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Zeitschrift

Respiratory Research

Respiratory Research 1/2017

Ausgabe 1/2017

Inhaltsverzeichnis ( 218 Artikel )

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Atrial natriuretic peptide protects against bleomycin-induced pulmonary fibrosis via vascular endothelial cells in mice

ANP for pulmonary fibrosis
Atsuko Okamoto, Takashi Nojiri, Kazuhisa Konishi, Takeshi Tokudome, Koichi Miura, Hiroshi Hosoda, Jun Hino, Mikiya Miyazato, Yohkoh Kyomoto, Kazuhisa Asai, Kazuto Hirata, Kenji Kangawa

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Cigarette smoke destabilizes NLRP3 protein by promoting its ubiquitination

SeungHye Han, Jacob A. Jerome, Alyssa D. Gregory, Rama K. Mallampalli

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Gene profile of fibroblasts identify relation of CCL8 with idiopathic pulmonary fibrosis

Jong-Uk Lee, Hyun Sub Cheong, Eun-Young Shim, Da-Jeong Bae, Hun Soo Chang, Soo-Taek Uh, Young Hoon Kim, Jong-Sook Park, Bora Lee, Hyoung Doo Shin, Choon-Sik Park

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Bioinformatic analysis of microRNA and mRNA Regulation in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease

Xiaomin Dang, Xiaoyan Qu, Weijia Wang, Chongbing Liao, Ying Li, Xiaojin Zhang, Dan Xu, Carolyn J. Baglole, Dong Shang, Ying Chang

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

Eligibility of real-life patients with COPD for inclusion in RCTs: a commentary

Salvatore Battaglia, Nicola Scichilone

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The main rhinovirus respiratory tract adhesion site (ICAM-1) is upregulated in smokers and patients with chronic airflow limitation (CAL)

Shakti Dhar Shukla, Malik Quasir Mahmood, Steven Weston, Roger Latham, Hans Konrad Muller, Sukhwinder Singh Sohal, Eugene Haydn Walters

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Effect of active vitamin D3 on VEGF-induced ADAM33 expression and proliferation in human airway smooth muscle cells: implications for asthma treatment

Sung-Ho Kim, Qing-Mei Pei, Ping Jiang, Min Yang, Xue-Jiao Qian, Jiang-Bo Liu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A randomized, seven-day study to assess the efficacy and safety of a glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler using novel Co-Suspension™ Delivery Technology in patients with moderate-to-very severe chronic obstructive pulmonary disease

Colin Reisner, Leonardo M. Fabbri, Edward M. Kerwin, Charles Fogarty, Selwyn Spangenthal, Klaus F. Rabe, Gary T. Ferguson, Fernando J. Martinez, James F. Donohue, Patrick Darken, Earl St. Rose, Chad Orevillo, Shannon Strom, Tracy Fischer, Michael Golden, Sarvajna Dwivedi

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Non-linear parameters of specific resistance loops to characterise obstructive airways diseases

Marko Topalovic, Vasileios Exadaktylos, Thierry Troosters, Geert Celis, Jean-Marie Aerts, Wim Janssens

01.12.2017 | Research | Ausgabe 1/2017 Open Access

End-stage cystic fibrosis lung disease is characterised by a diverse inflammatory pattern: an immunohistochemical analysis

Elise J. Lammertyn, Elly Vandermeulen, Hannelore Bellon, Stephanie Everaerts, Stijn E. Verleden, Kathleen Van Den Eynde, Ken R. Bracke, Guy G. Brusselle, Pieter C. Goeminne, Erik K. Verbeken, Bart M. Vanaudenaerde, Lieven J. Dupont

01.12.2017 | Research | Ausgabe 1/2017 Open Access

No convincing association between genetic markers and respiratory symptoms: results of a GWA study

Xiang Zeng, Judith M. Vonk, Kim de Jong, Xijin Xu, Xia Huo, H. Marike Boezen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Whole Transcriptome Analysis of Pre-invasive and Invasive Early Squamous Lung Carcinoma in Archival Laser Microdissected Samples

Andre Koper, Leo A. H. Zeef, Leena Joseph, Keith Kerr, John Gosney, Mark A. Lindsay, Richard Booton

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Indacaterol and glycopyrronium versus indacaterol on body plethysmography measurements in COPD—a randomised controlled study

Joerg Salomon, Daiana Stolz, Guido Domenighetti, Jean-Georges Frey, Alexander J. Turk, Andrea Azzola, Thomas Sigrist, Jean-William Fitting, Ulrich Schmidt, Thomas Geiser, Corinne Wild, Konstantinos Kostikas, Andreas Clemens, Martin Brutsche

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort

Kathrin Kahnert, Tanja Lucke, Frank Biertz, Andreas Lechner, Henrik Watz, Peter Alter, Robert Bals, Jürgen Behr, Rolf Holle, Rudolf M. Huber, Stefan Karrasch, Beate Stubbe, Margarethe Wacker, Sandra Söhler, Emiel F. M. Wouters, Claus Vogelmeier, Rudolf A. Jörres, for the COSYCONET study group

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter

Sridhar Jaligama, Jordy Saravia, Dahui You, Nikki Yadav, Greg I. Lee, Bishwas Shrestha, Stephania A. Cormier

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Comparing accelerometer, pedometer and a questionnaire for measuring physical activity in bronchiectasis: a validity and feasibility study

B. O’Neill, S. M. McDonough, J. J. Wilson, I. Bradbury, K. Hayes, A. Kirk, L. Kent, D. Cosgrove, J. M. Bradley, M. A. Tully

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Vascular function in asthmatic children and adolescents

Leonardo Silva Augusto, Grazielle Caroline Silva, José Felippe Pinho, Rosária Dias Aires, Virgínia Soares Lemos, Lidiana Fátima Correa Ramalho, Nulma Souto Jentzsch, Maria Glória Rodrigues-Machado

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The St. George’s Respiratory Questionnaire as a prognostic factor in IPF

Taiki Furukawa, Hiroyuki Taniguchi, Masahiko Ando, Yasuhiro Kondoh, Kensuke Kataoka, Osamu Nishiyama, Takeshi Johkoh, Junya Fukuoka, Koji Sakamoto, Yoshinori Hasegawa

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Is aclidinium alone or combined with a LABA a rational choice for symptomatic COPD patients?

F. Blasi, G. W. Canonica, M. Miravitlles

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

Clara E. Green, Alice M. Turner

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Association of stem cell factor gene expression with severity and atopic state in patients with bronchial asthma

Safaa I. Tayel, Sally M. El-Hefnway, Eman M. Abd El Gayed, Gehan A. Abdelaal

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD

Asger Reinstrup Bihlet, Morten Asser Karsdal, Jannie Marie Bülow Sand, Diana Julie Leeming, Mustimbo Roberts, Wendy White, Russell Bowler

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma

Utako Fujii, Nobuaki Miyahara, Akihiko Taniguchi, Naohiro Oda, Daisuke Morichika, Etsuko Murakami, Hikari Nakayama, Koichi Waseda, Mikio Kataoka, Hiroki Kakuta, Mitsune Tanimoto, Arihiko Kanehiro

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Subtypes of asthma based on asthma control and severity: a latent class analysis

Elina M. S. Mäkikyrö, Maritta S. Jaakkola, Jouni J. K. Jaakkola

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Admission levels of asymmetric and symmetric dimethylarginine predict long-term outcome in patients with community-acquired pneumonia

Alaadin Vögeli, Manuel Ottiger, Marc A. Meier, Christian Steuer, Luca Bernasconi, Prasad Kulkarni, Andreas Huber, Mirjam Christ-Crain, Christoph Henzen, Claus Hoess, Robert Thomann, Werner Zimmerli, Beat Mueller, Philipp Schuetz

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Pharmacological investigation on the anti-oxidant and anti-inflammatory activity of N-acetylcysteine in an ex vivo model of COPD exacerbation

Mario Cazzola, Luigino Calzetta, Francesco Facciolo, Paola Rogliani, Maria Gabriella Matera

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Diesel exhaust alters the response of cultured primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD) to non-typeable Haemophilus influenzae

Maria C. Zarcone, Annemarie van Schadewijk, Evert Duistermaat, Pieter S. Hiemstra, Ingeborg M. Kooter

01.12.2017 | Research | Ausgabe 1/2017 Open Access

High throughput 16SrRNA gene sequencing reveals the correlation between Propionibacterium acnes and sarcoidosis

