Ausgabe 1/2014
Inhalt (159 Artikel)
Exhaled breath condensate in intubated neonates- a window into the lung’s glutathione status
Maria I Rosso, Susan Roark, Esther Taylor, XiaoDu Ping, Janine M Ward, Katherine Roche, Courtney McCracken, Lou Ann S Brown, Theresa W Gauthier
Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion
Shannon Bruse, Hans Petersen, Joel Weissfeld, Maria Picchi, Randall Willink, Kieu Do, Jill Siegfried, Steven A Belinsky, Yohannes Tesfaigzi
Preserved function and reduced angiogenesis potential of the quadriceps in patients with mild COPD
Philippe Gagnon, Bruno B Lemire, Annie Dubé, Didier Saey, Alexandra Porlier, Marilie Croteau, Steeve Provencher, Richard Debigaré, François Maltais
New GOLD classification: longitudinal data on group assignment
Ciro Casanova, Jose M Marin, Cristina Martinez-Gonzalez, Pilar de Lucas-Ramos, Isabel Mir-Viladrich, Borja Cosio, German Peces-Barba, Miryam Calle-Rubio, Ingrid Solanes-García, Ramón Agüero, Alfredo de Diego-Damia, Nuria Feu-Collado, Inmaculada Alfageme, Rosa Irigaray, Eva Balcells, Antonia Llunell, Juan Bautista Galdiz, Margarita Marín, Juan José Soler-Cataluña, Jose Luis Lopez-Campos, Joan B Soriano, Juan P de-Torres
Early versus later response to treatment in patients with community-acquired pneumonia: analysis of the REACH study
Francesco Blasi, Helmut Ostermann, Jill Racketa, Jesús Medina, Kyle McBride, Javier Garau
Ageing and endurance training effects on quantity and quality of pulmonary vascular bed in healthy men
Ghanima Al Dandachi, Cécile Londner, Aurore Caumont-Prim, Laurent Plantier, Brigitte Chevalier-Bidaud, Jean-François Toussaint, François-Denis Desgorces, Christophe Delclaux
Reviewer acknowledgement 2013
Jan Lötvall, Reynold A Panettieri Jr
MMP-2 and TIMP-1 predict healing of WTC-lung injury in New York City firefighters
Anna Nolan, Sophia Kwon, Soo Jung Cho, Bushra Naveed, Ashley L Comfort, David J Prezant, William N Rom, Michael D Weiden
dsRNA-induced changes in gene expression profiles of primary nasal and bronchial epithelial cells from patients with asthma, rhinitis and controls
Ariane H Wagener, Aeilko H Zwinderman, Silvia Luiten, Wytske J Fokkens, Elisabeth H Bel, Peter J Sterk, Cornelis M van Drunen
High-resolution CT scoring system-based grading scale predicts the clinical outcomes in patients with idiopathic pulmonary fibrosis
Keishi Oda, Hiroshi Ishimoto, Kazuhiro Yatera, Keisuke Naito, Takaaki Ogoshi, Kei Yamasaki, Tomotoshi Imanaga, Toru Tsuda, Hiroyuki Nakao, Toshinori Kawanami, Hiroshi Mukae
Pulmonary vasoreactivity in spontaneously hypertensive rats - Effects of endothelin-1 and leptin
Samantha Gomart, Cécile Damoiseaux, Pascale Jespers, Martine Makanga, Nathalie Labranche, Stéphanie Pochet, Charles Michaux, Guy Berkenboom, Robert Naeije, Kathleen McEntee, Laurence Dewachter
Analysis of comorbid factors that increase the COPD assessment test scores
Masaki Miyazaki, Hidetoshi Nakamura, Shotaro Chubachi, Mamoru Sasaki, Mizuha Haraguchi, Shuichi Yoshida, Keishi Tsuduki, Toru Shirahata, Saeko Takahashi, Naoto Minematsu, Hidefumi Koh, Morio Nakamura, Fumio Sakamaki, Takeshi Terashima, Koichi Sayama, Paul W Jones, Koichiro Asano, Tomoko Betsuyaku
Evaluation of coagulation activation after Rhinovirus infection in patients with asthma and healthy control subjects: an observational study
Christof J Majoor, Marianne A van de Pol, Pieter Willem Kamphuisen, Joost CM Meijers, Richard Molenkamp, Katja C Wolthers, Tom van der Poll, Rienk Nieuwland, Sebastian L Johnston, Peter J Sterk, Elisabeth HD Bel, Rene Lutter, Koenraad F van der Sluijs
Cardiac involvement in Caucasian patients with pulmonary sarcoidosis
Pernilla Darlington, Anders Gabrielsen, Peder Sörensson, Kerstin Cederlund, Anders Eklund, Johan Grunewald
Impact of heterozygote CFTR Mutations in COPD patients with Chronic Bronchitis
S Vamsee Raju, Jody H Tate, Sandra KG Peacock, Ping Fang, Robert A Oster, Mark T Dransfield, Steven M Rowe
Combined exposure to cigarette smoke and nontypeable Haemophilus influenzae drives development of a COPD phenotype in mice
Shyamala Ganesan, Adam T Comstock, Brenton Kinker, Peter Mancuso, James M Beck, Uma S Sajjan
Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis
Minoru Inomata, Koichiro Kamio, Arata Azuma, Kuniko Matsuda, Nariaki Kokuho, Yukiko Miura, Hiroki Hayashi, Takahito Nei, Kazue Fujita, Yoshinobu Saito, Akihiko Gemma
Impact of gender on COPD expression in a real-life cohort
Nicolas Roche, Gaetan Deslée, Denis Caillaud, Graziella Brinchault, Isabelle Court-Fortune, Pascale Nesme-Meyer, Pascale Surpas, Roger Escamilla, Thierry Perez, Pascal Chanez, Christophe Pinet, Gilles Jebrak, Jean-Louis Paillasseur, Pierre-Régis Burgel
Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells
Kazuaki Nomura, Kazufumi Obata, Takashi Keira, Ryo Miyata, Satoshi Hirakawa, Ken-ichi Takano, Takayuki Kohno, Norimasa Sawada, Tetsuo Himi, Takashi Kojima
Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3β signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells
Eun Young Kim, Arum Kim, Se Kyu Kim, Hyung Jung Kim, Joon Chang, Chul Min Ahn, Yoon Soo Chang
Association of plasma sRAGE, but not esRAGE with lung function impairment in COPD
Poornima Gopal, Niki L Reynaert, Jean L J M Scheijen, Casper G Schalkwijk, Frits M E Franssen, Emiel F M Wouters, Erica P A Rutten
Lung density on high resolution computer tomography (HRCT) reflects degree of inflammation in smokers
Reza Karimi, Göran Tornling, Helena Forsslund, Mikael Mikko, Åsa M Wheelock, Sven Nyrén, Carl Magnus Sköld
TRIP-1 via AKT modulation drives lung fibroblast/myofibroblast trans-differentiation
Michael F Nyp, Angels Navarro, Mohammad H Rezaiekhaligh, Ricardo E Perez, Sherry M Mabry, Ikechukwu I Ekekezie
Evidence suggesting that oral corticosteroids increase mortality in stable chronic obstructive pulmonary disease
Nobuyuki Horita, Naoki Miyazawa, Satoshi Morita, Ryota Kojima, Miyo Inoue, Yoshiaki Ishigatsubo, Takeshi Kaneko
Shifting paradigms of nontuberculous mycobacteria in cystic fibrosis
Tavs Qvist, Tania Pressler, Niels Høiby, Terese L Katzenstein
Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study
Guoping Zheng, Lanfang Huang, Haijiang Tong, Qiang Shu, Yaoqin Hu, Menghua Ge, Keqin Deng, Liuya Zhang, Bin Zou, Baoli Cheng, Jianguo Xu
Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease
Wan-Guang Zhang, Li He, Xue-Mei Shi, Si-Si Wu, Bo Zhang, Li Mei, Yong-Jian Xu, Zhen-Xiang Zhang, Jian-Ping Zhao, Hui-Lan Zhang
JNK suppresses pulmonary fibroblast elastogenesis during alveolar development
Sheng Liu, Harikrishnan Parameswaran, Sarah M Young, Brian M Varisco
Regenerative defect in vastus lateralis muscle of patients with chronic obstructive pulmonary disease
Marie-Eve Thériault, Marie-Ève Paré, Bruno B Lemire, François Maltais, Richard Debigaré
A randomized clinical trial to assess the influence of a three months training program (Gym-based individualized vs. Calisthenics-based non-invidualized) in COPD-patients
Timm Greulich, Katharina Kehr, Christoph Nell, Janine Koepke, Daniel Haid, Ulrich Koehler, Kay Koehler, Silke Filipovic, Klaus Kenn, Claus Vogelmeier, Andreas-Rembert Koczulla
The short and long term effects of exercise training in non-cystic fibrosis bronchiectasis – a randomised controlled trial
Annemarie L Lee, Catherine J Hill, Nola Cecins, Sue Jenkins, Christine F McDonald, Angela T Burge, Linda Rautela, Robert G Stirling, Philip J Thompson, Anne E Holland
Heparin binding VEGF isoforms attenuate hyperoxic embryonic lung growth retardation via a FLK1-neuropilin-1-PKC dependent pathway
Americo E Esquibies, Anil Karihaloo, Susan E Quaggin, Alia Bazzy-Asaad, Lloyd G Cantley
Frequent utilization of the emergency department for acute exacerbation of chronic obstructive pulmonary disease
Kohei Hasegawa, Yusuke Tsugawa, Chu-Lin Tsai, David FM Brown, Carlos A Camargo Jr
Association of serum Clara cell protein CC16 with respiratory infections and immune response to respiratory pathogens in elite athletes
Marcin Kurowski, Janusz Jurczyk, Marzanna Jarzębska, Sylwia Moskwa, Joanna S Makowska, Hubert Krysztofiak, Marek L Kowalski
A large kindred of pulmonary fibrosis associated with a novel ABCA3 gene variant
Ilaria Campo, Michele Zorzetto, Francesca Mariani, Zamir Kadija, Patrizia Morbini, Roberto Dore, Eva Kaltenborn, Sabrina Frixel, Ralf Zarbock, Gerhard Liebisch, Jan Hegermann, Christoph Wrede, Matthias Griese, Maurizio Luisetti
Impact of smoking on dendritic cell phenotypes in the airway lumen of patients with COPD
Paul Stoll, Ann-Sophie Heinz, Kai Bratke, Andrea Bier, Katharina Garbe, Michael Kuepper, J Christian Virchow, Marek Lommatzsch
Persistence of pulmonary tertiary lymphoid tissues and anti-nuclear antibodies following cessation of cigarette smoke exposure
Mathieu C Morissette, Brian N Jobse, Danya Thayaparan, Jake K Nikota, Pamela Shen, Nancy Renée Labiris, Roland Kolbeck, Parameswaran Nair, Alison A Humbles, Martin R Stämpfli
Impact of inflammation, emphysema, and smoking cessation on V/Q in mouse models of lung obstruction
Brian N Jobse, Cory AJR McCurry, Mathieu C Morissette, Rod G Rhem, Martin R Stämpfli, Nancy Renée Labiris
Inflammatory cytokines in pulmonary hypertension
Alexandra Groth, Bart Vrugt, Matthias Brock, Rudolf Speich, Silvia Ulrich, Lars C Huber
Lung ultrasound for the diagnosis of pneumonia in adults: a systematic review and meta-analysis
