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Erschienen in: Medical Oncology 8/2021

01.08.2021 | Review Article

Resveratrol effects in oral cancer cells: a comprehensive review

verfasst von: Tamires Cunha Almeida, Glenda Nicioli da Silva, Daniel Vitor de Souza, Andrea Cristina de Moraes Malinverni, Odair Aguiar Jr, Debora Estadella, Daniel Araki Ribeiro

Erschienen in: Medical Oncology | Ausgabe 8/2021

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Abstract

Oral cancer is a very common tumor worldwide with high incidence and mortality. The treatment of oral cancer involves surgery, radio- and chemotherapy; however, high failure rates and toxicity are noticed. Thus, the search of new drugs aiming a more effective treatment is welcomed. Natural products present chemopreventive and anti-cancer effects. Resveratrol is a naturally occurring antioxidant that contains several health benefits, including anti-inflammatory and antiproliferative activities. This review discusses the different action mechanisms of resveratrol related in the in vitro and in vivo studies using models of oral cancer.
Literatur
1.
Zurück zum Zitat Jitender S, Sarika G, Varada HR, Omprakash Y, Mohsin K. Screening for oral cancer. J Exp Ther Oncol. 2016;11(4):303–7 (PMID: 27849341).PubMed Jitender S, Sarika G, Varada HR, Omprakash Y, Mohsin K. Screening for oral cancer. J Exp Ther Oncol. 2016;11(4):303–7 (PMID: 27849341).PubMed
10.
Zurück zum Zitat Xie A, Liu J. Chemoprevention of oral cancer in leukoplakia patients: a systematic review and meta-analysis. J Pak Med Assoc. 2017;67(9):1415–9 (PMID: 28924285).PubMed Xie A, Liu J. Chemoprevention of oral cancer in leukoplakia patients: a systematic review and meta-analysis. J Pak Med Assoc. 2017;67(9):1415–9 (PMID: 28924285).PubMed
14.
Zurück zum Zitat Tokuşoglu O, Unal MK, Yemiş F. Determination of the phytoalexin resveratrol (3,5,4’-trihydroxystilbene) in peanuts and pistachios by high-performance liquid chromatographic diode array (HPLC-DAD) and gas chromatography-mass spectrometry (GC-MS). J Agric Food Chem. 2005;53(12):5003–9. https://doi.org/10.1021/jf050496+.CrossRefPubMed Tokuşoglu O, Unal MK, Yemiş F. Determination of the phytoalexin resveratrol (3,5,4’-trihydroxystilbene) in peanuts and pistachios by high-performance liquid chromatographic diode array (HPLC-DAD) and gas chromatography-mass spectrometry (GC-MS). J Agric Food Chem. 2005;53(12):5003–9. https://​doi.​org/​10.​1021/​jf050496+.CrossRefPubMed
26.
Zurück zum Zitat Berta NB, Salamone P, Sprio AE, Scipio FD, Marinos LM, Sapino S, Carlotti ME, Cavalli R, Di Carlo F. Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of resveratrol complexed with 2-hydroxypropyl-beta-cyclodextrin. Oral Oncol. 2010;46(1):42–8.CrossRef Berta NB, Salamone P, Sprio AE, Scipio FD, Marinos LM, Sapino S, Carlotti ME, Cavalli R, Di Carlo F. Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of resveratrol complexed with 2-hydroxypropyl-beta-cyclodextrin. Oral Oncol. 2010;46(1):42–8.CrossRef
27.
Zurück zum Zitat Hu FW, Tsai LL, Yu CH, Chen PN, Chou MY, Yu CC. Impairment of tumor-initiating stem-like property and reversal of epithelial-mesenchymal transdifferentiation in head and neck cancer by resveratrol treatment. Mol Nutr Food Res. 2012;56(8):1247–58.CrossRef Hu FW, Tsai LL, Yu CH, Chen PN, Chou MY, Yu CC. Impairment of tumor-initiating stem-like property and reversal of epithelial-mesenchymal transdifferentiation in head and neck cancer by resveratrol treatment. Mol Nutr Food Res. 2012;56(8):1247–58.CrossRef
28.
