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International Journal of Colorectal Disease

Erschienen in:

05.08.2017 | Original Article

Risk factors for delayed colonic post-polypectomy bleeding: a systematic review and meta-analysis

verfasst von: Veeravich Jaruvongvanich, Narut Prasitlumkum, Buravej Assavapongpaiboon, Sakolwan Suchartlikitwong, Anawin Sanguankeo, Sikarin Upala

Erschienen in: International Journal of Colorectal Disease | Ausgabe 10/2017

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Abstract

Purpose

Delayed post-polypectomy bleeding (PPB) is an infrequent but serious adverse event after colonoscopic polypectomy. Several studies have tried to identify risk factors for delayed PPB, with inconsistent results. This meta-analysis aims to identify significant risk factors for delayed PPB.

Methods

MEDLINE and EMBASE databases were searched through January 2016 for studies that investigated the risk factors for delayed PPB. Pooled odds ratio (OR) for categorical variables and mean differences (MD) for continuous variables and 95% confidence interval (CI) were calculated using a random-effect model, generic inverse variance method. The between-study heterogeneity of effect size was quantified using the Q statistic and I ².

Results

Twelve articles involving 14,313 patients were included. The pooled delayed PPB rate was 1.5% (95%CI, 0.7–3.4%), I ² = 96%. Cardiovascular disease (OR = 1.55), hypertension (OR = 1.53), polyp size > 10 mm (OR = 3.41), and polyps located in the right colon (OR = 1.60) were identified as significant risk factors for delayed PPB, whereas age, sex, alcohol use, smoking, diabetes, cerebrovascular disease, pedunculated morphology, and carcinoma histology were not.

Conclusions

Cardiovascular disease, hypertension, polyp size, and polyp location were associated with delayed PPB. More caution is needed when removing polyps in patients with these risk factors. Future studies are warranted to determine appropriate preventive hemostatic measures in these patients.

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Titel: Risk factors for delayed colonic post-polypectomy bleeding: a systematic review and meta-analysis
verfasst von: Veeravich Jaruvongvanich
Narut Prasitlumkum
Buravej Assavapongpaiboon
Sakolwan Suchartlikitwong
Anawin Sanguankeo
Sikarin Upala
Publikationsdatum: 05.08.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: International Journal of Colorectal Disease / Ausgabe 10/2017
Print ISSN: 0179-1958
Elektronische ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-017-2870-0

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Risk factors for delayed colonic post-polypectomy bleeding: a systematic review and meta-analysis