Ausgabe 1/2017
Inhalt (218 Artikel)
Atrial natriuretic peptide protects against bleomycin-induced pulmonary fibrosis via vascular endothelial cells in mice
Atsuko Okamoto, Takashi Nojiri, Kazuhisa Konishi, Takeshi Tokudome, Koichi Miura, Hiroshi Hosoda, Jun Hino, Mikiya Miyazato, Yohkoh Kyomoto, Kazuhisa Asai, Kazuto Hirata, Kenji Kangawa
Cigarette smoke destabilizes NLRP3 protein by promoting its ubiquitination
SeungHye Han, Jacob A. Jerome, Alyssa D. Gregory, Rama K. Mallampalli
Gene profile of fibroblasts identify relation of CCL8 with idiopathic pulmonary fibrosis
Jong-Uk Lee, Hyun Sub Cheong, Eun-Young Shim, Da-Jeong Bae, Hun Soo Chang, Soo-Taek Uh, Young Hoon Kim, Jong-Sook Park, Bora Lee, Hyoung Doo Shin, Choon-Sik Park
Bioinformatic analysis of microRNA and mRNA Regulation in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease
Xiaomin Dang, Xiaoyan Qu, Weijia Wang, Chongbing Liao, Ying Li, Xiaojin Zhang, Dan Xu, Carolyn J. Baglole, Dong Shang, Ying Chang
Eligibility of real-life patients with COPD for inclusion in RCTs: a commentary
Salvatore Battaglia, Nicola Scichilone
The main rhinovirus respiratory tract adhesion site (ICAM-1) is upregulated in smokers and patients with chronic airflow limitation (CAL)
Shakti Dhar Shukla, Malik Quasir Mahmood, Steven Weston, Roger Latham, Hans Konrad Muller, Sukhwinder Singh Sohal, Eugene Haydn Walters
Effect of active vitamin D3 on VEGF-induced ADAM33 expression and proliferation in human airway smooth muscle cells: implications for asthma treatment
Sung-Ho Kim, Qing-Mei Pei, Ping Jiang, Min Yang, Xue-Jiao Qian, Jiang-Bo Liu
A randomized, seven-day study to assess the efficacy and safety of a glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler using novel Co-Suspension™ Delivery Technology in patients with moderate-to-very severe chronic obstructive pulmonary disease
Colin Reisner, Leonardo M. Fabbri, Edward M. Kerwin, Charles Fogarty, Selwyn Spangenthal, Klaus F. Rabe, Gary T. Ferguson, Fernando J. Martinez, James F. Donohue, Patrick Darken, Earl St. Rose, Chad Orevillo, Shannon Strom, Tracy Fischer, Michael Golden, Sarvajna Dwivedi
Non-linear parameters of specific resistance loops to characterise obstructive airways diseases
Marko Topalovic, Vasileios Exadaktylos, Thierry Troosters, Geert Celis, Jean-Marie Aerts, Wim Janssens
End-stage cystic fibrosis lung disease is characterised by a diverse inflammatory pattern: an immunohistochemical analysis
Elise J. Lammertyn, Elly Vandermeulen, Hannelore Bellon, Stephanie Everaerts, Stijn E. Verleden, Kathleen Van Den Eynde, Ken R. Bracke, Guy G. Brusselle, Pieter C. Goeminne, Erik K. Verbeken, Bart M. Vanaudenaerde, Lieven J. Dupont
No convincing association between genetic markers and respiratory symptoms: results of a GWA study
Xiang Zeng, Judith M. Vonk, Kim de Jong, Xijin Xu, Xia Huo, H. Marike Boezen
Whole Transcriptome Analysis of Pre-invasive and Invasive Early Squamous Lung Carcinoma in Archival Laser Microdissected Samples
Andre Koper, Leo A. H. Zeef, Leena Joseph, Keith Kerr, John Gosney, Mark A. Lindsay, Richard Booton
Indacaterol and glycopyrronium versus indacaterol on body plethysmography measurements in COPD—a randomised controlled study
Joerg Salomon, Daiana Stolz, Guido Domenighetti, Jean-Georges Frey, Alexander J. Turk, Andrea Azzola, Thomas Sigrist, Jean-William Fitting, Ulrich Schmidt, Thomas Geiser, Corinne Wild, Konstantinos Kostikas, Andreas Clemens, Martin Brutsche
Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort
Kathrin Kahnert, Tanja Lucke, Frank Biertz, Andreas Lechner, Henrik Watz, Peter Alter, Robert Bals, Jürgen Behr, Rolf Holle, Rudolf M. Huber, Stefan Karrasch, Beate Stubbe, Margarethe Wacker, Sandra Söhler, Emiel F. M. Wouters, Claus Vogelmeier, Rudolf A. Jörres
Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter
Sridhar Jaligama, Jordy Saravia, Dahui You, Nikki Yadav, Greg I. Lee, Bishwas Shrestha, Stephania A. Cormier
Comparing accelerometer, pedometer and a questionnaire for measuring physical activity in bronchiectasis: a validity and feasibility study
B. O’Neill, S. M. McDonough, J. J. Wilson, I. Bradbury, K. Hayes, A. Kirk, L. Kent, D. Cosgrove, J. M. Bradley, M. A. Tully
Vascular function in asthmatic children and adolescents
Leonardo Silva Augusto, Grazielle Caroline Silva, José Felippe Pinho, Rosária Dias Aires, Virgínia Soares Lemos, Lidiana Fátima Correa Ramalho, Nulma Souto Jentzsch, Maria Glória Rodrigues-Machado
The St. George’s Respiratory Questionnaire as a prognostic factor in IPF
Taiki Furukawa, Hiroyuki Taniguchi, Masahiko Ando, Yasuhiro Kondoh, Kensuke Kataoka, Osamu Nishiyama, Takeshi Johkoh, Junya Fukuoka, Koji Sakamoto, Yoshinori Hasegawa
Is aclidinium alone or combined with a LABA a rational choice for symptomatic COPD patients?
F. Blasi, G. W. Canonica, M. Miravitlles
The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)
Clara E. Green, Alice M. Turner
Association of stem cell factor gene expression with severity and atopic state in patients with bronchial asthma
Safaa I. Tayel, Sally M. El-Hefnway, Eman M. Abd El Gayed, Gehan A. Abdelaal
Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD
Asger Reinstrup Bihlet, Morten Asser Karsdal, Jannie Marie Bülow Sand, Diana Julie Leeming, Mustimbo Roberts, Wendy White, Russell Bowler
Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma
Utako Fujii, Nobuaki Miyahara, Akihiko Taniguchi, Naohiro Oda, Daisuke Morichika, Etsuko Murakami, Hikari Nakayama, Koichi Waseda, Mikio Kataoka, Hiroki Kakuta, Mitsune Tanimoto, Arihiko Kanehiro
Subtypes of asthma based on asthma control and severity: a latent class analysis
Elina M. S. Mäkikyrö, Maritta S. Jaakkola, Jouni J. K. Jaakkola
Admission levels of asymmetric and symmetric dimethylarginine predict long-term outcome in patients with community-acquired pneumonia
Alaadin Vögeli, Manuel Ottiger, Marc A. Meier, Christian Steuer, Luca Bernasconi, Prasad Kulkarni, Andreas Huber, Mirjam Christ-Crain, Christoph Henzen, Claus Hoess, Robert Thomann, Werner Zimmerli, Beat Mueller, Philipp Schuetz
Pharmacological investigation on the anti-oxidant and anti-inflammatory activity of N-acetylcysteine in an ex vivo model of COPD exacerbation
Mario Cazzola, Luigino Calzetta, Francesco Facciolo, Paola Rogliani, Maria Gabriella Matera
Diesel exhaust alters the response of cultured primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD) to non-typeable Haemophilus influenzae
Maria C. Zarcone, Annemarie van Schadewijk, Evert Duistermaat, Pieter S. Hiemstra, Ingeborg M. Kooter
High throughput 16SrRNA gene sequencing reveals the correlation between Propionibacterium acnes and sarcoidosis
Meng-Meng Zhao, Shan-Shan Du, Qiu-Hong Li, Tao Chen, Hui Qiu, Qin Wu, Shan-Shan Chen, Ying Zhou, Yuan Zhang, Yang Hu, Yi-Liang Su, Li Shen, Fen Zhang, Dong Weng, Hui-Ping Li
Changes in the respiratory microbiome during acute exacerbations of idiopathic pulmonary fibrosis
Philip L. Molyneaux, Michael J Cox, Athol U. Wells, Ho Cheol Kim, Wonjun Ji, William O. C. Cookson, Miriam F. Moffatt, Dong Soon Kim, Toby M. Maher
The role of serum procalcitonin in establishing the diagnosis and prognosis of pleural infection
Giles Dixon, Adriana Lama-Lopez, Oliver J. Bintcliffe, Anna J. Morley, Clare E. Hooper, Nick A. Maskell
Associations between chronic comorbidity and exacerbation risk in primary care patients with COPD
Janine A. M. Westerik, Esther I. Metting, Job F. M. van Boven, Waling Tiersma, Janwillem W. H. Kocks, Tjard R. Schermer
Imatinib relaxes the pulmonary venous bed of guinea pigs
Nina A. Maihöfer, Said Suleiman, Daniela Dreymüller, Paul W. Manley, Rolf Rossaint, Stefan Uhlig, Christian Martin, Annette D. Rieg
Acute effects of nicotine-free and flavour-free electronic cigarette use on lung functions in healthy and asthmatic individuals
Marie-Ève Boulay, Cyndi Henry, Ynuk Bossé, Louis-Philippe Boulet, Mathieu C. Morissette
Collaboration between specialties for respiratory allergies in the International Classification of Diseases (ICD)-11
Luciana Kase Tanno, Moises Calderon, Jeffrey F. Linzer Sr, Robert J.G. Chalmers, Pascal Demoly
Erratum to: Is aclidinium alone or combined with a LABA a rational choice for symptomatic COPD patients?
