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Erschienen in: Journal of Gastrointestinal Surgery 3/2014

01.03.2014 | Original Article

Resection of Isolated Renal Cell Carcinoma Metastases of the Pancreas: Outcomes from the Johns Hopkins Hospital

verfasst von: J. J. Tosoian, J. L. Cameron, M. E. Allaf, R. H. Hruban, C. B. Nahime, T. M. Pawlik, P. M. Pierorazio, S Reddy, C. L. Wolfgang

Erschienen in: Journal of Gastrointestinal Surgery | Ausgabe 3/2014

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Abstract

Purpose

This study aims to assess outcomes and characteristics associated with resection of metastatic renal cell carcinoma (mRCC) to the pancreas.

Materials and Methods

From April 1989 to July 2012, a total of 42 patients underwent resection of pancreatic mRCC at our institution. We retrospectively reviewed records from a prospectively managed database and analyzed patient demographics, comorbidities, perioperative outcomes, and overall survival. Cox proportional hazards models were used to evaluate the association between patient-specific factors and overall survival.

Results

The mean time from resection of the primary tumor to reoperation for pancreatic mRCC was 11.2 years (range, 0–28.0 years). In total, 17 patients underwent pancreaticoduodenectomy, 16 underwent distal pancreatectomy, and 9 underwent total pancreatectomy. Perioperative complications occurred in 18 (42.9 %) patients; there were two (4.8 %) perioperative mortalities. After pancreatic resection, the median follow-up was 7.0 years (0.1–23.2 years), and median survival was 5.5 years (range, 0.4–21.9). The overall 5-year survival was 51.8 %. On univariate analysis, vascular invasion (hazard ratio, 5.15; p = 0.005) was significantly associated with increased risk of death.

Conclusions

Pancreatic resection of mRCC can be safely achieved in the majority of cases and is associated with long-term survival. Specific pathological factors may predict which patients will benefit most from resection.
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Metadaten
Titel
Resection of Isolated Renal Cell Carcinoma Metastases of the Pancreas: Outcomes from the Johns Hopkins Hospital
verfasst von
J. J. Tosoian
J. L. Cameron
M. E. Allaf
R. H. Hruban
C. B. Nahime
T. M. Pawlik
P. M. Pierorazio
S Reddy
C. L. Wolfgang
Publikationsdatum
01.03.2014
Verlag
Springer US
Erschienen in
Journal of Gastrointestinal Surgery / Ausgabe 3/2014
Print ISSN: 1091-255X
Elektronische ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-013-2278-2

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