Skip to main content
main-content

Zeitschrift

Respiratory Research

Respiratory Research 1/2014

Ausgabe 1/2014

Inhaltsverzeichnis ( 159 Artikel )

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Exhaled breath condensate in intubated neonates- a window into the lung’s glutathione status

Maria I Rosso, Susan Roark, Esther Taylor, XiaoDu Ping, Janine M Ward, Katherine Roche, Courtney McCracken, Lou Ann S Brown, Theresa W Gauthier

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion

Shannon Bruse, Hans Petersen, Joel Weissfeld, Maria Picchi, Randall Willink, Kieu Do, Jill Siegfried, Steven A Belinsky, Yohannes Tesfaigzi

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Preserved function and reduced angiogenesis potential of the quadriceps in patients with mild COPD

Philippe Gagnon, Bruno B Lemire, Annie Dubé, Didier Saey, Alexandra Porlier, Marilie Croteau, Steeve Provencher, Richard Debigaré, François Maltais

01.12.2014 | Research | Ausgabe 1/2014 Open Access

New GOLD classification: longitudinal data on group assignment

Ciro Casanova, Jose M Marin, Cristina Martinez-Gonzalez, Pilar de Lucas-Ramos, Isabel Mir-Viladrich, Borja Cosio, German Peces-Barba, Miryam Calle-Rubio, Ingrid Solanes-García, Ramón Agüero, Alfredo de Diego-Damia, Nuria Feu-Collado, Inmaculada Alfageme, Rosa Irigaray, Eva Balcells, Antonia Llunell, Juan Bautista Galdiz, Margarita Marín, Juan José Soler-Cataluña, Jose Luis Lopez-Campos, Joan B Soriano, Juan P de-Torres, for the COPD History Assessment In SpaiN (CHAIN) cohort

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Early versus later response to treatment in patients with community-acquired pneumonia: analysis of the REACH study

Francesco Blasi, Helmut Ostermann, Jill Racketa, Jesús Medina, Kyle McBride, Javier Garau

01.12.2014 | Letter to the Editor | Ausgabe 1/2014 Open Access

Ageing and endurance training effects on quantity and quality of pulmonary vascular bed in healthy men

Ghanima Al Dandachi, Cécile Londner, Aurore Caumont-Prim, Laurent Plantier, Brigitte Chevalier-Bidaud, Jean-François Toussaint, François-Denis Desgorces, Christophe Delclaux

01.12.2014 | Reviewer acknowledgement | Ausgabe 1/2014 Open Access

Reviewer acknowledgement 2013

Jan Lötvall, Reynold A Panettieri Jr

01.12.2014 | Research | Ausgabe 1/2014 Open Access

MMP-2 and TIMP-1 predict healing of WTC-lung injury in New York City firefighters

Anna Nolan, Sophia Kwon, Soo Jung Cho, Bushra Naveed, Ashley L Comfort, David J Prezant, William N Rom, Michael D Weiden

01.12.2014 | Research | Ausgabe 1/2014 Open Access

dsRNA-induced changes in gene expression profiles of primary nasal and bronchial epithelial cells from patients with asthma, rhinitis and controls

Ariane H Wagener, Aeilko H Zwinderman, Silvia Luiten, Wytske J Fokkens, Elisabeth H Bel, Peter J Sterk, Cornelis M van Drunen

01.12.2014 | Research | Ausgabe 1/2014 Open Access

High-resolution CT scoring system-based grading scale predicts the clinical outcomes in patients with idiopathic pulmonary fibrosis

Keishi Oda, Hiroshi Ishimoto, Kazuhiro Yatera, Keisuke Naito, Takaaki Ogoshi, Kei Yamasaki, Tomotoshi Imanaga, Toru Tsuda, Hiroyuki Nakao, Toshinori Kawanami, Hiroshi Mukae

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Pulmonary vasoreactivity in spontaneously hypertensive rats - Effects of endothelin-1 and leptin

Samantha Gomart, Cécile Damoiseaux, Pascale Jespers, Martine Makanga, Nathalie Labranche, Stéphanie Pochet, Charles Michaux, Guy Berkenboom, Robert Naeije, Kathleen McEntee, Laurence Dewachter

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Analysis of comorbid factors that increase the COPD assessment test scores

Masaki Miyazaki, Hidetoshi Nakamura, Shotaro Chubachi, Mamoru Sasaki, Mizuha Haraguchi, Shuichi Yoshida, Keishi Tsuduki, Toru Shirahata, Saeko Takahashi, Naoto Minematsu, Hidefumi Koh, Morio Nakamura, Fumio Sakamaki, Takeshi Terashima, Koichi Sayama, Paul W Jones, Koichiro Asano, Tomoko Betsuyaku, The Keio COPD Comorbidity Research (K-CCR) Group

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Evaluation of coagulation activation after Rhinovirus infection in patients with asthma and healthy control subjects: an observational study

Christof J Majoor, Marianne A van de Pol, Pieter Willem Kamphuisen, Joost CM Meijers, Richard Molenkamp, Katja C Wolthers, Tom van der Poll, Rienk Nieuwland, Sebastian L Johnston, Peter J Sterk, Elisabeth HD Bel, Rene Lutter, Koenraad F van der Sluijs

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Cardiac involvement in Caucasian patients with pulmonary sarcoidosis

Pernilla Darlington, Anders Gabrielsen, Peder Sörensson, Kerstin Cederlund, Anders Eklund, Johan Grunewald

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Impact of heterozygote CFTR Mutations in COPD patients with Chronic Bronchitis

S Vamsee Raju, Jody H Tate, Sandra KG Peacock, Ping Fang, Robert A Oster, Mark T Dransfield, Steven M Rowe

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Combined exposure to cigarette smoke and nontypeable Haemophilus influenzae drives development of a COPD phenotype in mice

Shyamala Ganesan, Adam T Comstock, Brenton Kinker, Peter Mancuso, James M Beck, Uma S Sajjan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis

Minoru Inomata, Koichiro Kamio, Arata Azuma, Kuniko Matsuda, Nariaki Kokuho, Yukiko Miura, Hiroki Hayashi, Takahito Nei, Kazue Fujita, Yoshinobu Saito, Akihiko Gemma