F. Blasi, G. W. Canonica, M. Miravitlles
Malondialdehyde-acetaldehyde (MAA) adducted surfactant protein induced lung inflammation is mediated through scavenger receptor a (SR-A1)
Muna Sapkota, Jane M. DeVasure, Kusum K. Kharbanda, Todd A. Wyatt
Clarithromycin attenuates IL-13–induced periostin production in human lung fibroblasts
Kosaku Komiya, Shoichiro Ohta, Kazuhiko Arima, Masahiro Ogawa, Shoichi Suzuki, Yasutaka Mitamura, Satoshi Nunomura, Yasuhiro Nanri, Tomohito Yoshihara, Atsushi Kawaguchi, Jun-ichi Kadota, Bruce K. Rubin, Kenji Izuhara
Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis
Yan Liu, Hong Xu, Yucong Geng, Dingjie Xu, Lijuan Zhang, Yi Yang, Zhongqiu Wei, Bonan Zhang, Shifeng Li, Xuemin Gao, Ruimin Wang, Xianghong Zhang, Darrell Brann, Fang Yang
Cluster analysis of sputum cytokine-high profiles reveals diversity in T(h)2-high asthma patients
Sven F. Seys, Hans Scheers, Paul Van den Brande, Gudrun Marijsse, Ellen Dilissen, Annelies Van Den Bergh, Pieter C. Goeminne, Peter W Hellings, Jan L. Ceuppens, Lieven J Dupont, Dominique M. A. Bullens
Dual polarization of human alveolar macrophages progressively increases with smoking and COPD severity
Erica Bazzan, Graziella Turato, Mariaenrica Tinè, Claudia M. Radu, Elisabetta Balestro, Chiara Rigobello, Davide Biondini, Marco Schiavon, Francesca Lunardi, Simonetta Baraldo, Federico Rea, Paolo Simioni, Fiorella Calabrese, Marina Saetta, Manuel G. Cosio
Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation
Amanda B. Chai, Alaina J. Ammit, Ingrid C. Gelissen
GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease
Carlos H. Martinez, Christine M. Freeman, Joshua D. Nelson, Susan Murray, Xin Wang, Matthew J. Budoff, Mark T. Dransfield, John E. Hokanson, Ella A. Kazerooni, Gregory L. Kinney, Elizabeth A. Regan, J. Michael Wells, Fernando J. Martinez, MeiLan K. Han, Jeffrey L. Curtis
Low tissue levels of miR-125b predict malignancy in solitary fibrous tumors of the pleura
Matthias Brock, Selma Hottinger, Matthias Diebold, Alex Soltermann, Wolfram Jochum, Malcolm Kohler, Lars C. Huber, Daniel P. Franzen
The relationship between the Leicester cough questionnaire, eosinophilic airway inflammation and asthma patient related outcomes in severe adult asthma
Sushiladevi Natarajan, Robert C. Free, Peter Bradding, Lorcan McGarvey, Salman Siddiqui
Densitometric and local histogram based analysis of computed tomography images in patients with idiopathic pulmonary fibrosis
Samuel Y. Ash, Rola Harmouche, Diego Lassala Lopez Vallejo, Julian A. Villalba, Kris Ostridge, River Gunville, Carolyn E. Come, Jorge Onieva Onieva, James C. Ross, Gary M. Hunninghake, Souheil Y. El-Chemaly, Tracy J. Doyle, Pietro Nardelli, Gonzalo V. Sanchez-Ferrero, Hilary J. Goldberg, Ivan O. Rosas, Raul San Jose Estepar, George R. Washko
Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes
Yukiko Namba, Shinsaku Togo, Miniwan Tulafu, Kotaro Kadoya, Kumi Yoneda Nagahama, Hikari Taka, Naoko Kaga, Akira Orimo, Xiangde Liu, Kazuhisa Takahashi
Chronic hypoxia aggravates monocrotaline-induced pulmonary arterial hypertension: a rodent relevant model to the human severe form of the disease
Florence Coste, Christelle Guibert, Julie Magat, Emma Abell, Fanny Vaillant, Mathilde Dubois, Arnaud Courtois, Philippe Diolez, Bruno Quesson, Roger Marthan, Jean-Pierre Savineau, Bernard Muller, Véronique Freund-Michel
Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF
Abraham B. Roos, Michiko Mori, Harpreet K. Gura, Axel Lorentz, Leif Bjermer, Hans Jürgen Hoffmann, Jonas S. Erjefält, Martin R. Stampfli
Interaction of CD14 haplotypes and soluble CD14 on pulmonary function in agricultural workers
Tricia D. LeVan, Lynette M. Smith, Art J. Heires, Ted R. Mikuls, Jane L. Meza, Lisa A. Weissenburger-Moser, Debra J. Romberger
Cigarette smoke challenges bone marrow mesenchymal stem cell capacities in guinea pig
Olga Tura-Ceide, Borja Lobo, Tanja Paul, Raquel Puig-Pey, Núria Coll-Bonfill, Jéssica García-Lucio, Valérie Smolders, Isabel Blanco, Joan A. Barberà, Víctor I. Peinado
Caffeine modulates glucocorticoid-induced expression of CTGF in lung epithelial cells and fibroblasts
Markus Fehrholz, Kirsten Glaser, Christian P. Speer, Silvia Seidenspinner, Barbara Ottensmeier, Steffen Kunzmann
ABCB1 and ABCG2 drug transporters are differentially expressed in non-small cell lung cancers (NSCLC) and expression is modified by cisplatin treatment via altered Wnt signaling
M. Vesel, J. Rapp, D. Feller, E. Kiss, L. Jaromi, M. Meggyes, G. Miskei, B. Duga, G. Smuk, T. Laszlo, I. Karner, J.E. Pongracz
Altered mTOR and Beclin-1 mediated autophagic activation during right ventricular remodeling in monocrotaline-induced pulmonary hypertension
Yan Deng, Weifeng Wu, Shenglan Guo, Yuming Chen, Chang Liu, Xingcui Gao, Bin Wei
The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration
Dale D. Tang, Brennan D. Gerlach
Characterisation of a murine model of the late asthmatic response
Katie Baker, Kristof Raemdonck, Robert J. Snelgrove, Maria G. Belvisi, Mark A. Birrell
Ku80 correlates with neoadjuvant chemotherapy resistance in human lung adenocarcinoma, but reduces cisplatin/pemetrexed-induced apoptosis in A549 cells
Bin Shang, Yang Jia, Gang Chen, Zhou Wang
Determining the presence of asthma-related molecules and salivary contamination in exhaled breath condensate
Charmion Cruickshank-Quinn, Michael Armstrong, Roger Powell, Joe Gomez, Marc Elie, Nichole Reisdorph
CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives
Lourdes Cortes-Dericks, Ralph Alexander Schmid
Telomere shortening and accelerated aging in COPD: findings from the BODE cohort