Zurück zum Zitat Chang CH, Lee CY, Lu CC, Tsai FJ, Hsu YM, Tsao JW, Juan YN, Chiu HY, Yang JS, Wang CC. Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling. Int J Oncol. 2017;50(3):873–82.CrossRef Chang CH, Lee CY, Lu CC, Tsai FJ, Hsu YM, Tsao JW, Juan YN, Chiu HY, Yang JS, Wang CC. Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling. Int J Oncol. 2017;50(3):873–82.CrossRef
29.
Zurück zum Zitat Kim SE, Shin SH, Lee JY, Kim CH, Chung IK, Kang HM, Park HR, Park BS. Kim IR resveratrol induces mitochondrial apoptosis and inhibits epithelial-mesenchymal transition in oral squamous cell carcinoma cells. Nutr Cancer. 2018;70(1):125–35.CrossRef Kim SE, Shin SH, Lee JY, Kim CH, Chung IK, Kang HM, Park HR, Park BS. Kim IR resveratrol induces mitochondrial apoptosis and inhibits epithelial-mesenchymal transition in oral squamous cell carcinoma cells. Nutr Cancer. 2018;70(1):125–35.CrossRef
30.
Zurück zum Zitat Chen L, Xia JS, Wu JH, Chen YG, Qiu CJ. Resveratrol inhibits oral squamous cell carcinoma cells proliferation while promoting apoptosis through inhibition of CBX7 protein. Environ Toxicol. 2020;35(11):1234–40.CrossRef Chen L, Xia JS, Wu JH, Chen YG, Qiu CJ. Resveratrol inhibits oral squamous cell carcinoma cells proliferation while promoting apoptosis through inhibition of CBX7 protein. Environ Toxicol. 2020;35(11):1234–40.CrossRef
31.
Zurück zum Zitat Singh V, Singh R, Kujur PK, Singh RP. Combination of resveratrol and quercetin causes cell growth inhibition, DNA damage, cell cycle arrest, and apoptosis in oral cancer cells. Assay Drug Dev Technol. 2020;18(5):226–38.CrossRef Singh V, Singh R, Kujur PK, Singh RP. Combination of resveratrol and quercetin causes cell growth inhibition, DNA damage, cell cycle arrest, and apoptosis in oral cancer cells. Assay Drug Dev Technol. 2020;18(5):226–38.CrossRef
32.
Zurück zum Zitat Chen YR, Chen YS, Chin YT, Li ZL, Shih YJ, Yang YSH, ChangOu CA, Su PY, Wang SH, Wu YH, Chiu HC, Lee SY, Liu LF, Whang-Peng J, Lin HY, Mousa SA, Davis PJ, Wang K. Thyroid hormone-induced expression of inflammatory cytokines interfere with resveratrol-induced anti-proliferation of oral cancer cells. Food Chem Toxicol. 2019;132:110693.CrossRef Chen YR, Chen YS, Chin YT, Li ZL, Shih YJ, Yang YSH, ChangOu CA, Su PY, Wang SH, Wu YH, Chiu HC, Lee SY, Liu LF, Whang-Peng J, Lin HY, Mousa SA, Davis PJ, Wang K. Thyroid hormone-induced expression of inflammatory cytokines interfere with resveratrol-induced anti-proliferation of oral cancer cells. Food Chem Toxicol. 2019;132:110693.CrossRef
33.
Zurück zum Zitat Yu XD, Yang JL, Zhang WL, Liu DX. Resveratrol inhibits oral squamous cell carcinoma through induction of apoptosis and G2/M phase cell cycle arrest. Tumour Biol. 2016;37(3):2871–7.CrossRef Yu XD, Yang JL, Zhang WL, Liu DX. Resveratrol inhibits oral squamous cell carcinoma through induction of apoptosis and G2/M phase cell cycle arrest. Tumour Biol. 2016;37(3):2871–7.CrossRef
34.
Zurück zum Zitat Hayashi F, Kasamatsu A, Endo-Sakamoto Y, Eizuka K, Hiroshima K, Kita A, Saito T, Koike K, Tanzawa H, Uzawa K. Increased expression of tripartite motif (TRIM) like 2 promotes tumoral growth in human oral cancer. Biochem Biophys Commun. 2019;508(4):1133–8.CrossRef Hayashi F, Kasamatsu A, Endo-Sakamoto Y, Eizuka K, Hiroshima K, Kita A, Saito T, Koike K, Tanzawa H, Uzawa K. Increased expression of tripartite motif (TRIM) like 2 promotes tumoral growth in human oral cancer. Biochem Biophys Commun. 2019;508(4):1133–8.CrossRef
35.