01.12.2014 | Letter to the Editor | Ausgabe 1/2014 Open Access

Impact of gender on COPD expression in a real-life cohort

Nicolas Roche, Gaetan Deslée, Denis Caillaud, Graziella Brinchault, Isabelle Court-Fortune, Pascale Nesme-Meyer, Pascale Surpas, Roger Escamilla, Thierry Perez, Pascal Chanez, Christophe Pinet, Gilles Jebrak, Jean-Louis Paillasseur, Pierre-Régis Burgel, the INITIATIVES BPCO Scientific Committee

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells

Kazuaki Nomura, Kazufumi Obata, Takashi Keira, Ryo Miyata, Satoshi Hirakawa, Ken-ichi Takano, Takayuki Kohno, Norimasa Sawada, Tetsuo Himi, Takashi Kojima

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3β signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells

Eun Young Kim, Arum Kim, Se Kyu Kim, Hyung Jung Kim, Joon Chang, Chul Min Ahn, Yoon Soo Chang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Association of plasma sRAGE, but not esRAGE with lung function impairment in COPD

Poornima Gopal, Niki L Reynaert, Jean L J M Scheijen, Casper G Schalkwijk, Frits M E Franssen, Emiel F M Wouters, Erica P A Rutten

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Lung density on high resolution computer tomography (HRCT) reflects degree of inflammation in smokers

Reza Karimi, Göran Tornling, Helena Forsslund, Mikael Mikko, Åsa M Wheelock, Sven Nyrén, Carl Magnus Sköld

01.12.2014 | Research | Ausgabe 1/2014 Open Access

TRIP-1 via AKT modulation drives lung fibroblast/myofibroblast trans-differentiation

Michael F Nyp, Angels Navarro, Mohammad H Rezaiekhaligh, Ricardo E Perez, Sherry M Mabry, Ikechukwu I Ekekezie

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Evidence suggesting that oral corticosteroids increase mortality in stable chronic obstructive pulmonary disease

Nobuyuki Horita, Naoki Miyazawa, Satoshi Morita, Ryota Kojima, Miyo Inoue, Yoshiaki Ishigatsubo, Takeshi Kaneko

01.12.2014 | Commentary | Ausgabe 1/2014 Open Access

Shifting paradigms of nontuberculous mycobacteria in cystic fibrosis

Tavs Qvist, Tania Pressler, Niels Høiby, Terese L Katzenstein

01.12.2014 | Commentary | Ausgabe 1/2014 Open Access

Systemic steroids in COPD-the beauty and the beast

Claus F Vogelmeier

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study

Guoping Zheng, Lanfang Huang, Haijiang Tong, Qiang Shu, Yaoqin Hu, Menghua Ge, Keqin Deng, Liuya Zhang, Bin Zou, Baoli Cheng, Jianguo Xu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease

Wan-Guang Zhang, Li He, Xue-Mei Shi, Si-Si Wu, Bo Zhang, Li Mei, Yong-Jian Xu, Zhen-Xiang Zhang, Jian-Ping Zhao, Hui-Lan Zhang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

JNK suppresses pulmonary fibroblast elastogenesis during alveolar development

Sheng Liu, Harikrishnan Parameswaran, Sarah M Young, Brian M Varisco

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Regenerative defect in vastus lateralis muscle of patients with chronic obstructive pulmonary disease

Marie-Eve Thériault, Marie-Ève Paré, Bruno B Lemire, François Maltais, Richard Debigaré

01.12.2014 | Research | Ausgabe 1/2014 Open Access

A randomized clinical trial to assess the influence of a three months training program (Gym-based individualized vs. Calisthenics-based non-invidualized) in COPD-patients

Timm Greulich, Katharina Kehr, Christoph Nell, Janine Koepke, Daniel Haid, Ulrich Koehler, Kay Koehler, Silke Filipovic, Klaus Kenn, Claus Vogelmeier, Andreas-Rembert Koczulla

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The short and long term effects of exercise training in non-cystic fibrosis bronchiectasis – a randomised controlled trial

Annemarie L Lee, Catherine J Hill, Nola Cecins, Sue Jenkins, Christine F McDonald, Angela T Burge, Linda Rautela, Robert G Stirling, Philip J Thompson, Anne E Holland

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Heparin binding VEGF isoforms attenuate hyperoxic embryonic lung growth retardation via a FLK1-neuropilin-1-PKC dependent pathway

Americo E Esquibies, Anil Karihaloo, Susan E Quaggin, Alia Bazzy-Asaad, Lloyd G Cantley

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Frequent utilization of the emergency department for acute exacerbation of chronic obstructive pulmonary disease

Kohei Hasegawa, Yusuke Tsugawa, Chu-Lin Tsai, David FM Brown, Carlos A Camargo Jr

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Association of serum Clara cell protein CC16 with respiratory infections and immune response to respiratory pathogens in elite athletes

Marcin Kurowski, Janusz Jurczyk, Marzanna Jarzębska, Sylwia Moskwa, Joanna S Makowska, Hubert Krysztofiak, Marek L Kowalski

01.12.2014 | Research | Ausgabe 1/2014 Open Access

A large kindred of pulmonary fibrosis associated with a novel ABCA3 gene variant

Ilaria Campo, Michele Zorzetto, Francesca Mariani, Zamir Kadija, Patrizia Morbini, Roberto Dore, Eva Kaltenborn, Sabrina Frixel, Ralf Zarbock, Gerhard Liebisch, Jan Hegermann, Christoph Wrede, Matthias Griese, Maurizio Luisetti

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Impact of smoking on dendritic cell phenotypes in the airway lumen of patients with COPD

Paul Stoll, Ann-Sophie Heinz, Kai Bratke, Andrea Bier, Katharina Garbe, Michael Kuepper, J Christian Virchow, Marek Lommatzsch

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Persistence of pulmonary tertiary lymphoid tissues and anti-nuclear antibodies following cessation of cigarette smoke exposure

Mathieu C Morissette, Brian N Jobse, Danya Thayaparan, Jake K Nikota, Pamela Shen, Nancy Renée Labiris, Roland Kolbeck, Parameswaran Nair, Alison A Humbles, Martin R Stämpfli