Miguel A Chavez, Navid Shams, Laura E Ellington, Neha Naithani, Robert H Gilman, Mark C Steinhoff, Mathuram Santosham, Robert E Black, Carrie Price, Margaret Gross, William Checkley
Atrial fibrosis in a chronic murine model of obstructive sleep apnea: mechanisms and prevention by mesenchymal stem cells
Pablo Ramos, Cira Rubies, Marta Torres, Montserrat Batlle, Ramon Farre, Josep Brugada, Josep M Montserrat, Isaac Almendros, Lluís Mont
Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-β1
Christine R Keenan, Josephine SL Mok, Trudi Harris, Yuxiu Xia, Saad Salem, Alastair G Stewart
Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity
Shailendra R Singh, Charlotte K Billington, Ian Sayers, Ian P Hall
Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo
Fayong Luo, Yan Zhuang, Mark D Sides, Cecilia G Sanchez, Bin Shan, Eric S White, Joseph A Lasky
The effects of salbutamol on epithelial ion channels depend on the etiology of acute respiratory distress syndrome but not the route of administration
Christopher Uhlig, Pedro L Silva, Débora Ornellas, Raquel S Santos, Paulo J Miranda, Peter M Spieth, Thomas Kiss, Michael Kasper, Bärbel Wiedemann, Thea Koch, Marcelo M Morales, Paolo Pelosi, Marcelo Gama de Abreu, Patricia RM Rocco
Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma
Seil Sagar, Mary E Morgan, Si Chen, Arjan P Vos, Johan Garssen, Jeroen van Bergenhenegouwen, Louis Boon, Niki A Georgiou, Aletta D Kraneveld, Gert Folkerts
Lung clearance index in adults with non-cystic fibrosis bronchiectasis
Sherif Gonem, Alys Scadding, Marcia Soares, Amisha Singapuri, Per Gustafsson, Chandra Ohri, Simon Range, Christopher E Brightling, Ian Pavord, Alex Horsley, Salman Siddiqui
Role of non-coding RNAs in maintaining primary airway smooth muscle cells
Mark M Perry, Eleni Tsitsiou, Philip J Austin, Mark A Lindsay, David S Gibeon, Ian M Adcock, Kian Fan Chung
Effective pulmonary delivery of an aerosolized plasmid DNA vaccine via surface acoustic wave nebulization
Anushi E Rajapaksa, Jenny J Ho, Aisha Qi, Rob Bischof, Tri-Hung Nguyen, Michelle Tate, David Piedrafita, Michelle P McIntosh, Leslie Y Yeo, Els Meeusen, Ross L Coppel, James R Friend
Impact of self-reported Gastroesophageal reflux disease in subjects from COPDGene cohort
Carlos H Martinez, Yuka Okajima, Susan Murray, George R Washko, Fernando J Martinez, Edwin K Silverman, Jin Hwa Lee, Elizabeth A Regan, James D Crapo, Jeffrey L Curtis, Hiroto Hatabu, MeiLan K Han
Tiotropium might improve survival in subjects with COPD at high risk of mortality
Pierre-Régis Burgel, Jean-Louis Paillasseur, Daniel Dusser, Nicolas Roche, Dacheng Liu, Yufeng Liu, Armin Furtwaengler, Norbert Metzdorf, Marc Decramer
Tiotropium Respimat® in asthma: a double-blind, randomised, dose-ranging study in adult patients with moderate asthma
Kai-Michael Beeh, Petra Moroni-Zentgraf, Othmar Ablinger, Zuzana Hollaenderova, Anna Unseld, Michael Engel, Stephanie Korn
Macrophage activation state determines the response to rhinovirus infection in a mouse model of allergic asthma
Jun Young Hong, Yutein Chung, Jessica Steenrod, Qiang Chen, Jing Lei, Adam T Comstock, Adam M Goldsmith, J Kelley Bentley, Uma S Sajjan, Marc B Hershenson
N-acetylcysteine improves established monocrotaline-induced pulmonary hypertension in rats
Marie-Camille Chaumais, Benoît Ranchoux, David Montani, Peter Dorfmüller, Ly Tu, Florence Lecerf, Nicolas Raymond, Christophe Guignabert, Laura Price, Gérald Simonneau, Sylvia Cohen-Kaminsky, Marc Humbert, Frédéric Perros
Improving inhaler adherence in patients with Chronic Obstructive Pulmonary Disease: a cost-effectiveness analysis
Job FM van Boven, Eline Tommelein, Koen Boussery, Els Mehuys, Stefan Vegter, Guy GO Brusselle, Maureen PMH Rutten-van Mölken, Maarten J Postma
Developmental lung expression and transcriptional regulation of Claudin-6 by TTF-1, Gata-6, and FoxA2
Felix R Jimenez, Joshua B Lewis, Samuel T Belgique, Tyler T Wood, Paul R Reynolds
Rac2 is involved in bleomycin-induced lung inflammation leading to pulmonary fibrosis
Narcy Arizmendi, Lakshmi Puttagunta, Kerri L Chung, Courtney Davidson, Juliana Rey-Parra, Danny V Chao, Bernard Thebaud, Paige Lacy, Harissios Vliagoftis
Impaired macrophage phagocytosis of bacteria in severe asthma
Zhike Liang, Qingling Zhang, Catherine MR Thomas, Kirandeep K Chana, David Gibeon, Peter J Barnes, Kian Fan Chung, Pankaj K Bhavsar, Louise E Donnelly
FEV1 inversely correlates with metalloproteinases 1, 7, 9 and CRP in COPD by biomass smoke exposure
Martha Montaño, Raul H Sansores, Carina Becerril, Jose Cisneros, Georgina González-Avila, Bettina Sommer, Leticia Ochoa, Iliana Herrera, Alejandra Ramírez-Venegas, Carlos Ramos
Controlled and uncontrolled asthma display distinct alveolar tissue matrix compositions
