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20.01.2023 | Review Article

Risk Factors for Anticoagulant-Associated Intracranial Hemorrhage: A Systematic Review and Meta-analysis

verfasst von: Zhiwei Zeng, Jiana Chen, Jiafen Qian, Fuxin Ma, Meina Lv, Jinhua Zhang

Erschienen in: Neurocritical Care | Ausgabe 3/2023

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Abstract

Background

Anticoagulant-associated intracranial hemorrhage has a high mortality rate, and many factors can cause intracranial hemorrhage. Until now, systematic reviews and assessments of the certainty of the evidence have not been published.

Methods

We conducted a systematic review to identify risk factors for anticoagulant-associated intracranial hemorrhage. The protocol for this systematic review was prospectively registered with PROSPERO (CRD42022316750). All English studies that met the inclusion criteria published before January 2022 were obtained from PubMed, EMBASE, Web of Science, and Cochrane Library. Two researchers independently screened articles, extracted data, and evaluated the quality and evidence of the included studies. Risk factors for intracranial hemorrhage were used as the outcome index of this review. Random or fixed-effect models were used in statistical methods. I2 statistics were used to evaluate heterogeneity.

Results

Of 7322 citations, we included 20 studies in our analysis. For intracranial hemorrhage, moderate-certainty evidence showed a probable association with race, Glasgow Coma Scale, stroke, leukoaraiosis, cerebrovascular disease, tumor, atrial fibrillation, previous bleeding, international normalized ratio, serum albumin, prothrombin time, diastolic blood pressure, and anticoagulant. Low-certainty evidence may be associated with age, cerebral microbleeds, smoking, alcohol intake, platelet count, and antiplatelet drug. In addition, we found very low-certainty evidence that there may be little to no association between the risk of intracranial hemorrhage and hypertension and creatinine clearance. Leukoaraiosis, cerebral microbleeds, cerebrovascular disease, and international normalized ratio are not included in most risk assessment models.

Conclusions

This study informs risk prediction for anticoagulant-associated intracranial hemorrhage and informs guidelines for intracranial hemorrhage prevention and future research.
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Literatur
1.
Zurück zum Zitat Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007;146:857–67.PubMedCrossRef Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007;146:857–67.PubMedCrossRef
2.
Zurück zum Zitat Fang MC, Go AS, Chang Y, Hylek EM, Henault LE, Jensvold NG, et al. Death and disability from warfarin-associated intracranial and extracranial hemorrhages. Am J Med. 2007;120:700–5.PubMedPubMedCentralCrossRef Fang MC, Go AS, Chang Y, Hylek EM, Henault LE, Jensvold NG, et al. Death and disability from warfarin-associated intracranial and extracranial hemorrhages. Am J Med. 2007;120:700–5.PubMedPubMedCentralCrossRef
3.
Zurück zum Zitat Flaherty ML, Kissela B, Woo D, Kleindorfer D, Alwell K, Sekar P, et al. The increasing incidence of anticoagulant-associated intracerebral hemorrhage. Neurology. 2007;68:116–21.PubMedCrossRef Flaherty ML, Kissela B, Woo D, Kleindorfer D, Alwell K, Sekar P, et al. The increasing incidence of anticoagulant-associated intracerebral hemorrhage. Neurology. 2007;68:116–21.PubMedCrossRef
4.
Zurück zum Zitat Huhtakangas J, Tetri S, Juvela S, Saloheimo P, Bode MK, Hillbom M. Effect of increased warfarin use on warfarin-related cerebral hemorrhage: a longitudinal population-based study. Stroke. 2011;42:2431–5.PubMedCrossRef Huhtakangas J, Tetri S, Juvela S, Saloheimo P, Bode MK, Hillbom M. Effect of increased warfarin use on warfarin-related cerebral hemorrhage: a longitudinal population-based study. Stroke. 2011;42:2431–5.PubMedCrossRef
5.
Zurück zum Zitat Hart RG, Diener HC, Yang S, Connolly SJ, Wallentin L, Reilly PA, et al. Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: the RE-LY trial. Stroke. 2012;43:1511–7.PubMedCrossRef Hart RG, Diener HC, Yang S, Connolly SJ, Wallentin L, Reilly PA, et al. Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: the RE-LY trial. Stroke. 2012;43:1511–7.PubMedCrossRef
6.
Zurück zum Zitat Palareti G, Leali N, Coccheri S, et al. Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT). Italian study on complications of oral anticoagulant therapy. Lancet. 1996;348:423–8.PubMedCrossRef Palareti G, Leali N, Coccheri S, et al. Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT). Italian study on complications of oral anticoagulant therapy. Lancet. 1996;348:423–8.PubMedCrossRef
7.