Meng-Meng Zhao, Shan-Shan Du, Qiu-Hong Li, Tao Chen, Hui Qiu, Qin Wu, Shan-Shan Chen, Ying Zhou, Yuan Zhang, Yang Hu, Yi-Liang Su, Li Shen, Fen Zhang, Dong Weng, Hui-Ping Li

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Changes in the respiratory microbiome during acute exacerbations of idiopathic pulmonary fibrosis

Philip L. Molyneaux, Michael J Cox, Athol U. Wells, Ho Cheol Kim, Wonjun Ji, William O. C. Cookson, Miriam F. Moffatt, Dong Soon Kim, Toby M. Maher

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The role of serum procalcitonin in establishing the diagnosis and prognosis of pleural infection

Giles Dixon, Adriana Lama-Lopez, Oliver J. Bintcliffe, Anna J. Morley, Clare E. Hooper, Nick A. Maskell

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Associations between chronic comorbidity and exacerbation risk in primary care patients with COPD

Janine A. M. Westerik, Esther I. Metting, Job F. M. van Boven, Waling Tiersma, Janwillem W. H. Kocks, Tjard R. Schermer

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Imatinib relaxes the pulmonary venous bed of guinea pigs

Nina A. Maihöfer, Said Suleiman, Daniela Dreymüller, Paul W. Manley, Rolf Rossaint, Stefan Uhlig, Christian Martin, Annette D. Rieg

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Acute effects of nicotine-free and flavour-free electronic cigarette use on lung functions in healthy and asthmatic individuals

Marie-Ève Boulay, Cyndi Henry, Ynuk Bossé, Louis-Philippe Boulet, Mathieu C. Morissette

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Collaboration between specialties for respiratory allergies in the International Classification of Diseases (ICD)-11

Luciana Kase Tanno, Moises Calderon, Jeffrey F. Linzer Sr, Robert J.G. Chalmers, Pascal Demoly, on behalf of the Joint Allergy Academies

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Is aclidinium alone or combined with a LABA a rational choice for symptomatic COPD patients?

F. Blasi, G. W. Canonica, M. Miravitlles

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Malondialdehyde-acetaldehyde (MAA) adducted surfactant protein induced lung inflammation is mediated through scavenger receptor a (SR-A1)

Muna Sapkota, Jane M. DeVasure, Kusum K. Kharbanda, Todd A. Wyatt

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Clarithromycin attenuates IL-13–induced periostin production in human lung fibroblasts

Kosaku Komiya, Shoichiro Ohta, Kazuhiko Arima, Masahiro Ogawa, Shoichi Suzuki, Yasutaka Mitamura, Satoshi Nunomura, Yasuhiro Nanri, Tomohito Yoshihara, Atsushi Kawaguchi, Jun-ichi Kadota, Bruce K. Rubin, Kenji Izuhara

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis

Yan Liu, Hong Xu, Yucong Geng, Dingjie Xu, Lijuan Zhang, Yi Yang, Zhongqiu Wei, Bonan Zhang, Shifeng Li, Xuemin Gao, Ruimin Wang, Xianghong Zhang, Darrell Brann, Fang Yang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Cluster analysis of sputum cytokine-high profiles reveals diversity in T(h)2-high asthma patients

Sven F. Seys, Hans Scheers, Paul Van den Brande, Gudrun Marijsse, Ellen Dilissen, Annelies Van Den Bergh, Pieter C. Goeminne, Peter W Hellings, Jan L. Ceuppens, Lieven J Dupont, Dominique M. A. Bullens

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Dual polarization of human alveolar macrophages progressively increases with smoking and COPD severity

Erica Bazzan, Graziella Turato, Mariaenrica Tinè, Claudia M. Radu, Elisabetta Balestro, Chiara Rigobello, Davide Biondini, Marco Schiavon, Francesca Lunardi, Simonetta Baraldo, Federico Rea, Paolo Simioni, Fiorella Calabrese, Marina Saetta, Manuel G. Cosio

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation

Amanda B. Chai, Alaina J. Ammit, Ingrid C. Gelissen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease

Carlos H. Martinez, Christine M. Freeman, Joshua D. Nelson, Susan Murray, Xin Wang, Matthew J. Budoff, Mark T. Dransfield, John E. Hokanson, Ella A. Kazerooni, Gregory L. Kinney, Elizabeth A. Regan, J. Michael Wells, Fernando J. Martinez, MeiLan K. Han, Jeffrey L. Curtis, for the COPDGene Investigators

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Low tissue levels of miR-125b predict malignancy in solitary fibrous tumors of the pleura

Matthias Brock, Selma Hottinger, Matthias Diebold, Alex Soltermann, Wolfram Jochum, Malcolm Kohler, Lars C. Huber, Daniel P. Franzen

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

The relationship between the Leicester cough questionnaire, eosinophilic airway inflammation and asthma patient related outcomes in severe adult asthma

Sushiladevi Natarajan, Robert C. Free, Peter Bradding, Lorcan McGarvey, Salman Siddiqui

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Densitometric and local histogram based analysis of computed tomography images in patients with idiopathic pulmonary fibrosis

Samuel Y. Ash, Rola Harmouche, Diego Lassala Lopez Vallejo, Julian A. Villalba, Kris Ostridge, River Gunville, Carolyn E. Come, Jorge Onieva Onieva, James C. Ross, Gary M. Hunninghake, Souheil Y. El-Chemaly, Tracy J. Doyle, Pietro Nardelli, Gonzalo V. Sanchez-Ferrero, Hilary J. Goldberg, Ivan O. Rosas, Raul San Jose Estepar, George R. Washko

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes

Yukiko Namba, Shinsaku Togo, Miniwan Tulafu, Kotaro Kadoya, Kumi Yoneda Nagahama, Hikari Taka, Naoko Kaga, Akira Orimo, Xiangde Liu, Kazuhisa Takahashi

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Chronic hypoxia aggravates monocrotaline-induced pulmonary arterial hypertension: a rodent relevant model to the human severe form of the disease

Florence Coste, Christelle Guibert, Julie Magat, Emma Abell, Fanny Vaillant, Mathilde Dubois, Arnaud Courtois, Philippe Diolez, Bruno Quesson, Roger Marthan, Jean-Pierre Savineau, Bernard Muller, Véronique Freund-Michel

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF

Abraham B. Roos, Michiko Mori, Harpreet K. Gura, Axel Lorentz, Leif Bjermer, Hans Jürgen Hoffmann, Jonas S. Erjefält, Martin R. Stampfli

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Interaction of CD14 haplotypes and soluble CD14 on pulmonary function in agricultural workers

Tricia D. LeVan, Lynette M. Smith, Art J. Heires, Ted R. Mikuls, Jane L. Meza, Lisa A. Weissenburger-Moser, Debra J. Romberger

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Cigarette smoke challenges bone marrow mesenchymal stem cell capacities in guinea pig

Olga Tura-Ceide, Borja Lobo, Tanja Paul, Raquel Puig-Pey, Núria Coll-Bonfill, Jéssica García-Lucio, Valérie Smolders, Isabel Blanco, Joan A. Barberà, Víctor I. Peinado

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Caffeine modulates glucocorticoid-induced expression of CTGF in lung epithelial cells and fibroblasts

Markus Fehrholz, Kirsten Glaser, Christian P. Speer, Silvia Seidenspinner, Barbara Ottensmeier, Steffen Kunzmann

01.12.2017 | Research | Ausgabe 1/2017 Open Access

ABCB1 and ABCG2 drug transporters are differentially expressed in non-small cell lung cancers (NSCLC) and expression is modified by cisplatin treatment via altered Wnt signaling

M. Vesel, J. Rapp, D. Feller, E. Kiss, L. Jaromi, M. Meggyes, G. Miskei, B. Duga, G. Smuk, T. Laszlo, I. Karner, J.E. Pongracz

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Altered mTOR and Beclin-1 mediated autophagic activation during right ventricular remodeling in monocrotaline-induced pulmonary hypertension

Yan Deng, Weifeng Wu, Shenglan Guo, Yuming Chen, Chang Liu, Xingcui Gao, Bin Wei

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration

Dale D. Tang, Brennan D. Gerlach

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Characterisation of a murine model of the late asthmatic response

Katie Baker, Kristof Raemdonck, Robert J. Snelgrove, Maria G. Belvisi, Mark A. Birrell

