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Pediatric Cardiology

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01.10.2013 | Case Report

Response to a Single Dose of Sildenafil in Single-Ventricle Patients: An Echocardiographic Evaluation

verfasst von: Kimberly W. Jackson, Ryan J. Butts, Amy J. Svenson, Tim C. McQuinn, Andrew M. Atz

Erschienen in: Pediatric Cardiology | Ausgabe 7/2013

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Abstract

New evidence of increased phosphodiesterase-5 (PDE-5) in hypertrophied human myocardium suggests that sildenafil, a selective PDE-5 inhibitor, may improve muscle contraction and therefore improve ventricular function. The purpose of this study was to compare ventricular function as assessed by echocardiography in 10 surgically palliated single-ventricle patients at baseline and again after a single dose of sildenafil. The velocity time integral of the ventricular outflow tract was increased 2 h after sildenafil administration (p = 0.01), thus suggesting an improvement in cardiac output.

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Titel: Response to a Single Dose of Sildenafil in Single-Ventricle Patients: An Echocardiographic Evaluation
verfasst von: Kimberly W. Jackson
Ryan J. Butts
Amy J. Svenson
Tim C. McQuinn
Andrew M. Atz
Publikationsdatum: 01.10.2013
Verlag: Springer US
Erschienen in: Pediatric Cardiology / Ausgabe 7/2013
Print ISSN: 0172-0643
Elektronische ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-012-0415-4

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