01.12.2016 | Research | Ausgabe 1/2016
Open Access
Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease
Kyoko Abe, Hisatoshi Sugiura, Yuichiro Hashimoto, Tomohiro Ichikawa, Akira Koarai, Mitsuhiro Yamada, Tadahisa Numakura, Katsuhiro Onodera, Rie Tanaka, Kei Sato, Satoru Yanagisawa, Tatsuma Okazaki, Tsutomu Tamada, Toshiaki Kikuchi, Masakazu Ichinose
01.12.2016 | Research | Ausgabe 1/2016
Open Access
C-type natriuretic peptide ameliorates pulmonary fibrosis by acting on lung fibroblasts in mice
Toru Kimura, Takashi Nojiri, Jun Hino, Hiroshi Hosoda, Koichi Miura, Yasushi Shintani, Masayoshi Inoue, Masahiro Zenitani, Hiroyuki Takabatake, Mikiya Miyazato, Meinoshin Okumura, Kenji Kangawa
01.12.2016 | Research | Ausgabe 1/2016
Open Access
A randomized trial of the efficacy and safety of quilizumab in adults with inadequately controlled allergic asthma
Jeffrey M. Harris, Romeo Maciuca, Mary S. Bradley, Christopher R. Cabanski, Heleen Scheerens, Jeremy Lim, Fang Cai, Mona Kishnani, X. Charlene Liao, Divya Samineni, Rui Zhu, Colette Cochran, Weily Soong, Joseph D. Diaz, Patrick Perin, Miguel Tsukayama, Dimo Dimov, Ioana Agache, Steven G. Kelsen
01.12.2016 | Research | Ausgabe 1/2016
Open Access
YKL-40 expression in chronic obstructive pulmonary disease: relation to acute exacerbations and airway remodeling
Tianwen Lai, Dong Wu, Min Chen, Chao Cao, Zhiliang Jing, Li Huang, Yingying Lv, Xuanna Zhao, Quanchao Lv, Yajun Wang, Dongming Li, Bin Wu, Huahao Shen
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study
P. E. Silkoff, M. Laviolette, D. Singh, J. M. FitzGerald, S. Kelsen, V. Backer, C. Porsbjerg, P. O. Girodet, P. Berger, J. N. Kline, S. Khatri, P. Chanez, V. S. Susulic, E. S. Barnathan, F. Baribaud, M. J. Loza, for the ADEPT Investigators
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Advanced glycation endproducts and their receptor in different body compartments in COPD
Susan J. M. Hoonhorst, Adèle T. Lo Tam Loi, Simon D. Pouwels, Alen Faiz, Eef D. Telenga, Maarten van den Berge, Leo Koenderman, Jan-Willem J. Lammers, H. Marike Boezen, Antoon J. M. van Oosterhout, Monique E. Lodewijk, Wim Timens, Dirkje S. Postma, Nick H. T. ten Hacken
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Occupational and environmental risk factors for chronic rhinosinusitis in China: a multicentre cross-sectional study
Wen-Xiang Gao, Chun-Quan Ou, Shu-Bin Fang, Yue-Qi Sun, Hua Zhang, Lei Cheng, Yan-Jun Wang, Dong-Dong Zhu, Wei Lv, Shi-Xi Liu, P. Z. Li, Geng Xu, Jianbo Shi, Qing-Ling Fu
01.12.2016 | Research | Ausgabe 1/2016
Open Access
A rapid NGS strategy for comprehensive molecular diagnosis of Birt-Hogg-Dubé syndrome in patients with primary spontaneous pneumothorax
Xinxin Zhang, Dehua Ma, Wei Zou, Yibing Ding, Chengchu Zhu, Haiyan Min, Bin Zhang, Wei Wang, Baofu Chen, Minhua Ye, Minghui Cai, Yanqing Pan, Lei Cao, Yueming Wan, Yu Jin, Qian Gao, Long Yi
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Risk factors for an acute exacerbation of idiopathic pulmonary fibrosis
Tomoyuki Kakugawa, Noriho Sakamoto, Shuntaro Sato, Hirokazu Yura, Tatsuhiko Harada, Shota Nakashima, Atsuko Hara, Keishi Oda, Hiroshi Ishimoto, Kazuhiro Yatera, Yuji Ishimatsu, Yasushi Obase, Shigeru Kohno, Hiroshi Mukae
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Risk factors for mortality in patients admitted to intensive care units with pneumonia