Zurück zum Zitat Pradhan R, Chatterjee S, Hembram KC, Sethy C, Mandal M, Kundu CN. Nano formulated resveratrol inhibits metastasis and angiogenesis by reducing inflammatory cytokines in oral cancer cells by targeting tumor associated macrophages. J Nutr Biochem. 2021;92:108624.CrossRef Pradhan R, Chatterjee S, Hembram KC, Sethy C, Mandal M, Kundu CN. Nano formulated resveratrol inhibits metastasis and angiogenesis by reducing inflammatory cytokines in oral cancer cells by targeting tumor associated macrophages. J Nutr Biochem. 2021;92:108624.CrossRef
36.
Zurück zum Zitat Biesaga B, Kołodziej-Rzepa M, Janecka-Widła A, Słonina D, Halaszka K, Przewoźnik M, Mucha-Małecka A. Lack of CD44 overexpression and application of concurrent chemoradiotherapy with cisplatin independently indicate excellent prognosis in patients with HPV-positive oropharyngeal cancer. Tumour Biol. 2021;43(1):99–113.CrossRef Biesaga B, Kołodziej-Rzepa M, Janecka-Widła A, Słonina D, Halaszka K, Przewoźnik M, Mucha-Małecka A. Lack of CD44 overexpression and application of concurrent chemoradiotherapy with cisplatin independently indicate excellent prognosis in patients with HPV-positive oropharyngeal cancer. Tumour Biol. 2021;43(1):99–113.CrossRef
37.
Zurück zum Zitat Tu DG, Lin WT, Yu CC, Lee SS, Peng CY, Lin T, Yu CH. Chemotherapeutic effects of luteolin on radio-sensitivity enhancement and interleukin-6/signal transducer and activator of transcription 3 signaling repression of oral cancer stem cells. J Formos Med Assoc. 2016;115(12):1032–8.CrossRef Tu DG, Lin WT, Yu CC, Lee SS, Peng CY, Lin T, Yu CH. Chemotherapeutic effects of luteolin on radio-sensitivity enhancement and interleukin-6/signal transducer and activator of transcription 3 signaling repression of oral cancer stem cells. J Formos Med Assoc. 2016;115(12):1032–8.CrossRef
38.
Zurück zum Zitat Shan Z, Yang G, Xiang W, Pei-jun W, Bin Z. Effects of resveratrol on oral squamous cell carcinoma (OSCC) cells in vitro. J Cancer Res Clin Oncol. 2014;140(3):371–4.CrossRef Shan Z, Yang G, Xiang W, Pei-jun W, Bin Z. Effects of resveratrol on oral squamous cell carcinoma (OSCC) cells in vitro. J Cancer Res Clin Oncol. 2014;140(3):371–4.CrossRef
39.
Zurück zum Zitat Hsieh MJ, Chin MC, Lin CC, His YT, Lo YS, Chuang YC, Chen MK. pinostilbene hydrate suppresses human oral cancer cell metastasis by downregulation of matrix metalloproteinase-2 through the mitogen-activated protein kinase signaling pathway. Cell Physiol Biochem. 2018;50(3):911–23.CrossRef Hsieh MJ, Chin MC, Lin CC, His YT, Lo YS, Chuang YC, Chen MK. pinostilbene hydrate suppresses human oral cancer cell metastasis by downregulation of matrix metalloproteinase-2 through the mitogen-activated protein kinase signaling pathway. Cell Physiol Biochem. 2018;50(3):911–23.CrossRef
40.
Zurück zum Zitat Lin FY, Hsieh YH, Yang SF, Chen CT, Tang CH, Chou MY, Chuang YT, Lin CW, Chen MK. Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells. J Oral Pathol Med. 2015;44(9):699–706.CrossRef Lin FY, Hsieh YH, Yang SF, Chen CT, Tang CH, Chou MY, Chuang YT, Lin CW, Chen MK. Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells. J Oral Pathol Med. 2015;44(9):699–706.CrossRef
41.