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Impact of inflammation, emphysema, and smoking cessation on V/Q in mouse models of lung obstruction

Brian N Jobse, Cory AJR McCurry, Mathieu C Morissette, Rod G Rhem, Martin R Stämpfli, Nancy Renée Labiris

01.12.2014 | Review | Ausgabe 1/2014 Open Access

Inflammatory cytokines in pulmonary hypertension

Alexandra Groth, Bart Vrugt, Matthias Brock, Rudolf Speich, Silvia Ulrich, Lars C Huber

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Lung ultrasound for the diagnosis of pneumonia in adults: a systematic review and meta-analysis

Miguel A Chavez, Navid Shams, Laura E Ellington, Neha Naithani, Robert H Gilman, Mark C Steinhoff, Mathuram Santosham, Robert E Black, Carrie Price, Margaret Gross, William Checkley

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Atrial fibrosis in a chronic murine model of obstructive sleep apnea: mechanisms and prevention by mesenchymal stem cells

Pablo Ramos, Cira Rubies, Marta Torres, Montserrat Batlle, Ramon Farre, Josep Brugada, Josep M Montserrat, Isaac Almendros, Lluís Mont

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-β1

Christine R Keenan, Josephine SL Mok, Trudi Harris, Yuxiu Xia, Saad Salem, Alastair G Stewart

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity

Shailendra R Singh, Charlotte K Billington, Ian Sayers, Ian P Hall

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo

Fayong Luo, Yan Zhuang, Mark D Sides, Cecilia G Sanchez, Bin Shan, Eric S White, Joseph A Lasky

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The effects of salbutamol on epithelial ion channels depend on the etiology of acute respiratory distress syndrome but not the route of administration

Christopher Uhlig, Pedro L Silva, Débora Ornellas, Raquel S Santos, Paulo J Miranda, Peter M Spieth, Thomas Kiss, Michael Kasper, Bärbel Wiedemann, Thea Koch, Marcelo M Morales, Paolo Pelosi, Marcelo Gama de Abreu, Patricia RM Rocco

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma

Seil Sagar, Mary E Morgan, Si Chen, Arjan P Vos, Johan Garssen, Jeroen van Bergenhenegouwen, Louis Boon, Niki A Georgiou, Aletta D Kraneveld, Gert Folkerts

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Lung clearance index in adults with non-cystic fibrosis bronchiectasis

Sherif Gonem, Alys Scadding, Marcia Soares, Amisha Singapuri, Per Gustafsson, Chandra Ohri, Simon Range, Christopher E Brightling, Ian Pavord, Alex Horsley, Salman Siddiqui

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Role of non-coding RNAs in maintaining primary airway smooth muscle cells

Mark M Perry, Eleni Tsitsiou, Philip J Austin, Mark A Lindsay, David S Gibeon, Ian M Adcock, Kian Fan Chung

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Effective pulmonary delivery of an aerosolized plasmid DNA vaccine via surface acoustic wave nebulization

Anushi E Rajapaksa, Jenny J Ho, Aisha Qi, Rob Bischof, Tri-Hung Nguyen, Michelle Tate, David Piedrafita, Michelle P McIntosh, Leslie Y Yeo, Els Meeusen, Ross L Coppel, James R Friend

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Impact of self-reported Gastroesophageal reflux disease in subjects from COPDGene cohort

Carlos H Martinez, Yuka Okajima, Susan Murray, George R Washko, Fernando J Martinez, Edwin K Silverman, Jin Hwa Lee, Elizabeth A Regan, James D Crapo, Jeffrey L Curtis, Hiroto Hatabu, MeiLan K Han, the COPDGene Investigators

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Tiotropium might improve survival in subjects with COPD at high risk of mortality

Pierre-Régis Burgel, Jean-Louis Paillasseur, Daniel Dusser, Nicolas Roche, Dacheng Liu, Yufeng Liu, Armin Furtwaengler, Norbert Metzdorf, Marc Decramer

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Tiotropium Respimat® in asthma: a double-blind, randomised, dose-ranging study in adult patients with moderate asthma

Kai-Michael Beeh, Petra Moroni-Zentgraf, Othmar Ablinger, Zuzana Hollaenderova, Anna Unseld, Michael Engel, Stephanie Korn

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Macrophage activation state determines the response to rhinovirus infection in a mouse model of allergic asthma

Jun Young Hong, Yutein Chung, Jessica Steenrod, Qiang Chen, Jing Lei, Adam T Comstock, Adam M Goldsmith, J Kelley Bentley, Uma S Sajjan, Marc B Hershenson

01.12.2014 | Research | Ausgabe 1/2014 Open Access

N-acetylcysteine improves established monocrotaline-induced pulmonary hypertension in rats

Marie-Camille Chaumais, Benoît Ranchoux, David Montani, Peter Dorfmüller, Ly Tu, Florence Lecerf, Nicolas Raymond, Christophe Guignabert, Laura Price, Gérald Simonneau, Sylvia Cohen-Kaminsky, Marc Humbert, Frédéric Perros

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Improving inhaler adherence in patients with Chronic Obstructive Pulmonary Disease: a cost-effectiveness analysis

Job FM van Boven, Eline Tommelein, Koen Boussery, Els Mehuys, Stefan Vegter, Guy GO Brusselle, Maureen PMH Rutten-van Mölken, Maarten J Postma

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Developmental lung expression and transcriptional regulation of Claudin-6 by TTF-1, Gata-6, and FoxA2

Felix R Jimenez, Joshua B Lewis, Samuel T Belgique, Tyler T Wood, Paul R Reynolds

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Rac2 is involved in bleomycin-induced lung inflammation leading to pulmonary fibrosis

Narcy Arizmendi, Lakshmi Puttagunta, Kerri L Chung, Courtney Davidson, Juliana Rey-Parra, Danny V Chao, Bernard Thebaud, Paige Lacy, Harissios Vliagoftis

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Impaired macrophage phagocytosis of bacteria in severe asthma