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Ku80 correlates with neoadjuvant chemotherapy resistance in human lung adenocarcinoma, but reduces cisplatin/pemetrexed-induced apoptosis in A549 cells

Bin Shang, Yang Jia, Gang Chen, Zhou Wang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Determining the presence of asthma-related molecules and salivary contamination in exhaled breath condensate

Charmion Cruickshank-Quinn, Michael Armstrong, Roger Powell, Joe Gomez, Marc Elie, Nichole Reisdorph

01.12.2017 | Review | Ausgabe 1/2017 Open Access

CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives

Lourdes Cortes-Dericks, Ralph Alexander Schmid

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Telomere shortening and accelerated aging in COPD: findings from the BODE cohort

Elizabeth Córdoba-Lanús, Sara Cazorla-Rivero, Adriana Espinoza-Jiménez, Juan P. de-Torres, María J. Pajares, Armando Aguirre-Jaime, Bartolomé Celli, Ciro Casanova

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Costs and health-related quality of life in Alpha-1-Antitrypsin Deficient COPD patients

Florian M. Karl, Rolf Holle, Robert Bals, Timm Greulich, Rudolf A. Jörres, Annika Karch, Armin Koch, Stefan Karrasch, Reiner Leidl, Holger Schulz, Claus Vogelmeier, Margarethe E. Wacker, for the COSYCONET Study Group

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Mechanisms of corticosteroid insensitivity in COPD alveolar macrophages exposed to NTHi

Rana M. Khalaf, Simon R. Lea, Hannah J. Metcalfe, Dave Singh

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Computational modeling of airway instability and collapse in tracheomalacia

Scott J. Hollister, Maximilian P. Hollister, Sebastian K. Hollister

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children

Kyung Hwa Jung, David Torrone, Stephanie Lovinsky-Desir, Matthew Perzanowski, Joshua Bautista, Jacqueline R. Jezioro, Lori Hoepner, Jamie Ross, Frederica P. Perera, Steven N. Chillrud, Rachel L. Miller

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Interleukin-6 displays lung anti-inflammatory properties and exerts protective hemodynamic effects in a double-hit murine acute lung injury

Guillaume Voiriot, Keyvan Razazi, Valérie Amsellem, Jeanne Tran Van Nhieu, Shariq Abid, Serge Adnot, Armand Mekontso Dessap, Bernard Maitre

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Protein antigen of bird-related hypersensitivity pneumonitis in pigeon serum and dropping

Tsuyoshi Shirai, Haruhiko Furusawa, Asuka Furukawa, Yuki Ishige, Keisuke Uchida, Yasunari Miyazaki, Yoshinobu Eishi, Naohiko Inase

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Monitoring mandibular movements to detect Cheyne-Stokes Breathing

Jean-Benoît Martinot, Jean-Christian Borel, Nhat-Nam Le-Dong, Hervé Jean-Pierre Guénard, Valerie Cuthbert, Philip E. Silkoff, David Gozal, Jean-Louis Pepin

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Understanding the impact of symptoms on the burden of COPD

Marc Miravitlles, Anna Ribera

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Outcomes after early and delayed rehabilitation for exacerbation of chronic obstructive pulmonary disease: a nationwide retrospective cohort study in Japan

Hiroki Matsui, Taisuke Jo, Kiyohide Fushimi, Hideo Yasunaga

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung

Aoi Kuroda, Ahmed E. Hegab, Gao Jingtao, Shuji Yamashita, Nobuyuki Hizawa, Tohru Sakamoto, Hideyasu Yamada, Satoshi Suzuki, Makoto Ishii, Ho Namkoong, Takanori Asakura, Mari Ozaki, Hiroyuki Yasuda, Junko Hamamoto, Shizuko Kagawa, Kenzo Soejima, Tomoko Betsuyaku

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Exogenous gene transfer of Rab38 small GTPase ameliorates aberrant lung surfactant homeostasis in Ruby rats

Kazuhiro Osanai, Keisuke Nakase, Takashi Sakuma, Kazuaki Nishiki, Masafumi Nojiri, Ryo Kato, Masatoshi Saito, Yuki Fujimoto, Shiro Mizuno, Hirohisa Toga

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Targeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia/reperfusion in rats

Geng-Chin Wu, Wen-I Liao, Shu-Yu Wu, Hsin-Ping Pao, Shih-En Tang, Min-Hui Li, Kun-Lun Huang, Shi-Jye Chu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Network-based analysis reveals novel gene signatures in peripheral blood of patients with chronic obstructive pulmonary disease

Ma’en Obeidat, Yunlong Nie, Virginia Chen, Casey P. Shannon, Anand Kumar Andiappan, Bernett Lee, Olaf Rotzschke, Peter J. Castaldi, Craig P. Hersh, Nick Fishbane, Raymond T. Ng, Bruce McManus, Bruce E. Miller, Stephen Rennard, Peter D. Paré, Don D. Sin

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Clinical characteristics of eosinophilic COPD versus COPD patients with a history of asthma

Umme Kolsum, Arjun Ravi, Paul Hitchen, Satyanarayana Maddi, Thomas Southworth, Dave Singh

01.12.2017 | Research | Ausgabe 1/2017 Open Access

[18F]FDG PET/CT predicts progression-free survival in patients with idiopathic pulmonary fibrosis

Aurélien Justet, Astrid Laurent-Bellue, Gabriel Thabut, Arnaud Dieudonné, Marie-Pierre Debray, Raphael Borie, Michel Aubier, Rachida Lebtahi, Bruno Crestani

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Differential regulation of muscle protein turnover in response to emphysema and acute pulmonary inflammation

Judith J. M. Ceelen, Annemie M. W. J. Schols, Stefan J. van Hoof, Chiel C. de Theije, Frank Verhaegen, Ramon C. J. Langen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Impact of High-Intensity-NIV on the heart in stable COPD: a randomised cross-over pilot study

Marieke Leontine Duiverman, Petra Maagh, Friederike Sophie Magnet, Claudia Schmoor, Maria Paola Arellano-Maric, Axel Meissner, Jan Hendrik Storre, Peter Jan Wijkstra, Wolfram Windisch, Jens Callegari

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease

Julie Weidner, Linnea Jarenbäck, Kim de Jong, Judith M. Vonk, Maarten van den Berge, Corry-Anke Brandsma, H. Marike Boezen, Don Sin, Yohan Bossé, David Nickle, Jaro Ankerst, Leif Bjermer, Dirkje S. Postma, Alen Faiz, Ellen Tufvesson

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Secretion of the endoplasmic reticulum stress protein, GRP78, into the BALF is increased in cigarette smokers

Mark O. Aksoy, Victor Kim, William D. Cornwell, Thomas J. Rogers, Beata Kosmider, Karim Bahmed, Carlos Barrero, Salim Merali, Neena Shetty, Steven G. Kelsen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

β2 adrenergic agonist suppresses eosinophil-induced epithelial-to-mesenchymal transition of bronchial epithelial cells

Keigo Kainuma, Tetsu Kobayashi, Corina N. D’Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Kota Nishihama, Hajime Fujimoto, Yu Kuwabara, Koa Hosoki, Mizuho Nagao, Takao Fujisawa, Esteban C. Gabazza

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts

Sze-Kwan Lam, Yuan-Yuan Li, Shi Xu, Leanne Lee Leung, Kin-Pong U, Yan-Fang Zheng, Paul Ning-Man Cheng, James Chung-Man Ho

01.12.2017 | Research | Ausgabe 1/2017 Open Access

2D-DIGE proteomic analysis of vastus lateralis from COPD patients with low and normal fat free mass index and healthy controls

Ramzi Lakhdar, Ellen M. Drost, William MacNee, Ricardo Bastos, Roberto A. Rabinovich

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium

Lynne A. Murray, Rebecca Dunmore, Ana Camelo, Carla A. Da Silva, Malin J. Gustavsson, David M. Habiel, Tillie L Hackett, Cory M. Hogaboam, Matthew A. Sleeman, Darryl A. Knight

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

Augmenting autophagy for prognosis based intervention of COPD-pathophysiology

Manish Bodas, Neeraj Vij

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Rhinovirus C targets ciliated airway epithelial cells

Theodor F. Griggs, Yury A. Bochkov, Sarmila Basnet, Thomas R. Pasic, Rebecca A. Brockman-Schneider, Ann C. Palmenberg, James E. Gern

