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Erschienen in:
18.05.2017 | Inflammatory Disorders
Retinal pigmentary changes in chronic uveitis mimicking retinitis pigmentosa
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 9/2017
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Purpose
To present retinal pigmentary changes mimicking retinitis pigmentosa (RP) as a finding of advanced uveitis.
Methods
We retrospectively reviewed charts of patients without a family history of inherited retinal degenerations who presented with retinal pigment changes and signs of past or present intraocular inflammation. Comprehensive eye examination including best-corrected visual acuity, slit-lamp examination and dilated fundus examination was performed on all patients in addition to color fundus photography, optical coherence tomography, fluorescein angiography (FA), and full-field electroretinogram testing.
Results
We identified five patients with ages ranging from 33 to 66 years, who presented with RP-like retinal pigmentary changes which were eventually attributed to longstanding uveitis. The changes were bilateral in three cases and unilateral in two cases. Four of five cases presented with active inflammation, and the remaining case showed evidence of active intraocular inflammation during follow-up.
Conclusion
This study highlights the overlapping features of advanced uveitis and RP including the extensive pigmentary changes. Careful review of possible past uveitis history, detailed examination of signs of past or present inflammation and ancillary testing, with FA often being most helpful, are required for the correct diagnosis. This is important, because intervention can prevent further damage if the cause of the pigmentary changes is destructive inflammation.