Elizabeth Córdoba-Lanús, Sara Cazorla-Rivero, Adriana Espinoza-Jiménez, Juan P. de-Torres, María J. Pajares, Armando Aguirre-Jaime, Bartolomé Celli, Ciro Casanova
Costs and health-related quality of life in Alpha-1-Antitrypsin Deficient COPD patients
Florian M. Karl, Rolf Holle, Robert Bals, Timm Greulich, Rudolf A. Jörres, Annika Karch, Armin Koch, Stefan Karrasch, Reiner Leidl, Holger Schulz, Claus Vogelmeier, Margarethe E. Wacker
Mechanisms of corticosteroid insensitivity in COPD alveolar macrophages exposed to NTHi
Rana M. Khalaf, Simon R. Lea, Hannah J. Metcalfe, Dave Singh
Computational modeling of airway instability and collapse in tracheomalacia
Scott J. Hollister, Maximilian P. Hollister, Sebastian K. Hollister
Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children
Kyung Hwa Jung, David Torrone, Stephanie Lovinsky-Desir, Matthew Perzanowski, Joshua Bautista, Jacqueline R. Jezioro, Lori Hoepner, Jamie Ross, Frederica P. Perera, Steven N. Chillrud, Rachel L. Miller
Interleukin-6 displays lung anti-inflammatory properties and exerts protective hemodynamic effects in a double-hit murine acute lung injury
Guillaume Voiriot, Keyvan Razazi, Valérie Amsellem, Jeanne Tran Van Nhieu, Shariq Abid, Serge Adnot, Armand Mekontso Dessap, Bernard Maitre
Protein antigen of bird-related hypersensitivity pneumonitis in pigeon serum and dropping
Tsuyoshi Shirai, Haruhiko Furusawa, Asuka Furukawa, Yuki Ishige, Keisuke Uchida, Yasunari Miyazaki, Yoshinobu Eishi, Naohiko Inase
Monitoring mandibular movements to detect Cheyne-Stokes Breathing
Jean-Benoît Martinot, Jean-Christian Borel, Nhat-Nam Le-Dong, Hervé Jean-Pierre Guénard, Valerie Cuthbert, Philip E. Silkoff, David Gozal, Jean-Louis Pepin
Understanding the impact of symptoms on the burden of COPD
Marc Miravitlles, Anna Ribera
Outcomes after early and delayed rehabilitation for exacerbation of chronic obstructive pulmonary disease: a nationwide retrospective cohort study in Japan
Hiroki Matsui, Taisuke Jo, Kiyohide Fushimi, Hideo Yasunaga
Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung
Aoi Kuroda, Ahmed E. Hegab, Gao Jingtao, Shuji Yamashita, Nobuyuki Hizawa, Tohru Sakamoto, Hideyasu Yamada, Satoshi Suzuki, Makoto Ishii, Ho Namkoong, Takanori Asakura, Mari Ozaki, Hiroyuki Yasuda, Junko Hamamoto, Shizuko Kagawa, Kenzo Soejima, Tomoko Betsuyaku
Exogenous gene transfer of Rab38 small GTPase ameliorates aberrant lung surfactant homeostasis in Ruby rats
Kazuhiro Osanai, Keisuke Nakase, Takashi Sakuma, Kazuaki Nishiki, Masafumi Nojiri, Ryo Kato, Masatoshi Saito, Yuki Fujimoto, Shiro Mizuno, Hirohisa Toga
Targeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia/reperfusion in rats
Geng-Chin Wu, Wen-I Liao, Shu-Yu Wu, Hsin-Ping Pao, Shih-En Tang, Min-Hui Li, Kun-Lun Huang, Shi-Jye Chu
Network-based analysis reveals novel gene signatures in peripheral blood of patients with chronic obstructive pulmonary disease
Ma’en Obeidat, Yunlong Nie, Virginia Chen, Casey P. Shannon, Anand Kumar Andiappan, Bernett Lee, Olaf Rotzschke, Peter J. Castaldi, Craig P. Hersh, Nick Fishbane, Raymond T. Ng, Bruce McManus, Bruce E. Miller, Stephen Rennard, Peter D. Paré, Don D. Sin
Clinical characteristics of eosinophilic COPD versus COPD patients with a history of asthma
Umme Kolsum, Arjun Ravi, Paul Hitchen, Satyanarayana Maddi, Thomas Southworth, Dave Singh
[18F]FDG PET/CT predicts progression-free survival in patients with idiopathic pulmonary fibrosis
Aurélien Justet, Astrid Laurent-Bellue, Gabriel Thabut, Arnaud Dieudonné, Marie-Pierre Debray, Raphael Borie, Michel Aubier, Rachida Lebtahi, Bruno Crestani
Differential regulation of muscle protein turnover in response to emphysema and acute pulmonary inflammation
Judith J. M. Ceelen, Annemie M. W. J. Schols, Stefan J. van Hoof, Chiel C. de Theije, Frank Verhaegen, Ramon C. J. Langen
Impact of High-Intensity-NIV on the heart in stable COPD: a randomised cross-over pilot study
Marieke Leontine Duiverman, Petra Maagh, Friederike Sophie Magnet, Claudia Schmoor, Maria Paola Arellano-Maric, Axel Meissner, Jan Hendrik Storre, Peter Jan Wijkstra, Wolfram Windisch, Jens Callegari
Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease
Julie Weidner, Linnea Jarenbäck, Kim de Jong, Judith M. Vonk, Maarten van den Berge, Corry-Anke Brandsma, H. Marike Boezen, Don Sin, Yohan Bossé, David Nickle, Jaro Ankerst, Leif Bjermer, Dirkje S. Postma, Alen Faiz, Ellen Tufvesson
Secretion of the endoplasmic reticulum stress protein, GRP78, into the BALF is increased in cigarette smokers
Mark O. Aksoy, Victor Kim, William D. Cornwell, Thomas J. Rogers, Beata Kosmider, Karim Bahmed, Carlos Barrero, Salim Merali, Neena Shetty, Steven G. Kelsen
β2 adrenergic agonist suppresses eosinophil-induced epithelial-to-mesenchymal transition of bronchial epithelial cells
Keigo Kainuma, Tetsu Kobayashi, Corina N. D’Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Kota Nishihama, Hajime Fujimoto, Yu Kuwabara, Koa Hosoki, Mizuho Nagao, Takao Fujisawa, Esteban C. Gabazza
Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts
Sze-Kwan Lam, Yuan-Yuan Li, Shi Xu, Leanne Lee Leung, Kin-Pong U, Yan-Fang Zheng, Paul Ning-Man Cheng, James Chung-Man Ho
2D-DIGE proteomic analysis of vastus lateralis from COPD patients with low and normal fat free mass index and healthy controls
Ramzi Lakhdar, Ellen M. Drost, William MacNee, Ricardo Bastos, Roberto A. Rabinovich
Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium
Lynne A. Murray, Rebecca Dunmore, Ana Camelo, Carla A. Da Silva, Malin J. Gustavsson, David M. Habiel, Tillie L Hackett, Cory M. Hogaboam, Matthew A. Sleeman, Darryl A. Knight