Zurück zum Zitat Albers GW. Atrial fibrillation and stroke. Three new studies, three remaining questions. Arch Intern Med. 1994;154:1443–8.PubMedCrossRef Albers GW. Atrial fibrillation and stroke. Three new studies, three remaining questions. Arch Intern Med. 1994;154:1443–8.PubMedCrossRef
8.
Zurück zum Zitat Darzi AJ, Karam SG, Charide R, et al. Prognostic factors for VTE and bleeding in hospitalized medical patients: a systematic review and meta-analysis. Blood. 2020;135(20):1788–810.PubMedPubMedCentralCrossRef Darzi AJ, Karam SG, Charide R, et al. Prognostic factors for VTE and bleeding in hospitalized medical patients: a systematic review and meta-analysis. Blood. 2020;135(20):1788–810.PubMedPubMedCentralCrossRef
9.
Zurück zum Zitat Riley RD, Moons KG, Snell KI, Ensor J, Hooft L, Altman DG, et al. A guide to systematic review and meta-analysis of prognostic factor studies. BMJ. 2019;364:k4597.PubMedCrossRef Riley RD, Moons KG, Snell KI, Ensor J, Hooft L, Altman DG, et al. A guide to systematic review and meta-analysis of prognostic factor studies. BMJ. 2019;364:k4597.PubMedCrossRef
10.
Zurück zum Zitat Wolff RWP, Whiting P, Mallett S, et al. eds. PROBAST: a “risk of bias” tool for prediction modelling studies [abstract]. Cochrane Colloquium Abstracts. 2015. Wolff RWP, Whiting P, Mallett S, et al. eds. PROBAST: a “risk of bias” tool for prediction modelling studies [abstract]. Cochrane Colloquium Abstracts. 2015.
11.
Zurück zum Zitat Tang SW, Zhang Y, Tao BL, Yang ZR, Sun F, Zhan SY. Risk of bias assessment: (7) assessing bias in studies of prognostic factors [in Chinese]. Zhong Hua Liu Xing Bing Xue Za Zhi. 2018;39(7):1003–8. Tang SW, Zhang Y, Tao BL, Yang ZR, Sun F, Zhan SY. Risk of bias assessment: (7) assessing bias in studies of prognostic factors [in Chinese]. Zhong Hua Liu Xing Bing Xue Za Zhi. 2018;39(7):1003–8.
12.
Zurück zum Zitat Hayden JA, van der Windt DA, Cartwright JL, Côté P, Bombardier C. Assessing bias in studies of prognostic factors. Ann Intern Med. 2013;158(4):280–6.PubMedCrossRef Hayden JA, van der Windt DA, Cartwright JL, Côté P, Bombardier C. Assessing bias in studies of prognostic factors. Ann Intern Med. 2013;158(4):280–6.PubMedCrossRef
13.
Zurück zum Zitat Reeves BC, Deeks JJ, Higgins JPT, Wells GA. Including non-randomized studies. In: Cochrane handbook for systematic reviews of interventions. 2008. p. 391. Reeves BC, Deeks JJ, Higgins JPT, Wells GA. Including non-randomized studies. In: Cochrane handbook for systematic reviews of interventions. 2008. p. 391.
14.
Zurück zum Zitat Iorio A, Spencer FA, Falavigna M, et al. Use of GRADE for assessment of evidence about prognosis: rating confidence in estimates of event rates in broad categories of patients. BMJ. 2015;350:h870.PubMedCrossRef Iorio A, Spencer FA, Falavigna M, et al. Use of GRADE for assessment of evidence about prognosis: rating confidence in estimates of event rates in broad categories of patients. BMJ. 2015;350:h870.PubMedCrossRef
15.
Zurück zum Zitat Ahn S, Fessler JA. Standard errors of mean, variance, and standard deviation estimators. Ann Arbor: Electrical Engineering and Computer Science Department, The University of Michigan; 2003. p. 1–2. Ahn S, Fessler JA. Standard errors of mean, variance, and standard deviation estimators. Ann Arbor: Electrical Engineering and Computer Science Department, The University of Michigan; 2003. p. 1–2.
16.
Zurück zum Zitat Grant RL. Converting an odds ratio to a range of plausible relative risks for better communication of research findings. BMJ. 2014;348(1):f7450.PubMedCrossRef Grant RL. Converting an odds ratio to a range of plausible relative risks for better communication of research findings. BMJ. 2014;348(1):f7450.PubMedCrossRef
17.
Zurück zum Zitat Wang Z. Converting odds ratio to relative risk in cohort studies with partial data information. J Stat Softw. 2013;55(5):1–11.CrossRef Wang Z. Converting odds ratio to relative risk in cohort studies with partial data information. J Stat Softw. 2013;55(5):1–11.CrossRef
18.