Guowei Li, Deborah J. Cook, Lehana Thabane, Jan O. Friedrich, Tim M. Crozier, John Muscedere, John Granton, Sangeeta Mehta, Steven C. Reynolds, Renato D. Lopes, Lauzier Francois, Andreas P. Freitag, Mitchell A. H. Levine, the PROTECT Investigators for the Canadian Critical Care Trials Group, and the Australian and New Zealand Intensive Care Society Clinical Trials Group
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Relative impact of COPD and comorbidities on generic health-related quality of life: a pooled analysis of the COSYCONET patient cohort and control subjects from the KORA and SHIP studies
Margarethe E. Wacker, Rudolf A. Jörres, Annika Karch, Armin Koch, Joachim Heinrich, Stefan Karrasch, Holger Schulz, Annette Peters, Sven Gläser, Ralf Ewert, Sebastian E. Baumeister, Claus Vogelmeier, Reiner Leidl, Rolf Holle, for the COSYCONET study group
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague–Dawley rats
Joanna Seiffert, Alison Buckley, Bey Leo, Nicholas G. Martin, Jie Zhu, Ranran Dai, Farhana Hussain, Chang Guo, James Warren, Alan Hodgson, Jicheng Gong, Mary P. Ryan, Junfeng (Jim) Zhang, Alexandra Porter, Terry D. Tetley, Andrew Gow, Rachel Smith, Kian Fan Chung
01.12.2016 | Research | Ausgabe 1/2016
Open Access
A phase II trial evaluating the efficacy and safety of perioperative pirfenidone for prevention of acute exacerbation of idiopathic pulmonary fibrosis in lung cancer patients undergoing pulmonary resection: West Japan Oncology Group 6711 L (PEOPLE Study)
Takekazu Iwata, Ichiro Yoshino, Shigetoshi Yoshida, Norihiko Ikeda, Masahiro Tsuboi, Yuji Asato, Nobuyuki Katakami, Kazuhiro Sakamoto, Yoshinori Yamashita, Jiro Okami, Tetsuya Mitsudomi, Motohiro Yamashita, Hiroshi Yokouchi, Kenichi Okubo, Morihito Okada, Mitsuhiro Takenoyama, Masayuki Chida, Keisuke Tomii, Motoki Matsuura, Arata Azuma, Tae Iwasawa, Kazuyoshi Kuwano, Shuji Sakai, Kenzo Hiroshima, Junya Fukuoka, Kenichi Yoshimura, Hirohito Tada, Kazuhiko Nakagawa, Yoichi Nakanishi, West Japan Oncology Group
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases
Kristoffer Ostridge, Nicholas Williams, Viktoriya Kim, Stephen Harden, Simon Bourne, Ngaire A. Coombs, Paul T. Elkington, Raul San Jose Estepar, George Washko, Karl J. Staples, Tom M. A. Wilkinson
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Cigarette smoke alters the ability of human dendritic cells to promote anti-Streptococcus pneumoniae Th17 response
Olivier Le Rouzic, Bachirou Koné, Jerome Kluza, Philippe Marchetti, Florence Hennegrave, Cécile Olivier, Gwenola Kervoaze, Eva Vilain, Clémence Mordacq, Nicolas Just, Thierry Perez, Nathalie Bautin, Muriel Pichavant, Philippe Gosset
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Cardiovascular autonomic alterations in hospitalized patients with community-acquired pneumonia
Stefano Aliberti, Eleonora Tobaldini, Fabio Giuliani, Vanessa Nunziata, Giovanni Casazza, Giulia Suigo, Alice D’Adda, Giulia Bonaiti, Andrea Roveda, Andreia Queiroz, Valter Monzani, Alberto Pesci, Francesco Blasi, Nicola Montano
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Lung-specific RNA interference of coupling factor 6, a novel peptide, attenuates pulmonary arterial hypertension in rats
Jie Yin, Shuling You, Nannan Li, Shouhai Jiao, Hesheng Hu, Mei Xue, Ye Wang, Wenjuan Cheng, Ju Liu, Min Xu, Suhua Yan, Xiaolu Li
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis
