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Erschienen in: Indian Journal of Gastroenterology 5/2017

04.10.2017 | Original Article

Risk factors for non-alcoholic fatty liver disease are common in patients with non-B non-C hepatocellular carcinoma in India

verfasst von: Deepu David, Anantharam Raghavendran, Ashish Goel, C. Bharath Kumar, Thomas Alex Kodiatte, Deepak Burad, Priya Abraham, Banumathi Ramakrishna, Philip Joseph, Jeyamani Ramachandran, C. E. Eapen

Erschienen in: Indian Journal of Gastroenterology | Ausgabe 5/2017

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Abstract

Aim of the study

The aim of the study was to analyze the prevalence of risk factors for non-alcoholic fatty liver disease (NAFLD) in patients with non-B non-C hepatocellular carcinoma (HCC).

Methods

Between June 2012 and November 2014, patients with HCC, negative for hepatitis B surface antigen and hepatitis C virus antibody, were included in this study. All patients were assessed for risk factors for NAFLD such as diabetes mellitus (DM), hypertension, dyslipidemia, metabolic syndrome, and obesity.

Results

Forty-seven patients with non-B non-C HCC (males, 37; age, 60±10 years; mean±SD) were studied. Model for end-stage liver disease score was 11±4. Twenty-five patients were in Child’s class A. History of significant alcohol intake was noted in 11 (23%) patients. Prevalence of risk factors for NAFLD were obesity 24 (51%), DM 22 (47%), metabolic syndrome 21 (45%), hypertension 16 (34%), and dyslipidemia 13 (28%). Forty (85%) patients had at least one risk factor for NAFLD. The mean duration of at least one NAFLD risk factor was 7.5 years, prior to diagnosis of HCC. Thirteen (28%) patients were positive for anti-HBc; however, none of the study patients had detectable HBV DNA in blood.

Conclusions

Eighty-five percent of the patients with non-B non-C HCC had at least one risk factor for NAFLD. None of the study patients had occult hepatitis B infection. NAFLD is emerging as the major etiological contributing factor for non-B non-C HCC in India.
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Metadaten
Titel
Risk factors for non-alcoholic fatty liver disease are common in patients with non-B non-C hepatocellular carcinoma in India
verfasst von
Deepu David
Anantharam Raghavendran
Ashish Goel
C. Bharath Kumar
Thomas Alex Kodiatte
Deepak Burad
Priya Abraham
Banumathi Ramakrishna
Philip Joseph
Jeyamani Ramachandran
C. E. Eapen
Publikationsdatum
04.10.2017
Verlag
Springer India
Erschienen in
Indian Journal of Gastroenterology / Ausgabe 5/2017
Print ISSN: 0254-8860
Elektronische ISSN: 0975-0711
DOI
https://doi.org/10.1007/s12664-017-0785-x

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