Zhike Liang, Qingling Zhang, Catherine MR Thomas, Kirandeep K Chana, David Gibeon, Peter J Barnes, Kian Fan Chung, Pankaj K Bhavsar, Louise E Donnelly

01.12.2014 | Research | Ausgabe 1/2014 Open Access

FEV1 inversely correlates with metalloproteinases 1, 7, 9 and CRP in COPD by biomass smoke exposure

Martha Montaño, Raul H Sansores, Carina Becerril, Jose Cisneros, Georgina González-Avila, Bettina Sommer, Leticia Ochoa, Iliana Herrera, Alejandra Ramírez-Venegas, Carlos Ramos

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Controlled and uncontrolled asthma display distinct alveolar tissue matrix compositions

Maria Weitoft, Cecilia Andersson, Annika Andersson-Sjöland, Ellen Tufvesson, Leif Bjermer, Jonas Erjefält, Gunilla Westergren-Thorsson

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Allergic airway inflammation induces the migration of dendritic cells into airway sensory ganglia

Duc Dung Le, Sabine Rochlitzer, Axel Fischer, Sebastian Heck, Thomas Tschernig, Martina Sester, Robert Bals, Tobias Welte, Armin Braun, Quoc Thai Dinh

01.12.2014 | Research | Ausgabe 1/2014 Open Access

TLR4 activation induces IL-1β release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung

Suffwan Eltom, Maria G Belvisi, Liang Yew-Booth, Bilel Dekkak, Sarah A Maher, Eric D Dubuis, Victoria Jones, Kate A Fitzgerald, Mark A Birrell

01.12.2014 | Letter to the Editor | Ausgabe 1/2014 Open Access

Surfactant protein A mediates pulmonary clearance of Staphylococcus aureus

Nils T Veith, Thomas Tschernig, Birgitt Gutbier, Martin Witzenrath, Carola Meier, Michael Menger, Markus Bischoff

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Nitric oxide exerts protective effects against bleomycin-induced pulmonary fibrosis in mice

Shingo Noguchi, Kazuhiro Yatera, Ke-Yong Wang, Keishi Oda, Kentarou Akata, Kei Yamasaki, Toshinori Kawanami, Hiroshi Ishimoto, Yumiko Toyohira, Hiroaki Shimokawa, Nobuyuki Yanagihara, Masato Tsutsui, Hiroshi Mukae

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene

Emily S Wan, Peter J Castaldi, Michael H Cho, John E Hokanson, Elizabeth A Regan, Barry J Make, Terri H Beaty, MeiLan K Han, Jeffrey L Curtis, Douglas Curran-Everett, David A Lynch, Dawn L DeMeo, James D Crapo, Edwin K Silverman

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Airway wall thickness is increased in COPD patients with bronchodilator responsiveness

Victor Kim, Parag Desai, John D Newell, Barry J Make, George R Washko, Edwin K Silverman, James D Crapo, Surya P Bhatt, Gerard J Criner

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Efficacy and safety of once-daily fluticasone furoate 50 mcg in adults with persistent asthma: a 12-week randomized trial

Paul M O’Byrne, Ashley Woodcock, Eugene R Bleecker, Eric D Bateman, Jan Lötvall, Richard Forth, Hilary Medley, Loretta Jacques, William W Busse

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Roxithromycin treatment inhibits TGF-β1-induced activation of ERK and AKT and down-regulation of Caveolin-1 in rat airway smooth muscle cells

Yuanrong Dai, Fengqin Li, Liqin Wu, Ruili Wang, Ping Li, Sunshun Yan, Hui Xu, Mengling Xia, Chunxue Bai

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction

John R Greenland, Xiang Xu, David M Sayah, Feng Chun Liu, Kirk D Jones, Mark R Looney, George H Caughey

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Adjuvant-dependent regulation of interleukin-17 expressing γδ T cells and inhibition of Th2 responses in allergic airways disease

Emily M Nakada, Jichuan Shan, Margaret W Kinyanjui, Elizabeth D Fixman

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Murine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor

Cassiano Felippe Gonçalves-de-Albuquerque, Patrícia Burth, Adriana Ribeiro Silva, Isabel Matos Medeiros de Moraes, Flora Magno de Jesus Oliveira, Ricardo Erthal Santelli, Aline Soares Freire, Gerson Silva de Lima, Emilson Domingos da Silva, Camila Ignácio da Silva, Verônica Morandi, Patrícia Torres Bozza, Mauricio Younes-Ibrahim, Hugo Caire de Castro Faria Neto, Mauro Velho de Castro Faria

01.12.2014 | Research | Ausgabe 1/2014 Open Access

DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease

Jin Hwa Lee, Merry-Lynn N McDonald, Michael H Cho, Emily S Wan, Peter J Castaldi, Gary M Hunninghake, Nathaniel Marchetti, David A Lynch, James D Crapo, David A Lomas, Harvey O Coxson, Per S Bakke, Edwin K Silverman, Craig P Hersh

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Disposal of iNKT cell deficiency and an increase in expression of SLAM signaling factors characterizes sarcoidosis remission: a 4-year longitudinal study

Katarina Osolnik, Matija Rijavec, Peter Korosec

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Compartment differences of inflammatory activity in chronic obstructive pulmonary disease

Jie Ji, Ida von Schéele, Jan Bergström, Bo Billing, Barbro Dahlén, Ann-Sofie Lantz, Kjell Larsson, Lena Palmberg

01.12.2014 | Review | Ausgabe 1/2014 Open Access

Prostaglandin E2 receptors in asthma and in chronic rhinosinusitis/nasal polyps with and without aspirin hypersensitivity

Liliana Machado-Carvalho, Jordi Roca-Ferrer, César Picado

01.12.2014 | Research | Ausgabe 1/2014 Open Access

A clinical in-hospital prognostic score for acute exacerbations of COPD

Nicolas Roche, Jean-Michel Chavaillon, Cyril Maurer, Mahmoud Zureik, Jacques Piquet

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Small airway dysfunction is associated to excessive bronchoconstriction in asthmatic patients

Veronica Alfieri, Marina Aiello, Roberta Pisi, Panagiota Tzani, Elisa Mariani, Emilio Marangio, Dario Olivieri, Gabriele Nicolini, Alfredo Chetta

