Research development of a new GnRH antagonist (Elagolix) for the treatment of endometriosis: a review of the literature
- 03.03.2017
- Review
Erschienen in:
- Verfasst von
- Pontis Alessandro
- Nappi Luigi
- Sorrentino Felice
- Paoletti Anna Maria
- Melis Gian Benedetto
- Angioni Stefano
- Erschienen in
- Archives of Gynecology and Obstetrics | Ausgabe 4/2017
Abstract
Purpose
Limitated studies have reported the efficacy of GnRH antagonist on endometriosis symptoms. The aim of our study was to review all available trials to investigate the medical treatment of endometriosis with only GnRH antagonists, with special attention to pharmacodynamic activity, safety, and efficacy.
Methods
Pub Med and Sciencedirect database were searched using terms of “endometriosis treatment”, “GnRH antagonist”, and “Elagolix”. The search was limited to clinical studies published in English. Title and abstract were screened to identify relevant articles.
Results
Five studies covering use of GnRH antagonist were found. A phase 1 study evaluated the safety, pharmacokinetics, and inhibitory effects on gonadotropins and estradiol of single dose and 7 day elagolix administration to healthy premenopausal women; two phase II studies evaluated efficacy in patient with endometriosis. Moreover, there are two Phase III clinical trials just completed.
Conclusion
GnRH antagonists may have the advantage of oral administration and lower incidence of adverse events. Currently, only Phase II studies have been published demonstrating promising results in terms of efficacy, safety, and tolerability. From the results of the phase III studies, elagolix may become a valuable addition to the armamentarium of pharmacological agents to treat endometriosis-related pain.
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- Titel
- Research development of a new GnRH antagonist (Elagolix) for the treatment of endometriosis: a review of the literature
- Verfasst von
-
Pontis Alessandro
Nappi Luigi
Sorrentino Felice
Paoletti Anna Maria
Melis Gian Benedetto
Angioni Stefano
- Publikationsdatum
- 03.03.2017
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Archives of Gynecology and Obstetrics / Ausgabe 4/2017
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711 - DOI
- https://doi.org/10.1007/s00404-017-4328-6
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