Augmenting autophagy for prognosis based intervention of COPD-pathophysiology
Manish Bodas, Neeraj Vij
Rhinovirus C targets ciliated airway epithelial cells
Theodor F. Griggs, Yury A. Bochkov, Sarmila Basnet, Thomas R. Pasic, Rebecca A. Brockman-Schneider, Ann C. Palmenberg, James E. Gern
Pulmonary arterial wall disease in COPD and interstitial lung diseases candidates for lung transplantation
Enric Domingo, Juan C. Grignola, Rio Aguilar, Manuel López Messeguer, Antonio Roman
Rescue medication use as a patient-reported outcome in COPD: a systematic review and regression analysis
Yogesh Suresh Punekar, Sheetal Sharma, Ankit Pahwa, Jitender Takyar, Ian Naya, Paul W. Jones
Selective gene expression analysis of the neuroepithelial body microenvironment in postnatal lungs with special interest for potential stem cell characteristics
Line Verckist, Robrecht Lembrechts, Sofie Thys, Isabel Pintelon, Jean-Pierre Timmermans, Inge Brouns, Dirk Adriaensen
Blood and sputum eosinophils in COPD; relationship with bacterial load
Umme Kolsum, Gavin C. Donaldson, Richa Singh, Bethan L. Barker, Vandana Gupta, Leena George, Adam J. Webb, Sarah Thurston, Anthony J Brookes, Timothy D. McHugh, Jadwiga A. Wedzicha, Christopher E. Brightling, Dave Singh
Role of heparin in pulmonary cell populations in an in-vitro model of acute lung injury
Marta Camprubí–Rimblas, Raquel Guillamat-Prats, Thomas Lebouvier, Josep Bringué, Laura Chimenti, Manuela Iglesias, Carme Obiols, Jessica Tijero, Lluís Blanch, Antonio Artigas
COPD monocytes demonstrate impaired migratory ability
Arjun K Ravi, Jonathan Plumb, Rosemary Gaskell, Sarah Mason, Caroline S Broome, George Booth, Matthew Catley, Jørgen Vestbo, Dave Singh
Genome-wide DNA methylation analysis in lung fibroblasts co-cultured with silica-exposed alveolar macrophages
Juan Li, Wu Yao, Lin Zhang, Lei Bao, Huiting Chen, Di Wang, Zhongzheng Yue, Yiping Li, Miao Zhang, Changfu Hao
Attenuating immune pathology using a microbial-based intervention in a mouse model of cigarette smoke-induced lung inflammation
Mark Bazett, Agnieszka Biala, Ryan D. Huff, Matthew R. Zeglinksi, Philip M. Hansbro, Momir Bosiljcic, Hal Gunn, Shirin Kalyan, Jeremy A. Hirota
An association between pulmonary Mycobacterium avium-intracellulare complex infections and biomarkers of Th2-type inflammation
Paul E. Pfeffer, Susan Hopkins, Ian Cropley, David M. Lowe, Marc Lipman
Immunohistology and remodeling in fatal pediatric and adolescent asthma
Kristiina Malmström, Jouko Lohi, Antti Sajantila, Frode L. Jahnsen, Merja Kajosaari, Seppo Sarna, Mika J. Mäkelä
High-resolution mucociliary transport measurement in live excised large animal trachea using synchrotron X-ray imaging
Martin Donnelley, Kaye S. Morgan, Maged Awadalla, Nigel R. Farrow, Chris Hall, David W. Parsons
Lung function imaging methods in Cystic Fibrosis pulmonary disease
Magdalena Kołodziej, Michael J. de Veer, Marian Cholewa, Gary F. Egan, Bruce R. Thompson
Genome-wide association study of subclinical interstitial lung disease in MESA
Ani Manichaikul, Xin-Qun Wang, Li Sun, Josée Dupuis, Alain C. Borczuk, Jennifer N. Nguyen, Ganesh Raghu, Eric A. Hoffman, Suna Onengut-Gumuscu, Emily A. Farber, Joel D. Kaufman, Dan Rabinowitz, Karen D. Hinckley Stukovsky, Steven M. Kawut, Gary M. Hunninghake, George R. Washko, George T. O’Connor, Stephen S. Rich, R. Graham Barr, David J. Lederer
Infection-mediated asthma: etiology, mechanisms and treatment options, with focus on Chlamydia pneumoniae and macrolides
Wilmore C. Webley, David L. Hahn
Reduced HDAC2 in skeletal muscle of COPD patients
Masako To, Elisabeth B. Swallow, Kenich Akashi, Kosuke Haruki, S Amanda Natanek, Michael I. Polkey, Kazuhiro Ito, Peter J. Barnes
Proteomic profiling of peripheral blood neutrophils identifies two inflammatory phenotypes in stable COPD patients
Adèle Lo Tam Loi, Susan Hoonhorst, Corneli van Aalst, Jeroen Langereis, Vera Kamp, Simone Sluis-Eising, Nick ten Hacken, Jan-Willem Lammers, Leo Koenderman
Endexpiratory lung volume measurement correlates with the ventilation/perfusion mismatch in lung injured pigs
Jens Kamuf, Andreas Garcia-Bardon, Bastian Duenges, Tanghua Liu, Antje Jahn-Eimermacher, Florian Heid, Matthias David, Erik K. Hartmann
In smokers, Sonic hedgehog modulates pulmonary endothelial function through vascular endothelial growth factor
Priscilla Henno, Stanislas Grassin-Delyle, Emeline Belle, Marion Brollo, Emmanuel Naline, Edouard Sage, Philippe Devillier, Dominique Israël-Biet
Evaluation of two strategies for the interpretation of tumour markers in pleural effusions
Jaume Trapé, Francesc Sant, Josefina Franquesa, Jesús Montesinos, Anna Arnau, Maria Sala, Oscar Bernadich, Esperanza Martín, Damià Perich, Concha Pérez, Joan Lopez, Sandra Ros, Enrique Esteve, Rafael Pérez, Jordi Aligué, Gabriel Gurt, Silvia Catot, Montserrat Domenech, Joan Bosch, Josep Miquel Badal, Mariona Bonet, Rafael Molina, Josep Ordeig
Sex-specific lung functional changes in adult mice exposed only to second-hand smoke in utero
Alexandra Noël, Rui Xiao, Zakia Perveen, Hasan Zaman, Viviana Le Donne, Arthur Penn
Long-term clinical outcomes following treatment with alpha 1-proteinase inhibitor for COPD associated with alpha-1 antitrypsin deficiency: a look at the evidence
Franck F. Rahaghi, Marc Miravitlles
Reduction in clinically important deterioration in chronic obstructive pulmonary disease with aclidinium/formoterol
Dave Singh, Anthony D. D’Urzo, Ferran Chuecos, Anna Muñoz, Esther Garcia Gil
Which bronchodilator reversibility criteria can predict severe acute exacerbation in chronic obstructive pulmonary disease patients?
