Automated analysis
Improved workflow for quantification of left ventricular volumes and mass using free-breathing motion corrected cine imaging.
Traditional breath-hold cine CMR can be problematic. Free breathing alternatives have relied on multiple averages or real-time imaging. The use of distributed computing was recently proposed as a way to improve clinical workflow with such algorithms. Cross et al. [
136] studied 25 patients and 25 healthy subjects with free breathing with averaging and breath-hold balanced steady state free precession (bSSFP) compared with motion corrected re-binning. Motion corrected re-binning and averaged free-breathing compared favorably with bSSFP for left ventricular (LV) mass, end-diastolic volume (EDV) and end-systolic volume (ESV). Both motion corrected re-binning and averaged free-breathing SSFP acquisitions and reconstruction times were shorter than the breath-hold bSSFP method – with an average 37%/3 min shorter time for motion corrected re-binning (vs breath-hold SSFP).
Systolic MOLLI T1 mapping with heart-rate dependent pulse sequence sampling scheme is feasible in patients with atrial fibrillation.
The irregular rhythm of atrial fibrillation (AF) may cause inaccurate T1 estimation due to mis-triggering and inadequate magnetization recovery. Zhao et al. [
137] used systolic T1 mapping with a heart-rate dependent pulse sequence to overcome this issue. Thirty patients with AF and 13 healthy subjects underwent 3T CMR using a modified Look-Locker Inversion Recovery (MOLLI) sequence. For AF patients, both the fixed and the heart rate dependent sampling scheme were performed in systole and diastole. In healthy subjects, the native T1 and ECV generated from the fixed sampling scheme were lower than the heart-rate dependent and 2nd fixed sampling scheme. In AF patients, more T1 mapping artifacts were found in diastole than in systole. The overall left ventricular (LV) T1 time and ECV were greater with diastolic acquisitions.
Evaluation of an automated method for arterial input function detection for first pass myocardial perfusion cardiovascular magnetic resonance.
Quantitative assessment of myocardial blood flow (MBF) with first-pass perfusion CMR requires a measurement of the arterial input function. In this study, Jacobs et al. [
138] propose an automated method to improve the objectivity and reduce processing time. First-pass rest and stress perfusion CMR data were analyzed from 270 clinical studies. Automated imaging processing steps included motion correction, intensity correction, detection of the left ventricle (LV), independent component analysis, and LV pixel thresholding to calculate the arterial input function. Data were compared with manual reference measurements. Their proposed method was successfully processed in 99.63% of the images. Manual and automated arterial input function were highly correlated and required less processing time that the manual approach with similar myocardial blood flow estimates.
Validation of T2* in-line analysis for tissue iron quantification at 1.5T.
There is a need for a simple on-line T2* analysis for T2* so as to improve analysis reproducibility, especially with low volume centers. In this study, Alam and co-workers [
139] compared a clinically validated T2* method and a novel works-in-progress sequence with in-line T2* measurements in 78 iron overload patients and 22 healthy subjects. Liver T2* varied from 0.8 to 35.7 ms and cardiac T2* from 6.0 to 52.3 ms. The novel in-line method had difficulty with accurate delineation of the septum due to artifacts and had some overestimation due to the inability to manually correct for noise by truncation of erroneous later echo times. Reproducibility for the existing method was superior to the in-line method.
The effects of extracellular contrast agent (gadobutrol) on the precision and reproducibility of cardiovascular magnetic resonance feature tracking.
CMR feature tracking is an area receiving considerable interest. In this study, Kuetting and colleagues [
140] perform cine mid-ventricular short axis and horizontal long axis cine 1.5T CMR in 40 healthy subjects before and 10-15 min after injection of a double dose of gadobutrol. Feature tracking derived basal, mid and apical peak systolic circumferential strain, peak longitudinal strain, and midventricular epicardial and mid-ventricular peak systolic circumferential strain rate were all
reduced after gadobutrol . Post-contrast strain assessment also showed higher intra and inter-observer variability.
Accelerated two-dimensional cine DENSE cardiovascular magnetic resonance using compressed sensing and parallel imaging.
Cine displacement encoding and stimulated echoes (DENSE) provides accurate quantitative imaging of cardiac mechanics with rapid displacement and strain analysis, but image acquisition times are relatively long. In this study, Chen et al. [
141] describe an accelerated cine DENSE sequence with variable-density spiral k-space sampling and golden angle rotations through time. A compressed sensing method, Block Low-rank Sparsity with Motion-guidance (BLOSM) was also combined with sensitivity encoding (SENSE). For retrospectively-under sampled data, BLOSM-SENSE provided similar or lower root mean square error at rates 2 at rate-2 and lower at rate-4 acceleration compared with SENSE.
Comparison of 3T and 1.5T for T2* magnetic resonance of tissue iron.
