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16.11.2016 | Radiation Oncology | Ausgabe 5/2017

Annals of Surgical Oncology 5/2017

Risk Factors Leading to Complications in Early-Stage Breast Cancer Following Breast-Conserving Surgery and Intraoperative Radiotherapy

Zeitschrift:
Annals of Surgical Oncology > Ausgabe 5/2017
Autoren:
MD Sunpreet Rakhra, MD Kevin Bethke, MD, MBA Jonathan Strauss, MD John P. Hayes, MD Nora Hansen, MD Seema A. Khan, PhD Irene Helenowski, MD Eric D. Donnelly
Wichtige Hinweise
This work was presented as a poster at the 56th Annual Meeting of the American Society of Radiation Oncology, San Francisco, CA, USA, 14–17 September 2014.

Abstract

Objective

The aim of this study was to evaluate outcomes after breast-conserving surgery (BCS) and intraoperative radiotherapy (IORT), and to identify risk factors associated with complications.

Materials/Methods

We evaluated patients with early-stage breast cancer treated from January 1, 2011 to January 31, 2014 with BCS and IORT at a single institution. The presence of breast cancer recurrences, complications, or fat necrosis were assessed at subsequent follow-up visits using physical examination and breast imaging.

Results

Overall, 113 patients, of whom three were undergoing bilateral treatments, were identified. The median length of time for IORT was 29 min and 36 s (range 15:50–59:00). Fifteen patients received additional external beam radiotherapy (EBRT), and the median follow-up was 40.3 months (range 1.6–58.3) for all patients. To date, one biopsy-proven ipsilateral recurrence has been noted (0.9%), for which the patient elected to undergo a mastectomy. Nine patients were found to have wound complications (7.7%) and two had fat necrosis (1.7%) on follow-up. Of all the evaluated risk factors, only applicator size (p < 0.01) had a statistically significant association with an increase in complications.

Conclusions

With a short follow-up, IORT appears to be a safe treatment modality for a select group of patients, leading to a reasonable increase in operating room time and complication rates following BCS. The utilization of larger applicators at the time of IORT was associated with an increase in wound complications and fat necrosis.

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