Junghyun Kim, Woo Jin Kim, Chang-Hoon Lee, Sang Haak Lee, Myung-Goo Lee, Kyeong-Cheol Shin, Kwang Ha Yoo, Ji-Hyun Lee, Seong Yong Lim, Ju Ock Na, Hun-Gyu Hwang, Yoonki Hong, Myoung Nam Lim, Chul-Gyu Yoo, Ki Suck Jung, Sang-Do Lee
Electronic applications for the CFQ-R scoring
Andreas Ronit, Marco Gelpi, Jonathan Argentiero, Inger Mathiesen, Susanne D. Nielsen, Tanja Pressler, Alexandra L. Quittner
Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori
Seung Won Ra, Marc A. Sze, Eun Chong Lee, Sheena Tam, Yeni Oh, Nick Fishbane, Gerard J. Criner, Prescott G. Woodruff, Stephen C. Lazarus, Richard Albert, John E. Connett, Meilan K. Han, Fernando J. Martinez, Shawn D. Aaron, Robert M. Reed, S. F. Paul Man, Don D. Sin
Role of human rhinovirus in triggering human airway epithelial-mesenchymal transition
Danielle M. Minor, David Proud
Extracellular heat shock protein 90α mediates HDM-induced bronchial epithelial barrier dysfunction by activating RhoA/MLC signaling
Hang-ming Dong, Yan-qing Le, Yan-hong Wang, Hai-jin Zhao, Chao-wen Huang, Ya-hui Hu, Li-shan Luo, Xuan Wan, Yi-lan Wei, Zi-qiang Chu, Wei Li, Shao-xi Cai
Prediction of long-term clinical outcomes using simple functional exercise performance tests in patients with COPD: a 5-year prospective cohort study
Sarah Crook, Anja Frei, Gerben ter Riet, Milo A. Puhan
Erratum to: Telomere shortening and accelerated aging in COPD: findings from the BODE cohort
Elizabeth Cordoba-Lanus, Sara Cazorla-Rivero, Adriana Espinoza-Jimenez, Juan P. de-Torres, María J. Pajares, Armando Aguirre-Jaime, Bartolomé Celli, Ciro Casanova
Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy
Yusuke Kurita, Jun Araya, Shunsuke Minagawa, Hiromichi Hara, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Kazuya Tsubouchi, Nahoko Sato, Masahiro Yoshida, Kenji Kobayashi, Saburo Ito, Yu Fujita, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Yutaka Yoshii, Takeo Ishikawa, Takanori Numata, Yumi Kaneko, Hisatoshi Asano, Makoto Yamashita, Makoto Odaka, Toshiaki Morikawa, Katsutoshi Nakayama, Kazuyoshi Kuwano
Nicotine stimulates collagen type I expression in lung via α7 nicotinic acetylcholine receptors
Glenn W. Vicary, Jeffrey D. Ritzenthaler, Tanmay S. Panchabhai, Edilson Torres-González, Jesse Roman
VEGF isoforms have differential effects on permeability of human pulmonary microvascular endothelial cells
Khadija Ourradi, Thomas Blythe, Caroline Jarrett, Shaney L. Barratt, Gavin I. Welsh, Ann B. Millar
Multiple biomarkers predict disease severity, progression and mortality in COPD
Rachel L. Zemans, Sean Jacobson, Jason Keene, Katerina Kechris, Bruce E. Miller, Ruth Tal-Singer, Russell P. Bowler
Hepatocyte growth factor produced in lung fibroblasts enhances non-small cell lung cancer cell survival and tumor progression
Nobuhiro Kanaji, Masanao Yokohira, Yuko Nakano-Narusawa, Naoki Watanabe, Katsumi Imaida, Norimitsu Kadowaki, Shuji Bandoh
Human adipose-derived mesenchymal stem cells alleviate obliterative bronchiolitis in a murine model via IDO
Guoping Zheng, Guanguan Qiu, Menghua Ge, Jianping He, Lanfang Huang, Ping Chen, Wei Wang, Qi Xu, Yaoqin Hu, Qiang Shu, Jianguo Xu
Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses
Alice Guyard, Claire Danel, Nathalie Théou-Anton, Marie-Pierre Debray, Laure Gibault, Pierre Mordant, Yves Castier, Bruno Crestani, Gérard Zalcman, Hélène Blons, Aurélie Cazes
Erratum to: Imatinib relaxes the pulmonary venous bed of guinea pigs
Nina A. Maihöfer, Said Suleiman, Daniela Dreymüller, Paul W. Manley, Rolf Rossaint, Stefan Uhlig, Christian Martin, Annette D. Rieg
Fibroblast paracrine TNF-α signaling elevates integrin A5 expression in idiopathic pulmonary fibrosis (IPF)
Gali Epstein Shochet, Elizabetha Brook, Lilach Israeli-Shani, Evgeny Edelstein, David Shitrit
Forced expiration measurements in mouse models of obstructive and restrictive lung diseases
Fien C. Devos, André Maaske, Annette Robichaud, Lore Pollaris, Sven Seys, Carolina Aznar Lopez, Erik Verbeken, Matthias Tenbusch, Rik Lories, Benoit Nemery, Peter HM Hoet, Jeroen AJ Vanoirbeek
Effect of beta-blockers on exacerbation rate and lung function in chronic obstructive pulmonary disease (COPD)
Sean Duffy, Robert Marron, Helen Voelker, Richard Albert, John Connett, William Bailey, Richard Casaburi, J. Allen Cooper Jr., Jeffrey L. Curtis, Mark Dransfield, MeiLan K. Han, Barry Make, Nathaniel Marchetti, Fernando Martinez, Stephen Lazarus, Dennis Niewoehner, Paul D. Scanlon, Frank Sciurba, Steven Scharf, Robert M. Reed, George Washko, Prescott Woodruff, Charlene McEvoy, Shawn Aaron, Don Sin, Gerard J. Criner
Optimizing bronchodilation in the prevention of COPD exacerbations
Marc Miravitlles, Antonio Anzueto, José R. Jardim
Human lung and monocyte-derived macrophages differ with regard to the effects of β2-adrenoceptor agonists on cytokine release
Tatiana Victoni, Hélène Salvator, Charlotte Abrial, Marion Brollo, Luis Cristovão Sobrino Porto, Vincent Lagente, Emmanuel Naline, Stanislas Grassin-Delyle, Philippe Devillier
Role of P2X7R in the development and progression of pulmonary hypertension
Jie Yin, Shuling You, Haopeng Liu, Li Chen, Chengdong Zhang, Hesheng Hu, Mei Xue, Wenjuan Cheng, Ye Wang, Xinran Li, Yugen Shi, Nannan Li, Suhua Yan, Xiaolu Li
Decreased T helper 17 cells in tuberculosis is associated with increased percentages of programmed death ligand 1, T helper 2 and regulatory T cells
Chin-Chung Shu, Ming-Fang Wu, Jann-Yuan Wang, Hsin-Chih Lai, Li-Na Lee, Bor-Luen Chiang, Chong-Jen Yu
The cost of systemic corticosteroid-induced morbidity in severe asthma: a health economic analysis
L. E. Barry, J. Sweeney, C. O’Neill, D. Price, L. G. Heaney
Independent associations between arterial bicarbonate, apnea severity and hypertension in obstructive sleep apnea
Davoud Eskandari, Ding Zou, Ludger Grote, Hartmut Schneider, Thomas Penzel, Jan Hedner
Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation
Elizabeth A. Lendermon, Tiffany A. Coon, Joseph S. Bednash, Nathaniel M. Weathington, John F. McDyer, Rama K. Mallampalli
Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies
Phuong-Uyen C. Dinh, Jhon Cores, M. Taylor Hensley, Adam C. Vandergriff, Junnan Tang, Tyler A. Allen, Thomas G. Caranasos, Kenneth B. Adler, Leonard J. Lobo, Ke Cheng
Is it possible to claim or refute sputum eosinophils ≥ 3% in asthmatics with sufficient accuracy using biomarkers?
