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06.09.2024

Risk of incident venous thromboembolism in patients with atopic dermatitis: systematic analysis of the literature and meta-analysis

verfasst von: Yifei Wang, Zhiqiang Chen, Ting He, Changzheng Huang, Chen Shen

Erschienen in: Journal of Thrombosis and Thrombolysis

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Highlights

Previous studies have showed conflicting results regarding the association between atopic dermatitis (AD) and venous thromboembolism (VTE) events.

Based on our systematic review of 6 cohort studies, patients with AD have an increased risk of VTE events.

These findings provide key evidence-based estimates to inform decision-making that VTE is a comorbidity of AD.

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Langan SM, Irvine AD, Weidinger S (2020) Atopic dermatitis. Lancet 396(10247):345–360. https://doi.org/10.1016/s0140-6736(20)31286-1CrossRefPubMed

Weidinger S et al (2018) Atopic dermatitis. Nat Rev Dis Primers 4(1). https://doi.org/10.1038/s41572-018-0001-z

Eichenfield LF et al (2014) Guidelines of care for the management of atopic dermatitis: Sect. 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol 70(2):338–351. https://doi.org/10.1016/j.jaad.2013.10.010CrossRefPubMed

Ascott A et al (2019) Atopic eczema and major cardiovascular outcomes: a systematic review and meta-analysis of population-based studies. J Allergy Clin Immunol 143(5):1821–1829. https://doi.org/10.1016/j.jaci.2018.11.030CrossRefPubMedPubMedCentral

Silverwood RJ et al (2018) Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study. BMJ (clinical research ed. 361. https://doi.org/10.1136/bmj.k1786

Arshad N et al (2017) Recurrence and mortality after first venous thromboembolism in a large population-based cohort. J Thromb Haemostasis: JTH 15(2):295–303. https://doi.org/10.1111/jth.13587CrossRef

Cohen AT et al (2017) Epidemiology of first and recurrent venous thromboembolism in patients with active cancer. A population-based cohort study. Thromb Haemost 117(1):57–65. https://doi.org/10.1160/TH15-08-0686CrossRefPubMed

Riva N, Donadini MP, Ageno W (2015) Epidemiology and pathophysiology of venous thromboembolism: similarities with atherothrombosis and the role of inflammation. Thromb Haemost 113(6):1176–1183. https://doi.org/10.1160/TH14-06-0563CrossRefPubMed

Tamagawa-Mineoka R et al (2008) Elevated platelet activation in patients with atopic dermatitis and psoriasis: increased plasma levels of beta-thromboglobulin and platelet factor 4. Allergology International: Official J Japanese Soc Allergology 57(4):391–396. https://doi.org/10.2332/allergolint.O-08-537CrossRef

10.

Piazza G, Ridker PM (2015) Is venous thromboembolism a chronic inflammatory disease? Clin Chem 61(2):313–316. https://doi.org/10.1373/clinchem.2014.234088CrossRefPubMed

11.

Shaheen MS, Silverberg JI (2021) Association of inflammatory skin diseases with venous thromboembolism in US adults. Arch Dermatol Res 313(4):281–289. https://doi.org/10.1007/s00403-020-02099-6CrossRefPubMed

12.

Chen T-L et al (2022) Association of risk of incident venous thromboembolism with atopic dermatitis and treatment with Janus kinase inhibitors: a systematic review and Meta-analysis. JAMA Dermatology 158(11):1254–1261. https://doi.org/10.1001/jamadermatol.2022.3516CrossRefPubMedPubMedCentral

13.

Merola JF et al (2024) Venous thromboembolism risk is lower in patients with atopic dermatitis than other immune-mediated inflammatory diseases: a retrospective, observational, comparative cohort study using US claims data. J Am Acad Dermatol 90(5):935–944. https://doi.org/10.1016/j.jaad.2023.12.027CrossRefPubMed

14.

Afonso J et al (2023) The perils of Misinterpreting and Misusing Publication Bias in Meta-analyses: an Education Review on Funnel plot-based methods. Sports Medicine (Auckland, N.Z.) https://doi.org/10.1007/s40279-023-01927-9

15.

Meyers KJ et al (2021) Risk of venous thromboembolism among patients with atopic dermatitis: a Cohort Study in a US administrative claims database. Dermatology Therapy 11(3):1041–1052. https://doi.org/10.1007/s13555-021-00538-4CrossRefPubMedPubMedCentral

16.

Zirpel H et al (2024) Atopic dermatitis is associated with an increased risk of cardiovascular diseases: a large-scale, propensity-matched US-based retrospective study. Clin Exp Dermatol. https://doi.org/10.1093/ced/llae164CrossRefPubMed

17.

