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Erschienen in: International Ophthalmology 9/2020

02.05.2020 | Original Paper

Retinal, choroidal and optic disc analysis in patients with Graves’ disease with or without orbitopathy

verfasst von: Giamberto Casini, Michele Marinò, Marisa Rubino, Serena Licari, Giuseppe Covello, Barbara Mazzi, Ilaria Ionni, Roberto Rocchi, Angela Tindara Sframeli, Michele Figus, Pasquale Loiudice

Erschienen in: International Ophthalmology | Ausgabe 9/2020

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Abstract

Purpose

To compare optic disc, retinal and choroidal measurements in patients with Graves’ disease with or without orbitopathy, and healthy controls.

Methods

Optical coherence tomography and Heidelberg retinal tomography were performed in 40 patients with Graves’ orbitopathy (GO), 40 subjects with Graves’s disease (GD) with no sign of orbitopathy and 40 healthy controls. Degree of exophthalmos, ocular alignment, clinical activity score (CAS), choroidal thickness, retinal thickness, ganglion cell layer (GCL) thickness, disc area, cup area, rim area, cup/disc area ratio, linear cup/disc ratio and mean peripapillary retinal nerve fibre layer thickness were analysed.

Results

GO patients and healthy controls significantly differ regarding mean central retinal thickness (275 ± 19 µm and 285 ± 20 µm, P = 0.017); mean central GCL thickness (14.87 ± 3.0 µm and 17.92 ± 5.02 µm, P = 0.001); mean disc area (2.00 ± 0.44 mm2 and 1.72 ± 0.37 mm2, P = 0.003); mean cup area (0.53 ± 0.52 mm2 and 0.31 ± 0.20 mm2, P = 0.003); cup/disc area ratio (0.22 ± 0.10 and 0.17 ± 0.08, P = 0.010); and linear cup/disc ratio (0.47 ± 0.15 and 0.40 ± 0.13, respectively, P = 0.011). No difference was found between patients without orbitopathy and healthy controls. No significant difference was found regarding the choroidal thickness between the three groups. There was no statistically significant relationship between retinal thickness, ganglion cell layer thickness, mean disc area, mean cup area, cup/disc area ratio, linear cup/disc ratio, CAS, exophthalmometric value and ocular alignment.

Conclusion

GO patients showed significant changes in foveal and GCL thickness, and optic nerve head morphology suggesting a possible influence of the orbital inflammatory process.
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Metadaten
Titel
Retinal, choroidal and optic disc analysis in patients with Graves’ disease with or without orbitopathy
verfasst von
Giamberto Casini
Michele Marinò
Marisa Rubino
Serena Licari
Giuseppe Covello
Barbara Mazzi
Ilaria Ionni
Roberto Rocchi
Angela Tindara Sframeli
Michele Figus
Pasquale Loiudice
Publikationsdatum
02.05.2020
Verlag
Springer Netherlands
Erschienen in
International Ophthalmology / Ausgabe 9/2020
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-020-01392-7

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