Sophie F. Demarche, Florence N. Schleich, Virginie A. Paulus, Monique A. Henket, Thierry J. Van Hees, Renaud E. Louis
Bronchial thermoplasty: activations predict response
David Langton, Joy Sha, Alvin Ing, David Fielding, Francis Thien, Virginia Plummer
Prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers: a study on 1311 subjects
Matthieu Hein, Jean-Pol Lanquart, Gwénolé Loas, Philippe Hubain, Paul Linkowski
Sirolimus alters lung pathology and viral load following influenza A virus infection
Ahmed R. Alsuwaidi, Junu A. George, Saeeda Almarzooqi, Stacey M. Hartwig, Steven M. Varga, Abdul-Kader Souid
Stromal derived factor-1 mediates the lung regenerative effects of mesenchymal stem cells in a rodent model of bronchopulmonary dysplasia
Joel Reiter, Shelley Drummond, Ibrahim Sammour, Jian Huang, Victoria Florea, Polliana Dornas, Joshua M. Hare, Claudia O. Rodrigues, Karen C. Young
Which early life events or current environmental and lifestyle factors influence lung function in adolescents? – results from the GINIplus & LISAplus studies
Agnes Luzak, Elaine Fuertes, Claudia Flexeder, Marie Standl, Andrea von Berg, Dietrich Berdel, Sibylle Koletzko, Joachim Heinrich, Dennis Nowak, Holger Schulz
Health related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: insights-IPF registry
Michael Kreuter, Jeff Swigris, David Pittrow, Silke Geier, Jens Klotsche, Antje Prasse, Hubert Wirtz, Dirk Koschel, Stefan Andreas, Martin Claussen, Christian Grohé, Henrike Wilkens, Lars Hagmeyer, Dirk Skowasch, Joachim F Meyer, Joachim Kirschner, Sven Gläser, Felix J. F. Herth, Tobias Welte, Claus Neurohr, Martin Schwaiblmair, Matthias Held, Thomas Bahmer, Marion Frankenberger, Jürgen Behr
Efficacy and safety of direct switch to indacaterol/glycopyrronium in patients with moderate COPD: the CRYSTAL open-label randomised trial
Claus F. Vogelmeier, Mina Gaga, Maryam Aalamian-Mattheis, Timm Greulich, Jose M. Marin, Walter Castellani, Vincent Ninane, Stephen Lane, Xavier Nunez, Francesco Patalano, Andreas Clemens, Konstantinos Kostikas
Fibrocyte measurement in peripheral blood correlates with number of cultured mature fibrocytes in vitro and is a potential biomarker for interstitial lung disease in Rheumatoid Arthritis
Søren Andreas Just, Hanne Lindegaard, Eva Kildall Hejbøl, Jesper Rømhild Davidsen, Niels Bjerring, Søren Werner Karlskov Hansen, Henrik Daa Schrøder, Inger Marie Jensen Hansen, Torben Barington, Christian Nielsen
Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure
K. de Jong, J.M. Vonk, M. Imboden, L. Lahousse, A. Hofman, G.G. Brusselle, N.M. Probst-Hensch, D.S. Postma, H.M. Boezen
Exposure to ambient particulate matter alters the microbial composition and induces immune changes in rat lung
Naijian Li, Fang He, Baoling Liao, Yuming Zhou, Bing Li, Pixin Ran
The predictive value of respiratory function tests for non-invasive ventilation in amyotrophic lateral sclerosis
T. B. M. Tilanus, J. T. Groothuis, J. M. C. TenBroek-Pastoor, T. B. Feuth, Y. F. Heijdra, J. P. L. Slenders, J. Doorduin, B. G. Van Engelen, M. J. Kampelmacher, J. Raaphorst
Interactions between glycopyrronium and indacaterol on cholinergic neurotransmission and contractile response in bovine trachealis
Michele Baroffio, Giovanni Barisione, Vito Brusasco
The effect of glycopyrronium and indacaterol, as monotherapy and in combination, on the methacholine dose-response curve of mild asthmatics: a randomized three-way crossover study
Christianne M. Blais, Beth E. Davis, Donald W. Cockcroft
Airway and parenchyma immune cells in influenza A(H1N1)pdm09 viral and non-viral diffuse alveolar damage
Monique Buttignol, Ruy Camargo Pires-Neto, Renata Calciolari Rossi e Silva, Marina Ballarin Albino, Marisa Dolhnikoff, Thais Mauad
Small airway bronchodilator response to different doses of salbutamol in 7-year-old children
Dong Keon Yon, Hye Mi Jee, Eun Kyo Ha, Seung Jin Lee, Young-Ho Jung, Kyung Suk Lee, Man Yong Han
Using omics approaches to understand pulmonary diseases
Mengyuan Kan, Maya Shumyatcher, Blanca E. Himes
Fraction of MHCII and EpCAM expression characterizes distal lung epithelial cells for alveolar type 2 cell isolation
Koichi Hasegawa, Atsuyasu Sato, Kazuya Tanimura, Kiyoshi Uemasu, Yoko Hamakawa, Yoshinori Fuseya, Susumu Sato, Shigeo Muro, Toyohiro Hirai
Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers
Nicole E. Speck, Macé M. Schuurmans, Christian Benden, Cécile A. Robinson, Lars C. Huber
Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function
Leema George, Ankita Mitra, Tania A. Thimraj, Martin Irmler, Sangeetha Vishweswaraiah, Lars Lunding, Dorothea Hühn, Alicia Madurga, Johannes Beckers, Heinz Fehrenbach, Swapna Upadhyay, Holger Schulz, George D. Leikauf, Koustav Ganguly
A randomised, placebo-controlled trial of anti–interleukin-1 receptor 1 monoclonal antibody MEDI8968 in chronic obstructive pulmonary disease
Peter M. A. Calverley, Sanjay Sethi, Michelle Dawson, Christine K. Ward, Donna K. Finch, Mark Penney, Paul Newbold, René van der Merwe
Role and regulation of MKP-1 in airway inflammation
Seyed M. Moosavi, Pavan Prabhala, Alaina J. Ammit
MicroRNA-181c inhibits cigarette smoke–induced chronic obstructive pulmonary disease by regulating CCN1 expression
Yong Du, Yi Ding, Xuru Chen, Zhoufang Mei, Heyuan Ding, Yi Wu, Zhijun Jie
Regulation of human airway smooth muscle cell migration and relevance to asthma
Brittany Salter, Cara Pray, Katherine Radford, James G. Martin, Parameswaran Nair
24-h bronchodilation and inspiratory capacity improvements with glycopyrrolate/formoterol fumarate via co-suspension delivery technology in COPD
Colin Reisner, Gregory Gottschlich, Faisal Fakih, Andras Koser, James Krainson, Luis Delacruz, Samir Arora, Gregory Feldman, Krishna Pudi, Shahid Siddiqui, Chad Orevillo, Andrea Maes, Earl St. Rose, Ubaldo Martin
Erratum to: A randomized, seven-day study to assess the efficacy and safety of a glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler using novel Co-Suspension™ Delivery Technology in patients with moderate-to-very severe chronic obstructive pulmonary disease
Colin Reisner, Leonardo M. Fabbri, Edward M. Kerwin, Charles Fogarty, Selwyn Spangenthal, Klaus F. Rabe, Gary T. Ferguson, Fernando J. Martinez, James F. Donohue, Patrick Darken, Earl St. Rose, Chad Orevillo, Shannon Strom, Tracy Fischer, Michael Golden, Sarvajna Dwivedi
IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD
Emmanuel Briend, G. John Ferguson, Michiko Mori, Gautam Damera, Katherine Stephenson, Natasha A. Karp, Sanjay Sethi, Christine K. Ward, Matthew A. Sleeman, Jonas S. Erjefält, Donna K. Finch
Effect of smoking and comorbidities on survival in idiopathic pulmonary fibrosis
Miia Kärkkäinen, Hannu-Pekka Kettunen, Hanna Nurmi, Tuomas Selander, Minna Purokivi, Riitta Kaarteenaho
