, Fan Y, Cheng C, Pei D, Scheet P, Burchard EG, Eng C, Huntsman S, Torgerson DG, Dean M, Winick NJ, Martin PL, Camitta BM, Bowman WP, Willman CL, Carroll WL, Mullighan CG, Bhojwani D, Hunger SP, Pui CH, Evans WE, Relling MV, Loh ML, Yang JJ (2013) Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. J Natl Cancer Inst 105:733–742PubMedPubMedCentralCrossRef

Titel: Replication analysis confirms the association of several variants with acute myeloid leukemia in Chinese population
verfasst von: Songyu Cao
Guohua Yang
Juan Zhang
Yunfeng Shen
Hongxia Ma
Xifeng Qian
Zhibin Hu
Publikationsdatum: 01.01.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 1/2016
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-015-2010-6

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Replication analysis confirms the association of several variants with acute myeloid leukemia in Chinese population

Abstract

Purpose

Methods

Results

Conclusion

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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