Maria Weitoft, Cecilia Andersson, Annika Andersson-Sjöland, Ellen Tufvesson, Leif Bjermer, Jonas Erjefält, Gunilla Westergren-Thorsson
Allergic airway inflammation induces the migration of dendritic cells into airway sensory ganglia
Duc Dung Le, Sabine Rochlitzer, Axel Fischer, Sebastian Heck, Thomas Tschernig, Martina Sester, Robert Bals, Tobias Welte, Armin Braun, Quoc Thai Dinh
TLR4 activation induces IL-1β release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung
Suffwan Eltom, Maria G Belvisi, Liang Yew-Booth, Bilel Dekkak, Sarah A Maher, Eric D Dubuis, Victoria Jones, Kate A Fitzgerald, Mark A Birrell
Surfactant protein A mediates pulmonary clearance of Staphylococcus aureus
Nils T Veith, Thomas Tschernig, Birgitt Gutbier, Martin Witzenrath, Carola Meier, Michael Menger, Markus Bischoff
Nitric oxide exerts protective effects against bleomycin-induced pulmonary fibrosis in mice
Shingo Noguchi, Kazuhiro Yatera, Ke-Yong Wang, Keishi Oda, Kentarou Akata, Kei Yamasaki, Toshinori Kawanami, Hiroshi Ishimoto, Yumiko Toyohira, Hiroaki Shimokawa, Nobuyuki Yanagihara, Masato Tsutsui, Hiroshi Mukae
Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene
Emily S Wan, Peter J Castaldi, Michael H Cho, John E Hokanson, Elizabeth A Regan, Barry J Make, Terri H Beaty, MeiLan K Han, Jeffrey L Curtis, Douglas Curran-Everett, David A Lynch, Dawn L DeMeo, James D Crapo, Edwin K Silverman
Airway wall thickness is increased in COPD patients with bronchodilator responsiveness
Victor Kim, Parag Desai, John D Newell, Barry J Make, George R Washko, Edwin K Silverman, James D Crapo, Surya P Bhatt, Gerard J Criner
Efficacy and safety of once-daily fluticasone furoate 50 mcg in adults with persistent asthma: a 12-week randomized trial
Paul M O’Byrne, Ashley Woodcock, Eugene R Bleecker, Eric D Bateman, Jan Lötvall, Richard Forth, Hilary Medley, Loretta Jacques, William W Busse
Roxithromycin treatment inhibits TGF-β1-induced activation of ERK and AKT and down-regulation of Caveolin-1 in rat airway smooth muscle cells
Yuanrong Dai, Fengqin Li, Liqin Wu, Ruili Wang, Ping Li, Sunshun Yan, Hui Xu, Mengling Xia, Chunxue Bai
Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction
John R Greenland, Xiang Xu, David M Sayah, Feng Chun Liu, Kirk D Jones, Mark R Looney, George H Caughey
Adjuvant-dependent regulation of interleukin-17 expressing γδ T cells and inhibition of Th2 responses in allergic airways disease
Emily M Nakada, Jichuan Shan, Margaret W Kinyanjui, Elizabeth D Fixman
Murine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor
Cassiano Felippe Gonçalves-de-Albuquerque, Patrícia Burth, Adriana Ribeiro Silva, Isabel Matos Medeiros de Moraes, Flora Magno de Jesus Oliveira, Ricardo Erthal Santelli, Aline Soares Freire, Gerson Silva de Lima, Emilson Domingos da Silva, Camila Ignácio da Silva, Verônica Morandi, Patrícia Torres Bozza, Mauricio Younes-Ibrahim, Hugo Caire de Castro Faria Neto, Mauro Velho de Castro Faria
DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease
Jin Hwa Lee, Merry-Lynn N McDonald, Michael H Cho, Emily S Wan, Peter J Castaldi, Gary M Hunninghake, Nathaniel Marchetti, David A Lynch, James D Crapo, David A Lomas, Harvey O Coxson, Per S Bakke, Edwin K Silverman, Craig P Hersh
Disposal of iNKT cell deficiency and an increase in expression of SLAM signaling factors characterizes sarcoidosis remission: a 4-year longitudinal study
Katarina Osolnik, Matija Rijavec, Peter Korosec
Compartment differences of inflammatory activity in chronic obstructive pulmonary disease
Jie Ji, Ida von Schéele, Jan Bergström, Bo Billing, Barbro Dahlén, Ann-Sofie Lantz, Kjell Larsson, Lena Palmberg
Prostaglandin E2 receptors in asthma and in chronic rhinosinusitis/nasal polyps with and without aspirin hypersensitivity
Liliana Machado-Carvalho, Jordi Roca-Ferrer, César Picado
A clinical in-hospital prognostic score for acute exacerbations of COPD
Nicolas Roche, Jean-Michel Chavaillon, Cyril Maurer, Mahmoud Zureik, Jacques Piquet
Small airway dysfunction is associated to excessive bronchoconstriction in asthmatic patients
Veronica Alfieri, Marina Aiello, Roberta Pisi, Panagiota Tzani, Elisa Mariani, Emilio Marangio, Dario Olivieri, Gabriele Nicolini, Alfredo Chetta
Acute bronchodilator responses decline progressively over 4 years in patients with moderate to very severe COPD
Donald P Tashkin, Ning Li, Eric C Kleerup, David Halpin, Bartolome Celli, Marc Decramer, Robert Elashoff
MicroRNA-708 regulates CD38 expression through signaling pathways JNK MAP kinase and PTEN/AKT in human airway smooth muscle cells
Mythili Dileepan, Joseph A Jude, Savita P Rao, Timothy F Walseth, Reynold A Panettieri, Subbaya Subramanian, Mathur S Kannan
