Skip to main content
Erschienen in: Head and Neck Pathology 3/2014

01.09.2014 | Case Report

Reticular and Myxoid Non-keratinizing Nasopharyngeal Carcinoma: An Unusual Case Mimicking a Salivary Gland Carcinoma

verfasst von: Fredrik Petersson, Desai Vijayadwaja, Kwok Seng Loh, Kong-Bing Tan

Erschienen in: Head and Neck Pathology | Ausgabe 3/2014

Einloggen, um Zugang zu erhalten

Abstract

We present a case of non-keratinizing carcinoma of the nasopharynx (NK-NPC) with an unusual histopathological pattern. The neoplastic cells were arranged in anastomosing cords embedded in a stroma which contained a significant component of alcian blue-positive myxoid substance forming a reticular pattern. These histopathological features gave an initial impression of a salivary gland-type carcinoma. On immunohistochemistry the tumor cells were strongly and diffusely positive for cytokeratins (AE1-3 and 5/6) and p63 and there was strong and diffuse nuclear positivity for Epstein–Barr virus-encoded small RNA on in situ hybridization. This case highlights the histomorphological variability of NK-NPC. Awareness of the histological spectrum of NK-NPC is important in clinical practice and this is not always adequately highlighted in currently used standard textbooks of Head and Neck Pathology.
Literatur
1.
Zurück zum Zitat Shanmugaratnam K, Muir C. Cancer of the nasopharynx UICC Monograph series, vol. 1. Copenhagen: Munksgaard; 1967. Shanmugaratnam K, Muir C. Cancer of the nasopharynx UICC Monograph series, vol. 1. Copenhagen: Munksgaard; 1967.
2.
Zurück zum Zitat WHO Classification of Tumours. In: Barnes LE, Eveson JW, Reichart P, Sidransky D, editors. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005. WHO Classification of Tumours. In: Barnes LE, Eveson JW, Reichart P, Sidransky D, editors. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005.
3.
Zurück zum Zitat Yeh S. A histological classification of carcinomas of the nasopharynx with a critical review as to the existence of lymphoepitheliomas. Cancer. 1962;15:895–920.PubMedCrossRef Yeh S. A histological classification of carcinomas of the nasopharynx with a critical review as to the existence of lymphoepitheliomas. Cancer. 1962;15:895–920.PubMedCrossRef
4.
Zurück zum Zitat Liang P, Chen C, Chu C, et al. The histopathologic classification, biologic characteristics and histogenesis of nasopharyngeal carcinomas. Chin Med J. 1962;81:629–58.PubMed Liang P, Chen C, Chu C, et al. The histopathologic classification, biologic characteristics and histogenesis of nasopharyngeal carcinomas. Chin Med J. 1962;81:629–58.PubMed
5.
Zurück zum Zitat Shanmugaratnam K. The pathology of nasopharyngeal carcinoma a review oncogenesis and herpesviruses. Lyon: IARC; 1972. Shanmugaratnam K. The pathology of nasopharyngeal carcinoma a review oncogenesis and herpesviruses. Lyon: IARC; 1972.
6.
Zurück zum Zitat Petersson F, Loh KS, Lim D. Paucilymphoid non-keratinizing nasopharyngeal carcinoma with prominent stromal desmoplasia—an unusual case reported with brief comments on uncommon histological variants. Int J Clin Exp Pathol. 2011;4:410–5.PubMedCentralPubMed Petersson F, Loh KS, Lim D. Paucilymphoid non-keratinizing nasopharyngeal carcinoma with prominent stromal desmoplasia—an unusual case reported with brief comments on uncommon histological variants. Int J Clin Exp Pathol. 2011;4:410–5.PubMedCentralPubMed
7.
Zurück zum Zitat Diagnostic surgical pathology of the head and neck. In: Gnepp D, editor. Philadelphia: Elsevier; 2009. Diagnostic surgical pathology of the head and neck. In: Gnepp D, editor. Philadelphia: Elsevier; 2009.
8.
Zurück zum Zitat Mills SE, Gaffey MJ, Frierson HF. Tumors of the upper aerodigestive tract and ear. In: Rosai J, Robin LH, editors. Atlas of tumor pathology. Washington DC: Armed Forces Institute of Pathology; 2000. Mills SE, Gaffey MJ, Frierson HF. Tumors of the upper aerodigestive tract and ear. In: Rosai J, Robin LH, editors. Atlas of tumor pathology. Washington DC: Armed Forces Institute of Pathology; 2000.
9.
Zurück zum Zitat Wenig B. Atlas of head and neck pathology. Philadelphia: Saunders Elsevier; 2008. Wenig B. Atlas of head and neck pathology. Philadelphia: Saunders Elsevier; 2008.
