Reversible dilated cardiomyopathy as a complication of adrenal cortex insufficiency: a case report

Zeitschrift:: Journal of Medical Case Reports > Ausgabe 1/2018

Autoren:: Mohammad Alkhateeb, Mohammad Alsakkal, Mohammad Nour Alfauri, Diana Alasmar

» Zum Volltext PDF-Version jetzt herunterladen

Abstract

Background

Cardiovascular manifestations associated with Addison’s disease are previously documented. We described a case of an 11-year-old girl who developed dilated cardiomyopathy as a complication to Addison’s disease. Glucocorticoid replacement therapy resulted in near-complete recovery of cardiac function. It is the first reported case of reversible cardiomyopathy as a complication of primary adrenal insufficiency in Syria.

Case presentation

An 11-year-old Caucasian girl with no significant past medical history presented with abdominal pain, vomiting after meals, and a low-grade fever. A physical examination and laboratory evaluation suggested primary adrenal insufficiency. An echocardiogram showed changes consistent with dilated cardiomyopathy. Causes of primary adrenal insufficiency other than autoimmune were excluded.

Conclusions

Dilated cardiomyopathy is a rare complication of primary adrenal insufficiency. Proper treatment of adrenal insufficiency with glucocorticoid replacement therapy resulted in restoration of normal cardiac function.

Unsere Produktempfehlungen

e.Med Interdisziplinär

Kombi-Abonnement

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de.

Jetzt testen ¹

e.Med Allgemeinmedizin

Kombi-Abonnement

Mit e.Med Allgemeinmedizin erhalten Sie Zugang zu allen CME-Fortbildungen und Premium-Inhalten der allgemeinmedizinischen Zeitschriften, inklusive einer gedruckten Allgemeinmedizin-Zeitschrift Ihrer Wahl.

Jetzt testen ²

Martorell PM, Roep BO, Smit JWA. Autoimmunity in Addison’s disease. Neth J Med. 2002;60(7):269–75. PubMed

Mozolevska V, Schwartz A, Cheung D, Shaikh B, Bhagirath KM, Jassal DS. Addison’s Disease and Dilated Cardiomyopathy: A Case Report and Review of the Literature. Case Rep Cardiol. 2016;2016:1–5. https://doi.org/10.1155/2016/4362514. CrossRef

Perry R, Kecha O, Paquette J, Huot C, Van Vliet G, Deal C. Primary adrenal insufficiency in children: Twenty years experience at the Sainte-Justine Hospital, Montreal. J Clin Endocrinol Metab. 2005;90(6):3243–50. https://doi.org/10.1210/jc.2004-0016. CrossRefPubMed

Derish M, Eckert K, Chin C. Reversible cardiomyopathy in a child with Addison’s disease. Intensive Care Med. 1996;22(5):460–3. https://doi.org/10.1007/BF01712167. CrossRefPubMed

Conwell LS, Gray LM, Delbridge RG, Thomsett MJ, Batch JA. Reversible cardiomyopathy in paediatric Addison’s disease--a cautionary tale. J Pediatr Endocrinol Metab. 2003;16(8):1191–5. https://doi.org/10.1515/JPEM.2003.16.8.1191.

Ödek Ç, Kendirli T, Kocaay P, et al. Acute reversible cardiomyopathy and heart failure in a child with acute adrenal crisis. Paediatr Int Child Health. 2017;37(2):148-51. https://doi.org/10.1080/20469047.2015.1120410. CrossRef

Wolff B, Machill K, Schulzki I, Schumacher D, Werner D. Acute reversible cardiomyopathy with cardiogenic shock in a patient with Addisonian crisis: A case report. Int J Cardiol. 2007;116(2):71–3. https://doi.org/10.1016/j.ijcard.2006.07.207. CrossRef

Wani AI, Farooqui KJ, Bashir MI, Mir SA, et al. Autoimmune polyglandular syndrome type 1 with reversible dilated cardiomyopathy: complete recovery after correction of hypocalcemia and hypocortisolemia. J Pediatr Endocrinol Metab. 2013;26:373–6. https://doi.org/10.1515/jpem-2012-0201. CrossRefPubMed

Boston BA, DeGroff C, Hanna CE, Reller M. Reversible cardiomyopathy in an infant with unrecognized congenital adrenal hyperplasia. J Pediatr. 1994;124(6):936–8. https://doi.org/10.1016/S0022-3476(05)83186-5. CrossRefPubMed

10.

Walker C, Butt W. A case of cardiovascular collapse due to adrenal insufficiency. J Paediatr Child Health. 1988;24(3):197–8. https://doi.org/10.1111/j.1440-1754.1988.tb00325.x. CrossRef

11.

Shimizu M, Monguchi T, Takano T, Miwa Y. Isolated ACTH deficiency presenting with severe myocardial dysfunction. J Cardiol Cases. 2011;4(1):e26–30. https://doi.org/10.1016/j.jccase.2011.05.004. CrossRef

12.

Ullian ME. The role of corticosteriods in the regulation of vascular tone. Cardiovasc Res. 1999;41(1):55–64. https://doi.org/10.1016/S0008-6363(98)00230-2. CrossRefPubMed

13.

Rao MK, Xu A, Narayanan N. Glucocorticoid modulation of protein phosphorylation and sarcoplasmic reticulum function in rat myocardium. Am J Physiol Heart Circ Physiol. 2001;281(1):H325–33. https://doi.org/10.1152/ajpheart.2001.281.1.H325. CrossRefPubMed

14.

Wiltshire EJ, Wilson R, Pringle KC. Addison’s disease presenting with an acute abdomen and complicated by cardiomyopathy. J Paediatr Child Health. 2004;40(11):644-5. https://doi.org/10.1111/j.1440-1754.2004.00495.x. CrossRef

Titel: Reversible dilated cardiomyopathy as a complication of adrenal cortex insufficiency: a case report
Autoren:: Mohammad Alkhateeb
Mohammad Alsakkal
Mohammad Nour Alfauri
Diana Alasmar
Publikationsdatum: 01.12.2018
DOI: https://doi.org/10.1186/s13256-018-1899-1
Verlag: BioMed Central
Zeitschrift: Journal of Medical Case Reports
Ausgabe 1/2018
Elektronische ISSN: 1752-1947

Springer Medizin

Abstract

Background

Case presentation

Conclusions

Unsere Produktempfehlungen

e.Med Interdisziplinär

e.Med Allgemeinmedizin

Weitere Artikel der Ausgabe 1/2018

Coil embolization of intralobar pulmonary sequestration - an alternative to surgery: a case report

Correction to: Esophagus perforation and myocardial penetration caused by swallowing of a foreign body leading to a misdiagnosis of acute coronary syndrome: a case report

Postpartum acute fatty liver of pregnancy: a case report

Acute contrecoup epidural hematoma that developed without skull fracture in two adults: two case reports

Treatment of giant cervico-mediastinal lymphatic malformations: a case series

A prospective study of tinea capitis in children: making the diagnosis easier with a dermoscope