Autopsy analyses in acute exacerbation of idiopathic pulmonary fibrosis
Keishi Oda, Hiroshi Ishimoto, Sohsuke Yamada, Hisako Kushima, Hiroshi Ishii, Tomotoshi Imanaga, Tatsuhiko Harada, Yuji Ishimatsu, Nobuhiro Matsumoto, Keisuke Naito, Kazuhiro Yatera, Masamitsu Nakazato, Jun-ichi Kadota, Kentaro Watanabe, Shigeru Kohno, Hiroshi Mukae
Impact of traffic related air pollution indicators on non-cystic fibrosis bronchiectasis mortality: a cohort analysis
Pieter C Goeminne, Esmee Bijnens, Ben Nemery, Tim S Nawrot, Lieven J Dupont
Increased levels of soluble interleukin-6 receptor and CCL3 in COPD sputum
Arjun K Ravi, Shruti Khurana, Jonathan Lemon, Jonathan Plumb, George Booth, Louise Healy, Matthew Catley, Jørgen Vestbo, Dave Singh
PlGF mediates neutrophil elastase-induced airway epithelial cell apoptosis and emphysema
Hsin-Han Hou, Shih-Lung Cheng, Kuei-Pin Chung, Shu-Chen Wei, Po-Nien Tsao, Hsuan-Hsuan Lu, Hao-Chien Wang, Chong-Jen Yu
Low tidal volume pressure support versus controlled ventilation in early experimental sepsis in pigs
Alexander Ziebart, Erik K Hartmann, Rainer Thomas, Tanghua Liu, Bastian Duenges, Arno Schad, Marc Bodenstein, Serge C Thal, Matthias David
The effect of CSF-1 administration on lung maturation in a mouse model of neonatal hyperoxia exposure
Christina V Jones, Maliha A Alikhan, Megan O’Reilly, Foula Sozo, Timothy M Williams, Richard Harding, Graham Jenkin, Sharon D Ricardo
Inflammatory thresholds and the species-specific effects of colonising bacteria in stable chronic obstructive pulmonary disease
Richa Singh, Alexander J Mackay, Anant RC Patel, Davinder S Garcha, Beverly S Kowlessar, Simon E Brill, Louise E Donnelly, Peter J Barnes, Gavin C Donaldson, Jadwiga A Wedzicha
The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiency
Laura Pini, Laura Tiberio, Narayanan Venkatesan, Michela Bezzi, Luciano Corda, Maurizio Luisetti, Ilaria Ferrarotti, Mario Malerba, David A Lomas, Sabina Janciauskiene, Enrico Vizzardi, Denise Modina, Luisa Schiaffonati, Claudio Tantucci
Nebulized perflubron and carbon dioxide rapidly dilate constricted airways in an ovine model of allergic asthma
Tamer Y El Mays, Parichita Choudhury, Richard Leigh, Emmanuel Koumoundouros, Joanne Van der Velden, Grishma Shrestha, Cora A Pieron, John H Dennis, Francis HY Green, Ken J Snibson
Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease
Jin Hwa Lee, Michael H Cho, Craig P Hersh, Merry-Lynn N McDonald, James D Crapo, Per S Bakke, Amund Gulsvik, Alejandro P Comellas, Christine H Wendt, David A Lomas, Victor Kim, Edwin K Silverman
Smoking accelerates aging of the small airway epithelium
Matthew S Walters, Bishnu P De, Jacqueline Salit, Lauren J Buro-Auriemma, Timothy Wilson, Allison M Rogalski, Lindsay Lief, Neil R Hackett, Michelle R Staudt, Ann E Tilley, Ben-Gary Harvey, Robert J Kaner, Jason G Mezey, Beth Ashbridge, Malcolm A S Moore, Ronald G Crystal
Fluticasone propionate/salmeterol 250/50 μg versus salmeterol 50 μg after chronic obstructive pulmonary disease exacerbation
Jill A Ohar, Glenn D Crater, Amanda Emmett, Thomas J Ferro, Andrea N Morris, Ibrahim Raphiou, Peruvemba S Sriram, Mark T Dransfield
Network medicine analysis of COPD multimorbidities
Solène Grosdidier, Antoni Ferrer, Rosa Faner, Janet Piñero, Josep Roca, Borja Cosío, Alvar Agustí, Joaquim Gea, Ferran Sanz, Laura I Furlong
Effects of exercise training on pulmonary vessel muscularization and right ventricular function in an animal model of COPD
Erlend Hassel, Anne Marie Berre, Anne Jarstein Skjulsvik, Sigurd Steinshamn
Increased of exhaled breath condensate neutrophil chemotaxis in acute exacerbation of COPD
Jean Louis Corhay, Catherine Moermans, Monique Henket, Delphine Nguyen Dang, Bernard Duysinx, Renaud Louis
Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia
Lu Yin, Dahai Zheng, Gino V Limmon, Nicola HN Leung, Shuoyu Xu, Jagath C Rajapakse, Hanry Yu, Vincent TK Chow, Jianzhu Chen
Effects of different mesenchymal stromal cell sources and delivery routes in experimental emphysema
Mariana A Antunes, Soraia C Abreu, Fernanda F Cruz, Ana Clara Teixeira, Miquéias Lopes-Pacheco, Elga Bandeira, Priscilla C Olsen, Bruno L Diaz, Christina M Takyia, Isalira PRG Freitas, Nazareth N Rocha, Vera L Capelozzi, Débora G Xisto, Daniel J Weiss, Marcelo M Morales, Patricia RM Rocco
Measuring respiratory symptoms of COPD: performance of the EXACT- Respiratory Symptoms Tool (E-RS) in three clinical trials
Nancy K Leidy, Lindsey T Murray, Brigitta U Monz, Linda Nelsen, Mitchell Goldman, Paul W Jones, Elizabeth J Dansie, Sanjay Sethi
Severe alpha-1 antitrypsin deficiency in composite heterozygotes inheriting a new splicing mutation QOMadrid