Zurück zum Zitat Marsh EB, Llinas RH, Hillis AE, et al. Hemorrhagic transformation in patients with acute ischemic stroke and an indication for anticoagulation. Eur J Neurol. 2013;20(6):962–7.PubMedPubMedCentralCrossRef Marsh EB, Llinas RH, Hillis AE, et al. Hemorrhagic transformation in patients with acute ischemic stroke and an indication for anticoagulation. Eur J Neurol. 2013;20(6):962–7.PubMedPubMedCentralCrossRef
19.
Zurück zum Zitat Hankey GJ, Stevens SR, Piccini JP, et al. Intracranial hemorrhage among patients with atrial fibrillation anticoagulated with warfarin or rivaroxaban: the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation. Stroke. 2014;45(5):1304–12.PubMedCrossRef Hankey GJ, Stevens SR, Piccini JP, et al. Intracranial hemorrhage among patients with atrial fibrillation anticoagulated with warfarin or rivaroxaban: the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation. Stroke. 2014;45(5):1304–12.PubMedCrossRef
20.
Zurück zum Zitat Hippisley-Cox J, Coupland C. Predicting risk of upper gastrointestinal bleed and intracranial bleed with anticoagulants: cohort study to derive and validate the QBleed scores. BMJ. 2014;349:g4606.PubMedPubMedCentralCrossRef Hippisley-Cox J, Coupland C. Predicting risk of upper gastrointestinal bleed and intracranial bleed with anticoagulants: cohort study to derive and validate the QBleed scores. BMJ. 2014;349:g4606.PubMedPubMedCentralCrossRef
21.
Zurück zum Zitat Nieto JA, Solano R, Ruiz-Ribó MD, et al. Fatal bleeding in patients receiving anticoagulant therapy for venous thromboembolism: findings from the RIETE registry. J Thromb Haemost. 2010;8(6):1216–22.PubMedCrossRef Nieto JA, Solano R, Ruiz-Ribó MD, et al. Fatal bleeding in patients receiving anticoagulant therapy for venous thromboembolism: findings from the RIETE registry. J Thromb Haemost. 2010;8(6):1216–22.PubMedCrossRef
22.
Zurück zum Zitat Turcato G, Zaboli A, Zannoni M, et al. Risk factors associated with intracranial bleeding and neurosurgery in patients with mild traumatic brain injury who are receiving direct oral anticoagulants. Am J Emerg Med. 2021;43:180–5.PubMedCrossRef Turcato G, Zaboli A, Zannoni M, et al. Risk factors associated with intracranial bleeding and neurosurgery in patients with mild traumatic brain injury who are receiving direct oral anticoagulants. Am J Emerg Med. 2021;43:180–5.PubMedCrossRef
23.
Zurück zum Zitat Smith EE, Rosand J, Knudsen KA, Hylek EM, Greenberg SM. Leukoaraiosis is associated with warfarin-related hemorrhage following ischemic stroke. Neurology. 2002;59(2):193–7.PubMedCrossRef Smith EE, Rosand J, Knudsen KA, Hylek EM, Greenberg SM. Leukoaraiosis is associated with warfarin-related hemorrhage following ischemic stroke. Neurology. 2002;59(2):193–7.PubMedCrossRef
24.
Zurück zum Zitat Lee SH, Hong KS, Lee JS, et al. Prediction of hemorrhagic transformation in patients with mild atrial fibrillation-associated stroke treated with early anticoagulation: post hoc analysis of the Triple AXEL Trial. Clin Neurol Neurosurg. 2018;174:156–62.PubMedCrossRef Lee SH, Hong KS, Lee JS, et al. Prediction of hemorrhagic transformation in patients with mild atrial fibrillation-associated stroke treated with early anticoagulation: post hoc analysis of the Triple AXEL Trial. Clin Neurol Neurosurg. 2018;174:156–62.PubMedCrossRef
25.
Zurück zum Zitat Rendell S, Batchelor JS. An analysis of predictive markers for intracranial haemorrhage in warfarinised head injury patients. Emerg Med J. 2013;30(1):28–31.PubMedCrossRef Rendell S, Batchelor JS. An analysis of predictive markers for intracranial haemorrhage in warfarinised head injury patients. Emerg Med J. 2013;30(1):28–31.PubMedCrossRef
26.
Zurück zum Zitat Curtze S, Strbian D, Meretoja A, et al. Higher baseline international normalized ratio value correlates with higher mortality in intracerebral hemorrhage during warfarin use. Eur J Neurol. 2014;21(4):616–22.PubMedCrossRef Curtze S, Strbian D, Meretoja A, et al. Higher baseline international normalized ratio value correlates with higher mortality in intracerebral hemorrhage during warfarin use. Eur J Neurol. 2014;21(4):616–22.PubMedCrossRef
27.
