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Erschienen in:

01.12.2014 | Myelodysplastic Syndromes (M Sekeres, Section Editor)

Resuscitating a Dying Marrow: the Role of Hematopoietic Growth Factors

verfasst von: Aakriti Pandita, Sudipto Mukherjee

Erschienen in: Current Hematologic Malignancy Reports | Ausgabe 4/2014

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Abstract

The treatment landscape for myelodysplastic syndromes (MDS) has evolved over the last two decades, with a better understanding of the disease pathophysiology and the use of newer or combination therapies. For lower-risk MDS patients, hematopoietic growth factors have continued to be the mainstay of therapy. However, better patient selection criteria and decision tools to predict responses have made these therapies more beneficial to patients. As the range of newer drugs continues to expand in our treatment armamentarium for lower-risk MDS, questions still remain regarding the safety of these drugs with long-term use. This review will discuss the role of growth factors in MDS, focusing on dosing and combination strategies to improve responses, selecting the appropriate patient population, and recognizing the safety profile based on evidence from published literature.
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Metadaten
Titel
Resuscitating a Dying Marrow: the Role of Hematopoietic Growth Factors
verfasst von
Aakriti Pandita
Sudipto Mukherjee
Publikationsdatum
01.12.2014
Verlag
Springer US
Erschienen in
Current Hematologic Malignancy Reports / Ausgabe 4/2014
Print ISSN: 1558-8211
Elektronische ISSN: 1558-822X
DOI
https://doi.org/10.1007/s11899-014-0236-z

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