Utility of autoimmune serology testing in the assessment of uncharacterized interstitial lung disease: a large retrospective cohort review
Mohammad Alsumrain, Federica De Giacomi, Shireen Mirza, Teng Moua
Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study
Andreas Horner, Joan B. Soriano, Milo A. Puhan, Michael Studnicka, Bernhard Kaiser, Lowie E. G. W. Vanfleteren, Louisa Gnatiuc, Peter Burney, Marc Miravitlles, Francisco García-Rio, Julio Ancochea, Ana M. Menezes, Rogelio Perez-Padilla, Maria Montes de Oca, Carlos A. Torres-Duque, Andres Caballero, Mauricio González-García, Sonia Buist, Maria Flamm, Bernd Lamprecht
Expiratory central airway collapse in stable COPD and during exacerbations
Paul Leong, Anne Tran, Jhanavi Rangaswamy, Laurence E. Ruane, Michael W. Fernando, Martin I. MacDonald, Kenneth K. Lau, Philip G. Bardin
Comparing microbiota profiles in induced and spontaneous sputum samples in COPD patients
Solveig Tangedal, Marianne Aanerud, Rune Grønseth, Christine Drengenes, Harald G. Wiker, Per S. Bakke, Tomas M. Eagan
Extracellular histones are clinically relevant mediators in the pathogenesis of acute respiratory distress syndrome
Xin Lv, Tao Wen, Jiong Song, Dong Xie, Liang Wu, Xuemei Jiang, Ping Jiang, Zongmei Wen
RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection
Xiaoqiu Wang, Wenxin Wu, Wei Zhang, J. Leland Booth, Elizabeth S. Duggan, Lili Tian, Sunil More, Yan D. Zhao, Ravindranauth N. Sawh, Lin Liu, Ming-Hui Zou, Jordan P. Metcalf
WNT signaling – lung cancer is no exception
Judit Rapp, Luca Jaromi, Krisztian Kvell, Gyorgy Miskei, Judit E. Pongracz
Intersectin-1s deficiency in pulmonary pathogenesis
Niranjan Jeganathan, Dan Predescu, Sanda Predescu
Structure and functional impact of seed region variant in MIR-499 gene family in bronchial asthma
Eman A. Toraih, Mohammad H. Hussein, Essam Al Ageeli, Eman Riad, Nouran B. AbdAllah, Ghada M. Helal, Manal S. Fawzy
Increased activated regulatory T cells proportion correlate with the severity of idiopathic pulmonary fibrosis
Ziliang Hou, Qiao Ye, Meihua Qiu, Yu Hao, Junyan Han, Hui Zeng
Cardiovascular risk in patients with alpha-1-antitrypsin deficiency
Sebastian Fähndrich, Frank Biertz, Annika Karch, Björn Kleibrink, Armin Koch, Helmut Teschler, Tobias Welte, Hans-Ulrich Kauczor, Sabina Janciauskiene, Rudolf A. Jörres, Timm Greulich, Claus F. Vogelmeier, Robert Bals
Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity
Seidai Sato, Shintaro Shinohara, Shinya Hayashi, Shun Morizumi, Shuichi Abe, Hiroyasu Okazaki, Yanjuan Chen, Hisatsugu Goto, Yoshinori Aono, Hirohisa Ogawa, Kazuya Koyama, Haruka Nishimura, Hiroshi Kawano, Yuko Toyoda, Hisanori Uehara, Yasuhiko Nishioka
Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice
S. Vamsee Raju, Lawrence Rasmussen, Peter A. Sloane, Li Ping Tang, Emily Falk Libby, Steven M. Rowe
IL-4-induced caveolin-1-containing lipid rafts aggregation contributes to MUC5AC synthesis in bronchial epithelial cells
Yu Xia, Peng-Cheng Cai, Fan Yu, Liang Xiong, Xin-Liang He, Shan-Shan Rao, Feng Chen, Xiang-Ping Yang, Wan-Li Ma, Hong Ye
Prospective comparison of non-invasive risk markers of major cardiovascular events in COPD patients
Jorge Zagaceta, Gorka Bastarrika, Javier J. Zulueta, Inmaculada Colina, Ana B. Alcaide, Arantza Campo, Miguel Divo, Ciro Casanova, José M. Marin, Victor M. Pinto-Plata, Bartolome R. Celli, Juan P. de-Torres
Factors associated with hospitalization in bronchiectasis exacerbations: a one-year follow-up study
Rosario Menéndez, Raúl Méndez, Eva Polverino, Edmundo Rosales-Mayor, Isabel Amara-Elori, Soledad Reyes, Tomás Posadas, Laia Fernández-Barat, Antoni Torres
Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition
Toshio Suzuki, Yuji Tada, Santhi Gladson, Rintaro Nishimura, Iwao Shimomura, Satoshi Karasawa, Koichiro Tatsumi, James West
Development of breath test for pneumoconiosis: a case-control study
Hsiao-Yu Yang, Ruei-Hao Shie, Che-Jui Chang, Pau-Chung Chen
Serum bilirubin and the risk of chronic obstructive pulmonary disease exacerbations
Kirstin E. Brown, Don D. Sin, Helen Voelker, John E. Connett, Dennis E. Niewoehner, Ken M. Kunisaki
The value of blood cytokines and chemokines in assessing COPD
Eric Bradford, Sean Jacobson, Jason Varasteh, Alejandro P. Comellas, Prescott Woodruff, Wanda O’Neal, Dawn L. DeMeo, Xingnan Li, Victor Kim, Michael Cho, Peter J. Castaldi, Craig Hersh, Edwin K. Silverman, James D. Crapo, Katerina Kechris, Russell P. Bowler
Neutrophil extracellular traps in patients with pulmonary tuberculosis
Anne Jan van der Meer, Sacha Zeerleder, Dana C. Blok, Liesbeth M. Kager, Ivar O. Lede, Wahid Rahman, Rumana Afroz, Aniruddha Ghose, Caroline E. Visser, Abu Shahed Md Zahed, Md Anwar Husain, Khan Mashrequl Alam, Pravat Chandra Barua, Mahtabuddin Hassan, Md Abu Tayab, Arjen M. Dondorp, Tom van der Poll
A 28-day, randomized, double-blind, placebo-controlled, parallel group study of nebulized revefenacin in patients with chronic obstructive pulmonary disease
Krishna K. Pudi, Chris N. Barnes, Edmund J. Moran, Brett Haumann, Edward Kerwin
Asthma-COPD overlap is not a homogeneous disorder: further supporting data
Luis Pérez-de-Llano, Borja G. Cosio, Amanda Iglesias, Natividad de las Cuevas, Juan Jose Soler-Cataluña, Jose Luis Izquierdo, Jose Luis López-Campos, Carmen Calero, Vicente Plaza, Marc Miravitlles, Alfons Torrego, Eva Martínez Moragón, Joan B. Soriano, Antolin Lopez Viña, Irina Bobolea
Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 study
Jacob A. Winther, Jon Brynildsen, Arne Didrik Høiseth, Heidi Strand, Ivar Følling, Geir Christensen, Ståle Nygård, Helge Røsjø, Torbjørn Omland
Ghrelin therapy improves lung and cardiovascular function in experimental emphysema
Nazareth de Novaes Rocha, Milena Vasconcellos de Oliveira, Cássia Lisboa Braga, Gabriela Guimarães, Lígia de Albuquerque Maia, Gisele de Araújo Padilha, Johnatas Dutra Silva, Christina Maeda Takiya, Vera Luiza Capelozzi, Pedro Leme Silva, Patricia Rieken Macedo Rocco
Endobronchial one-way valves for treatment of persistent air leaks: a systematic review
Mei Ding, Ya-dong Gao, Xian-Tao Zeng, Yi Guo, Jiong Yang
Changes in vasoactive pathways in congenital diaphragmatic hernia associated pulmonary hypertension explain unresponsiveness to pharmacotherapy
Daphne S. Mous, Marjon J. Buscop-van Kempen, Rene M. H. Wijnen, Dick Tibboel, Robbert J. Rottier
RNA-sequencing analysis of lung primary fibroblast response to eosinophil-degranulation products predicts downstream effects on inflammation, tissue remodeling and lipid metabolism
Stephane Esnault, Ksenija Bernau, Elizabeth E. Torr, Yury A. Bochkov, Nizar N. Jarjour, Nathan Sandbo
Vitamin K deficiency: the linking pin between COPD and cardiovascular diseases?