Zurück zum Zitat Fang MC, Chang Y, Hylek EM, et al. Advanced age, anticoagulation intensity, and risk for intracranial hemorrhage among patients taking warfarin for atrial fibrillation. Ann Intern Med. 2004;141(10):745–52.PubMedCrossRef Fang MC, Chang Y, Hylek EM, et al. Advanced age, anticoagulation intensity, and risk for intracranial hemorrhage among patients taking warfarin for atrial fibrillation. Ann Intern Med. 2004;141(10):745–52.PubMedCrossRef
28.
Zurück zum Zitat Berwaerts J, Webster J. Analysis of risk factors involved in oral-anticoagulant-related intracranial haemorrhages. QJM. 2000;93(8):513–21.PubMedCrossRef Berwaerts J, Webster J. Analysis of risk factors involved in oral-anticoagulant-related intracranial haemorrhages. QJM. 2000;93(8):513–21.PubMedCrossRef
29.
Zurück zum Zitat Best JG, Barbato C, Ambler G, et al. Association of enlarged perivascular spaces and anticoagulant-related intracranial hemorrhage. Neurology. 2020;95(16):e2192–9.PubMedPubMedCentralCrossRef Best JG, Barbato C, Ambler G, et al. Association of enlarged perivascular spaces and anticoagulant-related intracranial hemorrhage. Neurology. 2020;95(16):e2192–9.PubMedPubMedCentralCrossRef
30.
Zurück zum Zitat Gorter JW. Major bleeding during anticoagulation after cerebral ischemia: patterns and risk factors. Stroke Prevention In Reversible Ischemia Trial (SPIRIT). European Atrial Fibrillation Trial (EAFT) study groups. Neurology. 1999;53(6):1319–27.PubMedCrossRef Gorter JW. Major bleeding during anticoagulation after cerebral ischemia: patterns and risk factors. Stroke Prevention In Reversible Ischemia Trial (SPIRIT). European Atrial Fibrillation Trial (EAFT) study groups. Neurology. 1999;53(6):1319–27.PubMedCrossRef
31.
Zurück zum Zitat Lee SH, Ryu WS, Roh JK. Cerebral microbleeds are a risk factor for warfarin-related intracerebral hemorrhage. Neurology. 2009;72(2):171–6.PubMedCrossRef Lee SH, Ryu WS, Roh JK. Cerebral microbleeds are a risk factor for warfarin-related intracerebral hemorrhage. Neurology. 2009;72(2):171–6.PubMedCrossRef
32.
Zurück zum Zitat Ueno H, Naka H, Ohshita T, et al. Association between cerebral microbleeds on T2*-weighted MR images and recurrent hemorrhagic stroke in patients treated with warfarin following ischemic stroke. AJNR Am J Neuroradiol. 2008;29(8):1483–6.PubMedPubMedCentralCrossRef Ueno H, Naka H, Ohshita T, et al. Association between cerebral microbleeds on T2*-weighted MR images and recurrent hemorrhagic stroke in patients treated with warfarin following ischemic stroke. AJNR Am J Neuroradiol. 2008;29(8):1483–6.PubMedPubMedCentralCrossRef
33.
Zurück zum Zitat Martí-Fàbregas J, Medrano-Martorell S, Merino E, et al. MRI predicts intracranial hemorrhage in patients who receive long-term oral anticoagulation. Neurology. 2019;92(21):e2432-443.PubMedPubMedCentralCrossRef Martí-Fàbregas J, Medrano-Martorell S, Merino E, et al. MRI predicts intracranial hemorrhage in patients who receive long-term oral anticoagulation. Neurology. 2019;92(21):e2432-443.PubMedPubMedCentralCrossRef
34.
Zurück zum Zitat Hylek EM, Singer DE. Risk factors for intracranial hemorrhage in outpatients taking warfarin. Ann Intern Med. 1994;120(11):897–902.PubMedCrossRef Hylek EM, Singer DE. Risk factors for intracranial hemorrhage in outpatients taking warfarin. Ann Intern Med. 1994;120(11):897–902.PubMedCrossRef
35.
Zurück zum Zitat Paciaroni M, Agnelli G, Giustozzi M, et al. Risk factors for intracerebral hemorrhage in patients with atrial fibrillation on non-vitamin K antagonist oral anticoagulants for stroke prevention. Stroke. 2021;52(4):1450–4.PubMedCrossRef Paciaroni M, Agnelli G, Giustozzi M, et al. Risk factors for intracerebral hemorrhage in patients with atrial fibrillation on non-vitamin K antagonist oral anticoagulants for stroke prevention. Stroke. 2021;52(4):1450–4.PubMedCrossRef
36.