Zurück zum Zitat Ribeiro DA, Salvadori DM, Marques ME. Abnormal expression of bcl-2 and bax in rat tongue mucosa during the development of squamous cell carcinoma induced by 4-nitroquinoline 1-oxide. Int J Exp Pathol. 2005;86(6):375–81.CrossRef Ribeiro DA, Salvadori DM, Marques ME. Abnormal expression of bcl-2 and bax in rat tongue mucosa during the development of squamous cell carcinoma induced by 4-nitroquinoline 1-oxide. Int J Exp Pathol. 2005;86(6):375–81.CrossRef
42.
Zurück zum Zitat Gonçalves Vde P, Ortega AA, Guimarães MR, Curylofo FA, Rossa Junior C, Ribeiro DA, Spolidorio LC. Chemopreventive activity of systemically administered curcumin on oral cancer in the 4-nitroquinoline 1-oxide model. J Cell Biochem. 2015;116(5):787–96.CrossRef Gonçalves Vde P, Ortega AA, Guimarães MR, Curylofo FA, Rossa Junior C, Ribeiro DA, Spolidorio LC. Chemopreventive activity of systemically administered curcumin on oral cancer in the 4-nitroquinoline 1-oxide model. J Cell Biochem. 2015;116(5):787–96.CrossRef
43.
Zurück zum Zitat Ho Y, Wu CY, Chin YT, Li ZL, Pan YS, Huang TY, Su PY, Lee SY, Crawford DR, Su KW, Chiu HC, Shih YJ, Changou CA, Yang YSH, Whang-Peng J, Chen YR, Lin HY, Mousa SA, Davis PJ, Wang K. NDAT suppresses pro-inflammatory gene expression to enhance resveratrol-induced anti-proliferation in oral cancer cells. Food Chem Toxicol. 2020;136:111092.CrossRef Ho Y, Wu CY, Chin YT, Li ZL, Pan YS, Huang TY, Su PY, Lee SY, Crawford DR, Su KW, Chiu HC, Shih YJ, Changou CA, Yang YSH, Whang-Peng J, Chen YR, Lin HY, Mousa SA, Davis PJ, Wang K. NDAT suppresses pro-inflammatory gene expression to enhance resveratrol-induced anti-proliferation in oral cancer cells. Food Chem Toxicol. 2020;136:111092.CrossRef
44.
Zurück zum Zitat Dukaew N, Chairatvit K, Pitchakarn P, Imsumran A, Karinchai J, Tuntiwechapikul W, Wongnoppavich A. Inactivation of AKT/NF-kappaB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin. Oncol Rep. 2020;44(4):1441–54.PubMedPubMedCentral Dukaew N, Chairatvit K, Pitchakarn P, Imsumran A, Karinchai J, Tuntiwechapikul W, Wongnoppavich A. Inactivation of AKT/NF-kappaB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin. Oncol Rep. 2020;44(4):1441–54.PubMedPubMedCentral
45.
Zurück zum Zitat Masuelli L, Di Stefano E, Fantini M, Mattera R, Benvenuto M, Marzocchella L, Sacchetti P, Focaccetti C, Bernardini R, Tresoldi I, Izzi V, Mattei M, Frajese GV, Lista F, Modesti A, Bei R. Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas. Oncotarget. 2014;5(21):10745–62.CrossRef Masuelli L, Di Stefano E, Fantini M, Mattera R, Benvenuto M, Marzocchella L, Sacchetti P, Focaccetti C, Bernardini R, Tresoldi I, Izzi V, Mattei M, Frajese GV, Lista F, Modesti A, Bei R. Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas. Oncotarget. 2014;5(21):10745–62.CrossRef
46.
Zurück zum Zitat Chang HJ, Chou CT, Chang HT, Liang WZ, Hung TY, Li YD, Fang YC, Kuo CC, Kuo DH, Shieh P, Jan CR. Mechanisms of resveratrol-induced changes in cytosolic free calcium ion concentrations and cell viability in OC2 human oral cancer cells. Hum Exp Toxicol. 2015;34(3):289–99.CrossRef Chang HJ, Chou CT, Chang HT, Liang WZ, Hung TY, Li YD, Fang YC, Kuo CC, Kuo DH, Shieh P, Jan CR. Mechanisms of resveratrol-induced changes in cytosolic free calcium ion concentrations and cell viability in OC2 human oral cancer cells. Hum Exp Toxicol. 2015;34(3):289–99.CrossRef
47.