Beatriz Lara, Maria Teresa Martínez, Ignacio Blanco, Cristina Hernández-Moro, Eladio A Velasco, Ilaria Ferrarotti, Francisco Rodriguez-Frias, Laura Perez, Irene Vazquez, Javier Alonso, Manuel Posada, Beatriz Martínez-Delgado
Up-regulation of hexokinase1 in the right ventricle of monocrotaline induced pulmonary hypertension
Wei-hua Zhang, Mei-hong Qiu, Xiao-jian Wang, Kai Sun, Yang Zheng, Zhi-cheng Jing
Impact of ozone exposure on the response to glucocorticoid in a mouse model of asthma: involvements of p38 MAPK and MKP-1
Aihua Bao, Feng Li, Min Zhang, Yuqing Chen, Pengyu Zhang, Xin Zhou
Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD
Susan JM Hoonhorst, Wim Timens, Leo Koenderman, Adèle T Lo Tam Loi, Jan-Willem J Lammers, H Marike Boezen, Antoon JM van Oosterhout, Dirkje S Postma, Nick HT ten Hacken
The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes
Brendan J Carolan, Grant Hughes, Jarrett Morrow, Craig P Hersh, Wanda K O’Neal, Stephen Rennard, Sreekumar G Pillai, Paula Belloni, Debra A Cockayne, Alejandro P Comellas, Meilan Han, Rachel L Zemans, Katerina Kechris, Russell P Bowler
Efficacy and safety of fixed-dose combinations of aclidinium bromide/formoterol fumarate: the 24-week, randomized, placebo-controlled AUGMENT COPD study
Anthony D D’Urzo, Stephen I Rennard, Edward M Kerwin, Victor Mergel, Anne R Leselbaum, Cynthia F Caracta
Therapeutic effects of amniotic fluid-derived mesenchymal stromal cells on lung injury in rats with emphysema
Yaqing Li, Chao Gu, Wulin Xu, Jianping Yan, Yingjie Xia, Yingyu Ma, Chun Chen, Xujun He, Houquan Tao
Observational study to characterise 24-hour COPD symptoms and their relationship with patient-reported outcomes: results from the ASSESS study
Marc Miravitlles, Heinrich Worth, Juan José Soler Cataluña, David Price, Fernando De Benedetto, Nicolas Roche, Nina Skavlan Godtfredsen, Thys van der Molen, Claes-Göran Löfdahl, Laura Padullés, Anna Ribera
Antenatal exposure of maternal secondhand smoke (SHS) increases fetal lung expression of RAGE and induces RAGE-mediated pulmonary inflammation
Duane R Winden, David B Barton, Bryce C Betteridge, Jared S Bodine, Cameron M Jones, Geraldine D Rogers, Michael Chavarria, Alex J Wright, Zac R Jergensen, Felix R Jimenez, Paul R Reynolds
Small interfering RNA against CD86 during allergen challenge blocks experimental allergic asthma
Yukari Asai-Tajiri, Koichiro Matsumoto, Satoru Fukuyama, Keiko Kan-o, Takako Nakano, Ken Tonai, Tatsukuni Ohno, Miyuki Azuma, Hiromasa Inoue, Yoichi Nakanishi
The prevalence of increased serum IgE and Aspergillus sensitization in patients with COPD and their association with symptoms and lung function
Jianmin Jin, Xiaofang Liu, Yongchang Sun
Conditionally induced RAGE expression by proximal airway epithelial cells in transgenic mice causes lung inflammation
B Garrett Bodine, Brock G Bennion, Emma Leatham, Felix R Jimenez, Alex J Wright, Zac R Jergensen, Connor J Erickson, Cameron M Jones, Jeff P Johnson, Steven M Knapp, Paul R Reynolds
Genetic variants associated with lung function: the long life family study
Bharat Thyagarajan, Mary Wojczynski, Ryan L Minster, Jason Sanders, Sandra Barral, Lene Christiansen, R Graham Barr, Anne Newman
Altered molecular specificity of surfactant phosphatidycholine synthesis in patients with acute respiratory distress syndrome
Ahilanandan Dushianthan, Victoria Goss, Rebecca Cusack, Michael PW Grocott, Anthony D Postle
Asthma incidence, remission, relapse and persistence: a population-based study in southern Taiwan
Tsung-Ju Wu, Chang-Fu Wu, Yungling Leo Lee, Tzuen-Ren Hsiue, Yue Leon Guo
Epigenetics of hyper-responsiveness to allergen challenge following intrauterine growth retardation rat
Xue-Feng Xu, Qiong-Yao Hu, Ling-Fang Liang, Lei Wu, Wei-Zhong Gu, Li-Li Tang, Lin-Chen Fu, Li-Zhong Du
Comparison of inflammatory markers in induced and spontaneous sputum in a cohort of COPD patients
Solveig Tangedal, Marianne Aanerud, Louise JP Persson, Karl A Brokstad, Per S Bakke, Tomas M Eagan
Quantifying the real life risk profile of inhaled corticosteroids in COPD by record linkage analysis
Rob W Flynn, Thomas M MacDonald, Adrian Hapca, Isla S MacKenzie, Stuart Schembri
Longitudinal increase in total IgE levels in patients with adult asthma: an association with poor asthma control
Akihiko Tanaka, Megumi Jinno, Kuniaki Hirai, Yoshito Miyata, Hiroko Mizuma, Munehiro Yamaguchi, Shin Ohta, Yoshio Watanabe, Mayumi Yamamoto, Shintaro Suzuki, Takuya Yokoe, Mitsuru Adachi, Hironori Sagara
Vitamin D regulating TGF-β induced epithelial-mesenchymal transition
Kimberly D Fischer, Devendra K Agrawal
Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury
Koji Takashima, Miyoko Matsushima, Katsunori Hashimoto, Haruka Nose, Mitsuo Sato, Naozumi Hashimoto, Yoshinori Hasegawa, Tsutomu Kawabe
Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease
Sofie Lock-Johansson, Jørgen Vestbo, Grith Lykke Sorensen
Glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats
Pil-Sung Yang, Dae-Hoon Kim, Yong Joon Lee, Sang-Eun Lee, Won Jun Kang, Hyuk-Jae Chang, Jeon-Soo Shin
Five microRNAs in plasma as novel biomarkers for screening of early-stage non-small cell lung cancer
Qing Geng, Tao Fan, Boyou Zhang, Wei Wang, Yao Xu, Hao Hu
Upregulation of IL-17A/F from human lung tissue explants with cigarette smoke exposure: implications for COPD
Ying Chang, Laila Al-Alwan, Sama Alshakfa, Severine Audusseau, Andrea Karen Mogas, Fazila Chouiali, Parameswaran Nair, Carolyn J Baglole, Qutayba Hamid, David H Eidelman
Delay of airway epithelial wound repair in COPD is associated with airflow obstruction severity
Jeanne-Marie Perotin, Damien Adam, Juliette Vella-Boucaud, Gonzague Delepine, Sebastian Sandu, Anne-Carole Jonvel, Alain Prevost, Gérard Berthiot, Christophe Pison, François Lebargy, Philippe Birembaut, Christelle Coraux, Gaëtan Deslee
Allergic diseases and asthma in the family predict the persistence and onset-age of asthma: a prospective cohort study
Elina MS Paaso, Maritta S Jaakkola, Aino K Rantala, Timo T Hugg, Jouni JK Jaakkola
Defining adult asthma endotypes by clinical features and patterns of volatile organic compounds in exhaled air
Norbert Meyer, Jan W Dallinga, Sarah Janine Nuss, Edwin JC Moonen, Joep JBN van Berkel, Cezmi Akdis, Frederik Jan van Schooten, Günter Menz
Surfactant protein D attenuates sub-epithelial fibrosis in allergic airways disease through TGF-β
Hirohisa Ogawa, Julie G Ledford, Sambuddho Mukherjee, Yoshinori Aono, Yasuhiko Nishioka, James J Lee, Keisuke Izumi, John W Hollingsworth
Pathophysiological characterization of asthma transitions across adolescence
Syed Hasan Arshad, Abid Raza, Laurie Lau, Khalid Bawakid, Wilfried Karmaus, Hongmei Zhang, Susan Ewart, Veersh Patil, Graham Roberts, Ramesh Kurukulaaratchy
Food allergy enhances allergic asthma in mice
Tiphaine Bihouée, Gregory Bouchaud, Julie Chesné, David Lair, Camille Rolland-Debord, Faouzi Braza, Marie-Aude Cheminant, Philippe Aubert, Guillaume Mahay, Christine Sagan, Michel Neunlist, Sophie Brouard, Marie Bodinier, Antoine Magnan
Predictors of diagnosis and survival in idiopathic pulmonary fibrosis and connective tissue disease-related usual interstitial pneumonia
Teng Moua, Ana C Zamora Martinez, Misbah Baqir, Robert Vassallo, Andrew H Limper, Jay H Ryu
RETRACTED ARTICLE: Activation of c-Src tyrosine kinase mediated the degradation of occludin in ventilator-induced lung injury
Tao Zhao, Mengjie Liu, Changping Gu, Xin Wang, Yuelan Wang
Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent
Katy M Roach, Heike Wulff, Carol Feghali-Bostwick, Yassine Amrani, Peter Bradding
Inhibition of AMPK expression in skeletal muscle by systemic inflammation in COPD rats
Yong Qi, Jun-yi Shang, Li-jun Ma, Bei-bei Sun, Xin-gang Hu, Bao Liu, Guo-jun Zhang
Erratum: New GOLD classification: longitudinal data on group assignment
Ciro Casanova, Jose M Marin, Cristina Martinez-Gonzalez, Pilar de Lucas-Ramos, Isabel Mir-Viladrich, Borja Cosio, German Peces-Barba, Miryam Calle-Rubio, Ingrid Solanes-García, Ramón Agüero, Alfredo de Diego-Damia, Nuria Feu-Collado, Inmaculada Alfageme, Rosa Irigaray, Eva Balcells, Antonia Llunel, Juan Bautista Galdiz-Iturri, Margarita Marín, Juan José Soler, Jose Luis Lopez-Campos, Joan B Soriano, Juan P de-Torres
Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis
Katrin E Hostettler, Jun Zhong, Eleni Papakonstantinou, George Karakiulakis, Michael Tamm, Petra Seidel, Qingzhu Sun, Jyotshna Mandal, Didier Lardinois, Christopher Lambers, Michael Roth
Severe vitamin D deficiency is associated with frequent exacerbations and hospitalization in COPD patients
Andrei Malinovschi, Monica Masoero, Michela Bellocchia, Antonio Ciuffreda, Paolo Solidoro, Alessio Mattei, Lorena Mercante, Enrico Heffler, Giovanni Rolla, Caterina Bucca
17β-estradiol suppresses lipopolysaccharide-induced acute lung injury through PI3K/Akt/SGK1 mediated up-regulation of epithelial sodium channel (ENaC) in vivo and in vitro
Di Qi, Jing He, Daoxin Wang, Wang Deng, Yan Zhao, Yuan Ye, Longhua Feng
Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas
Emily Van de Laar, Monica Clifford, Stefan Hasenoeder, Bo Ram Kim, Dennis Wang, Sharon Lee, Josh Paterson, Nancy M Vu, Thomas K Waddell, Shaf Keshavjee, Ming-Sound Tsao, Laurie Ailles, Nadeem Moghal
Frequent cough in unsatisfactory controlled asthma – results from the population-based West Sweden Asthma Study