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Pulmonary arterial wall disease in COPD and interstitial lung diseases candidates for lung transplantation

Enric Domingo, Juan C. Grignola, Rio Aguilar, Manuel López Messeguer, Antonio Roman

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Rescue medication use as a patient-reported outcome in COPD: a systematic review and regression analysis

Yogesh Suresh Punekar, Sheetal Sharma, Ankit Pahwa, Jitender Takyar, Ian Naya, Paul W. Jones

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Selective gene expression analysis of the neuroepithelial body microenvironment in postnatal lungs with special interest for potential stem cell characteristics

Line Verckist, Robrecht Lembrechts, Sofie Thys, Isabel Pintelon, Jean-Pierre Timmermans, Inge Brouns, Dirk Adriaensen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Blood and sputum eosinophils in COPD; relationship with bacterial load

Umme Kolsum, Gavin C. Donaldson, Richa Singh, Bethan L. Barker, Vandana Gupta, Leena George, Adam J. Webb, Sarah Thurston, Anthony J Brookes, Timothy D. McHugh, Jadwiga A. Wedzicha, Christopher E. Brightling, Dave Singh

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Role of heparin in pulmonary cell populations in an in-vitro model of acute lung injury

Marta Camprubí–Rimblas, Raquel Guillamat-Prats, Thomas Lebouvier, Josep Bringué, Laura Chimenti, Manuela Iglesias, Carme Obiols, Jessica Tijero, Lluís Blanch, Antonio Artigas

01.12.2017 | Research | Ausgabe 1/2017 Open Access

COPD monocytes demonstrate impaired migratory ability

Arjun K Ravi, Jonathan Plumb, Rosemary Gaskell, Sarah Mason, Caroline S Broome, George Booth, Matthew Catley, Jørgen Vestbo, Dave Singh

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Genome-wide DNA methylation analysis in lung fibroblasts co-cultured with silica-exposed alveolar macrophages

Juan Li, Wu Yao, Lin Zhang, Lei Bao, Huiting Chen, Di Wang, Zhongzheng Yue, Yiping Li, Miao Zhang, Changfu Hao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Attenuating immune pathology using a microbial-based intervention in a mouse model of cigarette smoke-induced lung inflammation

Mark Bazett, Agnieszka Biala, Ryan D. Huff, Matthew R. Zeglinksi, Philip M. Hansbro, Momir Bosiljcic, Hal Gunn, Shirin Kalyan, Jeremy A. Hirota

01.12.2017 | Research | Ausgabe 1/2017 Open Access

An association between pulmonary Mycobacterium avium-intracellulare complex infections and biomarkers of Th2-type inflammation

Paul E. Pfeffer, Susan Hopkins, Ian Cropley, David M. Lowe, Marc Lipman

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Immunohistology and remodeling in fatal pediatric and adolescent asthma

Kristiina Malmström, Jouko Lohi, Antti Sajantila, Frode L. Jahnsen, Merja Kajosaari, Seppo Sarna, Mika J. Mäkelä

01.12.2017 | Research | Ausgabe 1/2017 Open Access

High-resolution mucociliary transport measurement in live excised large animal trachea using synchrotron X-ray imaging

Martin Donnelley, Kaye S. Morgan, Maged Awadalla, Nigel R. Farrow, Chris Hall, David W. Parsons

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Lung function imaging methods in Cystic Fibrosis pulmonary disease

Magdalena Kołodziej, Michael J. de Veer, Marian Cholewa, Gary F. Egan, Bruce R. Thompson

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Genome-wide association study of subclinical interstitial lung disease in MESA

Ani Manichaikul, Xin-Qun Wang, Li Sun, Josée Dupuis, Alain C. Borczuk, Jennifer N. Nguyen, Ganesh Raghu, Eric A. Hoffman, Suna Onengut-Gumuscu, Emily A. Farber, Joel D. Kaufman, Dan Rabinowitz, Karen D. Hinckley Stukovsky, Steven M. Kawut, Gary M. Hunninghake, George R. Washko, George T. O’Connor, Stephen S. Rich, R. Graham Barr, David J. Lederer

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Infection-mediated asthma: etiology, mechanisms and treatment options, with focus on Chlamydia pneumoniae and macrolides

Wilmore C. Webley, David L. Hahn

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Reduced HDAC2 in skeletal muscle of COPD patients

Masako To, Elisabeth B. Swallow, Kenich Akashi, Kosuke Haruki, S Amanda Natanek, Michael I. Polkey, Kazuhiro Ito, Peter J. Barnes

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Proteomic profiling of peripheral blood neutrophils identifies two inflammatory phenotypes in stable COPD patients

Adèle Lo Tam Loi, Susan Hoonhorst, Corneli van Aalst, Jeroen Langereis, Vera Kamp, Simone Sluis-Eising, Nick ten Hacken, Jan-Willem Lammers, Leo Koenderman

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Endexpiratory lung volume measurement correlates with the ventilation/perfusion mismatch in lung injured pigs

Jens Kamuf, Andreas Garcia-Bardon, Bastian Duenges, Tanghua Liu, Antje Jahn-Eimermacher, Florian Heid, Matthias David, Erik K. Hartmann

01.12.2017 | Research | Ausgabe 1/2017 Open Access

In smokers, Sonic hedgehog modulates pulmonary endothelial function through vascular endothelial growth factor

Priscilla Henno, Stanislas Grassin-Delyle, Emeline Belle, Marion Brollo, Emmanuel Naline, Edouard Sage, Philippe Devillier, Dominique Israël-Biet

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Evaluation of two strategies for the interpretation of tumour markers in pleural effusions

Jaume Trapé, Francesc Sant, Josefina Franquesa, Jesús Montesinos, Anna Arnau, Maria Sala, Oscar Bernadich, Esperanza Martín, Damià Perich, Concha Pérez, Joan Lopez, Sandra Ros, Enrique Esteve, Rafael Pérez, Jordi Aligué, Gabriel Gurt, Silvia Catot, Montserrat Domenech, Joan Bosch, Josep Miquel Badal, Mariona Bonet, Rafael Molina, Josep Ordeig

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Sex-specific lung functional changes in adult mice exposed only to second-hand smoke in utero

Alexandra Noël, Rui Xiao, Zakia Perveen, Hasan Zaman, Viviana Le Donne, Arthur Penn

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Long-term clinical outcomes following treatment with alpha 1-proteinase inhibitor for COPD associated with alpha-1 antitrypsin deficiency: a look at the evidence

Franck F. Rahaghi, Marc Miravitlles

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Reduction in clinically important deterioration in chronic obstructive pulmonary disease with aclidinium/formoterol

Dave Singh, Anthony D. D’Urzo, Ferran Chuecos, Anna Muñoz, Esther Garcia Gil

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Which bronchodilator reversibility criteria can predict severe acute exacerbation in chronic obstructive pulmonary disease patients?

Junghyun Kim, Woo Jin Kim, Chang-Hoon Lee, Sang Haak Lee, Myung-Goo Lee, Kyeong-Cheol Shin, Kwang Ha Yoo, Ji-Hyun Lee, Seong Yong Lim, Ju Ock Na, Hun-Gyu Hwang, Yoonki Hong, Myoung Nam Lim, Chul-Gyu Yoo, Ki Suck Jung, Sang-Do Lee

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Electronic applications for the CFQ-R scoring

Andreas Ronit, Marco Gelpi, Jonathan Argentiero, Inger Mathiesen, Susanne D. Nielsen, Tanja Pressler, Alexandra L. Quittner

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori

Seung Won Ra, Marc A. Sze, Eun Chong Lee, Sheena Tam, Yeni Oh, Nick Fishbane, Gerard J. Criner, Prescott G. Woodruff, Stephen C. Lazarus, Richard Albert, John E. Connett, Meilan K. Han, Fernando J. Martinez, Shawn D. Aaron, Robert M. Reed, S. F. Paul Man, Don D. Sin, on behalf of the Canadian Respiratory Research Network

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Role of human rhinovirus in triggering human airway epithelial-mesenchymal transition

Danielle M. Minor, David Proud

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Extracellular heat shock protein 90α mediates HDM-induced bronchial epithelial barrier dysfunction by activating RhoA/MLC signaling