Zurück zum Zitat Wang S, Zhang Y, Huang J, Wong CC, Zhai J, Li C, Wei G, Zhao L, Wang G, Wei H, Zhao Z. Yu JTRIM67 Activates p53 to suppress colorectal cancer initiation and progression. Cancer Res. 2019;79(16):4086–98.PubMed Wang S, Zhang Y, Huang J, Wong CC, Zhai J, Li C, Wei G, Zhao L, Wang G, Wei H, Zhao Z. Yu JTRIM67 Activates p53 to suppress colorectal cancer initiation and progression. Cancer Res. 2019;79(16):4086–98.PubMed
48.
Zurück zum Zitat Kim JY, Cho KH, Jeong BY, Park CG, Lee HY. Zeb1 for RCP-induced oral cancer cell invasion and its suppression by resveratrol. Exp Mol Med. 2020;52(7):1152–63.CrossRef Kim JY, Cho KH, Jeong BY, Park CG, Lee HY. Zeb1 for RCP-induced oral cancer cell invasion and its suppression by resveratrol. Exp Mol Med. 2020;52(7):1152–63.CrossRef
49.
Zurück zum Zitat de Kort WWB, Spelier S, Devriese LA, van Es RJJ, Willems SM. Predictive value of EGFR-PI3K-AKT-mTOR-pathway inhibitor biomarkers for head and neck squamous cell carcinoma: a systematic review. Mol Diagn Ther. 2021;25(2):123–36.CrossRef de Kort WWB, Spelier S, Devriese LA, van Es RJJ, Willems SM. Predictive value of EGFR-PI3K-AKT-mTOR-pathway inhibitor biomarkers for head and neck squamous cell carcinoma: a systematic review. Mol Diagn Ther. 2021;25(2):123–36.CrossRef
50.
Zurück zum Zitat Shrotriya S, Tyagi A, Deep G, Orlicky DJ, Wisell J, Wang XJ, Sclafani RA, Agarwal R, Agarwal C. Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses. Mol Carcinog. 2015;54(4):291–300.CrossRef Shrotriya S, Tyagi A, Deep G, Orlicky DJ, Wisell J, Wang XJ, Sclafani RA, Agarwal R, Agarwal C. Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses. Mol Carcinog. 2015;54(4):291–300.CrossRef
51.
Zurück zum Zitat Atienzar AN, Camacho-Alonso F, Lopez-Jornet P. Effects of resveratrol and irradiation upon oral squamous cell carcinoma cells. Acta Odontol Scand. 2014;72(7):481–8.CrossRef Atienzar AN, Camacho-Alonso F, Lopez-Jornet P. Effects of resveratrol and irradiation upon oral squamous cell carcinoma cells. Acta Odontol Scand. 2014;72(7):481–8.CrossRef
52.
Zurück zum Zitat Sheng H, Ogawa T, Niwano Y, Sasaki K, Tachibana K. Effects of polyphenols on doxorubicin-induced oral keratinocyte cytotoxicity and anticancer potency against oral cancer cells. J Oral Pathol Med. 2018;47(4):368–74.CrossRef Sheng H, Ogawa T, Niwano Y, Sasaki K, Tachibana K. Effects of polyphenols on doxorubicin-induced oral keratinocyte cytotoxicity and anticancer potency against oral cancer cells. J Oral Pathol Med. 2018;47(4):368–74.CrossRef
53.
Zurück zum Zitat Tomikoshi Y, Nomura M, Okidaira N, Sakagami H, Wakabayashi H. Enhancement of cytotoxicity of three apoptosis-inducing agents against human oral squamous cell carcinoma cell line by benzoxazinotropone. In Vivo. 2016;30(5):645–50.PubMed Tomikoshi Y, Nomura M, Okidaira N, Sakagami H, Wakabayashi H. Enhancement of cytotoxicity of three apoptosis-inducing agents against human oral squamous cell carcinoma cell line by benzoxazinotropone. In Vivo. 2016;30(5):645–50.PubMed
54.
