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21.04.2018 | Original Paper

Risk factors for metastasis at presentation with conventional chondrosarcoma: a population-based study

Zeitschrift:
International Orthopaedics
Autoren:
Kehan Song, Xiao Shi, Xin Liang, Hongli Wang, Fei Zou, Feizhou Lu, Xiaosheng Ma, Jianyuan Jiang
Wichtige Hinweise
Kehan Song and Xiao Shi contributed equally to this work.

Abstract

Purpose

The aim of the study was to investigate risk factors for metastasis at diagnosis.

Methods

We collected patients diagnosed with conventional chondrosarcoma between 1983 and 2014 from the Surveillance, Epidemiology, and End Results (SEER) database. Each patient was classified as having metastatic or localized disease. Univariate and multivariate logistic regression analyses were applied to determine which characteristics were risk factors for metastasis at diagnosis.

Results

Two thousand three hundred forty-nine patients were collected and 180 patients had metastasis at presentation. Data on age, gender, primary site, grade, and tumour size were enrolled into the multivariate logistic analysis. Greater age (60 years or older: OR = 1.872, 95% CI, 1.206 to 2.904), axial or craniofacial location (spine: OR = 1.775, 95% CI, 1.188 to 2.651; thoracic cage: OR = 2.034, 95% CI, 1.321 to 3.134; craniofacial bones: OR = 5.507, 95% CI, 3.001 to 10.107), higher grade (grade II: OR = 1.849, 95%CI, 1.181 to 2.895; grade III: OR = 4.016, 95%CI, 2.513 to 6.418), and larger tumour size (size over 10 cm: OR = 7.135, 95%CI, 2.130 to 23.893) were associated with an increased risk of metastasis at presentation.

Conclusions

Conventional chondrosarcoma patients with greater age, axial or craniofacial tumour location, higher grade, and larger tumor size were more likely to have metastasis at diagnosis.

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