Hang-ming Dong, Yan-qing Le, Yan-hong Wang, Hai-jin Zhao, Chao-wen Huang, Ya-hui Hu, Li-shan Luo, Xuan Wan, Yi-lan Wei, Zi-qiang Chu, Wei Li, Shao-xi Cai

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Prediction of long-term clinical outcomes using simple functional exercise performance tests in patients with COPD: a 5-year prospective cohort study

Sarah Crook, Anja Frei, Gerben ter Riet, Milo A. Puhan

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Telomere shortening and accelerated aging in COPD: findings from the BODE cohort

Elizabeth Cordoba-Lanus, Sara Cazorla-Rivero, Adriana Espinoza-Jimenez, Juan P. de-Torres, María J. Pajares, Armando Aguirre-Jaime, Bartolomé Celli, Ciro Casanova

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy

Yusuke Kurita, Jun Araya, Shunsuke Minagawa, Hiromichi Hara, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Kazuya Tsubouchi, Nahoko Sato, Masahiro Yoshida, Kenji Kobayashi, Saburo Ito, Yu Fujita, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Yutaka Yoshii, Takeo Ishikawa, Takanori Numata, Yumi Kaneko, Hisatoshi Asano, Makoto Yamashita, Makoto Odaka, Toshiaki Morikawa, Katsutoshi Nakayama, Kazuyoshi Kuwano

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Nicotine stimulates collagen type I expression in lung via α7 nicotinic acetylcholine receptors

Glenn W. Vicary, Jeffrey D. Ritzenthaler, Tanmay S. Panchabhai, Edilson Torres-González, Jesse Roman

01.12.2017 | Research | Ausgabe 1/2017 Open Access

VEGF isoforms have differential effects on permeability of human pulmonary microvascular endothelial cells

Khadija Ourradi, Thomas Blythe, Caroline Jarrett, Shaney L. Barratt, Gavin I. Welsh, Ann B. Millar

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Multiple biomarkers predict disease severity, progression and mortality in COPD

Rachel L. Zemans, Sean Jacobson, Jason Keene, Katerina Kechris, Bruce E. Miller, Ruth Tal-Singer, Russell P. Bowler

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Hepatocyte growth factor produced in lung fibroblasts enhances non-small cell lung cancer cell survival and tumor progression

Nobuhiro Kanaji, Masanao Yokohira, Yuko Nakano-Narusawa, Naoki Watanabe, Katsumi Imaida, Norimitsu Kadowaki, Shuji Bandoh

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Human adipose-derived mesenchymal stem cells alleviate obliterative bronchiolitis in a murine model via IDO

Guoping Zheng, Guanguan Qiu, Menghua Ge, Jianping He, Lanfang Huang, Ping Chen, Wei Wang, Qi Xu, Yaoqin Hu, Qiang Shu, Jianguo Xu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses

Alice Guyard, Claire Danel, Nathalie Théou-Anton, Marie-Pierre Debray, Laure Gibault, Pierre Mordant, Yves Castier, Bruno Crestani, Gérard Zalcman, Hélène Blons, Aurélie Cazes

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Imatinib relaxes the pulmonary venous bed of guinea pigs

Nina A. Maihöfer, Said Suleiman, Daniela Dreymüller, Paul W. Manley, Rolf Rossaint, Stefan Uhlig, Christian Martin, Annette D. Rieg

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Fibroblast paracrine TNF-α signaling elevates integrin A5 expression in idiopathic pulmonary fibrosis (IPF)

Gali Epstein Shochet, Elizabetha Brook, Lilach Israeli-Shani, Evgeny Edelstein, David Shitrit

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Forced expiration measurements in mouse models of obstructive and restrictive lung diseases

Fien C. Devos, André Maaske, Annette Robichaud, Lore Pollaris, Sven Seys, Carolina Aznar Lopez, Erik Verbeken, Matthias Tenbusch, Rik Lories, Benoit Nemery, Peter HM Hoet, Jeroen AJ Vanoirbeek

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Effect of beta-blockers on exacerbation rate and lung function in chronic obstructive pulmonary disease (COPD)

Sean Duffy, Robert Marron, Helen Voelker, Richard Albert, John Connett, William Bailey, Richard Casaburi, J. Allen Cooper Jr., Jeffrey L. Curtis, Mark Dransfield, MeiLan K. Han, Barry Make, Nathaniel Marchetti, Fernando Martinez, Stephen Lazarus, Dennis Niewoehner, Paul D. Scanlon, Frank Sciurba, Steven Scharf, Robert M. Reed, George Washko, Prescott Woodruff, Charlene McEvoy, Shawn Aaron, Don Sin, Gerard J. Criner, the NIH COPD Clinical Research Network and the Canadian Institutes of Health Research

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Optimizing bronchodilation in the prevention of COPD exacerbations

Marc Miravitlles, Antonio Anzueto, José R. Jardim

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Human lung and monocyte-derived macrophages differ with regard to the effects of β2-adrenoceptor agonists on cytokine release

Tatiana Victoni, Hélène Salvator, Charlotte Abrial, Marion Brollo, Luis Cristovão Sobrino Porto, Vincent Lagente, Emmanuel Naline, Stanislas Grassin-Delyle, Philippe Devillier

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Role of P2X7R in the development and progression of pulmonary hypertension

Jie Yin, Shuling You, Haopeng Liu, Li Chen, Chengdong Zhang, Hesheng Hu, Mei Xue, Wenjuan Cheng, Ye Wang, Xinran Li, Yugen Shi, Nannan Li, Suhua Yan, Xiaolu Li

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Decreased T helper 17 cells in tuberculosis is associated with increased percentages of programmed death ligand 1, T helper 2 and regulatory T cells

Chin-Chung Shu, Ming-Fang Wu, Jann-Yuan Wang, Hsin-Chih Lai, Li-Na Lee, Bor-Luen Chiang, Chong-Jen Yu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The cost of systemic corticosteroid-induced morbidity in severe asthma: a health economic analysis

L. E. Barry, J. Sweeney, C. O’Neill, D. Price, L. G. Heaney

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Independent associations between arterial bicarbonate, apnea severity and hypertension in obstructive sleep apnea

Davoud Eskandari, Ding Zou, Ludger Grote, Hartmut Schneider, Thomas Penzel, Jan Hedner

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation

Elizabeth A. Lendermon, Tiffany A. Coon, Joseph S. Bednash, Nathaniel M. Weathington, John F. McDyer, Rama K. Mallampalli

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies

Phuong-Uyen C. Dinh, Jhon Cores, M. Taylor Hensley, Adam C. Vandergriff, Junnan Tang, Tyler A. Allen, Thomas G. Caranasos, Kenneth B. Adler, Leonard J. Lobo, Ke Cheng

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Is it possible to claim or refute sputum eosinophils ≥ 3% in asthmatics with sufficient accuracy using biomarkers?

Sophie F. Demarche, Florence N. Schleich, Virginie A. Paulus, Monique A. Henket, Thierry J. Van Hees, Renaud E. Louis

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Bronchial thermoplasty: activations predict response

David Langton, Joy Sha, Alvin Ing, David Fielding, Francis Thien, Virginia Plummer

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers: a study on 1311 subjects

Matthieu Hein, Jean-Pol Lanquart, Gwénolé Loas, Philippe Hubain, Paul Linkowski

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Sirolimus alters lung pathology and viral load following influenza A virus infection

Ahmed R. Alsuwaidi, Junu A. George, Saeeda Almarzooqi, Stacey M. Hartwig, Steven M. Varga, Abdul-Kader Souid

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Stromal derived factor-1 mediates the lung regenerative effects of mesenchymal stem cells in a rodent model of bronchopulmonary dysplasia

Joel Reiter, Shelley Drummond, Ibrahim Sammour, Jian Huang, Victoria Florea, Polliana Dornas, Joshua M. Hare, Claudia O. Rodrigues, Karen C. Young

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Which early life events or current environmental and lifestyle factors influence lung function in adolescents? – results from the GINIplus & LISAplus studies

Agnes Luzak, Elaine Fuertes, Claudia Flexeder, Marie Standl, Andrea von Berg, Dietrich Berdel, Sibylle Koletzko, Joachim Heinrich, Dennis Nowak, Holger Schulz

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Health related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: insights-IPF registry