T2* CMR tissue iron concentration has improved the outcome of transfusion dependent anemia patients. In this study, Alam and co-workers [
142] performed 1.5T and 3T T2* CMR in 104 transfusion dependent patients and 20 healthy subjects. Association between heart and liver T2* at 1.5T and 3T were non-linear and R2* approximately doubled at 3T with linear fits for both heart and liver. Coefficients of variation for intra and inter-observer reproducibility as well as inter-study reproducibility tended to be better at 1.5T. Artifact scores were also significantly worse at 3T black blood.
The impact of hematocrit on oxygenation-sensitive cardiovascular magnetic resonance.
Oxygen sensitive CMR is a promising technique in which images are generated through tissue deoxyhemoglobin which is negatively correlated with signal intensity. In this study, Guensch et al. [
143] performed oxygen sensitive CMR in 21 healthy subjects using vasoactive breathing stimuli and repeated after rapid infusion of 1 L of lactated Ringer’s solution. Rapid infusion resulted in a fall in hemoglobin while baseline myocardial signal intensity increased, and in males, there was a strong association between the change in hemoglobin concentration and percent change in signal intensity.
Ferumoxytol-enhanced magnetic resonance imaging methodology and normal values at 1.5T and 3T.
Ultrasmall supraparamagnetic particles of iron oxide (USPIO)-enhanced MRI can detect tissue-resident macrophage activity and thereby identify focal cellular inflammation. Stirrat and co-workers [
144] studied 20 healthy subjects who underwent late gadolinium enhancement (LGE) imaging at baseline and t2* imaging 24 h after USPIO infusion. Following USPIO, there were changes in R2* at 1.5T in the myocardium, skeletal muscle, kidney, liver, spleen and blood; and at 3T in the myocardium, kidney liver, spleen blood and bone. Tissues showing the greatest ferumoxytol enhancement were the reticuloendothelial system: liver, spleen, and bone marrow.
Robust free-breathing SASHA T1 mapping with high-contrast image registration.
Many widely used myocardial native T1 mapping sequences use breath-hold acquisitions that limit the precision of calculated T1 maps. In this study, Chow et al. [
145] propose a novel method for generating high-contrast SAturation-recovery single-SHot Acquisition (SASHA) images to enable a robust image registration approach to free breathing T1 mapping. Breath-hold SASHA, high-contrast SASHA and MOdified Look-Locker Inversion recovery (MOLLI) images were acquired in 10 subjects. Myocardial T1 from free breathing high-contrast SASHA were similar to breath-hold SASHA. In addition, T1 map quality scores were superior with free breathing high-contrast SASHA.
Compressed sensing real-time cine cardiovascular magnetic resonance: accurate assessment of left ventricular function in a single breath-hold.
Cine CMR accelerated by compressed sensing is used to assess left ventricular (LV) function. Kido and co-workers [
146] performed conventional breath-hold cine and breath-hold real-time compressed sensing cine CMR study to obtain a short-axis stack of 8 contiguous images. Total imaging time was shorter with compressed sensing, though compressed sensing had reduced image quality. Conventional and compressed sensing had similar quantitative metrics for all measurements (end-diastolic volume, end-systolic volume, stroke volume, ejection fraction, and mass).
An interactive videogame designed to improve respiratory navigator efficiency in children undergoing cardiovascular magnetic resonance.
Many CMR sequences have long scan durations that necessitate respiratory navigator gating, but breathing patterns are more often inconsistent in children. To address this, Hamlet and colleagues [
147] developed a custom software that processed the respiratory navigator image in real-time and provided diaphragmatic position to the patient as a cartoon avatar as visual feedback. Using this approach, average navigator efficiency improved from 33% to 58% and signal-to-noise ratio improved by 5%. There was no difference in either metric between trained and untrained participants.
Flow measurement at the aortic root – impact of location of through-plane phase contrast velocity mapping.
CMR aortic flow is often measured at the sinotubular junction even though placement of the slice just above the aortic valve may be more precise. Bertelsen et al. [
148] studied 121 patients >70 years by placing the slice at the sinotubular and valve levels. Overall, stroke volume measured at the sinotubular junction was 13-16%
lower. Among the 58 patients without any valvulopathy, stroke volume measured at the valve level was closest to that measured by left ventricular stroke volume, but still significantly lower than volumetric values.
A medical device-grade T1 and ECV phantom for global T1 mapping quality assurance – the T1 mapping and ECV Standardization in cardiovascular magnetic resonance (T1MES) program.
T1 mapping and extracellular volume (ECV) have the potential to diagnose disease and monitory therapies, but measurements differ between scanners and pulse sequences. Captur and co-workers [
149] designed a phantom incorporating nine clinically relevant ranges of T1 and T2 in blood and myocardium, pre and post-contrast and 1.5 T and 3 T. The coefficient of variation was 1% or less between repeat scans indicating good short-term reproducibility. Reproducible manufacture was established and the device received regulatory clearance from the United States Food and Drug Administration (FDA) and the Conformite Europeene (CE) marketing.