Zurück zum Zitat Pastori D, Carnevale R, Cangemi R, et al. Vitamin E serum levels and bleeding risk in patients receiving oral anticoagulant therapy: a retrospective cohort study. J Am Heart Assoc. 2013;2(6):e000364.PubMedPubMedCentralCrossRef Pastori D, Carnevale R, Cangemi R, et al. Vitamin E serum levels and bleeding risk in patients receiving oral anticoagulant therapy: a retrospective cohort study. J Am Heart Assoc. 2013;2(6):e000364.PubMedPubMedCentralCrossRef
37.
Zurück zum Zitat Alexandrov AV, Black SE, Ehrlich LE, Caldwell CB, Norris JW. Predictors of hemorrhagic transformation occurring spontaneously and on anticoagulants in patients with acute ischemic stroke. Stroke. 1997;28(6):1198–202.PubMedCrossRef Alexandrov AV, Black SE, Ehrlich LE, Caldwell CB, Norris JW. Predictors of hemorrhagic transformation occurring spontaneously and on anticoagulants in patients with acute ischemic stroke. Stroke. 1997;28(6):1198–202.PubMedCrossRef
38.
Zurück zum Zitat Gorter JW. Major bleeding during anticoagulation after cerebral ischemia: patterns and risk factors. Stroke Prevention In Reversible Ischemia Trial (SPIRIT). European Atrial Fibrillation Trial (EAFT) study groups. Neurology. 1999;53:1319–27.PubMedCrossRef Gorter JW. Major bleeding during anticoagulation after cerebral ischemia: patterns and risk factors. Stroke Prevention In Reversible Ischemia Trial (SPIRIT). European Atrial Fibrillation Trial (EAFT) study groups. Neurology. 1999;53:1319–27.PubMedCrossRef
39.
Zurück zum Zitat Warfarin versus aspirin for prevention of thromboembolism in atrial fibrillation: Stroke Prevention in Atrial Fibrillation II Study. Lancet. 1994;343:687–91. Warfarin versus aspirin for prevention of thromboembolism in atrial fibrillation: Stroke Prevention in Atrial Fibrillation II Study. Lancet. 1994;343:687–91.
40.
Zurück zum Zitat Fihn SD, Callahan CM, Martin DC, McDonell MB, Henikoff JG, White RH. The risk for and severity of bleeding complications in elderly patients treated with warfarin. The National Consortium of Anticoagulation Clinics. Ann Intern Med. 1996;124:970–9.PubMedCrossRef Fihn SD, Callahan CM, Martin DC, McDonell MB, Henikoff JG, White RH. The risk for and severity of bleeding complications in elderly patients treated with warfarin. The National Consortium of Anticoagulation Clinics. Ann Intern Med. 1996;124:970–9.PubMedCrossRef
41.
Zurück zum Zitat van der Meer FJ, Rosendaal FR, Vandenbroucke JP, Briet E. Bleeding complications in oral anticoagulant therapy. An analysis of risk factors. Arch Intern Med. 1993;153:1557–62.PubMedCrossRef van der Meer FJ, Rosendaal FR, Vandenbroucke JP, Briet E. Bleeding complications in oral anticoagulant therapy. An analysis of risk factors. Arch Intern Med. 1993;153:1557–62.PubMedCrossRef
42.
Zurück zum Zitat Mathiesen T, Benediktsdottir K, Johnsson H, Lindqvist M, von Holst H. Intracranial traumatic and non-traumatic haemorrhagic complications of warfarin treatment. Acta Neurol Scand. 1995;91:208–14.PubMedCrossRef Mathiesen T, Benediktsdottir K, Johnsson H, Lindqvist M, von Holst H. Intracranial traumatic and non-traumatic haemorrhagic complications of warfarin treatment. Acta Neurol Scand. 1995;91:208–14.PubMedCrossRef
43.
Zurück zum Zitat Lacroix P, Portefaix O, Boucher M, Ramiandrisoa H, Dumas M, Ravon R, Christides C, Laskar M. Conditions de survenue des accidents hemorragiques intracraniens des antivitamines K. Arch Mal Coeur. 1994;87:1715–9.PubMed Lacroix P, Portefaix O, Boucher M, Ramiandrisoa H, Dumas M, Ravon R, Christides C, Laskar M. Conditions de survenue des accidents hemorragiques intracraniens des antivitamines K. Arch Mal Coeur. 1994;87:1715–9.PubMed
44.
Zurück zum Zitat McGrath ER, Kapral MK, Fang J, Eikelboom JW, Conghaile AO, Canavan M, et al. Investigators of the Registry of the Canadian Stroke Network. Which risk factors are more associated with ischemic stroke than intracerebral hemorrhage in patients with atrial fibrillation? Stroke. 2012;43:2048–54.PubMedCrossRef McGrath ER, Kapral MK, Fang J, Eikelboom JW, Conghaile AO, Canavan M, et al. Investigators of the Registry of the Canadian Stroke Network. Which risk factors are more associated with ischemic stroke than intracerebral hemorrhage in patients with atrial fibrillation? Stroke. 2012;43:2048–54.PubMedCrossRef
45.