Yan Xie, Haihong Jiang, Qian Zhang, Suneet Mehrotra, Peter W. Abel, Myron L. Toews, Dennis W. Wolff, Stephen Rennard, Reynold A. Panettieri Jr., Thomas B. Casale, Yaping Tu
01.12.2016 | Research | Ausgabe 1/2016
Open Access
ALK gene copy number gains in non-small-cell lung cancer: prognostic impact and clinico-pathological correlations
U. Peretti, R. Ferrara, S. Pilotto, S. Kinspergher, M. Caccese, A. Santo, M. Brunelli, A. Caliò, L. Carbognin, I. Sperduti, M. Garassino, M. Chilosi, A. Scarpa, G. Tortora, E. Bria
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Metformin attenuates lung fibrosis development via NOX4 suppression
Nahoko Sato, Naoki Takasaka, Masahiro Yoshida, Kazuya Tsubouchi, Shunsuke Minagawa, Jun Araya, Nayuta Saito, Yu Fujita, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Hiromichi Hara, Tsukasa Kadota, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hirofumi Utsumi, Hiroshi Wakui, Jun Kojima, Takanori Numata, Yumi Kaneko, Makoto Odaka, Toshiaki Morikawa, Katsutoshi Nakayama, Hirotsugu Kohrogi, Kazuyoshi Kuwano
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension
Andrzej Fedorowicz, Łukasz Mateuszuk, Grzegorz Kopec, Tomasz Skórka, Barbara Kutryb-Zając, Agnieszka Zakrzewska, Maria Walczak, Andrzej Jakubowski, Magdalena Łomnicka, Ewa Słomińska, Stefan Chlopicki
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Dose-response to inhaled glycopyrrolate delivered with a novel Co-Suspension™ Delivery Technology metered dose inhaler (MDI) in patients with moderate-to-severe COPD
Leonardo M. Fabbri, Edward M. Kerwin, Selwyn Spangenthal, Gary T. Ferguson, Roberto Rodriguez-Roisin, James Pearle, Sanjay Sethi, Chad Orevillo, Patrick Darken, Earl St. Rose, Tracy Fischer, Michael Golden, Sarvajna Dwivedi, Colin Reisner
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis
Tomonori Makiguchi, Mitsuhiro Yamada, Yusuke Yoshioka, Hisatoshi Sugiura, Akira Koarai, Shigeki Chiba, Naoya Fujino, Yutaka Tojo, Chiharu Ota, Hiroshi Kubo, Seiichi Kobayashi, Masaru Yanai, Sanae Shimura, Takahiro Ochiya, Masakazu Ichinose
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses
Wenxin Wu, Wei Zhang, J. Leland Booth, David C. Hutchings, Xiaoqiu Wang, Vicky L. White, Houssein Youness, Cory D. Cross, Ming-Hui Zou, Dennis Burian, Jordan P. Metcalf
01.12.2016 | Erratum | Ausgabe 1/2016
Open Access
Erratum to: C-type natriuretic peptide ameliorates pulmonary fibrosis by acting on lung fibroblasts in mice
Toru Kimura, Takashi Nojiri, Jun Hino, Hiroshi Hosoda, Koichi Miura, Yasushi Shintani, Masayoshi Inoue, Masahiro Zenitani, Hiroyuki Takabatake, Mikiya Miyazato, Meinoshin Okumura, Kenji Kangawa
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Respiratory symptoms, sleep-disordered breathing and biomarkers in nocturnal gastroesophageal reflux
Össur Ingi Emilsson, Bryndís Benediktsdóttir, Ísleifur Ólafsson, Elizabeth Cook, Sigurður Júlíusson, Einar Stefán Björnsson, Sunna Guðlaugsdóttir, Anna Soffía Guðmundsdóttir, Ekaterina Mirgorodskaya, Evert Ljungström, Erna Sif Arnardóttir, Thórarinn Gislason, Christer Janson, Anna-Carin Olin
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium
Yutaka Shishikura, Akira Koarai, Hiroyuki Aizawa, Mutsuo Yamaya, Hisatoshi Sugiura, Mika Watanabe, Yuichiro Hashimoto, Tadahisa Numakura, Tomonori Makiguti, Kyoko Abe, Mituhiro Yamada, Toshiaki Kikuchi, Yasushi Hoshikawa, Yoshinori Okada, Masakazu Ichinose