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Acute bronchodilator responses decline progressively over 4 years in patients with moderate to very severe COPD

Donald P Tashkin, Ning Li, Eric C Kleerup, David Halpin, Bartolome Celli, Marc Decramer, Robert Elashoff

01.12.2014 | Research | Ausgabe 1/2014 Open Access

MicroRNA-708 regulates CD38 expression through signaling pathways JNK MAP kinase and PTEN/AKT in human airway smooth muscle cells

Mythili Dileepan, Joseph A Jude, Savita P Rao, Timothy F Walseth, Reynold A Panettieri, Subbaya Subramanian, Mathur S Kannan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Autopsy analyses in acute exacerbation of idiopathic pulmonary fibrosis

Keishi Oda, Hiroshi Ishimoto, Sohsuke Yamada, Hisako Kushima, Hiroshi Ishii, Tomotoshi Imanaga, Tatsuhiko Harada, Yuji Ishimatsu, Nobuhiro Matsumoto, Keisuke Naito, Kazuhiro Yatera, Masamitsu Nakazato, Jun-ichi Kadota, Kentaro Watanabe, Shigeru Kohno, Hiroshi Mukae

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Impact of traffic related air pollution indicators on non-cystic fibrosis bronchiectasis mortality: a cohort analysis

Pieter C Goeminne, Esmee Bijnens, Ben Nemery, Tim S Nawrot, Lieven J Dupont

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Increased levels of soluble interleukin-6 receptor and CCL3 in COPD sputum

Arjun K Ravi, Shruti Khurana, Jonathan Lemon, Jonathan Plumb, George Booth, Louise Healy, Matthew Catley, Jørgen Vestbo, Dave Singh

01.12.2014 | Research | Ausgabe 1/2014 Open Access

PlGF mediates neutrophil elastase-induced airway epithelial cell apoptosis and emphysema

Hsin-Han Hou, Shih-Lung Cheng, Kuei-Pin Chung, Shu-Chen Wei, Po-Nien Tsao, Hsuan-Hsuan Lu, Hao-Chien Wang, Chong-Jen Yu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Low tidal volume pressure support versus controlled ventilation in early experimental sepsis in pigs

Alexander Ziebart, Erik K Hartmann, Rainer Thomas, Tanghua Liu, Bastian Duenges, Arno Schad, Marc Bodenstein, Serge C Thal, Matthias David

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The effect of CSF-1 administration on lung maturation in a mouse model of neonatal hyperoxia exposure

Christina V Jones, Maliha A Alikhan, Megan O’Reilly, Foula Sozo, Timothy M Williams, Richard Harding, Graham Jenkin, Sharon D Ricardo

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Inflammatory thresholds and the species-specific effects of colonising bacteria in stable chronic obstructive pulmonary disease

Richa Singh, Alexander J Mackay, Anant RC Patel, Davinder S Garcha, Beverly S Kowlessar, Simon E Brill, Louise E Donnelly, Peter J Barnes, Gavin C Donaldson, Jadwiga A Wedzicha

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiency

Laura Pini, Laura Tiberio, Narayanan Venkatesan, Michela Bezzi, Luciano Corda, Maurizio Luisetti, Ilaria Ferrarotti, Mario Malerba, David A Lomas, Sabina Janciauskiene, Enrico Vizzardi, Denise Modina, Luisa Schiaffonati, Claudio Tantucci

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Nebulized perflubron and carbon dioxide rapidly dilate constricted airways in an ovine model of allergic asthma

Tamer Y El Mays, Parichita Choudhury, Richard Leigh, Emmanuel Koumoundouros, Joanne Van der Velden, Grishma Shrestha, Cora A Pieron, John H Dennis, Francis HY Green, Ken J Snibson

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease

Jin Hwa Lee, Michael H Cho, Craig P Hersh, Merry-Lynn N McDonald, James D Crapo, Per S Bakke, Amund Gulsvik, Alejandro P Comellas, Christine H Wendt, David A Lomas, Victor Kim, Edwin K Silverman

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Smoking accelerates aging of the small airway epithelium

Matthew S Walters, Bishnu P De, Jacqueline Salit, Lauren J Buro-Auriemma, Timothy Wilson, Allison M Rogalski, Lindsay Lief, Neil R Hackett, Michelle R Staudt, Ann E Tilley, Ben-Gary Harvey, Robert J Kaner, Jason G Mezey, Beth Ashbridge, Malcolm A S Moore, Ronald G Crystal

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Fluticasone propionate/salmeterol 250/50 μg versus salmeterol 50 μg after chronic obstructive pulmonary disease exacerbation

Jill A Ohar, Glenn D Crater, Amanda Emmett, Thomas J Ferro, Andrea N Morris, Ibrahim Raphiou, Peruvemba S Sriram, Mark T Dransfield

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Network medicine analysis of COPD multimorbidities

Solène Grosdidier, Antoni Ferrer, Rosa Faner, Janet Piñero, Josep Roca, Borja Cosío, Alvar Agustí, Joaquim Gea, Ferran Sanz, Laura I Furlong

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Effects of exercise training on pulmonary vessel muscularization and right ventricular function in an animal model of COPD

Erlend Hassel, Anne Marie Berre, Anne Jarstein Skjulsvik, Sigurd Steinshamn

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Increased of exhaled breath condensate neutrophil chemotaxis in acute exacerbation of COPD

Jean Louis Corhay, Catherine Moermans, Monique Henket, Delphine Nguyen Dang, Bernard Duysinx, Renaud Louis

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia

Lu Yin, Dahai Zheng, Gino V Limmon, Nicola HN Leung, Shuoyu Xu, Jagath C Rajapakse, Hanry Yu, Vincent TK Chow, Jianzhu Chen

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Effects of different mesenchymal stromal cell sources and delivery routes in experimental emphysema

Mariana A Antunes, Soraia C Abreu, Fernanda F Cruz, Ana Clara Teixeira, Miquéias Lopes-Pacheco, Elga Bandeira, Priscilla C Olsen, Bruno L Diaz, Christina M Takyia, Isalira PRG Freitas, Nazareth N Rocha, Vera L Capelozzi, Débora G Xisto, Daniel J Weiss, Marcelo M Morales, Patricia RM Rocco