46.
Zurück zum Zitat Tinetti ME, Williams CS. Falls, injuries due to falls, and the risk of admission to a nursing home. N Engl J Med. 1997;337:1279–84.PubMedCrossRef Tinetti ME, Williams CS. Falls, injuries due to falls, and the risk of admission to a nursing home. N Engl J Med. 1997;337:1279–84.PubMedCrossRef
47.
Zurück zum Zitat Kawai N, Keep RF, Betz AL. Hyperglycemia and the vascular effects of cerebral ischemia. Stroke. 1997;28:149–54.PubMedCrossRef Kawai N, Keep RF, Betz AL. Hyperglycemia and the vascular effects of cerebral ischemia. Stroke. 1997;28:149–54.PubMedCrossRef
48.
Zurück zum Zitat Tong X, George MG, Yang Q, Gillespie C. Predictors of in-hospital death and symptomatic intracranial hemorrhage in patients with acute ischemic stroke treated with thrombolytic therapy: Paul Coverdell Acute Stroke Registry 2008–2012. Int J Stroke. 2014;9(6):728–34.PubMedCrossRef Tong X, George MG, Yang Q, Gillespie C. Predictors of in-hospital death and symptomatic intracranial hemorrhage in patients with acute ischemic stroke treated with thrombolytic therapy: Paul Coverdell Acute Stroke Registry 2008–2012. Int J Stroke. 2014;9(6):728–34.PubMedCrossRef
49.
Zurück zum Zitat Limdi NA, McGwin G, Goldstein JA, Beasley TM, Arnett DK, Adler BK, et al. Influence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarin. Clin Pharmacol Ther. 2008;83:312–21.PubMedCrossRef Limdi NA, McGwin G, Goldstein JA, Beasley TM, Arnett DK, Adler BK, et al. Influence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarin. Clin Pharmacol Ther. 2008;83:312–21.PubMedCrossRef
50.
Zurück zum Zitat Lip GY, Frison L, Halperin JL, Lane DA. Comparative validation of a novel risk score for predicting bleeding risk in anticoagulated patients with atrial fibrillation: the HAS-BLED (Hypertension, Abnormal Renal/ Liver Function, Stroke, Bleeding History or Predisposition, Labile INR, Elderly, Drugs/Alcohol Concomitantly) score. J Am Coll Cardiol. 2011;57:173–80.PubMedCrossRef Lip GY, Frison L, Halperin JL, Lane DA. Comparative validation of a novel risk score for predicting bleeding risk in anticoagulated patients with atrial fibrillation: the HAS-BLED (Hypertension, Abnormal Renal/ Liver Function, Stroke, Bleeding History or Predisposition, Labile INR, Elderly, Drugs/Alcohol Concomitantly) score. J Am Coll Cardiol. 2011;57:173–80.PubMedCrossRef
51.
Zurück zum Zitat Warach S, Latour LL. Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption. Stroke. 2004;35:2659–61.PubMedCrossRef Warach S, Latour LL. Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption. Stroke. 2004;35:2659–61.PubMedCrossRef
52.
Zurück zum Zitat Whiteley WN, Slot KB, Fernandes P, Sandercock P, Wardlaw J. Risk factors for intracranial hemorrhage in acute ischemic stroke patients treated with recombinant tissue plasminogen activator: a systematic review and meta-analysis of 55 studies. Stroke. 2012;43:2904–9.PubMedCrossRef Whiteley WN, Slot KB, Fernandes P, Sandercock P, Wardlaw J. Risk factors for intracranial hemorrhage in acute ischemic stroke patients treated with recombinant tissue plasminogen activator: a systematic review and meta-analysis of 55 studies. Stroke. 2012;43:2904–9.PubMedCrossRef
53.
Zurück zum Zitat Tanne D, Kasner SE, Demchuk AM, Koren-Morag N, Hanson S, Grond M, et al. Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the Multicenter rt-PA Stroke Survey. Circulation. 2002;105:1679–85.PubMedCrossRef Tanne D, Kasner SE, Demchuk AM, Koren-Morag N, Hanson S, Grond M, et al. Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the Multicenter rt-PA Stroke Survey. Circulation. 2002;105:1679–85.PubMedCrossRef
54.
Zurück zum Zitat Saposnik G, Gladstone D, Raptis R, Zhou L, Hart RG. Investigators of the Registry of the Canadian Stroke N, and the Stroke Outcomes Research Canada Working G. Atrial fibrillation in ischemic stroke: predicting response to thrombolysis and clinical outcomes. Stroke. 2013;44:99–104.PubMedCrossRef Saposnik G, Gladstone D, Raptis R, Zhou L, Hart RG. Investigators of the Registry of the Canadian Stroke N, and the Stroke Outcomes Research Canada Working G. Atrial fibrillation in ischemic stroke: predicting response to thrombolysis and clinical outcomes. Stroke. 2013;44:99–104.PubMedCrossRef
55.