Michael Kreuter, Jeff Swigris, David Pittrow, Silke Geier, Jens Klotsche, Antje Prasse, Hubert Wirtz, Dirk Koschel, Stefan Andreas, Martin Claussen, Christian Grohé, Henrike Wilkens, Lars Hagmeyer, Dirk Skowasch, Joachim F Meyer, Joachim Kirschner, Sven Gläser, Felix J. F. Herth, Tobias Welte, Claus Neurohr, Martin Schwaiblmair, Matthias Held, Thomas Bahmer, Marion Frankenberger, Jürgen Behr

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Efficacy and safety of direct switch to indacaterol/glycopyrronium in patients with moderate COPD: the CRYSTAL open-label randomised trial

Claus F. Vogelmeier, Mina Gaga, Maryam Aalamian-Mattheis, Timm Greulich, Jose M. Marin, Walter Castellani, Vincent Ninane, Stephen Lane, Xavier Nunez, Francesco Patalano, Andreas Clemens, Konstantinos Kostikas, on behalf of the CRYSTAL study investigators

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Fibrocyte measurement in peripheral blood correlates with number of cultured mature fibrocytes in vitro and is a potential biomarker for interstitial lung disease in Rheumatoid Arthritis

Søren Andreas Just, Hanne Lindegaard, Eva Kildall Hejbøl, Jesper Rømhild Davidsen, Niels Bjerring, Søren Werner Karlskov Hansen, Henrik Daa Schrøder, Inger Marie Jensen Hansen, Torben Barington, Christian Nielsen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure

K. de Jong, J.M. Vonk, M. Imboden, L. Lahousse, A. Hofman, G.G. Brusselle, N.M. Probst-Hensch, D.S. Postma, H.M. Boezen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Exposure to ambient particulate matter alters the microbial composition and induces immune changes in rat lung

Naijian Li, Fang He, Baoling Liao, Yuming Zhou, Bing Li, Pixin Ran

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The predictive value of respiratory function tests for non-invasive ventilation in amyotrophic lateral sclerosis

T. B. M. Tilanus, J. T. Groothuis, J. M. C. TenBroek-Pastoor, T. B. Feuth, Y. F. Heijdra, J. P. L. Slenders, J. Doorduin, B. G. Van Engelen, M. J. Kampelmacher, J. Raaphorst

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Interactions between glycopyrronium and indacaterol on cholinergic neurotransmission and contractile response in bovine trachealis

Michele Baroffio, Giovanni Barisione, Vito Brusasco

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The effect of glycopyrronium and indacaterol, as monotherapy and in combination, on the methacholine dose-response curve of mild asthmatics: a randomized three-way crossover study

Christianne M. Blais, Beth E. Davis, Donald W. Cockcroft

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Airway and parenchyma immune cells in influenza A(H1N1)pdm09 viral and non-viral diffuse alveolar damage

Monique Buttignol, Ruy Camargo Pires-Neto, Renata Calciolari Rossi e Silva, Marina Ballarin Albino, Marisa Dolhnikoff, Thais Mauad

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Small airway bronchodilator response to different doses of salbutamol in 7-year-old children

Dong Keon Yon, Hye Mi Jee, Eun Kyo Ha, Seung Jin Lee, Young-Ho Jung, Kyung Suk Lee, Man Yong Han

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Using omics approaches to understand pulmonary diseases

Mengyuan Kan, Maya Shumyatcher, Blanca E. Himes

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Fraction of MHCII and EpCAM expression characterizes distal lung epithelial cells for alveolar type 2 cell isolation

Koichi Hasegawa, Atsuyasu Sato, Kazuya Tanimura, Kiyoshi Uemasu, Yoko Hamakawa, Yoshinori Fuseya, Susumu Sato, Shigeo Muro, Toyohiro Hirai

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers

Nicole E. Speck, Macé M. Schuurmans, Christian Benden, Cécile A. Robinson, Lars C. Huber

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function

Leema George, Ankita Mitra, Tania A. Thimraj, Martin Irmler, Sangeetha Vishweswaraiah, Lars Lunding, Dorothea Hühn, Alicia Madurga, Johannes Beckers, Heinz Fehrenbach, Swapna Upadhyay, Holger Schulz, George D. Leikauf, Koustav Ganguly

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A randomised, placebo-controlled trial of anti–interleukin-1 receptor 1 monoclonal antibody MEDI8968 in chronic obstructive pulmonary disease

Peter M. A. Calverley, Sanjay Sethi, Michelle Dawson, Christine K. Ward, Donna K. Finch, Mark Penney, Paul Newbold, René van der Merwe

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Role and regulation of MKP-1 in airway inflammation

Seyed M. Moosavi, Pavan Prabhala, Alaina J. Ammit

01.12.2017 | Research | Ausgabe 1/2017 Open Access

MicroRNA-181c inhibits cigarette smoke–induced chronic obstructive pulmonary disease by regulating CCN1 expression

Yong Du, Yi Ding, Xuru Chen, Zhoufang Mei, Heyuan Ding, Yi Wu, Zhijun Jie

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Regulation of human airway smooth muscle cell migration and relevance to asthma

Brittany Salter, Cara Pray, Katherine Radford, James G. Martin, Parameswaran Nair

01.12.2017 | Research | Ausgabe 1/2017 Open Access

24-h bronchodilation and inspiratory capacity improvements with glycopyrrolate/formoterol fumarate via co-suspension delivery technology in COPD

Colin Reisner, Gregory Gottschlich, Faisal Fakih, Andras Koser, James Krainson, Luis Delacruz, Samir Arora, Gregory Feldman, Krishna Pudi, Shahid Siddiqui, Chad Orevillo, Andrea Maes, Earl St. Rose, Ubaldo Martin

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: A randomized, seven-day study to assess the efficacy and safety of a glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler using novel Co-Suspension™ Delivery Technology in patients with moderate-to-very severe chronic obstructive pulmonary disease

Colin Reisner, Leonardo M. Fabbri, Edward M. Kerwin, Charles Fogarty, Selwyn Spangenthal, Klaus F. Rabe, Gary T. Ferguson, Fernando J. Martinez, James F. Donohue, Patrick Darken, Earl St. Rose, Chad Orevillo, Shannon Strom, Tracy Fischer, Michael Golden, Sarvajna Dwivedi

01.12.2017 | Research | Ausgabe 1/2017 Open Access

IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD

Emmanuel Briend, G. John Ferguson, Michiko Mori, Gautam Damera, Katherine Stephenson, Natasha A. Karp, Sanjay Sethi, Christine K. Ward, Matthew A. Sleeman, Jonas S. Erjefält, Donna K. Finch

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Effect of smoking and comorbidities on survival in idiopathic pulmonary fibrosis

Miia Kärkkäinen, Hannu-Pekka Kettunen, Hanna Nurmi, Tuomas Selander, Minna Purokivi, Riitta Kaarteenaho

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Utility of autoimmune serology testing in the assessment of uncharacterized interstitial lung disease: a large retrospective cohort review

Mohammad Alsumrain, Federica De Giacomi, Shireen Mirza, Teng Moua

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study

Andreas Horner, Joan B. Soriano, Milo A. Puhan, Michael Studnicka, Bernhard Kaiser, Lowie E. G. W. Vanfleteren, Louisa Gnatiuc, Peter Burney, Marc Miravitlles, Francisco García-Rio, Julio Ancochea, Ana M. Menezes, Rogelio Perez-Padilla, Maria Montes de Oca, Carlos A. Torres-Duque, Andres Caballero, Mauricio González-García, Sonia Buist, Maria Flamm, Bernd Lamprecht, for the BOLD Collaborative Research Group, the EPI-SCAN Team, the PLATINO Team, the PREPOCOL Study Group

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Expiratory central airway collapse in stable COPD and during exacerbations

Paul Leong, Anne Tran, Jhanavi Rangaswamy, Laurence E. Ruane, Michael W. Fernando, Martin I. MacDonald, Kenneth K. Lau, Philip G. Bardin

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Comparing microbiota profiles in induced and spontaneous sputum samples in COPD patients

Solveig Tangedal, Marianne Aanerud, Rune Grønseth, Christine Drengenes, Harald G. Wiker, Per S. Bakke, Tomas M. Eagan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Extracellular histones are clinically relevant mediators in the pathogenesis of acute respiratory distress syndrome

Xin Lv, Tao Wen, Jiong Song, Dong Xie, Liang Wu, Xuemei Jiang, Ping Jiang, Zongmei Wen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection