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Measuring respiratory symptoms of COPD: performance of the EXACT- Respiratory Symptoms Tool (E-RS) in three clinical trials

Nancy K Leidy, Lindsey T Murray, Brigitta U Monz, Linda Nelsen, Mitchell Goldman, Paul W Jones, Elizabeth J Dansie, Sanjay Sethi

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Severe alpha-1 antitrypsin deficiency in composite heterozygotes inheriting a new splicing mutation QOMadrid

Beatriz Lara, Maria Teresa Martínez, Ignacio Blanco, Cristina Hernández-Moro, Eladio A Velasco, Ilaria Ferrarotti, Francisco Rodriguez-Frias, Laura Perez, Irene Vazquez, Javier Alonso, Manuel Posada, Beatriz Martínez-Delgado

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Up-regulation of hexokinase1 in the right ventricle of monocrotaline induced pulmonary hypertension

Wei-hua Zhang, Mei-hong Qiu, Xiao-jian Wang, Kai Sun, Yang Zheng, Zhi-cheng Jing

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Impact of ozone exposure on the response to glucocorticoid in a mouse model of asthma: involvements of p38 MAPK and MKP-1

Aihua Bao, Feng Li, Min Zhang, Yuqing Chen, Pengyu Zhang, Xin Zhou

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD

Susan JM Hoonhorst, Wim Timens, Leo Koenderman, Adèle T Lo Tam Loi, Jan-Willem J Lammers, H Marike Boezen, Antoon JM van Oosterhout, Dirkje S Postma, Nick HT ten Hacken

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes

Brendan J Carolan, Grant Hughes, Jarrett Morrow, Craig P Hersh, Wanda K O’Neal, Stephen Rennard, Sreekumar G Pillai, Paula Belloni, Debra A Cockayne, Alejandro P Comellas, Meilan Han, Rachel L Zemans, Katerina Kechris, Russell P Bowler

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Efficacy and safety of fixed-dose combinations of aclidinium bromide/formoterol fumarate: the 24-week, randomized, placebo-controlled AUGMENT COPD study

Anthony D D’Urzo, Stephen I Rennard, Edward M Kerwin, Victor Mergel, Anne R Leselbaum, Cynthia F Caracta

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Therapeutic effects of amniotic fluid-derived mesenchymal stromal cells on lung injury in rats with emphysema

Yaqing Li, Chao Gu, Wulin Xu, Jianping Yan, Yingjie Xia, Yingyu Ma, Chun Chen, Xujun He, Houquan Tao

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Observational study to characterise 24-hour COPD symptoms and their relationship with patient-reported outcomes: results from the ASSESS study

Marc Miravitlles, Heinrich Worth, Juan José Soler Cataluña, David Price, Fernando De Benedetto, Nicolas Roche, Nina Skavlan Godtfredsen, Thys van der Molen, Claes-Göran Löfdahl, Laura Padullés, Anna Ribera

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Antenatal exposure of maternal secondhand smoke (SHS) increases fetal lung expression of RAGE and induces RAGE-mediated pulmonary inflammation

Duane R Winden, David B Barton, Bryce C Betteridge, Jared S Bodine, Cameron M Jones, Geraldine D Rogers, Michael Chavarria, Alex J Wright, Zac R Jergensen, Felix R Jimenez, Paul R Reynolds

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Small interfering RNA against CD86 during allergen challenge blocks experimental allergic asthma

Yukari Asai-Tajiri, Koichiro Matsumoto, Satoru Fukuyama, Keiko Kan-o, Takako Nakano, Ken Tonai, Tatsukuni Ohno, Miyuki Azuma, Hiromasa Inoue, Yoichi Nakanishi

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The prevalence of increased serum IgE and Aspergillus sensitization in patients with COPD and their association with symptoms and lung function

Jianmin Jin, Xiaofang Liu, Yongchang Sun

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Conditionally induced RAGE expression by proximal airway epithelial cells in transgenic mice causes lung inflammation

B Garrett Bodine, Brock G Bennion, Emma Leatham, Felix R Jimenez, Alex J Wright, Zac R Jergensen, Connor J Erickson, Cameron M Jones, Jeff P Johnson, Steven M Knapp, Paul R Reynolds

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Genetic variants associated with lung function: the long life family study

Bharat Thyagarajan, Mary Wojczynski, Ryan L Minster, Jason Sanders, Sandra Barral, Lene Christiansen, R Graham Barr, Anne Newman, CHARGE consortium, SpiroMeta consortium

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Altered molecular specificity of surfactant phosphatidycholine synthesis in patients with acute respiratory distress syndrome

Ahilanandan Dushianthan, Victoria Goss, Rebecca Cusack, Michael PW Grocott, Anthony D Postle

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Asthma incidence, remission, relapse and persistence: a population-based study in southern Taiwan

Tsung-Ju Wu, Chang-Fu Wu, Yungling Leo Lee, Tzuen-Ren Hsiue, Yue Leon Guo

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Epigenetics of hyper-responsiveness to allergen challenge following intrauterine growth retardation rat

Xue-Feng Xu, Qiong-Yao Hu, Ling-Fang Liang, Lei Wu, Wei-Zhong Gu, Li-Li Tang, Lin-Chen Fu, Li-Zhong Du

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Comparison of inflammatory markers in induced and spontaneous sputum in a cohort of COPD patients

Solveig Tangedal, Marianne Aanerud, Louise JP Persson, Karl A Brokstad, Per S Bakke, Tomas M Eagan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Quantifying the real life risk profile of inhaled corticosteroids in COPD by record linkage analysis

Rob W Flynn, Thomas M MacDonald, Adrian Hapca, Isla S MacKenzie, Stuart Schembri

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Longitudinal increase in total IgE levels in patients with adult asthma: an association with poor asthma control

Akihiko Tanaka, Megumi Jinno, Kuniaki Hirai, Yoshito Miyata, Hiroko Mizuma, Munehiro Yamaguchi, Shin Ohta, Yoshio Watanabe, Mayumi Yamamoto, Shintaro Suzuki, Takuya Yokoe, Mitsuru Adachi, Hironori Sagara