Zurück zum Zitat De Lorenzo F, Saba N, Kakkar VV. Blood coagulation in patients with chronic heart failure: evidence for hypercoagulable state and potential for pharmacological intervention. Drugs. 2003;63:565–76.PubMedCrossRef De Lorenzo F, Saba N, Kakkar VV. Blood coagulation in patients with chronic heart failure: evidence for hypercoagulable state and potential for pharmacological intervention. Drugs. 2003;63:565–76.PubMedCrossRef
56.
Zurück zum Zitat Steiner T, Rosand J, Diringer M. Intracerebral hemorrhage associated with oral anticoagulant therapy: current practices and unresolved questions. Stroke. 2006;37:256–62.PubMedCrossRef Steiner T, Rosand J, Diringer M. Intracerebral hemorrhage associated with oral anticoagulant therapy: current practices and unresolved questions. Stroke. 2006;37:256–62.PubMedCrossRef
57.
Zurück zum Zitat Rosand J, Eckman MH, Knudsen KA, Singer DE, Greenberg SM. The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage. Arch Intern Med. 2004;164:880–4.PubMedCrossRef Rosand J, Eckman MH, Knudsen KA, Singer DE, Greenberg SM. The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage. Arch Intern Med. 2004;164:880–4.PubMedCrossRef
58.
Zurück zum Zitat Wintzen AR, Tijssen JGP. Subdural hematoma and oral anticoagulant therapy. Arch Neurol. 1982;39:68–72.CrossRef Wintzen AR, Tijssen JGP. Subdural hematoma and oral anticoagulant therapy. Arch Neurol. 1982;39:68–72.CrossRef
59.
Zurück zum Zitat Hylek EM, Singer DE. Risk factors for intracranial hemorrhage in outpatients taking warfarin. Ann Intern Med. 1994;120:897–902.PubMedCrossRef Hylek EM, Singer DE. Risk factors for intracranial hemorrhage in outpatients taking warfarin. Ann Intern Med. 1994;120:897–902.PubMedCrossRef
60.
Zurück zum Zitat Kase CS, Robinson RK, Stein RW, DeWitt LD, Hier DB, Harp DL, et al. Anticoagulant-related intracerebral hemorrhage. Neurology. 1985;35:943–8.PubMedCrossRef Kase CS, Robinson RK, Stein RW, DeWitt LD, Hier DB, Harp DL, et al. Anticoagulant-related intracerebral hemorrhage. Neurology. 1985;35:943–8.PubMedCrossRef
61.
Zurück zum Zitat Fredriksson K, Norrving B, Stromblad L-G. Emergency reversal of anticoagulation after intracerebral hemorrhage. Stroke. 1992;23:972–7.PubMedCrossRef Fredriksson K, Norrving B, Stromblad L-G. Emergency reversal of anticoagulation after intracerebral hemorrhage. Stroke. 1992;23:972–7.PubMedCrossRef
62.
Zurück zum Zitat Pisters R, Lane DA, Nieuwlaat R, de Vos CB, Crijns HJ, Lip GY. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. Chest. 2010;138:1093–100.PubMedCrossRef Pisters R, Lane DA, Nieuwlaat R, de Vos CB, Crijns HJ, Lip GY. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. Chest. 2010;138:1093–100.PubMedCrossRef
63.
Zurück zum Zitat Fang MC, Go AS, Chang Y, Borowsky LH, Pomernacki NK, Udaltsova N, et al. A new risk scheme to predict warfarin-associated hemorrhage: the A TRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study. J Am Coll Cardiol. 2011;58:395–401.PubMedPubMedCentralCrossRef Fang MC, Go AS, Chang Y, Borowsky LH, Pomernacki NK, Udaltsova N, et al. A new risk scheme to predict warfarin-associated hemorrhage: the A TRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study. J Am Coll Cardiol. 2011;58:395–401.PubMedPubMedCentralCrossRef
64.
Zurück zum Zitat Olesen JB, Lip GYH, Kamper A-L, et al. Stroke and bleeding in atrial fibrillation with chronic kidney disease. NEJM. 2012;367:625–35.PubMedCrossRef Olesen JB, Lip GYH, Kamper A-L, et al. Stroke and bleeding in atrial fibrillation with chronic kidney disease. NEJM. 2012;367:625–35.PubMedCrossRef
65.
Zurück zum Zitat Boccardo P, Remuzzi G, Galbusera M. Platelet dysfunction in renal failure. Semin Thromb Hemost. 2004;30:579–89.PubMedCrossRef Boccardo P, Remuzzi G, Galbusera M. Platelet dysfunction in renal failure. Semin Thromb Hemost. 2004;30:579–89.PubMedCrossRef
66.