Wan J et al (2023) Incidence of Cardiovascular Disease and venous thromboembolism in patients with atopic dermatitis. The Journal of Allergy and Clinical Immunology. Practice 11(10). https://doi.org/10.1016/j.jaip.2023.08.007

18.

Warren RB et al (2023) The risk of venous thromboembolism in atopic dermatitis: a matched cohort analysis in UK primary care. Br J Dermatol 189(4):427–436. https://doi.org/10.1093/bjd/ljad212CrossRefPubMed

19.

Chen T-L et al (2023) Risk of venous thromboembolism among adults with atopic dermatitis. JAMA Dermatology 159(7):720–727. https://doi.org/10.1001/jamadermatol.2023.1300CrossRefPubMedPubMedCentral

20.

Schneeweiss MC et al (2021) Incidence of venous thromboembolism in patients with dermatologist-diagnosed chronic inflammatory skin diseases. JAMA Dermatology 157(7):805–816. https://doi.org/10.1001/jamadermatol.2021.1570CrossRefPubMed

21.

Bello N et al (2023) Systematic Literature Review and Meta-analysis of venous thromboembolism events in systemic Lupus Erythematosus. Rheumatol Therapy 10(1). https://doi.org/10.1007/s40744-022-00513-1

22.

Grainge MJ, West J, Card TR (2010) Venous thromboembolism during active disease and remission in inflammatory bowel disease: a cohort study. Lancet (London England) 375(9715):657–663. https://doi.org/10.1016/S0140-6736(09)61963-2CrossRefPubMed

23.

Chen T-L et al (2022) Association of Psoriasis With Incident venous thromboembolism and peripheral vascular disease: a systematic review and Meta-analysis. JAMA Dermatology 158(1):59–67. https://doi.org/10.1001/jamadermatol.2021.4918CrossRefPubMed

24.

Davis DMR et al (2022) American Academy of Dermatology Guidelines: awareness of comorbidities associated with atopic dermatitis in adults. J Am Acad Dermatol 86(6). https://www.jaad.org/article/S0190-9622(22)00080-9/fulltext

25.

Brunner PM et al (2017) The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins. Sci Rep 7(1):8707. https://doi.org/10.1038/s41598-017-09207-zCrossRefPubMedPubMedCentral

26.

Réau V et al (2021) Venous thrombosis and predictors of relapse in eosinophil-related diseases. Sci Rep 11(1):6388. https://doi.org/10.1038/s41598-021-85852-9CrossRefPubMedPubMedCentral

27.

Nastałek M, Wojas-Pelc A, Undas A (2010) Plasma fibrin clot properties in atopic dermatitis: links between thrombosis and atopy. J Thromb Thrombolysis 30(2):121–126. https://doi.org/10.1007/s11239-010-0478-0CrossRefPubMed

28.

Wollenberg A et al (2020) Summary of efficacy, impact on work productivity and activity, and safety of baricitinib in moderateto-severe atopic dermatitis from two monotherapy phase III trials. British Journal of Dermatology, 183(SUPPL 1): p. 66.https://doi.org/10.1111/bjd.18968

29.

Del Duca E et al (2023) Proteomic characterization of atopic dermatitis blood from infancy to adulthood. J Am Acad Dermatol 88(5):1083–1093. https://pubmed.ncbi.nlm.nih.gov/36773824/

30.

Pavel AB et al (2020) The proteomic skin profile of moderate-to-severe atopic dermatitis patients shows an inflammatory signature. J Am Acad Dermatol 82(3):690–699. https://doi.org/10.1016/j.jaad.2019.10.039CrossRefPubMed

31.

He H et al (2021) Mild atopic dermatitis lacks systemic inflammation and shows reduced nonlesional skin abnormalities. J Allergy Clin Immunol 147(4):1369–1380. https://doi.org/10.1016/j.jaci.2020.08.041CrossRefPubMed

32.

Hedderson MM et al (2022) Rates of cardiovascular events among patients with moderate-to-severe atopic dermatitis in an integrated health care system: a retrospective cohort study. PLoS ONE 17(11):e. https://doi.org/10.1371/journal.pone.0277469CrossRef

33.

Silverberg JI et al (2020) Validation of five patient-reported outcomes for atopic dermatitis severity in adults. Br J Dermatol 182(1):104–111. https://doi.org/10.1111/bjd.18002CrossRefPubMed

Titel: Risk of incident venous thromboembolism in patients with atopic dermatitis: systematic analysis of the literature and meta-analysis
verfasst von: Yifei Wang
Zhiqiang Chen
Ting He
Changzheng Huang
Chen Shen
Publikationsdatum: 06.09.2024
Verlag: Springer US
Erschienen in: Journal of Thrombosis and Thrombolysis
Print ISSN: 0929-5305
Elektronische ISSN: 1573-742X
DOI: https://doi.org/10.1007/s11239-024-03038-2

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