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Vitamin D regulating TGF-β induced epithelial-mesenchymal transition

Kimberly D Fischer, Devendra K Agrawal

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury

Koji Takashima, Miyoko Matsushima, Katsunori Hashimoto, Haruka Nose, Mitsuo Sato, Naozumi Hashimoto, Yoshinori Hasegawa, Tsutomu Kawabe

01.12.2014 | Review | Ausgabe 1/2014 Open Access

Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease

Sofie Lock-Johansson, Jørgen Vestbo, Grith Lykke Sorensen

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats

Pil-Sung Yang, Dae-Hoon Kim, Yong Joon Lee, Sang-Eun Lee, Won Jun Kang, Hyuk-Jae Chang, Jeon-Soo Shin

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Five microRNAs in plasma as novel biomarkers for screening of early-stage non-small cell lung cancer

Qing Geng, Tao Fan, Boyou Zhang, Wei Wang, Yao Xu, Hao Hu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Upregulation of IL-17A/F from human lung tissue explants with cigarette smoke exposure: implications for COPD

Ying Chang, Laila Al-Alwan, Sama Alshakfa, Severine Audusseau, Andrea Karen Mogas, Fazila Chouiali, Parameswaran Nair, Carolyn J Baglole, Qutayba Hamid, David H Eidelman

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Delay of airway epithelial wound repair in COPD is associated with airflow obstruction severity

Jeanne-Marie Perotin, Damien Adam, Juliette Vella-Boucaud, Gonzague Delepine, Sebastian Sandu, Anne-Carole Jonvel, Alain Prevost, Gérard Berthiot, Christophe Pison, François Lebargy, Philippe Birembaut, Christelle Coraux, Gaëtan Deslee

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Allergic diseases and asthma in the family predict the persistence and onset-age of asthma: a prospective cohort study

Elina MS Paaso, Maritta S Jaakkola, Aino K Rantala, Timo T Hugg, Jouni JK Jaakkola

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Defining adult asthma endotypes by clinical features and patterns of volatile organic compounds in exhaled air

Norbert Meyer, Jan W Dallinga, Sarah Janine Nuss, Edwin JC Moonen, Joep JBN van Berkel, Cezmi Akdis, Frederik Jan van Schooten, Günter Menz

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Surfactant protein D attenuates sub-epithelial fibrosis in allergic airways disease through TGF-β

Hirohisa Ogawa, Julie G Ledford, Sambuddho Mukherjee, Yoshinori Aono, Yasuhiko Nishioka, James J Lee, Keisuke Izumi, John W Hollingsworth

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Pathophysiological characterization of asthma transitions across adolescence

Syed Hasan Arshad, Abid Raza, Laurie Lau, Khalid Bawakid, Wilfried Karmaus, Hongmei Zhang, Susan Ewart, Veersh Patil, Graham Roberts, Ramesh Kurukulaaratchy

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Food allergy enhances allergic asthma in mice

Tiphaine Bihouée, Gregory Bouchaud, Julie Chesné, David Lair, Camille Rolland-Debord, Faouzi Braza, Marie-Aude Cheminant, Philippe Aubert, Guillaume Mahay, Christine Sagan, Michel Neunlist, Sophie Brouard, Marie Bodinier, Antoine Magnan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Predictors of diagnosis and survival in idiopathic pulmonary fibrosis and connective tissue disease-related usual interstitial pneumonia

Teng Moua, Ana C Zamora Martinez, Misbah Baqir, Robert Vassallo, Andrew H Limper, Jay H Ryu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Activation of c-Src tyrosine kinase mediated the degradation of occludin in ventilator-induced lung injury

Tao Zhao, Mengjie Liu, Changping Gu, Xin Wang, Yuelan Wang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent

Katy M Roach, Heike Wulff, Carol Feghali-Bostwick, Yassine Amrani, Peter Bradding

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Inhibition of AMPK expression in skeletal muscle by systemic inflammation in COPD rats

Yong Qi, Jun-yi Shang, Li-jun Ma, Bei-bei Sun, Xin-gang Hu, Bao Liu, Guo-jun Zhang

01.12.2014 | Erratum | Ausgabe 1/2014 Open Access

Erratum: New GOLD classification: longitudinal data on group assignment

Ciro Casanova, Jose M Marin, Cristina Martinez-Gonzalez, Pilar de Lucas-Ramos, Isabel Mir-Viladrich, Borja Cosio, German Peces-Barba, Miryam Calle-Rubio, Ingrid Solanes-García, Ramón Agüero, Alfredo de Diego-Damia, Nuria Feu-Collado, Inmaculada Alfageme, Rosa Irigaray, Eva Balcells, Antonia Llunel, Juan Bautista Galdiz-Iturri, Margarita Marín, Juan José Soler, Jose Luis Lopez-Campos, Joan B Soriano, Juan P de-Torres, the COPD History Assessment In SpaiN (CHAIN) cohort

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis

Katrin E Hostettler, Jun Zhong, Eleni Papakonstantinou, George Karakiulakis, Michael Tamm, Petra Seidel, Qingzhu Sun, Jyotshna Mandal, Didier Lardinois, Christopher Lambers, Michael Roth

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Severe vitamin D deficiency is associated with frequent exacerbations and hospitalization in COPD patients

Andrei Malinovschi, Monica Masoero, Michela Bellocchia, Antonio Ciuffreda, Paolo Solidoro, Alessio Mattei, Lorena Mercante, Enrico Heffler, Giovanni Rolla, Caterina Bucca

01.12.2014 | Research | Ausgabe 1/2014 Open Access

17β-estradiol suppresses lipopolysaccharide-induced acute lung injury through PI3K/Akt/SGK1 mediated up-regulation of epithelial sodium channel (ENaC) in vivo and in vitro

Di Qi, Jing He, Daoxin Wang, Wang Deng, Yan Zhao, Yuan Ye, Longhua Feng

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas

Emily Van de Laar, Monica Clifford, Stefan Hasenoeder, Bo Ram Kim, Dennis Wang, Sharon Lee, Josh Paterson, Nancy M Vu, Thomas K Waddell, Shaf Keshavjee, Ming-Sound Tsao, Laurie Ailles, Nadeem Moghal