Roxana Mincheva, Linda Ekerljung, Anders Bjerg, Malin Axelsson, Todor A Popov, Bo Lundbäck, Jan Lötvall
Prevention of hyperoxia-induced bronchial hyperreactivity by sildenafil and vasoactive intestinal peptide: impact of preserved lung function and structure
Dorottya Czövek, Ferenc Peták, Yves Donati, Xavier Belin, Jean-Claude Pache, Constance Barazzone Argiroffo, Walid Habre
Derivation of normative data for the COPD assessment test (CAT)
Lancelot M Pinto, Nisha Gupta, Wan Tan, Pei Z Li, Andrea Benedetti, Paul W Jones, Jean Bourbeau
Predicting treatment failure in patients with community acquired pneumonia: a case-control study
Ignacio Martin-Loeches, Xavier Valles, Rosario Menendez, Oriol Sibila, Beatriz Montull, Catia Cilloniz, Antonio Artigas, Antoni Torres
Raphe serotonergic neurons modulate genioglossus corticomotor activity in intermittent hypoxic rats
Jiao Su, Wei Wang, Longfeng Sun, Ting Li, Delei Kong, Jian Kang
Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels
Fatemat Hassan, Xiaohua Xu, Gerard Nuovo, David W Killilea, Jean Tyrrell, Chong Da Tan, Robert Tarran, Philip Diaz, Junbae Jee, Daren Knoell, Prosper N Boyaka, Estelle Cormet-Boyaka
Safety and tolerability of once-daily umeclidinium/vilanterol 125/25 mcg and umeclidinium 125 mcg in patients with chronic obstructive pulmonary disease: results from a 52-week, randomized, double-blind, placebo-controlled study
James F Donohue, Dennis Niewoehner, Jean Brooks, Dianne O’Dell, Alison Church
Statins reduce all-cause mortality in chronic obstructive pulmonary disease: a systematic review and meta-analysis of observational studies
Nobuyuki Horita, Naoki Miyazawa, Ryota Kojima, Miyo Inoue, Yoshiaki Ishigatsubo, Atsuhisa Ueda, Takeshi Kaneko
Moxifloxacin modulates inflammation during murine pneumonia
Christoph Beisswenger, Anja Honecker, Andreas Kamyschnikow, Markus Bischoff, Thomas Tschernig, Robert Bals
Withdrawal of inhaled corticosteroids can be safe in COPD patients at low risk of exacerbation: a real-life study on the appropriateness of treatment in moderate COPD patients (OPTIMO)
Andrea Rossi, Massimo Guerriero, Antonio Corrado
Long-acting beta-agonists plus inhaled corticosteroids safety: a systematic review and meta-analysis of non-randomized studies
Gimena Hernández, Mónica Avila, Àngels Pont, Olatz Garin, Jordi Alonso, Laurent Laforest, Christopher J Cates, Montserrat Ferrer
Importance of Aspergillus spp. isolation in Acute exacerbations of severe COPD: prevalence, factors and follow-up: the FUNGI-COPD study
Arturo Huerta, Nestor Soler, Mariano Esperatti, Mónica Guerrero, Rosario Menendez, Alexandra Gimeno, Rafael Zalacaín, Nuria Mir, Jose Maria Aguado, Antoni Torres
Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles
Sam Parnia, Lynnsey M Hamilton, Sarah M Puddicombe, Stephen T Holgate, Anthony J Frew, Donna E Davies
Acquired defects in CFTR-dependent β-adrenergic sweat secretion in chronic obstructive pulmonary disease
Clifford A Courville, Sherry Tidwell, Bo Liu, Frank J Accurso, Mark T Dransfield, Steven M Rowe
Phenotyping community-acquired pneumonia according to the presence of acute respiratory failure and severe sepsis
Stefano Aliberti, Anna Maria Brambilla, James D Chalmers, Catia Cilloniz, Julio Ramirez, Angelo Bignamini, Elena Prina, Eva Polverino, Paolo Tarsia, Alberto Pesci, Antoni Torres, Francesco Blasi, Roberto Cosentini
PPAR Gamma agonists regulate tobacco smoke-induced toll like receptor 4 expression in alveolar macrophages
Yan Yin, Gang Hou, Erran Li, Qiuyue Wang, Jian Kang
Hypo- and hypercapnia predict mortality in oxygen-dependent chronic obstructive pulmonary disease: a population-based prospective study
Zainab Ahmadi, Anna Bornefalk-Hermansson, Karl A Franklin, Bengt Midgren, Magnus P Ekström
The vitamin E isoforms α-tocopherol and γ-tocopherol have opposite associations with spirometric parameters: the CARDIA study
Michelle E Marchese, Rajesh Kumar, Laura A Colangelo, Pedro C Avila, David R Jacobs Jr, Myron Gross, Akshay Sood, Kiang Liu, Joan M Cook-Mills
Rosiglitazone is a superior bronchodilator compared to chloroquine and β-adrenoceptor agonists in mouse lung slices
Chantal Donovan, Mirjam Simoons, James Esposito, Jean Ni Cheong, Meaghan FitzPatrick, Jane Elizabeth Bourke
Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study
Victor Kim, Adam Davey, Alejandro P Comellas, Meilan K Han, George Washko, Carlos H Martinez, David Lynch, Jin Hwa Lee, Edwin K Silverman, James D Crapo, Barry J Make, Gerard J Criner
Vitamin D deficiency in community-acquired pneumonia: low levels of 1,25(OH)2 D are associated with disease severity
Mathias W Pletz, Christoph Terkamp, Ulrike Schumacher, Gernot Rohde, Hartwig Schütte, Tobias Welte, Robert Bals