Xiaoqiu Wang, Wenxin Wu, Wei Zhang, J. Leland Booth, Elizabeth S. Duggan, Lili Tian, Sunil More, Yan D. Zhao, Ravindranauth N. Sawh, Lin Liu, Ming-Hui Zou, Jordan P. Metcalf

01.12.2017 | Review | Ausgabe 1/2017 Open Access

WNT signaling – lung cancer is no exception

Judit Rapp, Luca Jaromi, Krisztian Kvell, Gyorgy Miskei, Judit E. Pongracz

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Intersectin-1s deficiency in pulmonary pathogenesis

Niranjan Jeganathan, Dan Predescu, Sanda Predescu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Structure and functional impact of seed region variant in MIR-499 gene family in bronchial asthma

Eman A. Toraih, Mohammad H. Hussein, Essam Al Ageeli, Eman Riad, Nouran B. AbdAllah, Ghada M. Helal, Manal S. Fawzy

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Increased activated regulatory T cells proportion correlate with the severity of idiopathic pulmonary fibrosis

Ziliang Hou, Qiao Ye, Meihua Qiu, Yu Hao, Junyan Han, Hui Zeng

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Cardiovascular risk in patients with alpha-1-antitrypsin deficiency

Sebastian Fähndrich, Frank Biertz, Annika Karch, Björn Kleibrink, Armin Koch, Helmut Teschler, Tobias Welte, Hans-Ulrich Kauczor, Sabina Janciauskiene, Rudolf A. Jörres, Timm Greulich, Claus F. Vogelmeier, Robert Bals, on behalf of the COSYCONET investigators

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity

Seidai Sato, Shintaro Shinohara, Shinya Hayashi, Shun Morizumi, Shuichi Abe, Hiroyasu Okazaki, Yanjuan Chen, Hisatsugu Goto, Yoshinori Aono, Hirohisa Ogawa, Kazuya Koyama, Haruka Nishimura, Hiroshi Kawano, Yuko Toyoda, Hisanori Uehara, Yasuhiko Nishioka

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice

S. Vamsee Raju, Lawrence Rasmussen, Peter A. Sloane, Li Ping Tang, Emily Falk Libby, Steven M. Rowe

01.12.2017 | Research | Ausgabe 1/2017 Open Access

IL-4-induced caveolin-1-containing lipid rafts aggregation contributes to MUC5AC synthesis in bronchial epithelial cells

Yu Xia, Peng-Cheng Cai, Fan Yu, Liang Xiong, Xin-Liang He, Shan-Shan Rao, Feng Chen, Xiang-Ping Yang, Wan-Li Ma, Hong Ye

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Prospective comparison of non-invasive risk markers of major cardiovascular events in COPD patients

Jorge Zagaceta, Gorka Bastarrika, Javier J. Zulueta, Inmaculada Colina, Ana B. Alcaide, Arantza Campo, Miguel Divo, Ciro Casanova, José M. Marin, Victor M. Pinto-Plata, Bartolome R. Celli, Juan P. de-Torres

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Factors associated with hospitalization in bronchiectasis exacerbations: a one-year follow-up study

Rosario Menéndez, Raúl Méndez, Eva Polverino, Edmundo Rosales-Mayor, Isabel Amara-Elori, Soledad Reyes, Tomás Posadas, Laia Fernández-Barat, Antoni Torres

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition

Toshio Suzuki, Yuji Tada, Santhi Gladson, Rintaro Nishimura, Iwao Shimomura, Satoshi Karasawa, Koichiro Tatsumi, James West

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Development of breath test for pneumoconiosis: a case-control study

Hsiao-Yu Yang, Ruei-Hao Shie, Che-Jui Chang, Pau-Chung Chen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Serum bilirubin and the risk of chronic obstructive pulmonary disease exacerbations

Kirstin E. Brown, Don D. Sin, Helen Voelker, John E. Connett, Dennis E. Niewoehner, Ken M. Kunisaki, for the COPD Clinical Research Network

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The value of blood cytokines and chemokines in assessing COPD

Eric Bradford, Sean Jacobson, Jason Varasteh, Alejandro P. Comellas, Prescott Woodruff, Wanda O’Neal, Dawn L. DeMeo, Xingnan Li, Victor Kim, Michael Cho, Peter J. Castaldi, Craig Hersh, Edwin K. Silverman, James D. Crapo, Katerina Kechris, Russell P. Bowler

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Neutrophil extracellular traps in patients with pulmonary tuberculosis

Anne Jan van der Meer, Sacha Zeerleder, Dana C. Blok, Liesbeth M. Kager, Ivar O. Lede, Wahid Rahman, Rumana Afroz, Aniruddha Ghose, Caroline E. Visser, Abu Shahed Md Zahed, Md Anwar Husain, Khan Mashrequl Alam, Pravat Chandra Barua, Mahtabuddin Hassan, Md Abu Tayab, Arjen M. Dondorp, Tom van der Poll

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A 28-day, randomized, double-blind, placebo-controlled, parallel group study of nebulized revefenacin in patients with chronic obstructive pulmonary disease

Krishna K. Pudi, Chris N. Barnes, Edmund J. Moran, Brett Haumann, Edward Kerwin

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Asthma-COPD overlap is not a homogeneous disorder: further supporting data

Luis Pérez-de-Llano, Borja G. Cosio, on behalf of the CHACOS study group

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 study

Jacob A. Winther, Jon Brynildsen, Arne Didrik Høiseth, Heidi Strand, Ivar Følling, Geir Christensen, Ståle Nygård, Helge Røsjø, Torbjørn Omland

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Ghrelin therapy improves lung and cardiovascular function in experimental emphysema

Nazareth de Novaes Rocha, Milena Vasconcellos de Oliveira, Cássia Lisboa Braga, Gabriela Guimarães, Lígia de Albuquerque Maia, Gisele de Araújo Padilha, Johnatas Dutra Silva, Christina Maeda Takiya, Vera Luiza Capelozzi, Pedro Leme Silva, Patricia Rieken Macedo Rocco

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Endobronchial one-way valves for treatment of persistent air leaks: a systematic review

Mei Ding, Ya-dong Gao, Xian-Tao Zeng, Yi Guo, Jiong Yang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Changes in vasoactive pathways in congenital diaphragmatic hernia associated pulmonary hypertension explain unresponsiveness to pharmacotherapy

Daphne S. Mous, Marjon J. Buscop-van Kempen, Rene M. H. Wijnen, Dick Tibboel, Robbert J. Rottier

01.12.2017 | Research | Ausgabe 1/2017 Open Access

RNA-sequencing analysis of lung primary fibroblast response to eosinophil-degranulation products predicts downstream effects on inflammation, tissue remodeling and lipid metabolism

Stephane Esnault, Ksenija Bernau, Elizabeth E. Torr, Yury A. Bochkov, Nizar N. Jarjour, Nathan Sandbo

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

Vitamin K deficiency: the linking pin between COPD and cardiovascular diseases?

Ianthe Piscaer, Emiel F. M. Wouters, Cees Vermeer, Wim Janssens, Frits M. E. Franssen, Rob Janssen

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Novel insights in cough and breathing patterns of patients with idiopathic pulmonary fibrosis performing repeated 24-hour-respiratory polygraphies

Anke Schertel, Manuela Funke-Chambour, Thomas Geiser, Anne-Kathrin Brill

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Virus-triggered exacerbation in allergic asthmatic children: neutrophilic airway inflammation and alteration of virus sensors characterize a subgroup of patients

Antoine Deschildre, Muriel Pichavant, Ilka Engelmann, Carole Langlois, Elodie Drumez, Guillaume Pouessel, Sophie Boileau, David Romero-Cubero, Irina Decleyre-Badiu, Anny Dewilde, Didier Hober, Véronique Néve, Caroline Thumerelle, Stéphanie Lejeune, Clémence Mordacq, Philippe Gosset

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The potential of interleukin-37 as an effective therapeutic agent in asthma

Lina Zhang, Jie Zhang, Peng Gao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Electronic cigarette vapor alters the lateral structure but not tensiometric properties of calf lung surfactant

Rebecca J. Przybyla, Jason Wright, Rajan Parthiban, Saeed Nazemidashtarjandi, Savas Kaya, Amir M. Farnoud

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Reduced suppressive effect of β2-adrenoceptor agonist on fibrocyte function in severe asthma

