Small for size and flow (SFSF) in porcine model:
SFSF is a clinical syndrome which cannot be diagnosed, confirmed, or ruled out considering only one aspect. In experimental settings, it has often been shown that resection of 90 % of the liver causes nonreversible hepatic failure and does not lead to SFSF.
11 , 12 Moreover, a combination of PVF >250 ml/min/100 g and remnant liver volume (RLV) <25 % has been considered as a prerequisite for SFSF.
2 , 4 However, in porcine model, this can only be confirmed in a long-term follow-up with clinical, laboratory, and histopathological evaluations. Interestingly, in both studies of Darnis et al.
13 and Mohkam et al.
16, the PVF levels following 75 % resection exceeded 250 ml/min/100 g, and it is quite likely that the animals would have developed SFSF syndrome if a long-term follow-up had taken place.