01.12.2016 | Letter to the Editor | Ausgabe 1/2016
Open Access
Periplakin is a target for autoimmunity in asthma
Camille Taillé, Sabine Grootenboer-Mignot, Candice Estellat, Carine Roy, Sophie Ly Ka So, Marina Pretolani, Michel Aubier, Bruno Crestani, Sylvie Chollet-Martin
01.12.2016 | Erratum | Ausgabe 1/2016
Open Access
Erratum to: Risk factors for mortality in patients admitted to intensive care units with pneumonia
Guowei Li, Deborah J. Cook, Lehana Thabane, Jan O. Friedrich, Tim M. Crozier, John Muscedere, John Granton, Sangeeta Mehta, Steven C. Reynolds, Renato D. Lopes, Francois Lauzier, Andreas P. Freitag, Mitchell A. H. Levine, the PROTECT Investigators for the Canadian Critical Care Trials Group, the Australian and New Zealand Intensive Care Society Clinical Trials Group
01.12.2016 | Erratum | Ausgabe 1/2016
Open Access
Erratum to: Respiratory symptoms, sleep-disordered breathing and biomarkers in nocturnal gastroesophageal reflux
Össur Ingi Emilsson, Bryndís Benediktsdóttir, Ísleifur Ólafsson, Elizabeth Cook, Sigurður Júlíusson, Einar Stefán Björnsson, Sunna Guðlaugsdóttir, Anna Soffía Guðmundsdóttir, Ekaterina Mirgorodskaya, Evert Ljungström, Erna Sif Arnardóttir, Þórarinn Gíslason, Christer Janson, Anna-Carin Olin
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Predicting survival of patients with idiopathic pulmonary fibrosis using GAP score: a nationwide cohort study
Sang Hoon Lee, Song Yee Kim, Dong Soon Kim, Young Whan Kim, Man Pyo Chung, Soo Taek Uh, Choon Sik Park, Sung Hwan Jeong, Yong Bum Park, Hong Lyeol Lee, Jong Wook Shin, Eun Joo Lee, Jin Hwa Lee, Yangin Jegal, Hyun Kyung Lee, Yong Hyun Kim, Jin Woo Song, Sung Woo Park, Moo Suk Park
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease
Ryo Kato, Shiro Mizuno, Maiko Kadowaki, Kohei Shiozaki, Masaya Akai, Ken Nakagawa, Taku Oikawa, Masaharu Iguchi, Kazuhiro Osanai, Takeshi Ishizaki, Norbert F Voelkel, Hirohisa Toga
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Variable ventilation improves pulmonary function and reduces lung damage without increasing bacterial translocation in a rat model of experimental pneumonia
Raquel F. de Magalhães, Cynthia S. Samary, Raquel S. Santos, Milena V. de Oliveira, Nazareth N. Rocha, Cintia L. Santos, Jamil Kitoko, Carlos A. M. Silva, Caroline L. Hildebrandt, Cassiano F. Goncalves-de-Albuquerque, Adriana R. Silva, Hugo C. Faria-Neto, Vanessa Martins, Vera L. Capelozzi, Robert Huhle, Marcelo M. Morales, Priscilla Olsen, Paolo Pelosi, Marcelo Gama de Abreu, Patricia R. M. Rocco, Pedro L. Silva
01.12.2016 | Research | Ausgabe 1/2016
Open Access
The cellular kinetics of lung alveolar epithelial cells and its relationship with lung tissue repair after acute lung injury
Ling Zeng, Xue-tao Yang, Hai-sheng Li, Yong Li, Ce Yang, Wei Gu, Yin-han Zhou, Juan Du, Hai-yan Wang, Jian-hui Sun, Da-lin Wen, Jian-xin Jiang
01.12.2016 | Research | Ausgabe 1/2016
Open Access
Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study
Matthew J. Loza, Ratko Djukanovic, Kian Fan Chung, Daniel Horowitz, Keying Ma, Patrick Branigan, Elliot S. Barnathan, Vedrana S. Susulic, Philip E. Silkoff, Peter J. Sterk, Frédéric Baribaud, For the ADEPT (Airways Disease Endotyping for Personalized Therapeutics) and U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome Consortium) investigators