Zurück zum Zitat Uzawa K, Amelio AL, Kasamatsu A, Saito T, Kita A, Fukamachi M, Sawai Y, Toeda Y, Eizuka K, Hayashi F, Kato-Kase I, Sunohara M, Iyoda M, Koike K, Nakashima D, Ogawara K, Endo-Sakamoto Y, Shiiba M, Takiguchi Y, Yamauchi M, Tanzawa H. Resveratrol targets urokinase-type plasminogen activator receptor expression to overcome cetuximab-resistance in oral squamous cell carcinoma. Sci Rep. 2019;9(1):12179.CrossRef Uzawa K, Amelio AL, Kasamatsu A, Saito T, Kita A, Fukamachi M, Sawai Y, Toeda Y, Eizuka K, Hayashi F, Kato-Kase I, Sunohara M, Iyoda M, Koike K, Nakashima D, Ogawara K, Endo-Sakamoto Y, Shiiba M, Takiguchi Y, Yamauchi M, Tanzawa H. Resveratrol targets urokinase-type plasminogen activator receptor expression to overcome cetuximab-resistance in oral squamous cell carcinoma. Sci Rep. 2019;9(1):12179.CrossRef
56.
Zurück zum Zitat Zhu W, Qin W, Zhang K, Rottinghaus GE, Chen YC, Kliethermes B, Sauter ER. Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer. Nutr Cancer. 2012;64(3):393–400.CrossRef Zhu W, Qin W, Zhang K, Rottinghaus GE, Chen YC, Kliethermes B, Sauter ER. Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer. Nutr Cancer. 2012;64(3):393–400.CrossRef
57.
Zurück zum Zitat Patel KR, Brown VA, Jones DJ, Britton RG, Hemingway D, Miller AS, West KP, Booth TD, Perloff M, Crowell JA, Brenner DE, Steward WP, Gescher AJ, Brown K. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Res. 2010;70(19):7392–9.CrossRef Patel KR, Brown VA, Jones DJ, Britton RG, Hemingway D, Miller AS, West KP, Booth TD, Perloff M, Crowell JA, Brenner DE, Steward WP, Gescher AJ, Brown K. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Res. 2010;70(19):7392–9.CrossRef
58.
Zurück zum Zitat Howells LM, Berry DP, Elliott PJ, Jacobson EW, Hoffmann E, Hegarty B, Brown K, Steward WP, Gescher AJ. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases–safety, pharmacokinetics, and pharmacodynamics. Cancer Prev Res. 2011;4(9):1419–25.CrossRef Howells LM, Berry DP, Elliott PJ, Jacobson EW, Hoffmann E, Hegarty B, Brown K, Steward WP, Gescher AJ. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases–safety, pharmacokinetics, and pharmacodynamics. Cancer Prev Res. 2011;4(9):1419–25.CrossRef
59.
Zurück zum Zitat Almeida L, Vaz-da-Silva M, Falcão A, Soares E, Costa R, Loureiro AI, Fernandes-Lopes C, Rocha JF, Nunes T, Wright L, et al. Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Mol Nutr Food Res. 2009;53:7–15.CrossRef Almeida L, Vaz-da-Silva M, Falcão A, Soares E, Costa R, Loureiro AI, Fernandes-Lopes C, Rocha JF, Nunes T, Wright L, et al. Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Mol Nutr Food Res. 2009;53:7–15.CrossRef
60.
Zurück zum Zitat Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Boo TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res. 2010;70:9003–11.CrossRef Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Boo TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res. 2010;70:9003–11.CrossRef
Metadaten
Titel
Resveratrol effects in oral cancer cells: a comprehensive review
verfasst von
Tamires Cunha Almeida
Glenda Nicioli da Silva
Daniel Vitor de Souza
Andrea Cristina de Moraes Malinverni
Odair Aguiar Jr
Debora Estadella
Daniel Araki Ribeiro
Publikationsdatum
01.08.2021
Verlag
Springer US
Erschienen in
Medical Oncology / Ausgabe 8/2021
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-021-01548-0

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