Chun-Yu Lo, Charalambos Michaeloudes, Pankaj K. Bhavsar, Chien-Da Huang, Po-Jui Chang, Chun-Hua Wang, Han-Pin Kuo, Kian Fan Chung

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A 3D epithelial–mesenchymal co-culture model of human bronchial tissue recapitulates multiple features of airway tissue remodeling by TGF-β1 treatment

Shinkichi Ishikawa, Kanae Ishimori, Shigeaki Ito

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Efficacy and safety of tiotropium and olodaterol in COPD: a systematic review and meta-analysis

Marc Miravitlles, Gerard Urrutia, Alexander G. Mathioudakis, Julio Ancochea

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Deficiency of innate-like T lymphocytes in chronic obstructive pulmonary disease

Mariann Szabó, Veronika Sárosi, Zoltán Balikó, Kornélia Bodó, Nelli Farkas, Tímea Berki, Péter Engelmann

01.12.2017 | Review | Ausgabe 1/2017 Open Access

A proposal for the withdrawal of inhaled corticosteroids in the clinical practice of chronic obstructive pulmonary disease

Marc Miravitlles, Borja G. Cosío, Aurelio Arnedillo, Myriam Calle, Bernardino Alcázar-Navarrete, Cruz González, Cristóbal Esteban, Juan Antonio Trigueros, José Miguel Rodríguez González-Moro, José Antonio Quintano Jiménez, Adolfo Baloira

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Roles of Bronchopulmonary C-fibers in airway Hyperresponsiveness and airway remodeling induced by house dust mite

Zhimei Yang, Jianguo Zhuang, Lei Zhao, Xiuping Gao, Zhengxiu Luo, Enmei Liu, Fadi Xu, Zhou Fu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Variability in adherence to clinical practice guidelines and recommendations in COPD outpatients: a multi-level, cross-sectional analysis of the EPOCONSUL study

Myriam Calle Rubio, José Luis López-Campos, Juan J. Soler-Cataluña, Bernardino Alcázar Navarrete, Joan B. Soriano, José Miguel Rodríguez González-Moro, Manuel E. Fuentes Ferrer, Juan Luis Rodríguez Hermosa, On behalf of the EPOCONSUL Study

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Autonomic nervous system involvement in pulmonary arterial hypertension

Mylène Vaillancourt, Pamela Chia, Shervin Sarji, Jason Nguyen, Nir Hoftman, Gregoire Ruffenach, Mansoureh Eghbali, Aman Mahajan, Soban Umar

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Dose selection for glycopyrrolate/eFlow® phase III clinical studies: results from GOLDEN (Glycopyrrolate for Obstructive Lung Disease via Electronic Nebulizer) phase II dose-finding studies

James F. Donohue, Thomas Goodin, Robert Tosiello, Alistair Wheeler

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Corticosteroid plus β2-agonist in a single inhaler as reliever therapy in intermittent and mild asthma: a proof-of-concept systematic review and meta-analysis

Gang Wang, Xin Zhang, Hong Ping Zhang, Lei Wang, De Ying Kang, Peter J. Barnes, Gang Wang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study

Sang Hoon Lee, Moo Suk Park, Song Yee Kim, Dong Soon Kim, Young Whan Kim, Man Pyo Chung, Soo Taek Uh, Choon Sik Park, Sung Woo Park, Sung Hwan Jeong, Yong Bum Park, Hong Lyeol Lee, Jong Wook Shin, Eun Joo Lee, Jin Hwa Lee, Yangin Jegal, Hyun Kyung Lee, Yong Hyun Kim, Jin Woo Song, Jong Sun Park

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Pulmonary function, exhaled nitric oxide and symptoms in asthma patients with obesity: a cross-sectional study

Marise J. Kasteleyn, Tobias N. Bonten, Renée de Mutsert, Willemien Thijs, Pieter S. Hiemstra, Saskia le Cessie, Frits R. Rosendaal, Niels H. Chavannes, Christian Taube

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Indacaterol/glycopyrronium is cost-effective compared to salmeterol/fluticasone in COPD: FLAME-based modelling in a Swedish population

Leif Bjermer, Job F. M. van Boven, Madlaina Costa-Scharplatz, Dorothy L. Keininger, Florian S. Gutzwiller, Karin Lisspers, Ronan Mahon, Petter Olsson, Nicolas Roche

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Neutrophil extracellular traps are downregulated by glucocorticosteroids in lungs in an equine model of asthma

Amandine Vargas, Roxane Boivin, Patricia Cano, Yoana Murcia, Isabelle Bazin, Jean-Pierre Lavoie

01.12.2017 | Research | Ausgabe 1/2017 Open Access

TLR3 promotes MMP-9 production in primary human airway epithelial cells through Wnt/β-catenin signaling

P.-J. Royer, K. Henrio, M. Pain, J. Loy, A. Roux, A. Tissot, P. Lacoste, C. Pison, S. Brouard, A. Magnan, the COLT consortium

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The role of Src & ERK1/2 kinases in inspiratory resistive breathing induced acute lung injury and inflammation

Dimitrios Toumpanakis, Vyronia Vassilakopoulou, Ioanna Sigala, Panagiotis Zacharatos, Ioanna Vraila, Vassiliki Karavana, Stamatios Theocharis, Theodoros Vassilakopoulos

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Prognostic value of MIB-1 proliferation index in solitary fibrous tumors of the pleura implemented in a new score – a multicenter study

Matthias Diebold, Alex Soltermann, Selma Hottinger, Sarah R. Haile, Lukas Bubendorf, Paul Komminoth, Wolfram Jochum, Rainer Grobholz, Dirk Theegarten, Sabina Berezowska, Kaid Darwiche, Filiz Oezkan, Malcolm Kohler, Daniel P. Franzen

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Neutrophil elastase in bronchiectasis

Andrea Gramegna, Francesco Amati, Leonardo Terranova, Giovanni Sotgiu, Paolo Tarsia, Daniela Miglietta, Maria Adelaide Calderazzo, Stefano Aliberti, Francesco Blasi

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death

Matthew L. Stone, Yunge Zhao, J. Robert Smith, Mark L. Weiss, Irving L. Kron, Victor E. Laubach, Ashish K. Sharma

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression

Ilse M. Boudewijn, Alen Faiz, Katrina Steiling, Erica van der Wiel, Eef D. Telenga, Susan J. M. Hoonhorst, Nick H. T. ten Hacken, Corry-Anke Brandsma, Huib A. M. Kerstjens, Wim Timens, Irene H. Heijink, Marnix R. Jonker, Harold G. de Bruin, J. Sebastiaan Vroegop, Henk R. Pasma, Wim G. Boersma, Pascal Wielders, Frank van den Elshout, Khaled Mansour, Avrum Spira, Marc E. Lenburg, Victor Guryev, Dirkje S. Postma, Maarten van den Berge

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A role for B cells in organic dust induced lung inflammation

Jill A. Poole, Ted R. Mikuls, Michael J. Duryee, Kristi J. Warren, Todd A. Wyatt, Amy J. Nelson, Debra J. Romberger, William W. West, Geoffrey M. Thiele

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Characterization of pediatric cystic fibrosis airway epithelial cell cultures at the air-liquid interface obtained by non-invasive nasal cytology brush sampling

Aline Schögler, Fabian Blank, Melanie Brügger, Seraina Beyeler, Stefan A. Tschanz, Nicolas Regamey, Carmen Casaulta, Thomas Geiser, Marco P. Alves

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Involvements of p38 MAPK and oxidative stress in the ozone-induced enhancement of AHR and pulmonary inflammation in an allergic asthma model

Aihua Bao, Hong Yang, Jie Ji, Yuqin Chen, Wuping Bao, Feng Li, Min Zhang, Xin Zhou, Qiang Li, Suqin Ben

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Lack of SOCS3 increases LPS-induced murine acute lung injury through modulation of Ly6C(+) macrophages

Zhilong Jiang, Zhihong Chen, Liyang Li, Wenjun Zhou, Lei Zhu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Upregulation of citrullination pathway: From Autoimmune to Idiopathic Lung Fibrosis

Katerina D. Samara, Athina Trachalaki, Eliza Tsitoura, Anastasios V. Koutsopoulos, Eleni D. Lagoudaki, Ismini Lasithiotaki, George Margaritopoulos, Panagiotis Pantelidis, Eleni Bibaki, Nikolaos M. Siafakas, Nikolaos Tzanakis, Athol U. Wells, Katerina M. Antoniou

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