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Frequent cough in unsatisfactory controlled asthma – results from the population-based West Sweden Asthma Study

Roxana Mincheva, Linda Ekerljung, Anders Bjerg, Malin Axelsson, Todor A Popov, Bo Lundbäck, Jan Lötvall

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Prevention of hyperoxia-induced bronchial hyperreactivity by sildenafil and vasoactive intestinal peptide: impact of preserved lung function and structure

Dorottya Czövek, Ferenc Peták, Yves Donati, Xavier Belin, Jean-Claude Pache, Constance Barazzone Argiroffo, Walid Habre

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Derivation of normative data for the COPD assessment test (CAT)

Lancelot M Pinto, Nisha Gupta, Wan Tan, Pei Z Li, Andrea Benedetti, Paul W Jones, Jean Bourbeau, For the CanCOLD study group

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Predicting treatment failure in patients with community acquired pneumonia: a case-control study

Ignacio Martin-Loeches, Xavier Valles, Rosario Menendez, Oriol Sibila, Beatriz Montull, Catia Cilloniz, Antonio Artigas, Antoni Torres

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Raphe serotonergic neurons modulate genioglossus corticomotor activity in intermittent hypoxic rats

Jiao Su, Wei Wang, Longfeng Sun, Ting Li, Delei Kong, Jian Kang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels

Fatemat Hassan, Xiaohua Xu, Gerard Nuovo, David W Killilea, Jean Tyrrell, Chong Da Tan, Robert Tarran, Philip Diaz, Junbae Jee, Daren Knoell, Prosper N Boyaka, Estelle Cormet-Boyaka

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Safety and tolerability of once-daily umeclidinium/vilanterol 125/25 mcg and umeclidinium 125 mcg in patients with chronic obstructive pulmonary disease: results from a 52-week, randomized, double-blind, placebo-controlled study

James F Donohue, Dennis Niewoehner, Jean Brooks, Dianne O’Dell, Alison Church

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Statins reduce all-cause mortality in chronic obstructive pulmonary disease: a systematic review and meta-analysis of observational studies

Nobuyuki Horita, Naoki Miyazawa, Ryota Kojima, Miyo Inoue, Yoshiaki Ishigatsubo, Atsuhisa Ueda, Takeshi Kaneko

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Moxifloxacin modulates inflammation during murine pneumonia

Christoph Beisswenger, Anja Honecker, Andreas Kamyschnikow, Markus Bischoff, Thomas Tschernig, Robert Bals

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Withdrawal of inhaled corticosteroids can be safe in COPD patients at low risk of exacerbation: a real-life study on the appropriateness of treatment in moderate COPD patients (OPTIMO)

Andrea Rossi, Massimo Guerriero, Antonio Corrado

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Long-acting beta-agonists plus inhaled corticosteroids safety: a systematic review and meta-analysis of non-randomized studies

Gimena Hernández, Mónica Avila, Àngels Pont, Olatz Garin, Jordi Alonso, Laurent Laforest, Christopher J Cates, Montserrat Ferrer, ASTRO-LAB group

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Importance of Aspergillus spp. isolation in Acute exacerbations of severe COPD: prevalence, factors and follow-up: the FUNGI-COPD study

Arturo Huerta, Nestor Soler, Mariano Esperatti, Mónica Guerrero, Rosario Menendez, Alexandra Gimeno, Rafael Zalacaín, Nuria Mir, Jose Maria Aguado, Antoni Torres

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles

Sam Parnia, Lynnsey M Hamilton, Sarah M Puddicombe, Stephen T Holgate, Anthony J Frew, Donna E Davies

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Acquired defects in CFTR-dependent β-adrenergic sweat secretion in chronic obstructive pulmonary disease

Clifford A Courville, Sherry Tidwell, Bo Liu, Frank J Accurso, Mark T Dransfield, Steven M Rowe

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Phenotyping community-acquired pneumonia according to the presence of acute respiratory failure and severe sepsis

Stefano Aliberti, Anna Maria Brambilla, James D Chalmers, Catia Cilloniz, Julio Ramirez, Angelo Bignamini, Elena Prina, Eva Polverino, Paolo Tarsia, Alberto Pesci, Antoni Torres, Francesco Blasi, Roberto Cosentini

01.12.2014 | Research | Ausgabe 1/2014 Open Access

PPAR Gamma agonists regulate tobacco smoke-induced toll like receptor 4 expression in alveolar macrophages

Yan Yin, Gang Hou, Erran Li, Qiuyue Wang, Jian Kang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Hypo- and hypercapnia predict mortality in oxygen-dependent chronic obstructive pulmonary disease: a population-based prospective study

Zainab Ahmadi, Anna Bornefalk-Hermansson, Karl A Franklin, Bengt Midgren, Magnus P Ekström

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The vitamin E isoforms α-tocopherol and γ-tocopherol have opposite associations with spirometric parameters: the CARDIA study

Michelle E Marchese, Rajesh Kumar, Laura A Colangelo, Pedro C Avila, David R Jacobs Jr, Myron Gross, Akshay Sood, Kiang Liu, Joan M Cook-Mills

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Rosiglitazone is a superior bronchodilator compared to chloroquine and β-adrenoceptor agonists in mouse lung slices

Chantal Donovan, Mirjam Simoons, James Esposito, Jean Ni Cheong, Meaghan FitzPatrick, Jane Elizabeth Bourke

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study

Victor Kim, Adam Davey, Alejandro P Comellas, Meilan K Han, George Washko, Carlos H Martinez, David Lynch, Jin Hwa Lee, Edwin K Silverman, James D Crapo, Barry J Make, Gerard J Criner, The COPDGene® Investigators

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Vitamin D deficiency in community-acquired pneumonia: low levels of 1,25(OH)2 D are associated with disease severity

Mathias W Pletz, Christoph Terkamp, Ulrike Schumacher, Gernot Rohde, Hartwig Schütte, Tobias Welte, Robert Bals, for the CAPNETZ-Study Group

Aktuelle Ausgaben