10.
Zurück zum Zitat Kusafuka K, Takizawa Y, Iida Y, et al. Primary nasopharyngeal mucoepidermoid carcinoma in Japanese patients: two case reports with histochemical and immunohistochemical analysis and a review of the literature. Virchows Arch. 2007;450:343–8.PubMedCrossRef Kusafuka K, Takizawa Y, Iida Y, et al. Primary nasopharyngeal mucoepidermoid carcinoma in Japanese patients: two case reports with histochemical and immunohistochemical analysis and a review of the literature. Virchows Arch. 2007;450:343–8.PubMedCrossRef
11.
Zurück zum Zitat Wei YC, Huang CC, Chien CY, et al. Polymorphous low-grade adenocarcinoma of the nasopharynx: a case report and brief review. J Clin Pathol. 2008;61:1124–6.PubMedCrossRef Wei YC, Huang CC, Chien CY, et al. Polymorphous low-grade adenocarcinoma of the nasopharynx: a case report and brief review. J Clin Pathol. 2008;61:1124–6.PubMedCrossRef
12.
Zurück zum Zitat Soprani F, Armaroli V, Venturini A, et al. A rare case of adenoid cystic carcinoma of the nasopharynx manifesting as Horner’s syndrome: discussion and review of the literature. Acta Otorhinolaryngol Ital. 2007;27:216–9.PubMedCentralPubMed Soprani F, Armaroli V, Venturini A, et al. A rare case of adenoid cystic carcinoma of the nasopharynx manifesting as Horner’s syndrome: discussion and review of the literature. Acta Otorhinolaryngol Ital. 2007;27:216–9.PubMedCentralPubMed
13.
Zurück zum Zitat Vandist V, Deridder F, Waelput W, et al. A neuroendocrine tumour of the sphenoid sinus and nasopharynx: a case report. B-Ent. 2010;6:147–51.PubMed Vandist V, Deridder F, Waelput W, et al. A neuroendocrine tumour of the sphenoid sinus and nasopharynx: a case report. B-Ent. 2010;6:147–51.PubMed
14.
Zurück zum Zitat Weinreb I, Perez-Ordonez B. Non-small cell neuroendocrine carcinoma of the sinonasal tract and nasopharynx. Report of 2 cases and review of the literature. Head Neck Pathol. 2007;1:21–6.PubMedCentralPubMedCrossRef Weinreb I, Perez-Ordonez B. Non-small cell neuroendocrine carcinoma of the sinonasal tract and nasopharynx. Report of 2 cases and review of the literature. Head Neck Pathol. 2007;1:21–6.PubMedCentralPubMedCrossRef
15.
Zurück zum Zitat Lee LY, Chang KP, Hsu CL, et al. Small-cell neuroendocrine carcinoma of the nasopharynx: report of a rare case lacking association with Epstein–Barr virus. Int J Surg Pathol. 2011;19(2):199–202.PubMedCrossRef Lee LY, Chang KP, Hsu CL, et al. Small-cell neuroendocrine carcinoma of the nasopharynx: report of a rare case lacking association with Epstein–Barr virus. Int J Surg Pathol. 2011;19(2):199–202.PubMedCrossRef
17.
Zurück zum Zitat Sinkre P, Lindberg G, Albores-Saavedra J. Nasopharyngeal gangliocytic paraganglioma. Arch Pathol Lab Med. 2001;125:1098–100.PubMed Sinkre P, Lindberg G, Albores-Saavedra J. Nasopharyngeal gangliocytic paraganglioma. Arch Pathol Lab Med. 2001;125:1098–100.PubMed
18.
Zurück zum Zitat Stelow EB, Bellizzi AM, Taneja K, et al. NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract. Am J Surg Pathol. 2008;32:828–34.PubMedCrossRef Stelow EB, Bellizzi AM, Taneja K, et al. NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract. Am J Surg Pathol. 2008;32:828–34.PubMedCrossRef
19.
Zurück zum Zitat Wan SK, Chan JK, Lau WH, et al. Basaloid-squamous carcinoma of the nasopharynx. An Epstein–Barr virus-associated neoplasm compared with morphologically identical tumors occurring in other sites. Cancer. 1995;76:1689–93.PubMedCrossRef Wan SK, Chan JK, Lau WH, et al. Basaloid-squamous carcinoma of the nasopharynx. An Epstein–Barr virus-associated neoplasm compared with morphologically identical tumors occurring in other sites. Cancer. 1995;76:1689–93.PubMedCrossRef
Metadaten
Titel
Reticular and Myxoid Non-keratinizing Nasopharyngeal Carcinoma: An Unusual Case Mimicking a Salivary Gland Carcinoma
verfasst von
Fredrik Petersson
Desai Vijayadwaja
Kwok Seng Loh
Kong-Bing Tan
Publikationsdatum
01.09.2014
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 3/2014
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-013-0512-6

Weitere Artikel der Ausgabe 3/2014

Head and Neck Pathology 3/2014 Zur Ausgabe

Neu im Fachgebiet Pathologie