Introduction
Methods
Study population
Procedures
Biochemistry
Functional assessment
Bone mineral density measurement
Statistical analysis
Results
Blood laboratory tests
RA patients (n = 24) | Controls (n = 24) |
p
| |
---|---|---|---|
Ca (mmol/l) | 2.37 [2.30; 2.45] | 2.44 [2.39; 2.50] | n.s. |
Ph (mmol/l) | 1.04 [0.97; 1.16] | 1.21 [1.13; 1.27] | <0.001 |
Creatinine (mg/dl) | 0.82 [0.63; 0.94] | 0.88 [0.74; 0.93] | n.s. |
GGT (U/l) | 20.5 [14.3; 34.0] | 18.5 [15.3; 25.8] | n.s. |
PTH (pg/ml) | 44.4 [35.1; 57.5] | 40.4 [31.8; 53.1] | n.s. |
25-OH-vitamin D (mmol/l) | 74 [54; 82] | 69 [57; 87] | n.s. |
AP (U/l) | 81.0 [73.0; 88.0] | 69.0 [57.5; 86.0] | n.s. |
BAP (ng/ml) | 13.7 [11.3; 15.3] | 12.9 [9.6; 17.5] | n.s. |
Oc (ng/ml) | 22.4 [16.0; 25.3] | 23.9 [20.7; 30.1] | n.s. |
P1NP (ng/ml) | 41.5 [36.3; 52.5] | 51.5 [40.0; 58.5] | n.s. |
CTX (ng/ml) | 0.27 [0.21; 0.34] | 0.32 [0.27; 0.39] | n.s. |
Myostatin (ng/ml) | 37.4 [29.9; 44.0] | 49.7 [45.3; 57.3] | <0.001 |
Follistatin (pg/ml) | 2054 [1696; 2655] | 1588 [1259; 1811] | 0.004 |
MSTN/FSTN | 0.02 [0.01; 0.02] | 0.03 [0.02; 0.04] | <0.001 |
GDF-15 (pg/ml) | 643.0 [534.7; 1076.2] | 586.3 [430.1; 666.1] | n.s. |
Sclerostin (pg/ml) | 28.2 [25.2; 33.1] | 29.0 [23.4; 41.1] | n.s. |
Dickkopf 1 (pg/ml) | 27.9 [20.4; 44.6] | 45.8 [32.0; 58.7] | 0.004 |
Periostin (ng/ml) | 3063 [2359; 4203] | 1021 [807; 1941] | <0.001 |
Functional tests
RA patients (n = 24) | Controls (n = 24) |
p
| |
---|---|---|---|
CHT | 11.2 [9.0; 14.8] | 7.1 [6.1; 7.9] | <0.001 |
TUG | 7.6 [7.0; 8.7] | 4.9 [4.4; 5.7] | <0.001 |
6MWT | 521 [447; 590] | 650 [605; 683] | <0.001 |
Grip strength left | 15.5 [10.3; 21.8] | 18.5 [14.8; 21.3] | n.s. |
Grip strength right | 18.0 [12.5; 22.3] | 19.0 [16.3; 24.3] | n.s. |
Back extensors: endurance | 43 [15.7; 62] | 118 [86; 184] | <0.001 |
Back extensors: strength | 159 [126; 186] | 157 [120; 193] | n.s. |
HAQ | 0 [0; 4] | 0 [0; 0] | 0.001 |
MOS-SF 36 | |||
Physical functioning | 90 [80; 98] | 100 [95; 100] | 0.008 |
Role, physical | 100 [100; 100] | 100 [100; 100] | n.s. |
Role, emotional | 100 [100; 100] | 100 [100; 100] | n.s. |
Social functioning | 100 [88; 100] | 100 [88; 100] | n.s. |
Mental health | 84 [72; 88] | 80 [68; 90] | n.s. |
Bodily pain | 80 [62; 100] | 100 [74; 100] | 0.05 |
Vitality | 70 [50; 75] | 75 [60; 80] | n.s. |
General health | 72 [58; 77] | 80 [67; 92] | 0.042 |
MSTN | FSTN | MST/FSTN | GDF-15 | Dkk1 | SOST | PSTN | |
---|---|---|---|---|---|---|---|
MSTN | 1 | 0.076 | 0.698** | 0.086 | −0.60 | 0.042 | 0.260 |
FSTN | 0.076 | 1 | −0.559** | 0.202 | 0.51 | −0.33 | 0.337* |
MSTN/FSTN | 0.698** | −0.559** | 1 | −0.063 | −0.103 | 0.068 | −0.100 |
GDF-15 | 0.086 | 0.202 | −0.063 | 1 | −0.126 | −0.027 | 0.345* |
PSTN | 0.260 | 0.337* | −0.100 | 0.345* | −0.321* | −0.296* | 1 |
Dkk1 | −0.60 | 0.51 | −0.103 | −0.126 | 1 | 0.205 | −0.321* |
SOST | 0.042 | −0.333 | 0.068 | −0.027 | 0.205 | 1 | −0.296* |
PSTN | 0.260 | 0.337* | −0.100 | 0.345* | −0.321* | −0.296* | 1 |
Chair rise | 0.221 | 0.328* | −0.073 | 0.473** | −0.282 | 0.058 | 0.606** |
TUG | 0.098 | 0.561** | −0.302* | 0.464** | −0.186 | −0.052 | 0.536** |
6MWT | −0.030 | −0.394** | 0.225 | −0.397** | 0.219 | 0.142 | −0.476** |
Biering S | −0.059 | −0.384** | 0.216 | −0.329* | 0.211 | 0.190 | −0.332* |
Grip strength left | −0.370** | −0.225 | −0.117 | −0.003 | −0.16 | 0.093 | −0.240 |
Grip strength right | −0.318* | −0.192 | −0.117 | −0.06 | 0.080 | 0.115 | −0.359* |
HAQ | 0.492** | 0.452** | 0.069 | 0.487** | −0.225 | −0.117 | 0.562** |