Zurück zum Zitat Fogelholm R, Eskola K, Kiminkinen T, Kunnamo I. Anticoagulant treatment as a risk factor for primary intracerebral haemorrhage. J Neurol Neurosurg Psychiatry. 1992;55:1121–4.PubMedPubMedCentralCrossRef Fogelholm R, Eskola K, Kiminkinen T, Kunnamo I. Anticoagulant treatment as a risk factor for primary intracerebral haemorrhage. J Neurol Neurosurg Psychiatry. 1992;55:1121–4.PubMedPubMedCentralCrossRef
67.
Zurück zum Zitat Radberg JA, Olsson JE, Radberg CT. Prognostic parameters in spontaneous intracerebral hematomas with special reference to anticoagulant treatment. Stroke. 1991;22:571–6.PubMedCrossRef Radberg JA, Olsson JE, Radberg CT. Prognostic parameters in spontaneous intracerebral hematomas with special reference to anticoagulant treatment. Stroke. 1991;22:571–6.PubMedCrossRef
68.
Zurück zum Zitat Launbjerg J, Egeblad H, Heaf J, Nielsen NH, Fugleholm AM, Ladefoged K. Bleeding complications to oral anticoagulant therapy: multivariate analysis of 1010 treatment years in 551 outpatients. J Intern Med. 1991;229:351–5.PubMedCrossRef Launbjerg J, Egeblad H, Heaf J, Nielsen NH, Fugleholm AM, Ladefoged K. Bleeding complications to oral anticoagulant therapy: multivariate analysis of 1010 treatment years in 551 outpatients. J Intern Med. 1991;229:351–5.PubMedCrossRef
69.
Zurück zum Zitat Fihn SD, McDonell M, Martin D, Henikoff J, Vermes D, Kent D, et al. Risk factors for complications of chronic anticoagulation. Ann Intern Med. 1993;118:511–20.PubMedCrossRef Fihn SD, McDonell M, Martin D, Henikoff J, Vermes D, Kent D, et al. Risk factors for complications of chronic anticoagulation. Ann Intern Med. 1993;118:511–20.PubMedCrossRef
70.
Zurück zum Zitat Tata LJ, Fortun PJ, Hubbard RB, Smeeth L, Hawkey CJ, Smith CJ, et al. Does concurrent prescription of selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs substantially increase the risk of upper gastrointestinal bleeding? Aliment Pharmacol Ther. 2005;22:175–81.PubMedCrossRef Tata LJ, Fortun PJ, Hubbard RB, Smeeth L, Hawkey CJ, Smith CJ, et al. Does concurrent prescription of selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs substantially increase the risk of upper gastrointestinal bleeding? Aliment Pharmacol Ther. 2005;22:175–81.PubMedCrossRef
71.
Zurück zum Zitat Hart RG, Boop BS, Anderson DC. Oral anticoagulants and intracranial hemorrhage: facts and hypotheses. Stroke. 1995;26:1471–7.PubMedCrossRef Hart RG, Boop BS, Anderson DC. Oral anticoagulants and intracranial hemorrhage: facts and hypotheses. Stroke. 1995;26:1471–7.PubMedCrossRef
72.
Zurück zum Zitat Thrift AG, McNeil JJ, Forbes A, Donnan GA. Risk factors for cerebral hemorrhage in the era of well-controlled hypertension. Stroke. 1996;27:2020–5.PubMedCrossRef Thrift AG, McNeil JJ, Forbes A, Donnan GA. Risk factors for cerebral hemorrhage in the era of well-controlled hypertension. Stroke. 1996;27:2020–5.PubMedCrossRef
73.
Zurück zum Zitat Thrift AG, McNeil JJ, Forbes A, Donnan GA. Risk of primary intracerebral haemorrhage associated with aspirin and non-steroidal anti-inflammatory drugs: case-control study. Br Med J. 1999;318:759–64.CrossRef Thrift AG, McNeil JJ, Forbes A, Donnan GA. Risk of primary intracerebral haemorrhage associated with aspirin and non-steroidal anti-inflammatory drugs: case-control study. Br Med J. 1999;318:759–64.CrossRef
Metadaten
Titel
Risk Factors for Anticoagulant-Associated Intracranial Hemorrhage: A Systematic Review and Meta-analysis
verfasst von
Zhiwei Zeng
Jiana Chen
Jiafen Qian
Fuxin Ma
Meina Lv
Jinhua Zhang
Publikationsdatum
20.01.2023
Verlag
Springer US
Erschienen in
Neurocritical Care / Ausgabe 3/2023
Print ISSN: 1541-6933
Elektronische ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-022-01671-4

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