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The homeostatic controls over eating are inextricably linked to the reward aspects of eating. The result is an integrated response that coordinates the internal milieu with the prevailing environment. Thus, appetite, which reflects a complex interaction among the external environment, behavioral profile, and subjective states as well as the storage and metabolism of energy, has an important role in the regulation of energy balance. In the prevailing food environment which offers an abundance of food choices it is likely that the motivation to consume from a wide range of delectable foods plays a greater role in contributing to overeating than in the past when the motivation to eat was largely governed by metabolic need. The response to food-related cues can promote strong desires to eat known as cravings by activating the mesocorticolimbic dopamine neurocircuitry. Cravings are associated with subsequent eating and weight-related outcomes. Being able to control food cravings is a determinant of success at adhering to an energy-restricted diet regimen. Increased understanding of the neurocircuitry of appetite regulation, especially reward-related eating behavior, has provided potential targets for therapeutic anti-obesity agents specifically directed at reward mechanisms. The naltrexone–bupropion combination and lorcaserin, which are both approved by the US Food and Drug Administration (FDA) for long-term weight management, have shown promise in addressing craving-related eating behavior. Phentermine and liraglutide are approved as monotherapies for weight management. Preliminary research suggests that liraglutide, as well as phentermine alone or in combination with lorcaserin, may be effective in targeting food cravings. Food components such as thylakoid membranes have also been shown to influence food cravings. This review explores the concepts related to appetite and reward-induced eating behavior, as well as the pharmacological options and food-derived components that may be used to address food cravings.
Prospective Studies C, Whitlock G, Lewington S, et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet. 2009;373:1083–96. CrossRef
Emerging Risk Factors C, Wormser D, Kaptoge S, et al. Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet. 2011;377:1085–95. CrossRef
Lu Y, Hajifathalian K, Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration, et al. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8 million participants. Lancet. 2014;383:970–83. CrossRefPubMed
Jequier E, Tappy L. Regulation of body weight in humans. Physiol Rev. 1999;79(2):451–80. PubMed
Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000;404:661–71. PubMed
Zheng H, Lenard NR, Shin AC, Berthoud HR. Appetite control and energy balance regulation in the modern world: reward-driven brain overrides repletion signals. Int J Obes (Lond). 2009;33(Suppl 2):S8–13. CrossRef
Kelley AE, Berridge KC. The neuroscience of natural rewards: relevance to addictive drugs. J Neurosci. 2002;22:3306–11. PubMed
Edwards CA, Johnson IT, Read NW. Do viscous polysaccharides slow absorption by inhibiting diffusion or convection? Eur J Clin Nutr. 1988;42:307–12. PubMed
la Fleur SE, van Rozen AJ, Luijendijk MC, Groeneweg F, Adan RA. A free-choice high-fat high-sugar diet induces changes in arcuate neuropeptide expression that support hyperphagia. Int J Obes (Lond). 2010;34:537–46. CrossRef
Apovian CM, Aronne L, Rubino D, et al. A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II). Obesity (Silver Spring). 2013;21:935–43. CrossRef
Cepeda-Benito A, Gleaves GH, Williams TL, Erath SA. Development and validation of the state and trait food cravings questionnaire. Behav Ther. 2000;31:151–73. CrossRef
Greenway FL, PIlson R, Ma T, Fain R. The impact of weight loss therapy on control of eating: an exploratory analysis from a 12-week pilot safety study. Obesity Society (TOS). 2015; Abstract. T-P-3153, Available at http://2015.obesityweek.com/app/uploads/2015/11/1104-Wednesday-ObesityWeek-2015-TOS-Poster-Abstracts.pdf. Accessed 4 Oct 2016.
Greenway FL, PIlson R, Ma T, Fain R. The impact of weight loss therapy on food cravings: an exploratory analysis from a 12-week pilot safety study with lorcaserin and phentermine. Obesity Week (TOS). 2015; Abstract. T-P-3154, Available at http://2015.obesityweek.com/app/uploads/2015/11/1104-Wednesday-ObesityWeek-2015-TOS-Poster-Abstracts.pdf. Accessed 4 Oct 2016.
Package Inserts. http://general.takedapharm.com/content/file.aspx?filetypecode=CONTRAVEPI&cacheRandomizer=eedcee06-8dad-4cf0-910b-06e13004a474 Accessed 17 Aug 2016.
Ascher JA, Cole JO, Colin JN, et al. Bupropion: a review of its mechanism of antidepressant activity. J Clin Psychiatry. 1995;56:395–401. PubMed
Wadden TA, Foreyt JP, Foster GD, et al. Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification: the COR-BMOD trial. Obesity (Silver Spring). 2011;19:110–20. CrossRef
Package Insert. http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/085128s065lbl.pdf. Accessed 17 Aug 2016.
Moldovan CP, Weldon AJ, Daher NS, et al. Effects of a meal replacement system alone or in combination with phentermine on weight loss and food cravings. Obesity (Silver Spring). 2016. doi: 10.1002/oby.21649.
Package Insert (Belviq). http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022529lbl.pdf. Accessed 17 Aug 2016.
O’Neil PM, Smith SR, Weissman NJ, et al. Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM study. Obesity (Silver Spring). 2012;20:1426–36. CrossRef
Grottick AJ, Fletcher PJ, Higgins GA. Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior. J Pharmacol Exp Ther. 2000;295:1183–91. PubMed
Farr OM, Sofopoulos M, Tsoukas MA, et al. GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled trial. Diabetologia. 2016;59:954–65. CrossRefPubMed
Package Insert Liraglutide. Available at http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206321Orig1s000lbl.pdf. Accessed 17 Aug 2016.
Farr OM, Tsoukas MA, Triantafyllou G, et al. Short-term administration of the GLP-1 analog liraglutide decreases circulating leptin and increases GIP levels and these changes are associated with alterations in CNS responses to food cues: a randomized, placebo-controlled, crossover study. Metabolism. 2016;65:945–53. CrossRefPubMed
Montelius C, Erlandsson D, Vitija E, Stenblom EL, Egecioglu E, Erlanson-Albertsson C. Body weight loss, reduced urge for palatable food and increased release of GLP-1 through daily supplementation with green-plant membranes for three months in overweight women. Appetite. 2014;81:295–304. CrossRefPubMed
Stenblom EL, Montelius C, Erlandsson D, et al. Decreased urge for palatable food after a two-month dietary intervention with green-plant membranes in overweight women. Obesity Weight Loss Therapy. 2014;4:238.
- Reward-Induced Eating: Therapeutic Approaches to Addressing Food Cravings
Candida J. Rebello
Frank L. Greenway
- Springer Healthcare
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