Ianthe Piscaer, Emiel F. M. Wouters, Cees Vermeer, Wim Janssens, Frits M. E. Franssen, Rob Janssen
Novel insights in cough and breathing patterns of patients with idiopathic pulmonary fibrosis performing repeated 24-hour-respiratory polygraphies
Anke Schertel, Manuela Funke-Chambour, Thomas Geiser, Anne-Kathrin Brill
Virus-triggered exacerbation in allergic asthmatic children: neutrophilic airway inflammation and alteration of virus sensors characterize a subgroup of patients
Antoine Deschildre, Muriel Pichavant, Ilka Engelmann, Carole Langlois, Elodie Drumez, Guillaume Pouessel, Sophie Boileau, David Romero-Cubero, Irina Decleyre-Badiu, Anny Dewilde, Didier Hober, Véronique Néve, Caroline Thumerelle, Stéphanie Lejeune, Clémence Mordacq, Philippe Gosset
The potential of interleukin-37 as an effective therapeutic agent in asthma
Lina Zhang, Jie Zhang, Peng Gao
Electronic cigarette vapor alters the lateral structure but not tensiometric properties of calf lung surfactant
Rebecca J. Przybyla, Jason Wright, Rajan Parthiban, Saeed Nazemidashtarjandi, Savas Kaya, Amir M. Farnoud
Reduced suppressive effect of β2-adrenoceptor agonist on fibrocyte function in severe asthma
Chun-Yu Lo, Charalambos Michaeloudes, Pankaj K. Bhavsar, Chien-Da Huang, Po-Jui Chang, Chun-Hua Wang, Han-Pin Kuo, Kian Fan Chung
A 3D epithelial–mesenchymal co-culture model of human bronchial tissue recapitulates multiple features of airway tissue remodeling by TGF-β1 treatment
Shinkichi Ishikawa, Kanae Ishimori, Shigeaki Ito
Efficacy and safety of tiotropium and olodaterol in COPD: a systematic review and meta-analysis
Marc Miravitlles, Gerard Urrutia, Alexander G. Mathioudakis, Julio Ancochea
Deficiency of innate-like T lymphocytes in chronic obstructive pulmonary disease
Mariann Szabó, Veronika Sárosi, Zoltán Balikó, Kornélia Bodó, Nelli Farkas, Tímea Berki, Péter Engelmann
A proposal for the withdrawal of inhaled corticosteroids in the clinical practice of chronic obstructive pulmonary disease
Marc Miravitlles, Borja G. Cosío, Aurelio Arnedillo, Myriam Calle, Bernardino Alcázar-Navarrete, Cruz González, Cristóbal Esteban, Juan Antonio Trigueros, José Miguel Rodríguez González-Moro, José Antonio Quintano Jiménez, Adolfo Baloira
Roles of Bronchopulmonary C-fibers in airway Hyperresponsiveness and airway remodeling induced by house dust mite
Zhimei Yang, Jianguo Zhuang, Lei Zhao, Xiuping Gao, Zhengxiu Luo, Enmei Liu, Fadi Xu, Zhou Fu
Variability in adherence to clinical practice guidelines and recommendations in COPD outpatients: a multi-level, cross-sectional analysis of the EPOCONSUL study
Myriam Calle Rubio, José Luis López-Campos, Juan J. Soler-Cataluña, Bernardino Alcázar Navarrete, Joan B. Soriano, José Miguel Rodríguez González-Moro, Manuel E. Fuentes Ferrer, Juan Luis Rodríguez Hermosa, Jose Luis Rojas Box, Jose Domingo Garcia Jimenez, Adolfo Domenech del Rio, Ana Muñoz, Antonia Soto Venegas, Aurelio Arnedillo Muñoz, Agustín Valido Morales, Jose Velasco Garrido, Carlos Rueda Ríos, Macarena Arroyo Varela, Francisco Ortega Ruiz, Eduardo Marquez Martin, Carmen Calero Acuña, Francisco Luis Garcia Gil, Joaquin Carlos Costan Galicia, Ana Boldova Loscertales, Cristina Martinez González, Rosirys Guzman Taveras, Juan Luis De la Torre Alvaro, Mª. Jesus Avilés Ingles, Rubén Andújar Espinosa, Juan Manuel Palmero Tejera, Juan Marco Figueira Conçalves, Ramon Agüero Balbín, Carlos Amado Diago, Beatriz Abascal Bolado, Juan Luis Garcia Rivero, Marcelle Cohen Escovar, Francisco Javier Callejas González, Angel Ortega Gonzalez, Rosario Vargas Gonzalez, Encarnación López Gabaldón, Raul Hidalgo Carvajal, Elena Bollo de Miguel, Silvia Fernández Huerga, Ana Pueyo Bastida, Jesus R. Hernández Hernández, Ruth Garcia García, Miguel Barrueco Ferrero, Marco López Zuibizarreta, E. Consuelo Fernández, David De la Rosa Carrillo, Jordi Esplugas Abós, Noelia Pablos Mateos, Elena De Miguel Campos, Pablo Rubinstein, Hernán Abraham Manrique Chávez, Miriam Barrecheguren, Carmen Aguar Benito, Pablo Catalán Serra, Eusebi Chiner Vives, Juan Antonio Royo Prats, Cristina Sabater Abad, Esther Verdejo Mengual, Eva Martínez-Moragon, Francisca Lourdes Marquez Perez, Alberto Fernandez Villar, Cristina Represas Represas, Ana Priegue Carrera, Marina Blanco Aparicio, Pedro Jorge Marcos Rodriguez, Federico Gonzalo Fiorentino, Mª. Magdalena Pan Naranjo, Antonia Fuster Gomila, German Peces Barba, Felipe Villar Alvarez, Carlos Jose Álvarez Martinez, Juan Luis Rodriguez Hermosa, J. L. Álvarez Sala-Walther, Juan Rigüal Bobillo, Gianna Vargas Centanaro, José Andrés García Romero de Tejada, Javier Jareño, Sergio Campos Tellez, Raul Galera Martinez, Rosa Mar Gómez Punter, Emma Vázquez Espinosa, Esther Alonso Peces, Juan Manuel Diez Piña, Raquel Pérez Rojo, Luis Puente Maestu, Julia Garcia de Pedro, Soledad Alonso Viteri, Maria Hernandez Bonaga, Maria Milagros Iriberri Pascual, Myriam Aburto Barrenechea, Sophe Garcia Fuika, Patricia Sobradillo Ecenarro
Autonomic nervous system involvement in pulmonary arterial hypertension
Mylène Vaillancourt, Pamela Chia, Shervin Sarji, Jason Nguyen, Nir Hoftman, Gregoire Ruffenach, Mansoureh Eghbali, Aman Mahajan, Soban Umar
Dose selection for glycopyrrolate/eFlow® phase III clinical studies: results from GOLDEN (Glycopyrrolate for Obstructive Lung Disease via Electronic Nebulizer) phase II dose-finding studies
James F. Donohue, Thomas Goodin, Robert Tosiello, Alistair Wheeler
Corticosteroid plus β2-agonist in a single inhaler as reliever therapy in intermittent and mild asthma: a proof-of-concept systematic review and meta-analysis
Gang Wang, Xin Zhang, Hong Ping Zhang, Lei Wang, De Ying Kang, Peter J. Barnes, Gang Wang
Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study
Sang Hoon Lee, Moo Suk Park, Song Yee Kim, Dong Soon Kim, Young Whan Kim, Man Pyo Chung, Soo Taek Uh, Choon Sik Park, Sung Woo Park, Sung Hwan Jeong, Yong Bum Park, Hong Lyeol Lee, Jong Wook Shin, Eun Joo Lee, Jin Hwa Lee, Yangin Jegal, Hyun Kyung Lee, Yong Hyun Kim, Jin Woo Song, Jong Sun Park
Pulmonary function, exhaled nitric oxide and symptoms in asthma patients with obesity: a cross-sectional study
Marise J. Kasteleyn, Tobias N. Bonten, Renée de Mutsert, Willemien Thijs, Pieter S. Hiemstra, Saskia le Cessie, Frits R. Rosendaal, Niels H. Chavannes, Christian Taube
Indacaterol/glycopyrronium is cost-effective compared to salmeterol/fluticasone in COPD: FLAME-based modelling in a Swedish population
Leif Bjermer, Job F. M. van Boven, Madlaina Costa-Scharplatz, Dorothy L. Keininger, Florian S. Gutzwiller, Karin Lisspers, Ronan Mahon, Petter Olsson, Nicolas Roche
Neutrophil extracellular traps are downregulated by glucocorticosteroids in lungs in an equine model of asthma
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