Hemodynamic evaluation in patients with transposition of the great arteries after the arterial switch operation: 4D flow and 2D phase contrast cardiovascular magnetic resonance compared with Doppler echocardiography.
Peak velocity measurements are used to evaluate stenosis in patients with transposition of the great arteries after the arterial switch operation. Jarvis and co-workers [
150] performed 4D flow and 2D phase contrast CMR in 19 patients 12-25 years after arterial switch operation for transposition. Data were compared with Doppler echocardiography. Significantly higher peak velocities were found with 4D flow vs 2D phase contrast, with no significant difference between 4D flow and Doppler measurements.
D’Errico L, Lamacie MM, Juan LJ, et al. Effects of slice orientation on reproducibility of sequential assessment of right ventricular volumes and ejection fraction: short-axis vs. transverse SSFP cine cardiovascular magnetic resonance.
Reproducibility of right ventricular (RV) volumes and function are of utmost importance, but the optimal slice orientation for RV measurements is unknown. In this study, D’Errico et al. [
151] performed cine CMR in the ventricular short axis and transverse slice orientations in addition to phase velocity mapping of the main pulmonary artery in 18 subjects. Both short axis and transverse imaging slices were found to provide similarly reliable and reproducible measures and thus suitable for baseline and follow-up studies.
Magnetic resonance imaging phantoms for quality-control of myocardial T1 and ECV mapping: specific formulation, long-term stability and variation with heart rate and temperature.
CMR phantoms are needed for quality assurance, but their long-term stability for verification of myocardial T1 and extracellular volume fraction (ECV) are unknown. In this study, Vassilous et al. [
152] examined nickel-chloride agarose gel phantoms to mimic blood and myocardial T1, T2, and post-gadolinium T1 and ECV. They found only small relative changes in all the native and post-gadolinium T1 values (up to 9.0%) and ECV (up to 8.3%) over a 12 month period. Native and post-gadolinium T2 had a < 2% change. Temperature sensitivity showed the MOLLI T1 values in the long T1 phantoms increasing by 23.9 ms per degree increase and short T1 phantoms increasing by 0.3 ms per degree increase. There was also a very small increase in ECV with temperature increase.
A clinical combined gadobutrol bolus and slow infusion protocol enabling angiography, inversion recovery whole heart, and late gadolinium enhancement imaging in a single study.
The ability to perform 3D inversion recovery CMR angiography and late gadolinium enhancement (LGE) in the same sequence is desirable. Tandon and co-workers [
153] propose the use of a bolus of 0.1 mmol/kg gadobutrol for the time resolved CMR angiogram followed by a slow infusion of 0.02-0.03 ml/s with image navigated 3D inversion recovery balanced steady state free precession initiated 45-60 s after the infusion onset. Data from 10 consecutive pediatric subjects were retrospectively assessed and found to have good image quality.
Improved dark blood imaging of the heart using radial balanced steady state free precession,
Dark blood CMR imaging is typically performed using a breath-hold, dual inversion Cartesian fast spin-echo pulse sequence. In this study, Edelman et al. [
154] implemented a novel radial balanced steady state free precession (bSSFP) pulse sequence and examined 6 healthy subjects and 27 patients referred for CMR. In both groups, the single shot dual inversion radial bSSFP images showed fewer motion artifacts with faster acquisition.
Dark blood late gadolinium enhancement.
Bright blood late gadolinium enhancement (LGE) displays excellent contrast between infarcted and normal myocardium, but the contrast between the infarcted myocardium and blood pool is often suboptimal. To address this, Kellman and colleagues [
155] developed a black blood LGE sequence in which an inversion recovery T2 preparation pulse was combined with a single shot steady state free precession imaging and respiratory corrected averaging to achieved dark blood LGE images. Thirty patients with subendocardial infarction were studied with the bright blood and dark blood LGE methods. The contrast-to-noise ratio (CNR) of the dark blood LGE method was 13% lower than the bright blood method, but the CNR between the infarction and blood pool was positive for all of the dark blood cases and was negative for 63% of the bright blood cases.
Feasibility of cardiovascular magnetic resonance derived coronary wave intensity analysis.
Wave intensity analysis of the coronary arteries allows for description of the predominant mechanisms influencing coronary flow during the cardiac cycle. Raphael et al. [
156] performed wave intensity analysis by CMR and compared data with invasive Doppler data in 12 arteries (8 left; 4 right). The combination of CMR-derived pressure and velocity data produced the expected pattern of forward and reverse compression and expansion waves with good correlation with invasive data and good intra-study CMR reproducibility.